Hanwool Cho, Jin-Hee Oh, Yeongsic Kim, Dae Chul Jeong
{"title":"The Profile of CD71+ Erythroid Cells in Korean Children: A Pilot Study.","authors":"Hanwool Cho, Jin-Hee Oh, Yeongsic Kim, Dae Chul Jeong","doi":"10.1089/ped.2024.0145","DOIUrl":null,"url":null,"abstract":"<p><p><b><i>Background:</i></b> CD71+ erythroid cells (CECs) play a complex immunoregulatory role. <b><i>Methods:</i></b> Flow cytometry was used to assess CECs in 84 individuals, from preterm infants to adults, divided into 5 age groups, 12 from infants under 6 months, 16 from young children (6 months-5 years), 24 from children (6-10 years), 22 from adolescents (11-19 years), and 10 from adults (≥20 years). <b><i>Results:</i></b> CECs are universally present at very low frequencies, except in individuals younger than 6 months (<i>P</i> < 0.001). Although preterm infants tended to have a higher median CECs than full-term infants, this difference was not statistically significant. Among individuals over 6 months, CECs showed significant negative correlations with hemoglobin (r = -0.448, <i>P</i> < 0.001) and hematocrit (r = -0.416, <i>P</i> < 0.001), but no such correlations were found in younger infants. <b><i>Conclusions:</i></b> CECs are present across all age groups, with higher levels in early infancy.</p>","PeriodicalId":54389,"journal":{"name":"Pediatric Allergy Immunology and Pulmonology","volume":" ","pages":""},"PeriodicalIF":1.1000,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Pediatric Allergy Immunology and Pulmonology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1089/ped.2024.0145","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"ALLERGY","Score":null,"Total":0}
引用次数: 0
Abstract
Background: CD71+ erythroid cells (CECs) play a complex immunoregulatory role. Methods: Flow cytometry was used to assess CECs in 84 individuals, from preterm infants to adults, divided into 5 age groups, 12 from infants under 6 months, 16 from young children (6 months-5 years), 24 from children (6-10 years), 22 from adolescents (11-19 years), and 10 from adults (≥20 years). Results: CECs are universally present at very low frequencies, except in individuals younger than 6 months (P < 0.001). Although preterm infants tended to have a higher median CECs than full-term infants, this difference was not statistically significant. Among individuals over 6 months, CECs showed significant negative correlations with hemoglobin (r = -0.448, P < 0.001) and hematocrit (r = -0.416, P < 0.001), but no such correlations were found in younger infants. Conclusions: CECs are present across all age groups, with higher levels in early infancy.
期刊介绍：
Pediatric Allergy, Immunology, and Pulmonology is a peer-reviewed journal designed to promote understanding and advance the treatment of respiratory, allergic, and immunologic diseases in children. The Journal delivers original translational, clinical, and epidemiologic research on the most common chronic illnesses of children—asthma and allergies—as well as many less common and rare diseases. It emphasizes the developmental implications of the morphological, physiological, pharmacological, and sociological components of these problems, as well as the impact of disease processes on families.
Pediatric Allergy, Immunology, and Pulmonology coverage includes:
-Functional and genetic immune deficiencies-
Interstitial lung diseases-
Both common and rare respiratory, allergic, and immunologic diseases-
Patient care-
Patient education research-
Public health policy-
International health studies
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