Pediatric Allergy Immunology and Pulmonology最新文献

{"title":"TauroSept-Induced Anaphylaxis: A Pediatric Case Report.","authors":"Elise Mank, Nancy Broos, Ingrid Terreehorst, Olivia Liem, Charlotte M Nusman, Anne-Loes E Gerards, Joep P M Derikx, Merit M Tabbers","doi":"10.1177/2151321X251379008","DOIUrl":"https://doi.org/10.1177/2151321X251379008","url":null,"abstract":"<p><p><b><i>Background:</i></b> Children with intestinal failure who are receiving parenteral nutrition through a central venous catheter are at risk of developing catheter-related bloodstream infections. For many years, a prophylactic lock with taurolidine has been used to decrease the incidence of these infections and is considered safe in children. <b><i>Case Presentation:</i></b> A 1-month-old boy with jejunal atresia was receiving parenteral nutrition through a central venous catheter. Shortly after administration of taurolidine (TauroSept®), he developed circulatory insufficiency and angioedema. His serum tryptase increased, which was suggestive of anaphylaxis (baseline tryptase 6.3 µg/L; 2 h after start of the reaction: 21 µg/L; cutoff criterion for clinically relevant increase: 1.2 × baseline tryptase level + 2). <b><i>Conclusions:</i></b> To the best of our knowledge, this is the first case of anaphylaxis in response to TauroSept® in an infant worldwide. Clinicians should be aware of this possible but very rare side effect.</p>","PeriodicalId":54389,"journal":{"name":"Pediatric Allergy Immunology and Pulmonology","volume":" ","pages":""},"PeriodicalIF":0.8,"publicationDate":"2025-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145034709","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Changes in Respiratory Care Use During the COVID-19 Pandemic in a Pediatric Long-Term Care Facility.","authors":"Rose Hawkins, Corrie Harris, Heather Huxol, Scott Bickel, Mary Elise McClanahan, Theresa Kluthe, Ronald Morton","doi":"10.1089/ped.2024.0125","DOIUrl":"10.1089/ped.2024.0125","url":null,"abstract":"<p><p><b><i>Background:</i></b> The COVID-19 pandemic impacted multiple aspects of care at pediatric long-term care facilities (pLTCFs). This study evaluated the effect of COVID-19 infection control policies on pLTCF resident's respiratory health. <b><i>Methods:</i></b> A retrospective study of 76 residents' oxygen, albuterol, hypertonic saline (HTS), and pulmonary hygiene treatment use from January 2019 to December 2022 was completed using de-identified billing data and chart review. <b><i>Results:</i></b> There was a statistically significant increase in rate of oxygen use among residents (5.67; 95% CI 3.44-7.8; <i>P</i> < 0.001) during the study period, but at a slower rate than expected by the pre-pandemic trend (-4.89; 95% CI -7.20-2.59; <i>P</i> < 0.001). HTS use decreased during the study period, with a change in the prior trend to downward (-3.43; -5.89-9.68; <i>P</i> = 0.007). There was no significant change in albuterol or pulmonary hygiene treatment. <b><i>Conclusions:</i></b> This study demonstrates that patterns of oxygen and HTS use in a pLTCF changed during the COVID-19 pandemic.</p>","PeriodicalId":54389,"journal":{"name":"Pediatric Allergy Immunology and Pulmonology","volume":" ","pages":"88-92"},"PeriodicalIF":0.8,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144477894","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Rare Clinical Course in Drug Reaction with Eosinophilia and Systemic Symptoms Syndrome: Lung Involvement.","authors":"Deniz Yılmaz, Zeynep Şengül Emeksiz, Gülsüm İclal, Işıl Bilgiç, Emine Dibek Mısırlıoğlu","doi":"10.1177/2151321X251372016","DOIUrl":"10.1177/2151321X251372016","url":null,"abstract":"<p><p><b><i>Background:</i></b> Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) syndrome is a rare, potentially life-threatening hypersensitivity reaction characterized by skin rash, fever, eosinophilia, and multi-organ involvement. Although pulmonary complications are uncommon, they can significantly impact prognosis. <b><i>Case Presentation:</i></b> Here, we present a 6-year-old male with antibiotic-induced DRESS syndrome complicated by pleural effusion and pneumonitis. The patient was treated successfully with systemic corticosteroids and intravenous immunoglobulin following multidisciplinary evaluation. <b><i>Conclusion:</i></b> Pulmonary involvement in DRESS is frequently mistaken for pneumonia. This case highlights the importance of recognizing pulmonary involvement in DRESS syndrome and differentiating it from bacterial pneumonia, as misdiagnosis may lead to delayed corticosteroid treatment and unnecessary antibiotic use.</p>","PeriodicalId":54389,"journal":{"name":"Pediatric Allergy Immunology and Pulmonology","volume":"38 3","pages":"108-111"},"PeriodicalIF":0.8,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144978716","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Value of the FEF50/0.5FVC Ratio in the Identification of Obstructive Ventilatory Defects in Asthmatic Children.","authors":"Khouloud Kchaou, Chaima Briki, Soumaya Rebai, Soumaya Khaldi, Saloua Ben Khamsa Jameleddine","doi":"10.1177/2151321X251360549","DOIUrl":"10.1177/2151321X251360549","url":null,"abstract":"<p><p><b><i>Introduction:</i></b> Pediatric asthma is a common condition that requires early detection of obstructive ventilatory defects (OVDs) for optimal management. While the forced expiratory volume in 1 second to forced vital capacity (FEV1/FVC) ratio is widely used in spirometry, it may lack sensitivity in children, especially in detecting mild or early obstruction. This study aimed to assess the utility of the forced expiratory flow (FEF) at 50% of FVC to the half of FVC (FEF50/0.5FVC) ratio as a complementary tool for identifying OVD in asthmatic children. <b><i>Methods:</i></b> This was a retrospective study conducted on 165 asthmatic children (aged 5-15 years). Spirometric data including FEV1, FVC, FEV1/FVC, FEF50, FEF at 25%-75% of FVC (FEF25%-75%), and peak expiratory flow were analyzed. The FEF50/0.5FVC ratio was calculated for each child. OVD was defined as an FEV1/FVC ratio below the lower limit of normal, based on Z-scores. Statistical analysis included <i>t</i>-tests, Pearson's correlation, and receiver operating characteristic (ROC) curve analysis to compare the diagnostic efficiency of the FEF50/0.5FVC ratio with traditional spirometric measures. <b><i>Results:</i></b> OVD was identified in 25.5% of participants. The FEF50/0.5FVC ratio was significantly lower in the OVD group (1.23 ± 0.24) compared with the normal spirometry group (2.08 ± 0.5, <i>P</i> < 0.0001). A strong correlation was observed between the FEV1/FVC ratio and FEF50/0.5FVC (r = 0.88, <i>P</i> < 0.001). ROC analysis showed that the FEF50/0.5FVC ratio had superior diagnostic accuracy for OVD (area under the curve = 0.948, 95% confidence interval 0.899-0.996) compared with other spirometric indices, with a sensitivity of 91% and specificity of 90.2% at an optimal threshold of 1.56. <b><i>Conclusion:</i></b> FEF50/0.5FVC ratio is a promising tool for detecting OVD in asthmatic children, demonstrating high sensitivity and specificity. It may outperform traditional spirometric measures in identifying subtle airway obstructions, offering a valuable addition to routine asthma diagnostics, particularly in pediatric patients with early-stage or mild asthma.</p>","PeriodicalId":54389,"journal":{"name":"Pediatric Allergy Immunology and Pulmonology","volume":" ","pages":"93-99"},"PeriodicalIF":0.8,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144857039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"What Are Alternatives to Oral Phenylephrine in Children?","authors":"Julia Young, Kimberly Novak, Paul M Boylan","doi":"10.1089/ped.2025.0031","DOIUrl":"10.1089/ped.2025.0031","url":null,"abstract":"<p><p>The United States Food and Drug Administration (FDA) proposed removing oral phenylephrine (PE) from over-the-counter single-agent and combination products because it is ineffective at FDA-approved doses to treat sinonasal congestion. Health care providers make thousands of recommendations per month for phenylephrine-containing over-the-counter products to treat adults and children with signs and symptoms of the common cold, specifically nasal congestion. Health care providers may feel compelled by parents to recommend over-the-counter medications to treat the common cold in children, despite resources suggesting those products may be mildly effective, ineffective, or possibly unsafe. The objective of this Pharmacotherapy Update is to suggest alternative treatments to PE in children with the common cold and nasal congestion.</p>","PeriodicalId":54389,"journal":{"name":"Pediatric Allergy Immunology and Pulmonology","volume":" ","pages":"83-87"},"PeriodicalIF":0.8,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144289759","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An <i>IRF2BP2</i> Variant in a Pediatric Patient with Common Variable Immunodeficiency.","authors":"Demet Tekcan, Ayca Ceylan, Ilknur Kulhas Celik, Hasibe Artac","doi":"10.1177/2151321X251360561","DOIUrl":"10.1177/2151321X251360561","url":null,"abstract":"<p><p><b><i>Background:</i></b> Interferon regulatory factor-2 binding protein 2 (<i>IRF2BP2</i>) is an important new transcriptional cofactor that interacts with IFN regulatory factor 2 (IRF-2) and an IRF-2-dependent transcriptional repressor. <i>IRF2BP2</i> plays a role in different cellular functions, including apoptosis, survival, and cell differentiation. In this study, we report a case with common variable immunodeficiency (CVID), which has a heterozygous variant in the <i>IRF2BP2</i> gene. <b><i>Case Presentation:</i></b> A 13-year-old girl was evaluated for immunodeficiency due to recurrent sinusitis and tonsillitis in the previous year. She had been suffering from chronic cough for 3 months. She was hospitalized with lobar pneumonia and bronchiectasis. She was the second child of consanguineous parents. On physical examination, there was no growth and development retardation. Immunological screening of the patient demonstrated panhypogammaglobulinemia with low total memory B and class-switching memory B cells. Specific antibody responses to rubella and hepatitis B were negative. T- and B-lymphocyte counts and T-cell responses to phytohemagglutinin (PHA) were normal. Exome sequencing identified a heterozygous variant in <i>IRF2BP2</i> (c.112C>Tp.Arg38Cys). On follow-up, she has maintained a good infection control with antibiotic prophylaxis and immunoglobulin replacement therapy. <b><i>Conclusion:</i></b> To the best of our knowledge, this case is the youngest CVID who was diagnosed with <i>IRF2BP2</i> in the literature. The low percentage of total memory and switched memory B cells in the proband suggested that <i>IRF2BP2</i> might have had a role in the development or survival of memory B cells. Functional studies are needed about the critical role of <i>IRF2BP2</i> protein in B-cell maturation and humoral immune responses.</p>","PeriodicalId":54389,"journal":{"name":"Pediatric Allergy Immunology and Pulmonology","volume":" ","pages":"100-104"},"PeriodicalIF":0.8,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144676536","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Rare Case of Systemic Reaction to Carrot Due to PR-10 in a Young Child.","authors":"C Ferrigno, C P Ratti, I Scavone, V Ortolani, Enza D'Auria","doi":"10.1089/ped.2025.0038","DOIUrl":"10.1089/ped.2025.0038","url":null,"abstract":"<p><p><b><i>Background:</i></b> Pollen-Food Allergy Syndrome (PFAS) typically presents as mild oral symptoms but can rarely progress to systemic reactions. Pathogenesis-related proteins group 10 (PR-10) are proteins usually associated with oral allergy syndrome due to their thermolabile and gastrolabile properties. <b><i>Case Presentation:</i></b> We report a 12-year-old boy with birch pollen allergy who developed anaphylaxis after raw carrot consumption without identified cofactors. Previously, he experienced only oral allergy syndrome with raw carrot and fennel. Molecular diagnostics confirmed isolated PR-10 sensitization. The reaction occurred during birch pollen season, and the patient tolerated cooked carrot, consistent with PR-10's thermal instability. <b><i>Conclusions:</i></b> This case highlights how PFAS, typically characterized by mild and localized symptoms, can occasionally manifest with systemic reactions. High levels of specific IgE for Bet v 1 and pollen season may represent risk factors for systemic reactions in PFAS patients. Clinicians must be aware that allergies due to pollen cross-reactive allergens can be associated with systemic reactions.</p>","PeriodicalId":54389,"journal":{"name":"Pediatric Allergy Immunology and Pulmonology","volume":" ","pages":"105-107"},"PeriodicalIF":0.8,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144477893","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multiple Organ Involvement in a Boy with Lipopolysaccharide-Responsive Beige-like Anchor Protein Deficiency Detected by F-18 Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography.","authors":"Ummuhan Abdulrezzak, Emre Temizer, Alper Ozcan","doi":"10.1177/2151321X251368265","DOIUrl":"10.1177/2151321X251368265","url":null,"abstract":"<p><p>Patients with pathogenic variants of <i>lipopolysaccharide-responsive beige-like anchor protein</i> (<i>LRBA</i>) are known to present with autoimmune diseases, inflammatory bowel disease, lymphoproliferative disorders, allergies, immunodeficiency, and malignancies. This condition, characterized by widespread infections that impact multiple systems, has various radiological findings reported in the literature. These include computed tomography (CT) findings indicating lung involvement and magnetic resonance imaging (MRI) findings showing neurological system involvement. However, F-18 fluorodeoxyglucose positron emission tomography-CT (FDG PET-CT) imaging findings in <i>LRBA</i> deficiency have not yet been described in the literature. This report presents multiple organ involvements detected by F-18 FDG PET-CT in a case with an <i>LRBA</i> gene variant. FDG PET-CT findings for diagnostic and primary focus evaluation were reviewed in a 17-year-old male patient with a pathogenic <i>LRBA</i> variant, prompted by multiple hypoechoic nodular appearances identified on abdominal ultrasonography. In this patient, who carried a pathogenic <i>LRBA</i> variant (c.3396-3397delAC, p.D975Yfs*15) and was treated with abatacept for liver involvement, FDG PET-CT revealed a wide range of system involvements. These included the lungs, liver, intestines, bone, bone marrow, and lymph nodes, as well as multiple joints and tendons. In immunodeficiency diseases with such extensive multisystem involvement, whole-body imaging techniques like F-18 FDG PET-CT can serve as valuable tools for physicians to comprehensively assess the disease and formulate effective treatment strategies.</p>","PeriodicalId":54389,"journal":{"name":"Pediatric Allergy Immunology and Pulmonology","volume":" ","pages":""},"PeriodicalIF":0.8,"publicationDate":"2025-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144876870","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Is Routine Skin Prick Testing Essential in Managing Pediatric Chronic Urticaria?","authors":"Muhammed Fatih Erbay, Şefika Kökçü Karadağ, Tuğba Üstün, Nilay Çalışkan, Güler Yıldırım, Hamit Bologur, Hilal Güngör, Merve Karaca Şahin, Aslı Berivan Topçak, Deniz Ozceker","doi":"10.1089/ped.2024.0070","DOIUrl":"10.1089/ped.2024.0070","url":null,"abstract":"<p><p><b><i>Background:</i></b> Chronic urticaria (CU) in children, persisting beyond six weeks, is less common than acute urticaria, with a prevalence of 0.1%-0.3%. CU is classified into chronic idiopathic urticaria (CIU) and chronic inducible urticaria (CIndU), with CIU having an often unknown etiology, whereas CIndU is triggered by physical stimuli. Our study aims to explore the clinical and demographic characteristics, laboratory results, and possible etiological factors in children diagnosed with CU, and to assess the necessity of aeroallergen skin prick tests (SPTs) in these patients. <b><i>Methods:</i></b> The study evaluated the medical records of 242 children with CU, treated at the Pediatric Allergy-Immunology Clinic of Prof. Dr. Cemil Taşcıoğlu City Hospital from January 2018 to January 2024. Data on age, gender, presence of angioedema, dermatographism, concomitant allergic diseases, family history of atopy, infection status, urticaria duration, SPT results, and laboratory tests were collected and analyzed. <b><i>Results:</i></b> Results showed that 48.3% of patients were females and 51.7% were males, with an average age of 12.8 years and an average onset age of 9.9 years. Angioedema was present in 15.7% of patients, dermatographism in 17.8%, concomitant allergic diseases in 24%, and a family history of atopy in 14.5%. Infections were documented in 10.8% of patients, with urinary tract infections, <i>Helicobacter pylori (H. pylori)</i> infections, and dental infections identified. <b><i>Discussion:</i></b> Our study found no significant differences in clinical features, treatment requirements, or response to treatments between patients with positive and negative SPT results. Laboratory parameters such as eosinophilia, total Immunoglobulin E (IgE), and thyroid function tests also showed no significant differences. These findings suggest that routine SPTs for the management of CU in children will only be useful if IgE-mediated allergic comorbidities are suspected but may not be necessary in other cases, prompting a reevaluation of their use in clinical practice to seek more cost-effective diagnostic methods.</p>","PeriodicalId":54389,"journal":{"name":"Pediatric Allergy Immunology and Pulmonology","volume":" ","pages":"43-48"},"PeriodicalIF":1.1,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143411460","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Changes in Breathing Reserves During Growth in Healthy Untrained Boys and Girls.","authors":"Xu Yatao, Fenfen Zhou, Philippe Kilian, Rui Hu, Prioux Jacques","doi":"10.1089/ped.2024.0087","DOIUrl":"10.1089/ped.2024.0087","url":null,"abstract":"<p><p><b><i>Background:</i></b> The assessment of breathing reserve (BR) is essential to determine if ventilatory function is limited during exercise. Few studies reported the values of BR in healthy children and adolescents of both sexes. This study aimed to analyze the effects of age and sex on changes in BR in healthy untrained children and adolescents during growth. <b><i>Methods:</i></b> A study was conducted in 186 healthy untrained children and adolescents (10-16 years old). Maximal ventilation (<math><mrow><mover><mrow><mi>V</mi></mrow><mo>˙</mo></mover></mrow></math>_Emax) and maximal oxygen uptake (<math><mrow><mover><mrow><mi>V</mi></mrow><mo>˙</mo></mover></mrow></math>O_2max) were measured during a maximal graded test. Forced vital capacity and forced expiratory volume in 1 s (FEV₁) were also measured. BR was expressed as a percentage of theoretical maximal voluntary ventilation (MVV) which was obtained by multiplying FEV₁ by 35. The data were assessed by one-way analysis of variance (ANOVA) and two-way ANOVA supplement a Newman-Keuls test when <i>P</i> was significant (<i>P</i> < 0.05). <b><i>Results:</i></b> Height, weight, and lean body mass increased between 11 and 16 years old. For boys,<math><mi> </mi><mrow><mover><mrow><mi>V</mi></mrow><mo>˙</mo></mover></mrow></math>O_2max, <math><mrow><mover><mrow><mi>V</mi></mrow><mo>˙</mo></mover></mrow></math>_Emax, FEV₁, and MVV increased (<i>P</i> < 0.05) between 12 and 16 years. For girls, <math><mrow><mover><mrow><mi>V</mi></mrow><mo>˙</mo></mover></mrow></math>O_2max increased (<i>P</i> < 0.05) only between 11 and 12 and 14 and 15 years. Increases in <math><mrow><mover><mrow><mi>V</mi></mrow><mo>˙</mo></mover></mrow></math>_Emax, FEV₁, and MVV were observed between 10 and 12 years and stabilized afterward. The BR in girls was higher than in boys (<i>P</i> < 0.05). There were no significant differences in BR at the same age correlated with sex during growth. <b><i>Discussion:</i></b> No significant changes were observed in BR as a function of age. BR changes during growth seem to be independent of changes in anthropometric characteristics.</p>","PeriodicalId":54389,"journal":{"name":"Pediatric Allergy Immunology and Pulmonology","volume":" ","pages":"49-56"},"PeriodicalIF":1.1,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144010238","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}