Is Bronchodilation Testing Routinely Useful in All Asthmatic Children?

IF 1.1 4区医学 Q4 ALLERGY

Pediatric Allergy Immunology and Pulmonology Pub Date : 2022-03-01 DOI:10.1089/ped.2021.0222

Maria Angela Tosca, Irene Schiavetti, Maria Binelli, Michele Miraglia Del Iudice, Giorgio Ciprandi

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引用次数: 0

Abstract

Background: The reversibility of bronchial obstruction is needed to diagnose asthma. Bronchodilation (BD) testing is, therefore, used in asthma work-up. This study explored the benefit of performing BD testing in asthmatic children without bronchial obstruction. Methods: The study included 60 subjects with asthma and normal lung function, 13 (21.7%) females and 47 (78.3%) males; the mean age was 11.5 years, 26 were adolescents, and 34 were children. Lung function, symptoms, use of asthma medications, type 2 inflammation, and asthma control were assessed in all subjects. Results: Eleven (18%) subjects positively responded to BD testing. Fifty-five percent of subjects were uncontrolled based on Global Initiative for Asthma (GINA) criteria. The multivariate analysis identified 2 factors associated with a positive response to BD testing: FEV₁ [odds ratio (OR) = 0.91) and ACT (OR = 0.79). Conclusions: This study showed that BD testing could give additional helpful information in clinical practice. In addition, uncontrolled asthma, based on GINA criteria, was prevalent in children with normal lung function.

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支气管扩张试验对所有哮喘儿童都有用吗?

背景:支气管梗阻的可逆性是诊断哮喘的必要条件。因此，支气管扩张(BD)测试用于哮喘检查。本研究探讨了在无支气管梗阻的哮喘儿童中进行BD检测的益处。方法:纳入60例肺功能正常的哮喘患者，女性13例(21.7%)，男性47例(78.3%);平均年龄11.5岁，青少年26例，儿童34例。评估所有受试者的肺功能、症状、哮喘药物使用、2型炎症和哮喘控制情况。结果:11名(18%)受试者对BD测试有积极反应。55%的受试者根据全球哮喘倡议(GINA)标准未得到控制。多因素分析确定了与BD检测阳性反应相关的2个因素:FEV1[比值比(OR) = 0.91)和ACT (OR = 0.79)。结论:本研究表明双相障碍检测可以在临床实践中提供额外的有用信息。此外，根据GINA标准，未控制的哮喘在肺功能正常的儿童中普遍存在。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Pediatric Allergy Immunology and Pulmonology ALLERGY-IMMUNOLOGY

CiteScore

2.00

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： Pediatric Allergy, Immunology, and Pulmonology is a peer-reviewed journal designed to promote understanding and advance the treatment of respiratory, allergic, and immunologic diseases in children. The Journal delivers original translational, clinical, and epidemiologic research on the most common chronic illnesses of children—asthma and allergies—as well as many less common and rare diseases. It emphasizes the developmental implications of the morphological, physiological, pharmacological, and sociological components of these problems, as well as the impact of disease processes on families. Pediatric Allergy, Immunology, and Pulmonology coverage includes: -Functional and genetic immune deficiencies- Interstitial lung diseases- Both common and rare respiratory, allergic, and immunologic diseases- Patient care- Patient education research- Public health policy- International health studies