Eurointervention最新文献

{"title":"Transcatheter edge-to-edge repair for primary mitral regurgitation: what lies ahead?","authors":"Anna Sonia Petronio, Matteo Mazzola","doi":"10.4244/EIJ-D-26-00394","DOIUrl":"10.4244/EIJ-D-26-00394","url":null,"abstract":"","PeriodicalId":54378,"journal":{"name":"Eurointervention","volume":"22 12","pages":"e650-e652"},"PeriodicalIF":9.2,"publicationDate":"2026-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13245444/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148254332","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antithrombotic therapy for secondary prevention in patients with acute coronary syndromes treated with percutaneous coronary intervention: options for personalization to reduce bleeding or ischaemic risks. A Clinical Consensus Statement of the ESC Working Group on Thrombosis, the Association for Acute CardioVascular Care of the ESC, the European Association of Percutaneous Cardiovascular Interventions of the ESC, and the ESC Working Group on Cardiovascular Pharmacology A Clinical Consensus Statement of the ESC Working Group on Thrombosis, the Association for Acute CardioVascular Care of the ESC, the European Association of Percutaneous Cardiovascular Interventions of the ESC, and the ESC Working Group on Cardiovascular Pharmacology.","authors":"Diana A Gorog, Jurriën M Ten Berg, Gianluca Campo, Tobias Geisler, Bruna Gigante, Erik L Grove, Sigrun Halvorsen, Kurt Huber, Young-Hoon Jeong, Gregory Y H Lip, Eliano P Navarese, Andrea Rubboli, Jolanta M Siller Matula, Robert F Storey, Marco Valgimigli, Christophe Vandenbriele, Gemma Vilahur, Ingo Ahrens, Jose Luis Ferreiro","doi":"10.4244/EIJ-E-26-00003","DOIUrl":"10.4244/EIJ-E-26-00003","url":null,"abstract":"<p><p>Dual antiplatelet therapy (DAPT) is required to prevent atherothrombotic events in patients with acute coronary syndrome (ACS) treated with percutaneous coronary intervention (PCI). The default DAPT strategy, namely a potent P2Y₁₂ inhibitor combined with aspirin for 12 months, exposes many patients to excess bleeding risk. Over the past years, alternative antithrombotic regimens have been proposed to reduce bleeding (DAPT abbreviation or de-escalation) or ischaemic (prolonged dual antithrombotic therapy) events. Abbreviation or de-escalation of DAPT is supported by (i) multiple trials showing these strategies to significantly reduce bleeding, particularly for the 20-40% of patients classified as high bleeding risk (HBR); (ii) low prevalence of stent thrombosis and recurrent myocardial infarction beyond 1-3 months post-ACS with the latest generation of drug-eluting stents, and (iii) the recognition that HBR is far more prevalent than high ischaemic risk. Amongst patients at HBR, standard DAPT, in comparison to abbreviated or de-escalated DAPT, increases the net risk of major adverse events, even in the presence of high ischaemic risk. Conversely, amongst patients at high ischaemic risk, without HBR, prolonged dual antithrombotic therapy reduces longer-term thrombotic risk. Recognizing risk factors and assessing the magnitude of bleeding and ischaemic risks are essential. Since there are no ideal scoring systems to balance ischaemic and bleeding risks, and many overlap, focus should be on managing the risk most amenable to modification, namely bleeding, which should dominate the decision-making over ischaemic risk when choosing a DAPT regimen. This document provides practical advice regarding best practice for personalizing DAPT in patients with ACS undergoing PCI, with evidence-based clinical consensus statements on selecting the most appropriate antiplatelet strategy to optimize clinical outcomes.</p>","PeriodicalId":54378,"journal":{"name":"Eurointervention","volume":"22 12","pages":"e653-e677"},"PeriodicalIF":9.2,"publicationDate":"2026-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13254929/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148254343","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Outcomes of intraprocedural haemodynamic changes in patients undergoing mitral transcatheter edge-to-edge repair.","authors":"Shingo Kuwata, Masaki Izumo, Tetsu Tanaka, Taishi Okuno, Yoshihiro J Akashi, Masanori Yamamoto, Tetsuro Shimura, Atsushi Sugiura, Shunsuke Kubo, Mike Saji, Yuki Izumi, Yusuke Enta, Shinichi Shirai, Shingo Mizuno, Yusuke Watanabe, Makoto Amaki, Kazuhisa Kodama, Junichi Yamaguchi, Toru Naganuma, Hiroki Bota, Yohei Ohno, Masahiko Asami, Daisuke Hachinohe, Masahiro Yamawaki, Hiroshi Ueno, Gaku Nakazawa, Toshiaki Otsuka, Kentaro Hayashida, On Behalf The Ocean-Mitral Investigators","doi":"10.4244/EIJ-D-26-00084","DOIUrl":"10.4244/EIJ-D-26-00084","url":null,"abstract":"<p><strong>Background: </strong>While the mean left atrial pressure (mLAP) reduction during mitral transcatheter edge-to-edge repair (M-TEER) has been suggested as a potential prognostic marker, comprehensive evidence from large-scale, real-world cohorts is limited, especially with stratification by mitral regurgitation (MR) aetiology.</p><p><strong>Aims: </strong>This study aimed to evaluate the prognostic significance of intraprocedural haemodynamic changes, particularly the mLAP reduction, during M-TEER for MR, using multicentre registry data.</p><p><strong>Methods: </strong>From the OCEAN-Mitral registry, 2,629 patients undergoing M-TEER with intraprocedural direct mLAP measurements were included. A decrease in the mLAP was defined as follows: postprocedural mLAP-preprocedural mLAP<0. The primary outcome was the composite of all-cause mortality and heart failure (HF) rehospitalisation.</p><p><strong>Results: </strong>Among 2,629 patients (degenerative MR [DMR]: 825 [31.4%], functional MR [FMR]: 1,804 [68.6%]), the postprocedural mLAP decreased in 1,548 patients (58.9%). In the DMR cohort, the mLAP reduction was associated with a significantly lower risk of the composite outcome (adjusted hazard ratio [HR] 0.66, 95% confidence interval [CI]: 0.45-0.96; p=0.028), while no such association was observed in the FMR cohort (adjusted HR 0.90, 95% CI: 0.75-1.08; p=0.251). Interaction analysis confirmed a significant difference in prognostic impact based on MR aetiology (p for interaction=0.006). Pulmonary vein flow patterns improved, with systolic waves becoming greater than diastolic waves across both groups; however, their combination with the mLAP reduction predicted better outcomes only in DMR patients.</p><p><strong>Conclusions: </strong>A reduction in the mLAP during M-TEER is independently associated with improved clinical outcomes in patients with DMR but not in those with FMR. These findings underscore the importance of real-time haemodynamic assessment - especially in DMR - as a valuable procedural endpoint that may aid in optimising long-term outcomes beyond anatomical MR reduction alone.</p>","PeriodicalId":54378,"journal":{"name":"Eurointervention","volume":"22 12","pages":"e690-e700"},"PeriodicalIF":9.2,"publicationDate":"2026-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13245450/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148254350","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transcatheter approximation of papillary muscles.","authors":"Lukasz Tekieli, Adam Mazurek, Leszek Drabik, Andrzej Gackowski, Piotr Musiałek","doi":"10.4244/EIJ-D-25-01353","DOIUrl":"10.4244/EIJ-D-25-01353","url":null,"abstract":"","PeriodicalId":54378,"journal":{"name":"Eurointervention","volume":"22 12","pages":"e712-e715"},"PeriodicalIF":9.2,"publicationDate":"2026-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13245451/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148254358","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Temporal trends in mitral edge-to-edge repair for primary mitral regurgitation.","authors":"Benedikt Koell, Sebastian Ludwig, Jessica Weimann, Dhairya Patel, Lukas Stolz, Tetsu Tanaka, Teresa Trenkwalder, Felix Rudolph, Daryoush Samim, Philipp von Stein, Cristina Giannini, Julien Dreyfus, Andrea Scotti, Jean-Michel Paradis, Marianna Adamo, Nicole Karam, Yohann Bohbot, Anne Bernard, Bruno Melica, Yusuke Kobari, Yoan Lavie-Badie, Mirjam Kessler, Omar Chehab, Simon Redwood, Edith Lubos, Ole de Backer, Marco Metra, Azeem Latib, Chiara Primerano, Christos Iliadis, Fabien Praz, Muhammed Gerçek, Erion Xhepa, Marcel Weber, Raj Makkar, Juan Granada, Thomas Modine, Erwan Donal, Jörg Hausleiter, Augustin Coisne, Daniel Kalbacher, On Behalf Of The Prime-Mr Investigators","doi":"10.4244/EIJ-D-25-01308","DOIUrl":"10.4244/EIJ-D-25-01308","url":null,"abstract":"<p><strong>Background: </strong>The evolving landscape of mitral valve transcatheter edge-to-edge repair (M-TEER) for mitral regurgitation (MR) has seen continuous advancements, driving improvements in therapeutic efficacy. Particularly in primary MR (PMR), contemporary device iterations of M-TEER offer technical advantages for improved management of complex anatomies. However, data on temporal trends in M-TEER for PMR are limited.</p><p><strong>Aims: </strong>The primary objective of our study was to analyse temporal trends in the safety, efficacy, and stability of M-TEER treatment.</p><p><strong>Methods: </strong>The PRIME-MR registry, a retrospective multicentre study, enrolled consecutive patients undergoing M-TEER for PMR at 27 centres in Europe and North America. M-TEER procedures were categorised into four time periods (2009-2013, 2014-2016, 2017-2019, and 2020-2023), to align with major device updates.</p><p><strong>Results: </strong>The analysis included 3,082 consecutive patients (median age 82 years [interquartile range 76.0-85.0], 45.1% female). Patients treated were highly symptomatic (New York Heart Association [NYHA] Class ≥III in 80.4%). Patient characteristics showed a decline in symptomatic severity (NYHA Class ≥III 85.9% in 2009-2013 vs 71.8% in 2020-2023), accompanied by lower mean Society of Thoracic Surgeons scores (5.6% [2009-2013] vs 4.6% [2020-2023]; p for trend<0.0001), and less severe MR. Over time, complication rates decreased (procedures with complications: 42.4% [2009-2013] vs 23.1% [2020-2023]; p for trend<0.0001), whereas technical efficacy increased (residual MR ≤1+: 54.0% [2009-2013] vs 68.4% [2020-2023]; p for trend<0.001). There was an increased occurrence of stable results without any deterioration at one-year follow-up (63.6% [2009-2013] vs 74.4% [2020-2023]; p for trend=0.03).</p><p><strong>Conclusions: </strong>Findings from the PRIME-MR registry highlight substantial reductions in residual MR severity and complication rates over time in PMR patients undergoing M-TEER.</p>","PeriodicalId":54378,"journal":{"name":"Eurointervention","volume":"22 12","pages":"e701-e711"},"PeriodicalIF":9.2,"publicationDate":"2026-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13245447/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148254391","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Early outcomes of redo-TAVI with the SAPIEN 3 platform: the prospective, multicentre ReTAVI registry.","authors":"Giuseppe Tarantini, Luca Nai Fovino, Héctor Alfonso Alvarez Covarrubias, Rafał Wolny, Tommaso Fabris, Joanna Nawara Skipirzepa, Matthias Eden, Jose Luis Zamorano, Michael Joner, Thomas Cuisset, Victoria Delgado, Josep Rodés-Cabau, Francesco Saia, Gintautas Bieliauskas, Eric Van Belle, Thomas Modine, Tobias Rheude, Philippe Garot, Christian Jung, Tanja K Rudolph, Lionel Leroux, Wolfgang Rottbauer, Thomas Nestelberger, Thibault Lhermusier, Mohammed Nejjari, Ander Regueiro, David Meier, Chiara Fraccaro, Tau Hartikainen, Nicole Karam, Martin Swaans, Alberto Rodrigues, Henryk Dreger, Christian Hengstenberg, Thomas Schmitz, Sarah Mauler-Wittwer, Nicolo Piazza, Nicolas Combaret, Vincent Letocart, Vincent Auffret, Eric Durand, Marina Urena-Alcázar, Raquel Del Valle-Fernández, Andrea Drago, Marco De Carlo, Victor Alfonso Jimenez Diaz, Maciej Dąbrowski, Julia Mascherbauer, Arnaud Sudre, Peter Ong, Birgid Gonska, Massimo Mancone, Enrico Fabris, Rui Campante Teles, Luis Nombela-Franco, Lluis Asmarats, Victoria Vilalta, Marcin Protasiewicz, John Graydon Webb, Gábor Tóth-Gayor, Andreas Zierer, Gilles Rioufol, Moritz Seiffert, Marianna Adamo, Francesco Meucci, Alfonso Ielasi, Francesco Burzotta, Maria Lopez Benito, Itamar Loewenstein, Paweł Kralisz, Jacek Legutko, Zenon Huczek, Andrea Pavei, Radka Raková, Wilbert Wesselink, Marie Zielinski, Nataliya Trushina, Peter Bramlage, Radoslaw Parma","doi":"10.4244/EIJ-D-25-01268","DOIUrl":"10.4244/EIJ-D-25-01268","url":null,"abstract":"<p><strong>Background: </strong>Transcatheter aortic valve implantation (TAVI) is increasingly performed in younger and lower-risk patients. Since many of these patients will outlive their transcatheter heart valve (THV), redo-TAVI procedures are expected to rise in number. Yet, real-world evidence on the procedural safety and efficacy of redo-TAVI remains limited.</p><p><strong>Aims: </strong>We aimed to evaluate the 30-day procedural and clinical outcomes of redo-TAVI using the balloon-expandable SAPIEN 3 platform.</p><p><strong>Methods: </strong>The ReTAVI registry is a prospective, international study enrolling consecutive patients with a failed aortic THV undergoing redo-TAVI with a balloon-expandable SAPIEN 3 THV. Data were collected across 59 international centres. All imaging was centrally analysed, and major clinical events were adjudicated by an independent committee.</p><p><strong>Results: </strong>â¨A total of 143 patients (median age 84 years; 40.6% female; median Society of Thoracic Surgeons risk score 7.0%) were enrolled. The predominant failing THVs were balloon-expandable SAPIEN 3 (30.1%), self-expanding CoreValve/Evolut (53.1%), and ACURATE (14.0%) platforms. The most common failure mode was isolated regurgitation (48.6%), followed by stenosis (35.2%) and a mixed pathology (16.2%). The replacement valve was successfully implanted in 95.1% of patients, with a 30-day mortality rate of 3.5%. The 30-day stroke and pacemaker implantation rates were 0.7% and 6.3%, respectively. Redo-TAVI significantly improved valve haemodynamics, with mean gradients decreasing overall (Δ=-12.0 mmHg), and a more pronounced reduction in stenotic failures (Δ=-29.0 mmHg). Coronary obstruction was observed in 1.4% of cases.</p><p><strong>Conclusions: </strong>Redo-TAVI with a balloon-expandable SAPIEN 3 THV platform is a safe and effective reintervention strategy across diverse failed THV types, when guided by the Heart Team, standardised procedural planning, and comprehensive imaging.</p><p><strong>Clinicaltrials: </strong>gov: NCT05601453.</p>","PeriodicalId":54378,"journal":{"name":"Eurointervention","volume":"22 11","pages":"e629-e641"},"PeriodicalIF":9.2,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13207894/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148139754","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"TAVI and coronary interventions: indications, technical considerations, and clinical scenarios.","authors":"Heberto Aquino Bruno, Ole De Backer, Gilbert H L Tang, Ignacio J Amat-Santos, Jacob Lønborg, Didier Tchetche, Marco Barbanti, Juan F García-García, Juan C Plata-Corona, Juan C Fuentes-Moreno, Jose R Gayosso-Ortiz, Hiram Vela-Vizcaino, Marco A Alcántara-Meléndez, Ander Regueiro, Nicolo Piazza, Giuseppe Tarantini","doi":"10.4244/EIJ-D-25-00874","DOIUrl":"10.4244/EIJ-D-25-00874","url":null,"abstract":"<p><p>Transcatheter aortic valve implantation (TAVI) has become the preferred treatment for severe aortic stenosis. Nonetheless, interplay between aortic valve disease, transcatheter valve implantation, and the coronary arteries is frequent and clinically relevant. Coronary intervention in the context of TAVI encompasses distinct but interrelated scenarios, including the management of concomitant coronary artery disease and the prevention or treatment of coronary artery obstruction. These aspects introduce additional complexity to procedural planning and long-term management. This review provides a comprehensive and practical overview of coronary interventions related to TAVI, encompassing coronary evaluation and physiological assessment, the indications and timing of percutaneous coronary intervention before and after valve implantation, and strategies for managing coronary obstruction. Particular emphasis is placed on anatomical and device-related factors influencing coronary access, including transcatheter heart valve design, aortic root anatomy, and commissural alignment. By structuring coronary interventions according to distinct clinical scenarios, this article aims to support tailored decision-making and optimise procedural safety, feasibility, and long-term coronary management in patients undergoing TAVI.</p>","PeriodicalId":54378,"journal":{"name":"Eurointervention","volume":"22 11","pages":"e603-e616"},"PeriodicalIF":9.2,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13220131/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148139818","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"First-in-human experience with a heterotopic cross-caval transcatheter tricuspid valve replacement.","authors":"Rodrigo Estévez-Loureiro, Manuel Barreiro-Perez, Omar Abdul-Jawad Altisent, Xavier Freixa, Jozef Bartunek, Marc Vanderheyden, Mohammad Sherif, Tobias Trippel, Irakly Gogorishvili, Jörg Hausleiter, Sami Alnasser, Neil Fam","doi":"10.4244/EIJ-D-25-01160","DOIUrl":"10.4244/EIJ-D-25-01160","url":null,"abstract":"","PeriodicalId":54378,"journal":{"name":"Eurointervention","volume":"22 11","pages":"e642-e644"},"PeriodicalIF":9.5,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13207887/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148139874","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Feasibility and challenges of the UNICORN technique in native aortic valve transcatheter aortic valve implantation.","authors":"Jean-Benoît Veillette, Anthony Poulin, Siddhartha Mengi, Erwan Salaun, Jean-Michel Paradis","doi":"10.4244/EIJ-D-25-01107","DOIUrl":"10.4244/EIJ-D-25-01107","url":null,"abstract":"","PeriodicalId":54378,"journal":{"name":"Eurointervention","volume":"22 11","pages":"e645-e647"},"PeriodicalIF":9.5,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13214564/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148139846","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fenestration and TAP stenting to restore side branch flow after covered stent implantation for coronary perforation.","authors":"Diluka Premawardhana, Mostafa Abdelmaaboud, Montasir Ali, Ahmed Hailan","doi":"10.4244/EIJCR-D-26-00034","DOIUrl":"https://doi.org/10.4244/EIJCR-D-26-00034","url":null,"abstract":"","PeriodicalId":54378,"journal":{"name":"Eurointervention","volume":" ","pages":""},"PeriodicalIF":9.5,"publicationDate":"2026-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148037621","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}