Pediatric Allergy Immunology and Pulmonology最新文献

{"title":"Acknowledgment of Reviewers 2021.","authors":"","doi":"10.1089/vio.2021.29029.ack","DOIUrl":"https://doi.org/10.1089/vio.2021.29029.ack","url":null,"abstract":"","PeriodicalId":54389,"journal":{"name":"Pediatric Allergy Immunology and Pulmonology","volume":" ","pages":""},"PeriodicalIF":0.9,"publicationDate":"2022-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48806877","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effect of Serum Vitamin D Level on Allergic Rhinitis Symptoms in Children.","authors":"Zeynep Haziroglu Okmen,&nbsp;Mehmet Halil Celiksoy,&nbsp;Erdem Topal","doi":"10.1089/ped.2021.0161","DOIUrl":"https://doi.org/10.1089/ped.2021.0161","url":null,"abstract":"<p><p><b><i>Background:</i></b> Allergic rhinitis (AR) is a chronic disease that is becoming increasingly common worldwide and has a negative impact on school performance, work performance, and quality of life. The aim of this study was to investigate the effect of vitamin D on the symptoms of AR in children. <b><i>Methods:</i></b> Serum vitamin D levels of children with AR and age-matched healthy controls were compared using the high-pressure liquid chromatography method. The relationship between serum vitamin D levels and symptoms and severity of AR was then examined. <b><i>Results:</i></b> The study included 137 patients diagnosed with AR (76 males, 61 females; median age: 11 years). Serum vitamin D levels were lower in the patient group than in the control group (<i>P</i> = 0.001), lower in all aeroallergen groups (mites, pollen, and multiple inhalants) than in the healthy control group (<i>P</i> = 0.001), and lower in both the perennial AR group and the seasonal AR group than in the control group (<i>P</i> = 0.001). Spearman correlation analysis showed that there was no correlation between symptom score and vitamin D level (<i>r</i>_s = -0.099; <i>P</i> = 0.25). <b><i>Conclusions:</i></b> We found no correlation between serum vitamin D level and symptoms and severity of AR. Serum vitamin D levels were lower in children with AR than in healthy children.</p>","PeriodicalId":54389,"journal":{"name":"Pediatric Allergy Immunology and Pulmonology","volume":"34 4","pages":"132-140"},"PeriodicalIF":0.9,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8817683/pdf/ped.2021.0161.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39854190","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Th17 Lymphocytes in Children with Asthma: Do They Influence Control?","authors":"Verónica Moreno-Córdova, Roberto Berra-Romani, Lilian K Flores Mendoza, Julio Reyes-Leyva","doi":"10.1089/ped.2021.0067","DOIUrl":"10.1089/ped.2021.0067","url":null,"abstract":"<p><p><b><i>Background:</i></b> Allergic asthma was considered as an inflammation mediated by specific CD4⁺ helper lymphocytes (Th2); however, this paradigm changed in 2005, when a third group of helper cells called Th17 cells were identified. Th17 lymphocytes are the main source of interleukin (IL)-17A-F, IL-21, and IL-22; however, their physiological role in children is unclear. This study aimed to determine the percentage of Th17 cells and IL-17A in pediatric patients diagnosed with asthma and to associate it with disease control using a validated questionnaire. <b><i>Methods:</i></b> This cross-sectional, prospective, comparative study included 92 asthma-diagnosed children 4-18 years of age. The Asthma Control Test was used as an assessment measure to classify patients as controlled (<i>n</i> = 30), partially controlled (<i>n</i> = 31), and uncontrolled (<i>n</i> = 31). Th17 cells and IL-17A were analyzed by flow cytometry. Patients receiving inhaled steroid therapy as monotherapy or associated with a long-acting bronchodilator were included. <b><i>Results:</i></b> The mean percentage of Th17 cells in the participants was 4.55 ± 7.34 (Controlled), 5.50 ± 8.09 (Partially Controlled), and 6.14 ± 7.11 (Uncontrolled). There was no significant difference between the 3 groups (<i>P</i> = 0.71). The mean percentage of IL-17A in all the participants was 9.84 ± 9.4 (Controlled), 10.10 ± 10.5 (Partially Controlled), and 11.42 ± 8.96 (Uncontrolled); no significant difference between the 3 groups (<i>P</i> = 0.79) was observed. Th17 lymphocyte levels were similar among the 3 groups and the same trend was observed with IL-17A. A significant correlation between Th17 or IL-17A and the degree of asthma control (Th17, <i>P</i> = 0.24; IL-17A, <i>P</i> = 0.23) was not found. <b><i>Conclusions:</i></b> The percentages of both Th17 lymphocytes and IL-17A found in children with asthma were not significantly different in the 3 groups, which suggests that they do not play an important role in asthma control. Our findings may contribute to the knowledge related to non-Th2 inflammation in children. Clinical-Trials.gov ID: 2015-2102-85.</p>","PeriodicalId":54389,"journal":{"name":"Pediatric Allergy Immunology and Pulmonology","volume":"34 4","pages":"147-152"},"PeriodicalIF":1.1,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8817680/pdf/ped.2021.0067.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39765089","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Salivary C-Reactive Protein and Mean Platelet Volume in the Diagnosis and Follow-Up of Community-Acquired Pneumonia in Infants.","authors":"Ahmed Omran,&nbsp;Hala Abohadid,&nbsp;Mai H S Mohammad,&nbsp;Sherien Shalaby","doi":"10.1089/ped.2021.0077","DOIUrl":"https://doi.org/10.1089/ped.2021.0077","url":null,"abstract":"<p><p><b><i>Background:</i></b> Community-acquired pneumonia (CAP) in infants is a major cause of morbidity and mortality, especially in developing countries. Increased salivary C-reactive protein (CRP) levels have been demonstrated in neonatal pneumonia and other diseases. We investigated the applicability of CRP and mean platelet volume (MPV) in the diagnosis and follow-up of CAP in infants. <b><i>Methods:</i></b> This prospective observational study included 45 infants admitted for CAP. We measured serum and salivary CRP levels via ELISA, while MPV was measured using an automated blood cell counter. <b><i>Results:</i></b> Both salivary and serum CRP values were significantly different in the studied population between admission and follow-up (<i>P</i> = 0.001 and <i>P</i> < 0.0001, respectively). The same was observed for MPV (<i>P</i> < 0.0001). We found significant positive correlations between serum and salivary CRP (<i>r</i> = 0.652, <i>P</i> < 0.0001) and between serum CRP and MPV (<i>r</i> = 0.495, <i>P</i> = 0.001), as well as between salivary CRP and MPV (<i>r</i> = 0.439, <i>P</i> = 0.003). Receiver operating curve analysis showed that salivary CRP at a cutoff value of 3.2 ng/L had a sensitivity of 97.2% and specificity of 90%, while MPV at a cutoff value of 8.4 fL showed 91% sensitivity and 90% specificity. <b><i>Conclusions:</i></b> The present study showed that both salivary CRP and MPV are reliable diagnostic markers of CAP in infants.</p>","PeriodicalId":54389,"journal":{"name":"Pediatric Allergy Immunology and Pulmonology","volume":"34 4","pages":"141-146"},"PeriodicalIF":0.9,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8817682/pdf/ped.2021.0077.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39942071","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diurnal Variations in Skin Prick Testing.","authors":"Elisa Ochfeld,&nbsp;Brian Cheng,&nbsp;Nina Bowsher,&nbsp;Anna Fishbein","doi":"10.1089/ped.2021.0055","DOIUrl":"https://doi.org/10.1089/ped.2021.0055","url":null,"abstract":"<p><p><b><i>Background:</i></b> Prior research suggests that skin prick testing (SPT) might be larger in the afternoon, with unclear clinical significance. <b><i>Methods:</i></b> This retrospective chart review analyzed SPT results from patients between June 2008 and June 2017, organized into 4 time groups for analysis (Group 1: 7:00 AM -10:29 AM, Group 2: 10:30 AM -11:59 AM, Group 3: 12:00 PM -2:29 PM, and Group 4: 2:30 PM -8:15 PM). <b><i>Results:</i></b> In total, 12,982 (<i>n</i>) patient test results had positive histamine and were included in final analysis. Histamine wheal size was not significantly increased in the PM compared with AM (<i>P</i> = 0.89). Food allergen and aeroallergen wheal sizes were not significantly increased in PM. Histamine erythema size was increased in the PM compared with AM (<i>P</i> ≤ 0.01). Food allergen and aeroallergen erythema sizes trended toward an increase in the PM. <b><i>Conclusions:</i></b> There were not significant differences in SPT wheal size based on time of day for histamine, food allergens, or aeroallergens. SPT can be reliably performed at any time of day.</p>","PeriodicalId":54389,"journal":{"name":"Pediatric Allergy Immunology and Pulmonology","volume":"34 4","pages":"125-129"},"PeriodicalIF":0.9,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8742273/pdf/ped.2021.0055.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39662046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Telehealth and Remote Patient Monitoring After the COVID Pandemic.","authors":"Satyanarayan Hegde,&nbsp;Nemr S Eid","doi":"10.1089/ped.2021.0162","DOIUrl":"https://doi.org/10.1089/ped.2021.0162","url":null,"abstract":"","PeriodicalId":54389,"journal":{"name":"Pediatric Allergy Immunology and Pulmonology","volume":"34 4","pages":"130-131"},"PeriodicalIF":0.9,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8817681/pdf/ped.2021.0162.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39581909","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Everything That Wheezes Is Not Asthma: A Case Report.","authors":"Sagar K Shah,&nbsp;Natalie Sabzghabaei","doi":"10.1089/ped.2021.0006","DOIUrl":"https://doi.org/10.1089/ped.2021.0006","url":null,"abstract":"<p><p><b><i>Background:</i></b> This case report provides the general pediatrician with insight on a unique presentation of an already rare disease. Plastic bronchitis (PB) is an exceedingly rare disease that presents with the formation of casts in the endobronchial tree. This typically occurs in patients with congenital heart defects that have undergone repair, however, it is atypical to be seen in otherwise healthy patients. Influenza A, lymphatic abnormalities, and single ventricle physiology are the only proven causes of PB. Asthma, toxic inhalation, and acute chest syndrome, however, are a few of the many conditions that have been proposed to predispose patients toward developing PB. <b><i>Case Presentation:</i></b> Thus, it is important to discuss the case of a 9-year-old boy with a history of uncontrolled asthma who presented with cough, chills, weight loss, and fevers. This patient was initially treated with broad-spectrum antibiotics due to concerns for necrotizing pneumonia, but due to failure in improvement, a direct laryngoscopy and bronchoscopy was performed, revealing the diagnosis of PB. Although this patient had a history of uncontrolled asthma, this was the only predisposing respiratory condition that put him at risk of developing PB. This patient went on to be treated with corticosteroids, chest physiotherapy, inhaled fibrinolytics, and direct fibrinolytic therapy with marked improvement in symptoms and imaging. <b><i>Conclusion:</i></b> PB, though rare, is a condition that all pediatricians must keep in their minds when patients present with respiratory symptoms with an unclear etiology. The delay in diagnosis and treatment of patients with PB can be detrimental as expectoration of these casts can result in asphyxiation and death. This article goes on to remind all providers, at all levels, the importance of conducting a thorough history/physical examination, creating a broad differential, and treating each patient holistically.</p>","PeriodicalId":54389,"journal":{"name":"Pediatric Allergy Immunology and Pulmonology","volume":"34 3","pages":"119-123"},"PeriodicalIF":0.9,"publicationDate":"2021-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8664116/pdf/ped.2021.0006.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39246189","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Serum Level of Squamous Cell Carcinoma Antigen as a Real-Time Biomarker of Atopic Dermatitis.","authors":"Masaki Shimomura,&nbsp;Yuka Okura,&nbsp;Yutaka Takahashi,&nbsp;Ichiro Kobayashi","doi":"10.1089/ped.2021.0049","DOIUrl":"https://doi.org/10.1089/ped.2021.0049","url":null,"abstract":"<p><p><b><i>Background:</i></b> Although serum levels of squamous cell carcinoma antigen (SCCA) are elevated in atopic dermatitis (AD), their clinical utility has not been fully elucidated. <b><i>Methods:</i></b> Thirty-three cases of AD who admitted to our hospital were analyzed. <b><i>Results:</i></b> Baseline characteristics on admission were as follows: median age 19 months [interquartile range (IQR), 12-52 months], median objective severity scoring of atopic dermatitis (O-SCORAD) 19.2 (IQR, 4.2-36.0), and median serum SCCA levels 3.2 ng/mL (IQR, 2.1-6.8 ng/mL). O-SCORAD significantly correlated with serum SCCA levels (rs = 0.865, <i>P</i> < 0.001). In 9 cases whose information before and after treatment was available (median interval, 3 days; IQR 2-5 days), median serum SCCA levels significantly decreased from 8.0 to 2.0 ng/mL (<i>P</i> = 0.008) after the treatment. <b><i>Conclusions:</i></b> Serum levels of total SCCA rapidly declined in response to the treatment and could be used as a real-time biomarker in childhood AD.</p>","PeriodicalId":54389,"journal":{"name":"Pediatric Allergy Immunology and Pulmonology","volume":"34 3","pages":"102-105"},"PeriodicalIF":0.9,"publicationDate":"2021-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8664118/pdf/ped.2021.0049.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39329432","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Determining the Best Tool Comparable with Global Initiative for Asthma Criteria for Assessing Pediatric Asthma Control.","authors":"Ayşegül Akan,&nbsp;Emine Dibek Mısırlıoğlu,&nbsp;Ersoy Civelek,&nbsp;Can Naci Kocabaş","doi":"10.1089/ped.2020.1334","DOIUrl":"https://doi.org/10.1089/ped.2020.1334","url":null,"abstract":"<p><p><b><i>Background:</i></b> Guidelines such as Global Initiative for Asthma (GINA) recommend disease control as the mainstay of asthma management. <b><i>Objective:</i></b> To investigate which measure of asthma control best correlates with the GINA criteria for determining asthma control in children. <b><i>Methods:</i></b> Child asthma-patients at a tertiary hospital were enrolled in the study after evaluation of response to treatment. Asthma control test (ACT)/pediatric asthma control test (PACT), Pediatric Asthma Quality of Life Questionnaire (PAQLQ), fractional exhaled nitric oxide (FeNO), and lung function parameters were evaluated. Patients were examined by asthma specialists and control status was evaluated based on GINA. <b><i>Results:</i></b> The median age (interquartile range) of patients was 10.7 (8.4-12.9) years, 57.9% of patients were boys. Of 228 children, 84.2%, 9.6%, and 6.1% displayed \"well-controlled\", \"partially controlled\", and \"uncontrolled\" asthma, respectively, according to GINA. The patients with \"partially controlled\" and \"uncontrolled\" asthma were grouped as \"not well-controlled.\" The cutoff levels were 22, 21, and 5.9 for PACT, ACT, and PAQLQ, respectively, for determining \"well-controlled\" asthma (<i>P</i> < 0.001). With these cutoff values, ACT exhibited higher comparability with GINA than PACT and PAQLQ (κ = 0.473, 0.221, and 0.150, respectively, <i>P</i> < 0.001). PAQLQ had higher agreement with GINA criteria in children ≥12 years old (κ = 0.326, <i>P</i> < 0.001 and κ = 0.151, <i>P</i> = 0.014, respectively). Correctly classified patients with PACT, ACT, and PALQLQ based on GINA with these cutoff levels were 93 (64.1%), 63 (75.9%), and 139 (62.9%), respectively. FeNO and lung function parameters were unsuccessful at revealing control status according to GINA. <b><i>Conclusion:</i></b> ACT is better than PACT for comparability with GINA. Better correlation of PAQLQ and ACT and better comparability of PAQLQ and GINA were evident in older children.</p>","PeriodicalId":54389,"journal":{"name":"Pediatric Allergy Immunology and Pulmonology","volume":"34 3","pages":"89-96"},"PeriodicalIF":0.9,"publicationDate":"2021-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8664125/pdf/ped.2020.1334.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39342695","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Progressive Multifocal Leukoencephalopathy in Children with Primary and Secondary Immune Deficiency.","authors":"Asuman Demirbuğa,&nbsp;Ozge Kaba,&nbsp;Selda Hançerli Törün,&nbsp;Edibe Pembegül Yıldız,&nbsp;Esra Yücel,&nbsp;Ayper Somer","doi":"10.1089/ped.2020.1330","DOIUrl":"https://doi.org/10.1089/ped.2020.1330","url":null,"abstract":"<p><p>Progressive multifocal leukoencephalopathy (PML) is a fatal demyelinating disease of the central nervous system that is caused by John Cunningham virus (JCV). It occurs almost exclusively in immunosuppressed individuals, for example, patients with AIDS and hematological and lymphoreticular malignancies. In this article, we present a review of the literature and 2 case reports with PML. The first report examines a 15-year-old male (who presented with dedicator of cytokinesis 8 deficiency) who was diagnosed as having PML based on characteristic magnetic resonance imaging (MRI) lesions and a positive PCR for JCV in cerebrospinal fluid. He was transferred for bone marrow transplantation after stabilization with therapy of maraviroc and cidofovir. The second report examines a 6-year-old male who presented with encephalitis and was also diagnosed with AIDS. He was diagnosed with PML and started treatment with cidofovir. His clinical status and MRI findings deteriorated rapidly. In immunosuppressive patients who developed encephalopathy, JCV ought to be considered.</p>","PeriodicalId":54389,"journal":{"name":"Pediatric Allergy Immunology and Pulmonology","volume":"34 3","pages":"109-111"},"PeriodicalIF":0.9,"publicationDate":"2021-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8664112/pdf/ped.2020.1330.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39243632","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}