Pediatric Allergy Immunology and Pulmonology最新文献

{"title":"An <i>IRF2BP2</i> Variant in a Pediatric Patient with Common Variable Immunodeficiency.","authors":"Demet Tekcan, Ayca Ceylan, Ilknur Kulhas Celik, Hasibe Artac","doi":"10.1177/2151321X251360561","DOIUrl":"https://doi.org/10.1177/2151321X251360561","url":null,"abstract":"<p><p><b><i>Background:</i></b> Interferon regulatory factor-2 binding protein 2 (<i>IRF2BP2</i>) is an important new transcriptional cofactor that interacts with IFN regulatory factor 2 (IRF-2) and an IRF-2-dependent transcriptional repressor. <i>IRF2BP2</i> plays a role in different cellular functions, including apoptosis, survival, and cell differentiation. In this study, we report a case with common variable immunodeficiency (CVID), which has a heterozygous variant in the <i>IRF2BP2</i> gene. <b><i>Case Presentation:</i></b> A 13-year-old girl was evaluated for immunodeficiency due to recurrent sinusitis and tonsillitis in the previous year. She had been suffering from chronic cough for 3 months. She was hospitalized with lobar pneumonia and bronchiectasis. She was the second child of consanguineous parents. On physical examination, there was no growth and development retardation. Immunological screening of the patient demonstrated panhypogammaglobulinemia with low total memory B and class-switching memory B cells. Specific antibody responses to rubella and hepatitis B were negative. T- and B-lymphocyte counts and T-cell responses to phytohemagglutinin (PHA) were normal. Exome sequencing identified a heterozygous variant in <i>IRF2BP2</i> (c.112C>Tp.Arg38Cys). On follow-up, she has maintained a good infection control with antibiotic prophylaxis and immunoglobulin replacement therapy. <b><i>Conclusion:</i></b> To the best of our knowledge, this case is the youngest CVID who was diagnosed with <i>IRF2BP2</i> in the literature. The low percentage of total memory and switched memory B cells in the proband suggested that <i>IRF2BP2</i> might have had a role in the development or survival of memory B cells. Functional studies are needed about the critical role of <i>IRF2BP2</i> protein in B-cell maturation and humoral immune responses.</p>","PeriodicalId":54389,"journal":{"name":"Pediatric Allergy Immunology and Pulmonology","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144676536","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Changes in Respiratory Care Use During the COVID-19 Pandemic in a Pediatric Long-Term Care Facility.","authors":"Rose Hawkins, Corrie Harris, Heather Huxol, Scott Bickel, Mary Elise McClanahan, Theresa Kluthe, Ronald Morton","doi":"10.1089/ped.2024.0125","DOIUrl":"https://doi.org/10.1089/ped.2024.0125","url":null,"abstract":"<p><p><b><i>Background:</i></b> The COVID-19 pandemic impacted multiple aspects of care at pediatric long-term care facilities (pLTCFs). This study evaluated the effect of COVID-19 infection control policies on pLTCF resident's respiratory health. <b><i>Methods:</i></b> A retrospective study of 76 residents' oxygen, albuterol, hypertonic saline (HTS), and pulmonary hygiene treatment use from January 2019 to December 2022 was completed using de-identified billing data and chart review. <b><i>Results:</i></b> There was a statistically significant increase in rate of oxygen use among residents (5.67; 95% CI 3.44-7.8; <i>P</i> < 0.001) during the study period, but at a slower rate than expected by the pre-pandemic trend (-4.89; 95% CI -7.20-2.59; <i>P</i> < 0.001). HTS use decreased during the study period, with a change in the prior trend to downward (-3.43; -5.89-9.68; <i>P</i> = 0.007). There was no significant change in albuterol or pulmonary hygiene treatment. <b><i>Conclusions:</i></b> This study demonstrates that patterns of oxygen and HTS use in a pLTCF changed during the COVID-19 pandemic.</p>","PeriodicalId":54389,"journal":{"name":"Pediatric Allergy Immunology and Pulmonology","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144477894","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Rare Case of Systemic Reaction to Carrot Due to PR-10 in a Young Child.","authors":"C Ferrigno, C P Ratti, I Scavone, V Ortolani, Enza D'Auria","doi":"10.1089/ped.2025.0038","DOIUrl":"https://doi.org/10.1089/ped.2025.0038","url":null,"abstract":"<p><p><b><i>Background:</i></b> Pollen-Food Allergy Syndrome (PFAS) typically presents as mild oral symptoms but can rarely progress to systemic reactions. Pathogenesis-related proteins group 10 (PR-10) are proteins usually associated with oral allergy syndrome due to their thermolabile and gastrolabile properties. <b><i>Case Presentation:</i></b> We report a 12-year-old boy with birch pollen allergy who developed anaphylaxis after raw carrot consumption without identified cofactors. Previously, he experienced only oral allergy syndrome with raw carrot and fennel. Molecular diagnostics confirmed isolated PR-10 sensitization. The reaction occurred during birch pollen season, and the patient tolerated cooked carrot, consistent with PR-10's thermal instability. <b><i>Conclusions:</i></b> This case highlights how PFAS, typically characterized by mild and localized symptoms, can occasionally manifest with systemic reactions. High levels of specific IgE for Bet v 1 and pollen season may represent risk factors for systemic reactions in PFAS patients. Clinicians must be aware that allergies due to pollen cross-reactive allergens can be associated with systemic reactions.</p>","PeriodicalId":54389,"journal":{"name":"Pediatric Allergy Immunology and Pulmonology","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144477893","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"What Are Alternatives to Oral Phenylephrine in Children?","authors":"Julia Young, Kimberly Novak, Paul M Boylan","doi":"10.1089/ped.2025.0031","DOIUrl":"https://doi.org/10.1089/ped.2025.0031","url":null,"abstract":"<p><p>The United States Food and Drug Administration (FDA) proposed removing oral phenylephrine (PE) from over-the-counter single-agent and combination products because it is ineffective at FDA-approved doses to treat sinonasal congestion. Health care providers make thousands of recommendations per month for phenylephrine-containing over-the-counter products to treat adults and children with signs and symptoms of the common cold, specifically nasal congestion. Health care providers may feel compelled by parents to recommend over-the-counter medications to treat the common cold in children, despite resources suggesting those products may be mildly effective, ineffective, or possibly unsafe. The objective of this Pharmacotherapy Update is to suggest alternative treatments to PE in children with the common cold and nasal congestion.</p>","PeriodicalId":54389,"journal":{"name":"Pediatric Allergy Immunology and Pulmonology","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144289759","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Is Routine Skin Prick Testing Essential in Managing Pediatric Chronic Urticaria?","authors":"Muhammed Fatih Erbay, Şefika Kökçü Karadağ, Tuğba Üstün, Nilay Çalışkan, Güler Yıldırım, Hamit Bologur, Hilal Güngör, Merve Karaca Şahin, Aslı Berivan Topçak, Deniz Ozceker","doi":"10.1089/ped.2024.0070","DOIUrl":"10.1089/ped.2024.0070","url":null,"abstract":"<p><p><b><i>Background:</i></b> Chronic urticaria (CU) in children, persisting beyond six weeks, is less common than acute urticaria, with a prevalence of 0.1%-0.3%. CU is classified into chronic idiopathic urticaria (CIU) and chronic inducible urticaria (CIndU), with CIU having an often unknown etiology, whereas CIndU is triggered by physical stimuli. Our study aims to explore the clinical and demographic characteristics, laboratory results, and possible etiological factors in children diagnosed with CU, and to assess the necessity of aeroallergen skin prick tests (SPTs) in these patients. <b><i>Methods:</i></b> The study evaluated the medical records of 242 children with CU, treated at the Pediatric Allergy-Immunology Clinic of Prof. Dr. Cemil Taşcıoğlu City Hospital from January 2018 to January 2024. Data on age, gender, presence of angioedema, dermatographism, concomitant allergic diseases, family history of atopy, infection status, urticaria duration, SPT results, and laboratory tests were collected and analyzed. <b><i>Results:</i></b> Results showed that 48.3% of patients were females and 51.7% were males, with an average age of 12.8 years and an average onset age of 9.9 years. Angioedema was present in 15.7% of patients, dermatographism in 17.8%, concomitant allergic diseases in 24%, and a family history of atopy in 14.5%. Infections were documented in 10.8% of patients, with urinary tract infections, <i>Helicobacter pylori (H. pylori)</i> infections, and dental infections identified. <b><i>Discussion:</i></b> Our study found no significant differences in clinical features, treatment requirements, or response to treatments between patients with positive and negative SPT results. Laboratory parameters such as eosinophilia, total Immunoglobulin E (IgE), and thyroid function tests also showed no significant differences. These findings suggest that routine SPTs for the management of CU in children will only be useful if IgE-mediated allergic comorbidities are suspected but may not be necessary in other cases, prompting a reevaluation of their use in clinical practice to seek more cost-effective diagnostic methods.</p>","PeriodicalId":54389,"journal":{"name":"Pediatric Allergy Immunology and Pulmonology","volume":" ","pages":"43-48"},"PeriodicalIF":1.1,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143411460","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Profile of CD71+ Erythroid Cells in Korean Children: A Pilot Study.","authors":"Hanwool Cho, Jin-Hee Oh, Yeongsic Kim, Dae Chul Jeong","doi":"10.1089/ped.2024.0145","DOIUrl":"10.1089/ped.2024.0145","url":null,"abstract":"<p><p><b><i>Background:</i></b> CD71+ erythroid cells (CECs) play a complex immunoregulatory role. <b><i>Methods:</i></b> Flow cytometry was used to assess CECs in 84 individuals, from preterm infants to adults, divided into 5 age groups, 12 from infants under 6 months, 16 from young children (6 months-5 years), 24 from children (6-10 years), 22 from adolescents (11-19 years), and 10 from adults (≥20 years). <b><i>Results:</i></b> CECs are universally present at very low frequencies, except in individuals younger than 6 months (<i>P</i> < 0.001). Although preterm infants tended to have a higher median CECs than full-term infants, this difference was not statistically significant. Among individuals over 6 months, CECs showed significant negative correlations with hemoglobin (r = -0.448, <i>P</i> < 0.001) and hematocrit (r = -0.416, <i>P</i> < 0.001), but no such correlations were found in younger infants. <b><i>Conclusions:</i></b> CECs are present across all age groups, with higher levels in early infancy.</p>","PeriodicalId":54389,"journal":{"name":"Pediatric Allergy Immunology and Pulmonology","volume":" ","pages":"78-81"},"PeriodicalIF":1.1,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143796269","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Atopic March in a Case of Filaggrin Gene Mutation.","authors":"Anahita Razaghian, Leila Moradi, Bahar Allahverdi, Maryam Khansari Asadabadi, Zahra Alizadeh, Raheleh Shokouhi Shoormasti, Mohammadreza Fazlollahi","doi":"10.1089/ped.2024.0118","DOIUrl":"10.1089/ped.2024.0118","url":null,"abstract":"<p><p><b><i>Introduction:</i></b> The atopic march refers to the progression of allergic disorders from atopic dermatitis (AD) in early childhood to food allergies, eosinophilic esophagitis (EOE), and later respiratory allergies such as asthma and allergic rhinitis. Mutations in the filaggrin gene, which compromise skin barrier function, are strongly associated with this progression and contribute to allergic sensitization. <b><i>Case Presentation:</i></b> We introduce a 7-year-old boy with severe AD, food anaphylaxis, EOE, allergic rhinitis, and asthma associated with a filaggrin mutation (c.5152C>T). His clinical course illustrates the atopic march, with initial skin involvement progressing to gastrointestinal and respiratory allergic manifestations. <b><i>Conclusion:</i></b> Understanding the genetic factors that drive this progression may help identify targets for early intervention to prevent the further development of allergic disease.</p>","PeriodicalId":54389,"journal":{"name":"Pediatric Allergy Immunology and Pulmonology","volume":" ","pages":"61-64"},"PeriodicalIF":1.1,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143804760","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Changes in Breathing Reserves During Growth in Healthy Untrained Boys and Girls.","authors":"Xu Yatao, Fenfen Zhou, Philippe Kilian, Rui Hu, Prioux Jacques","doi":"10.1089/ped.2024.0087","DOIUrl":"10.1089/ped.2024.0087","url":null,"abstract":"<p><p><b><i>Background:</i></b> The assessment of breathing reserve (BR) is essential to determine if ventilatory function is limited during exercise. Few studies reported the values of BR in healthy children and adolescents of both sexes. This study aimed to analyze the effects of age and sex on changes in BR in healthy untrained children and adolescents during growth. <b><i>Methods:</i></b> A study was conducted in 186 healthy untrained children and adolescents (10-16 years old). Maximal ventilation (<math><mrow><mover><mrow><mi>V</mi></mrow><mo>˙</mo></mover></mrow></math>_Emax) and maximal oxygen uptake (<math><mrow><mover><mrow><mi>V</mi></mrow><mo>˙</mo></mover></mrow></math>O_2max) were measured during a maximal graded test. Forced vital capacity and forced expiratory volume in 1 s (FEV₁) were also measured. BR was expressed as a percentage of theoretical maximal voluntary ventilation (MVV) which was obtained by multiplying FEV₁ by 35. The data were assessed by one-way analysis of variance (ANOVA) and two-way ANOVA supplement a Newman-Keuls test when <i>P</i> was significant (<i>P</i> < 0.05). <b><i>Results:</i></b> Height, weight, and lean body mass increased between 11 and 16 years old. For boys,<math><mi> </mi><mrow><mover><mrow><mi>V</mi></mrow><mo>˙</mo></mover></mrow></math>O_2max, <math><mrow><mover><mrow><mi>V</mi></mrow><mo>˙</mo></mover></mrow></math>_Emax, FEV₁, and MVV increased (<i>P</i> < 0.05) between 12 and 16 years. For girls, <math><mrow><mover><mrow><mi>V</mi></mrow><mo>˙</mo></mover></mrow></math>O_2max increased (<i>P</i> < 0.05) only between 11 and 12 and 14 and 15 years. Increases in <math><mrow><mover><mrow><mi>V</mi></mrow><mo>˙</mo></mover></mrow></math>_Emax, FEV₁, and MVV were observed between 10 and 12 years and stabilized afterward. The BR in girls was higher than in boys (<i>P</i> < 0.05). There were no significant differences in BR at the same age correlated with sex during growth. <b><i>Discussion:</i></b> No significant changes were observed in BR as a function of age. BR changes during growth seem to be independent of changes in anthropometric characteristics.</p>","PeriodicalId":54389,"journal":{"name":"Pediatric Allergy Immunology and Pulmonology","volume":" ","pages":"49-56"},"PeriodicalIF":1.1,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144010238","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impulse Oscillometry is Useful in Detecting Lung Function Abnormalities in Preschoolers with Primary Ciliary Dyskinesia but Not Cystic Fibrosis: A Cross-Sectional Study Results.","authors":"Birce Sunman, Ebru Yalcin, Didem Alboga, Burcu Capraz Yavuz, Emine Altay Tanyer, Nagehan Emiralioglu, Deniz Dogru, Uğur Özçelik","doi":"10.1089/ped.2024.0142","DOIUrl":"10.1089/ped.2024.0142","url":null,"abstract":"<p><p><b><i>Background:</i></b> Although the forced oscillation technique has been used for many years in children, there is still inconclusive results about its efficiency in cystic fibrosis (CF). Moreover, no studies have been conducted on impulse oscillometry (IOS) in children with primary ciliary dyskinesia (PCD). <b><i>Methods:</i></b> Age, sex, weight, height, body mass index, and oscillometric parameters were compared in 3-6-year-old children with CF and PCD and healthy children. <b><i>Results:</i></b> This prospective study included 27 children with CF, 21 with PCD, and 27 healthy children, with mean ages of 4.11 ± 1.08, 4.33 ± 1.23, and 4.41 ± 0.79 years, respectively. No significant differences were revealed in the comparison of the z-scores of the parameters of the CF group with those of the healthy group. However, in the PCD group, z-scores of R5 and Z5 were significantly higher than those in the healthy group (<i>P</i> = 0.018 and <i>P</i> = 0.008, respectively). In addition, z-scores of X10, X15, and X20 were significantly lower in children with PCD compared with the healthy group (<i>P</i> = 0.013, <i>P</i> = 0.033, and <i>P</i> = 0.029, respectively). <b><i>Conclusions:</i></b> This first study simultaneously reporting IOS results in preschool children with CF or PCD showed a significant difference of resistance and reactance of airways between PCD and healthy children. This study is also very significant in showing that IOS can be performed in young children who are unable to cooperate with spirometry. In contrast, no such differences were noted between CF and healthy controls, possibly due to thick mucus affecting sound wave transmission through the airways in CF. In addition, IOS may be less effective in detecting early pulmonary disease, as in some studies it failed to identify abnormalities in young children with CF even when spirometry is abnormal.</p>","PeriodicalId":54389,"journal":{"name":"Pediatric Allergy Immunology and Pulmonology","volume":" ","pages":"71-77"},"PeriodicalIF":1.1,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143784513","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Is a Life Without Water Possible? Aquagenic Urticaria: Report of a Case and Review of the Literature.","authors":"Gizem Kabadayı, Damla Baysal Bakır, Halime Yağmur, Özge Atay, Nevin Uzuner","doi":"10.1089/ped.2024.0135","DOIUrl":"10.1089/ped.2024.0135","url":null,"abstract":"<p><p><b><i>Background:</i></b> Aquagenic urticaria (AU) is a rare form of physical urticaria, characterized by pruritic skin eruptions triggered by water exposure, irrespective of the water's temperature. Fewer than 100 cases have been documented. The wet towel provocation test is the diagnostic standard for AU. <b><i>Case Presentation:</i></b> A 12-year-old female patient presented with urticarial eruptions induced by water exposure and was diagnosed with AU following the wet towel provocation test. Initially, she tolerated brief water exposure; however, over time, eruptions occurred even with exposure to her sweat. Partial symptom control was achieved through preventive measures and antihistamine therapy. <b><i>Conclusions:</i></b> AU is a rare chronic condition that necessitates prompt diagnosis and tailored management strategies to improve the patient's quality of life.</p>","PeriodicalId":54389,"journal":{"name":"Pediatric Allergy Immunology and Pulmonology","volume":" ","pages":"57-60"},"PeriodicalIF":1.1,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143765921","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}