Eurointervention最新文献

{"title":"Biodegradable-polymer versus durable-polymer drug-eluting stents in left main percutaneous coronary intervention: final results of the randomised IDEAL-LM trial.","authors":"Alexander M Griffioen, Robert-Jan M van Geuns, Margaret B McEntegart, Evgeny Merkulov, Oleg Krestyaninov, Evgeny Kretov, Maciej Lesiak, Peter O'Kane, Colm G Hanratty, Erwan Bressollette, Marc Silvestri, Adrian Wlodarczak, Paul Barragan, Richard Anderson, Aleksey Protopopov, Aaron Peace, Ian Menown, Paul Rocchiccioli, Yoshinobu Onuma, Keith G Oldroyd","doi":"10.4244/EIJ-D-24-00918","DOIUrl":"10.4244/EIJ-D-24-00918","url":null,"abstract":"","PeriodicalId":54378,"journal":{"name":"Eurointervention","volume":"21 11","pages":"e639-e641"},"PeriodicalIF":7.6,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12105665/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144217595","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Design and rationale of PRAGUE-26: a multicentre, randomised trial of catheter-directed thrombolysis for intermediate-high risk acute pulmonary embolism.","authors":"Josef Kroupa, Martin Radvan, Jan Mrozek, Martin Sluka, Stepan Jirous, Ota Hlinomaz, Milan Pliva, Jan Pudil, Hana Voberkova, Martin Kozel, Martin Poloczek, Martin Kamenik, Michal Brabec, Eva Lichnerova, Martin Hutyra, Ivo Bernat, Martin Novak, Petr Tousek, Viktor Kocka","doi":"10.4244/EIJ-D-24-01085","DOIUrl":"10.4244/EIJ-D-24-01085","url":null,"abstract":"","PeriodicalId":54378,"journal":{"name":"Eurointervention","volume":"21 11","pages":"e642-e648"},"PeriodicalIF":7.6,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12105664/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144217596","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of pericoronary adipose tissue attenuation on clinical outcomes after percutaneous coronary intervention.","authors":"Shota Naniwa, Hiroyuki Kawamori, Takayoshi Toba, Takashi Hiromasa, Yoichiro Sugizaki, Satoru Sasaki, Hiroyuki Fujii, Tomoyo Hamana, Yuto Osumi, Tetsuya Yamamoto, Seigo Iwane, Yuki Sakamoto, Koshi Matsuhama, Yuta Fukuishi, Hiroshi Tsunamoto, Kotaro Higuchi, Hiroya Okamoto, Masamichi Iwasaki, Tomofumi Takaya, Shinichiro Yamada, Ken-Ichi Hirata, Hiromasa Otake","doi":"10.4244/EIJ-D-24-00971","DOIUrl":"10.4244/EIJ-D-24-00971","url":null,"abstract":"<p><strong>Background: </strong>Pericoronary adipose tissue (PCAT) attenuation, measured using coronary computed tomography angiography (cCTA), is a potential marker of coronary inflammation.</p><p><strong>Aims: </strong>We aimed to examine the association between coronary inflammation, as assessed by measuring PCAT attenuation before percutaneous coronary intervention (PCI), and clinical outcomes of PCI using current-generation drug-eluting stents (DES).</p><p><strong>Methods: </strong>We retrospectively studied consecutive patients who underwent cCTA before PCI with current-generation DES. Adverse plaque characteristics, calcified plaque (CP) burden, and PCAT attenuation of the proximal right coronary artery (PCAT_RCA) were assessed using cCTA. The primary outcome was a patient-oriented composite endpoint (PoCE), including cardiovascular death, non-fatal myocardial infarction, any revascularisation, and stroke.</p><p><strong>Results: </strong>During a median follow-up of 1,540 days, 77 of 490 patients experienced PoCE. Patients with PoCE had higher PCAT_RCA (-76.3±6.4 Hounsfield units [HU] vs -82.5±8.1 HU; p<0.001). Multivariable analysis showed that the presence of adverse plaque, greater CP burden and higher PCAT_RCA were independently associated with PoCE (hazard ratio [HR] 2.05, 95% confidence interval [CI]: 1.26-3.34; p=0.004; HR 1.04, 95% CI: 1.02-1.07; p=0.002; and HR 2.20, 95% CI: 1.63-2.97; p<0.001, respectively). PoCE incidence was 3.9 times higher in patients with high PCAT_RCA (≥-79.9 HU) than those with low PCAT_RCA (.</p>","PeriodicalId":54378,"journal":{"name":"Eurointervention","volume":"21 11","pages":"e605-e616"},"PeriodicalIF":7.6,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12138251/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144217599","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prasugrel monotherapy versus standard DAPT in STEMI patients with OCT-guided or angio-guided complete revascularisation: design and rationale of the randomised, multifactorial COMPARE STEMI ONE trial.","authors":"Valeria Paradies, Nicolas M Van Mieghem, Rohit M Oemrawsingh, Gert Richardt, Giovanni Esposito, Gianluca Campo, Francesco Burzotta, Paolo Canova, Axel Linke, Italo Porto, Daniela Trabattoni, Koen Teeuwen, Tom Adriaenssens, Petr Kala, Goran Stankovic, Ria van Vliet, Daniele Giacoppo, Joost Daemen, Pieter C Smits","doi":"10.4244/EIJ-D-24-00829","DOIUrl":"10.4244/EIJ-D-24-00829","url":null,"abstract":"<p><p>Monotherapy with a potent P2Y₁₂ receptor antagonist after 1 month of dual antiplatelet therapy (DAPT) may reduce bleeding in the absence of increased ischaemic events compared to 12-month DAPT in patients with acute coronary syndrome undergoing percutaneous coronary intervention (PCI). PCI guidance with optical coherence tomography (OCT) may enhance stent expansion. COMPARE STEMI ONE is an international, multicentre, open-label, randomised controlled trial. In 1,656 ST-segment elevation myocardial infarction (STEMI) patients, prasugrel monotherapy after 1 month of DAPT, as compared to standard 12-month prasugrel-based DAPT, will be tested for non-inferiority for the primary composite endpoint of net adverse clinical events - defined as all-cause death, myocardial infarction, stroke, or Bleeding Academic Research Consortium Type 3 or 5 bleeding events - at 11 months after randomisation. Furthermore, an ancillary substudy will test the superiority of OCT-guided versus angiography-guided staged complete revascularisation in achieving a larger minimal stent area (MSA) in non-culprit lesions during staged procedures. COMPARE STEMI ONE is the first randomised controlled trial assessing an abbreviated 1-month DAPT regimen followed by prasugrel monotherapy in the context of STEMI. The trial will also study the value of OCT-guided PCI in terms of the MSA of non-culprit lesions and may elucidate potential synergies between intravascular imaging-guided PCI and abbreviated DAPT regimens. (ClinicalTrials.gov: NCT05491200).</p>","PeriodicalId":54378,"journal":{"name":"Eurointervention","volume":"21 10","pages":"571-580"},"PeriodicalIF":7.6,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12063550/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144082056","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ticagrelor-based antiplatelet therapy after percutaneous coronary intervention in chronic coronary syndrome.","authors":"Hirotoshi Watanabe, Takeshi Kimura","doi":"10.4244/EIJ-E-25-00015","DOIUrl":"10.4244/EIJ-E-25-00015","url":null,"abstract":"","PeriodicalId":54378,"journal":{"name":"Eurointervention","volume":"21 10","pages":"495-496"},"PeriodicalIF":7.6,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12063545/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144082060","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ticagrelor monotherapy versus ticagrelor plus aspirin in patients with chronic coronary syndrome and high ischaemic risk: a post hoc analysis of the TWILIGHT trial.","authors":"Mauro Gitto, Usman Baber, Samantha Sartori, Birgit Vogel, Dominick J Angiolillo, Carlo Briguori, David J Cohen, Timothy Collier, Dariusz Dudek, Angelo Oliva, Javier Escaned, Yihan Feng, C Michael Gibson, Ya-Ling Han, Francesca Maria Di Muro, Richard A Shlofmitz, Kurt Huber, Philippe Gabriel Steg, Samin Sharma, Gennaro Sardella, Adnan Kastrati, Upendra Kaul, Ran Kornowski, Vijay Kunadian, Giulio G Stefanini, Shamir R Mehta, George Dangas, Roxana Mehran","doi":"10.4244/EIJ-D-24-00973","DOIUrl":"10.4244/EIJ-D-24-00973","url":null,"abstract":"<p><strong>Background: </strong>Short dual antiplatelet therapy (DAPT) followed by ticagrelor monotherapy may be a valuable therapeutic option for patients with chronic coronary syndrome (CCS) and high ischaemic risk (HIR) undergoing percutaneous coronary intervention (PCI).</p><p><strong>Aims: </strong>We aimed to compare ticagrelor monotherapy with ticagrelor-based DAPT in CCS patients with and without HIR undergoing PCI.</p><p><strong>Methods: </strong>The present analysis included the CCS cohort of the TWILIGHT trial, which randomised PCI patients to ticagrelor alone or in combination with aspirin for 12 months after 3 months of ticagrelor-based DAPT. Patients were stratified into HIR and non-HIR based on the 2019 European Society of Cardiology (ESC) CCS guidelines definition. Outcomes of interest were major adverse cardiac and cerebrovascular events (MACCE), a composite of death, myocardial infarction or stroke, and Bleeding Academic Research Consortium (BARC) Type 2-5 bleeding at 1 year.</p><p><strong>Results: </strong>Of the 2,503 CCS patients who underwent randomisation, the ESC definition classified 1,264 (50.5%) as HIR and 1,239 (49.5%) as non-HIR. HIR patients displayed a higher risk of MACCE (3.9% vs 2.3%; p=0.015) and similar rates of BARC Type 2-5 bleeding (5.1% vs 5.7%; p=0.455) as compared to non-HIR patients. Ticagrelor monotherapy and ticagrelor-based DAPT were associated with similar risks of MACCE (HIR: 4.0% vs 3.8%, hazard ratio [HR] 1.06, 95% confidence interval [CI]: 0.60-1.85; non-HIR: 2.1% vs 2.6%, HR 0.80, 95% CI: 0.38-1.66, p_interaction=0.553) and bleeding (HIR: 4.7% vs 5.7%, HR 0.82, 95% CI: 0.50-1.33; non-HIR: 4.9% vs 6.7%, HR 0.71, 95% CI: 0.44-1.14; p_interaction=0.684) in both the HIR and non-HIR groups.</p><p><strong>Conclusions: </strong>In a post hoc analysis of the TWILIGHT trial that included CCS patients undergoing PCI, ticagrelor monotherapy after 3 months of DAPT appeared to be safe and was not associated with increased risks of ischaemic or bleeding events, regardless of baseline HIR status, compared with standard ticagrelor-based DAPT. These findings suggest the potential to expand guideline recommendations for ticagrelor monotherapy in CCS.</p>","PeriodicalId":54378,"journal":{"name":"Eurointervention","volume":"21 10","pages":"550-559"},"PeriodicalIF":7.6,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12063552/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144082059","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Platelet reactivity when switching from cangrelor to oral P2Y12 receptor inhibitors: insights from a real-world registry.","authors":"Francesco Franchi, Claudio Laudani","doi":"10.4244/EIJ-E-25-00008","DOIUrl":"10.4244/EIJ-E-25-00008","url":null,"abstract":"","PeriodicalId":54378,"journal":{"name":"Eurointervention","volume":"21 10","pages":"497-499"},"PeriodicalIF":7.6,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12063544/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144082054","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-term structural valve deterioration after TAVI: insights from the EORP ESC Valve Durability TAVI Registry.","authors":"Cristina Giannini, Davide Capodanno, Gabor G Toth, Stephan Windecker, Stefanie Schüpke, Daniel J Blackman, Stéphane Noble, Hélène Eltchaninoff, Claudia Fiorina, Alaide Chieffo, Antonio L Bartorelli, Albrecht Schmidt, Ole De Backer, Martine Gilard, Elizabeth Curtis, Guillaume L'Official, Erwan Donal, Cécile Laroche, Bernard Prendergast, Anna Sonia Petronio, On Behalf The European Valve Durability Tavi Registry Investigators","doi":"10.4244/EIJ-D-24-00662","DOIUrl":"10.4244/EIJ-D-24-00662","url":null,"abstract":"<p><strong>Background: </strong>Valve durability is a key consideration as the patient population eligible for transcatheter aortic valve implantation (TAVI) expands to include lower-risk and younger individuals who are expected to live many years after the procedure.</p><p><strong>Aims: </strong>This registry aimed to assess the incidence of long-term structural valve deterioration (SVD) beyond 5 years post-TAVI.</p><p><strong>Methods: </strong>Consecutive living patients who underwent TAVI up until 2014 using any commercially available transcatheter heart valve (THV) at 22 participant centres were enrolled in the European Valve Durability TAVI Registry. All patients underwent comprehensive echocardiographic assessments (61% were evaluated independently by a central core laboratory) within 6 months of enrolment and at least 5 years post-TAVI; SVD was defined according to Valve Academic Research Consortium 3 definitions.</p><p><strong>Results: </strong>A total of 597 patients (aged 79.6±7.1 years at the time of TAVI; 47.2% male, mean Society of Thoracic Surgeons score 5.0%) were included. At a median of 6.1 years of follow-up (interquartile range 5.2-7.3 years), the crude incidence of moderate/severe SVD was 9.5% (n=57; moderate: 6.2%, n=37; severe: 3.4%, n=20). Predictors of SVD identified by Cox regression analysis were use of an intra-annular THV (hazard ratio [HR] 38.44, 95% confidence interval [CI]: 10.8-136.3; p<0.001), a small THV size (HR 4.82, 95% CI: 2.42-9.60; p<0.001) and moderate/severe postprocedural paravalvular leak (HR 3.64, 95% CI: 1.59-8.32; p=0.002).</p><p><strong>Conclusions: </strong>The incidence of moderate/severe SVD during long-term follow-up after TAVI is low, with severe SVD being even rarer than moderate SVD. SVD occurs more frequently in patients treated with older-generation intra-annular valves and in those with small-sized THVs.</p>","PeriodicalId":54378,"journal":{"name":"Eurointervention","volume":"21 10","pages":"537-549"},"PeriodicalIF":7.6,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12063547/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144082049","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transcaval access with an IVUS-assisted aorta-outward puncture.","authors":"Juan Manuel Muñoz Bravo, Gerard Martí Aguasca, Álvaro Calabuig Goena, Vicenç Serra García, Andrea Monastyrski, Neus Bellera Gotarda, Imanol Otaegui Irurueta, Bernat Serra Creus, Yassin Belahnech, Bruno García Del Blanco","doi":"10.4244/EIJ-D-24-00429","DOIUrl":"10.4244/EIJ-D-24-00429","url":null,"abstract":"","PeriodicalId":54378,"journal":{"name":"Eurointervention","volume":"21 10","pages":"584-585"},"PeriodicalIF":7.6,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12063546/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144082061","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optical coherence tomography versus intravascular ultrasound- guided PCI in patients with and without acute coronary syndrome: a prespecified subanalysis of the OCTIVUS trial.","authors":"Ju Hyeon Kim, Soon Jun Hong, Subin Lim, Jung-Joon Cha, Hyung Joon Joo, Jae Hyoung Park, Cheol Woong Yu, Do-Sun Lim, Do-Yoon Kang, Jung-Min Ahn, Duk-Woo Park, Seung-Jung Park","doi":"10.4244/EIJ-D-24-00911","DOIUrl":"10.4244/EIJ-D-24-00911","url":null,"abstract":"","PeriodicalId":54378,"journal":{"name":"Eurointervention","volume":"21 10","pages":"581-583"},"PeriodicalIF":7.6,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12063548/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144082051","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}