Eurointervention最新文献

{"title":"Prevalence of vasomotor dysfunction in patients with residual or recurrent angina after percutaneous coronary intervention.","authors":"Caïa Crooijmans, Tijn P J Jansen, Behruz Yosofi, Fleur W Adriaansen, Joan G Meeder, Wouter S Remkes, Marcel A M Beijk, Yolande Appelman, Tim P van de Hoef, Annemiek de Vos, Valeria Paradies, Martijn Meuwissen, Nicola S Vos, Els G M Olde Bijvank, Michael Magro, Stijn C H van den Oord, Karin E Arkenbout, Ton A A C M Heestermans, Marlies M Kok, Pier Woudstra, Melina C den Haan, Patty Winkler, Arnoud van 't Hof, Hester M den Ruijter, Aysun Cetinyurek-Yavuz, Niels van Royen, Suzette Elias-Smale, Aukelien C Dimitriu-Leen, Peter Damman, On Behalf Of The Nl-Cft Investigators","doi":"10.4244/EIJ-D-25-01215","DOIUrl":"10.4244/EIJ-D-25-01215","url":null,"abstract":"","PeriodicalId":54378,"journal":{"name":"Eurointervention","volume":"22 14","pages":"e795-e797"},"PeriodicalIF":9.2,"publicationDate":"2026-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13358695/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148521363","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prosthesis-patient mismatch with intra-annular self-expanding valves: an analysis of the PORTICO IDE trial.","authors":"Gregory P Fontana, Ron Waksman, Arash Salemi, Marc Cohen, William Abernethy, James Hermiller, Craig Baker, Joseph Montarello, Neal Kleiman, Lars Sondergaard, Eric Gnall, Roberto Rodriguez, Hemal Gada, William Brinkman, Neil J Weissman, Paul Mahoney, Raj Makkar","doi":"10.4244/EIJ-D-26-00158","DOIUrl":"10.4244/EIJ-D-26-00158","url":null,"abstract":"<p><strong>Background: </strong>Aortic valve replacement in small aortic annuli is associated with an increased risk of impaired haemodynamics.</p><p><strong>Aims: </strong>We sought to evaluate haemodynamic outcomes and prosthesis-patient mismatch (PPM) in aortic stenosis (AS) patients treated with Portico, Evolut, and SAPIEN 3 transcatheter aortic valves (TAVs) in small (diameter ≤23 mm) and large (diameter >23 mm) aortic annuli.</p><p><strong>Methods: </strong>PORTICO IDE was a prospective, multicentre, international, premarket randomised controlled trial comparing Portico to Evolut and SAPIEN 3 TAVs. An independent core laboratory evaluated the mean transvalvular pressure gradient (MG) and the effective orifice area (EOA), and PPM was calculated based on the core lab results.</p><p><strong>Results: </strong>A total of 675 patients with severe AS at high or extreme surgical risk were included (Portico: 362 patients; Evolut: 109; SAPIEN 3: 204). At 30 days, the EOA and rates of severe PPM in small aortic annuli were similar between Portico and Evolut (EOA 1.65 cm² vs 1.78 cm²; p=0.09; PPM 3.3% vs 3.0%; p=1.0) with a higher MG (8.5 mmHg vs 6.9 mmHg; p=0.034) for Portico. No significant differences were observed between Portico and Evolut for large aortic annuli (MG 8.3 mmHg vs 7.4 mmHg; p=0.069; EOA 1.93 cm² vs 2.02 cm²; p=0.18; PPM 5.4% vs 3.2%; p=0.83). Portico was superior to SAPIEN 3 in both small (MG 8.5 mmHg vs 13.7 mmHg; p<0.0001; EOA 1.65 cm² vs 1.40 cm²; p<0.0001; PPM 3.3% vs 26.3%; p<0.0001) and large annuli (MG 8.3 mmHg vs 10.9 mmHg; p<0.0001; EOA 1.93 cm² vs 1.67 cm²; p<0.0001; PPM 5.4% vs 10.9%; p=0.0014). At 5 years, the rate of structural valve deterioration in patients with small aortic annuli was significantly lower in patients treated with Portico (2.2%) versus SAPIEN 3 (13.9%; p=0.03).</p><p><strong>Conclusions: </strong>Haemodynamic performance was similar for the intra-annular Portico and supra-annular Evolut. Portico haemodynamics outperformed the balloon-expandable SAPIEN 3 for PPM and mean gradient in both small and large aortic annuli.</p>","PeriodicalId":54378,"journal":{"name":"Eurointervention","volume":"22 13","pages":"e741-e747"},"PeriodicalIF":9.2,"publicationDate":"2026-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13330121/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148392577","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"AnchorMan versus Watchman 2.5: a randomised comparison in left atrial appendage closure.","authors":"Philippe Garot, Jens Erik Nielsen-Kudsk","doi":"10.4244/EIJ-D-26-00453","DOIUrl":"10.4244/EIJ-D-26-00453","url":null,"abstract":"","PeriodicalId":54378,"journal":{"name":"Eurointervention","volume":"22 13","pages":"e715-e716"},"PeriodicalIF":9.2,"publicationDate":"2026-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13330108/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148392569","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparing transcatheter aortic valves: time to look beyond simplistic categorisations.","authors":"Daniel J Blackman, Annette Maznyczka","doi":"10.4244/EIJ-E-26-00011","DOIUrl":"10.4244/EIJ-E-26-00011","url":null,"abstract":"","PeriodicalId":54378,"journal":{"name":"Eurointervention","volume":"22 13","pages":"e717-e719"},"PeriodicalIF":9.2,"publicationDate":"2026-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13330116/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148392593","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Concomitant transfemoral aortic and mitral valve replacement.","authors":"Ioannis Lianos, Tiffany Patterson, Karine Grigoryan, Bushra Rana, Simon Redwood","doi":"10.4244/EIJ-D-26-00128","DOIUrl":"10.4244/EIJ-D-26-00128","url":null,"abstract":"","PeriodicalId":54378,"journal":{"name":"Eurointervention","volume":"22 13","pages":"e754-e756"},"PeriodicalIF":9.2,"publicationDate":"2026-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13330111/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148392556","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Left atrial appendage closure with the AnchorMan or Watchman devices: 12-month results of the SAFE-PROTECT randomised trial.","authors":"Binhao Wang, Heng Cai, Yanqing Wu, Manhua Chen, Changqian Wang, Xiaofei Jiang, Siming Tao, Zhixiong Zhong, Jie Zeng, Fengling Wang, Zhongping Ning, Zuyi Yuan, Jiangui He, Dominic P Francese, Alexandra J Lansky, Ben He, Huimin Chu, On Behalf Of The Safe-Protect Investigators","doi":"10.4244/EIJ-D-25-01168","DOIUrl":"10.4244/EIJ-D-25-01168","url":null,"abstract":"<p><strong>Background: </strong>Percutaneous closure of the left atrial appendage (LAA) is an alternative to chronic oral anticoagulation to reduce stroke risk in patients with non-valvular atrial fibrillation (AF).</p><p><strong>Aims: </strong>The SAFE-PROTECT trial was designed to evaluate the safety and efficacy of the AnchorMan, a novel LAA closure device, compared with the Watchman 2.5 device for patients with AF at high risk of ischaemic stroke.</p><p><strong>Methods: </strong>SAFE-PROTECT was a multicentre, open-label, non-inferiority trial of patients with non-valvular AF at high risk of ischaemic stroke, randomised 1:1 to LAA closure with the AnchorMan or the Watchman device. The 12-month primary endpoint was clinical success (freedom from ischaemic/haemorrhagic stroke, systemic embolism, cardiovascular or unexplained death); the secondary efficacy endpoint was echocardiography-defined LAA occlusion (peridevice leak <5 mm) at 12 months.</p><p><strong>Results: </strong>A total of 216 patients were randomised to either an AnchorMan (n=108) or to a Watchman (n=108) device. The AnchorMan was non-inferior to Watchman for the primary endpoint (98.1% vs 98.1%;p>0.99; difference -0.3; 95% confidence interval [CI]: -3.9 to 3.5; p_{non-inferiority}=0.0004) and the powered secondary efficacy endpoint of LAA closure (100% vs 100%; difference 0%; 95% CI: -3.60 to 3.50; p_{non-inferiority}=not applicable). The rates of all-cause death, stroke, major bleeding, and device-related complications were low and similar between groups.</p><p><strong>Conclusions: </strong>Among patients with non-valvular AF at high risk of ischaemic stroke, the AnchorMan device met its prespecified non-inferiority primary clinical success and secondary LAA occlusion endpoints compared with the Watchman 2.5 device.</p><p><strong>Clinicaltrials: </strong>gov: NCT04479722.</p>","PeriodicalId":54378,"journal":{"name":"Eurointervention","volume":"22 13","pages":"e720-e729"},"PeriodicalIF":9.2,"publicationDate":"2026-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13330120/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148392607","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Validation of the VARC-HBR consensus for defining high bleeding risk in TAVI.","authors":"Manveer Singh, Davide Capodanno, Roxana Mehran, Marie-Claude Morice, Philippe Garot","doi":"10.4244/EIJ-D-26-00315","DOIUrl":"10.4244/EIJ-D-26-00315","url":null,"abstract":"","PeriodicalId":54378,"journal":{"name":"Eurointervention","volume":"22 13","pages":"e748-e750"},"PeriodicalIF":9.2,"publicationDate":"2026-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13330113/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148391803","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Outcomes of percutaneous mechanical aspiration in left-sided infective endocarditis.","authors":"Nahyr Sofía Lugo-Fagundo, Ali H Dakroub, Benjamin Hibbert, Pedro Villablanca, Marquand Patton, Sripal Bangalore, Mohammed Qintar, Stephanie El-Hajj, Paul Sorajja, Nadira Hamid, Evin Yucel, Larry Baddour, Pradeep Yadav, Sahil Parikh, Sanjum Sethi, Abdallah El Sabbagh, On Behalf Of The Clear-Ie Investigators","doi":"10.4244/EIJ-D-26-00271","DOIUrl":"10.4244/EIJ-D-26-00271","url":null,"abstract":"","PeriodicalId":54378,"journal":{"name":"Eurointervention","volume":" ","pages":"e751-e753"},"PeriodicalIF":9.2,"publicationDate":"2026-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13330112/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148018501","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unloading the clock: when timing meets physiology in STEMI shock.","authors":"Jacob E Møller, Benedikt Schrage","doi":"10.4244/EIJ-D-26-00601","DOIUrl":"10.4244/EIJ-D-26-00601","url":null,"abstract":"","PeriodicalId":54378,"journal":{"name":"Eurointervention","volume":"22 12","pages":"e648-e649"},"PeriodicalIF":9.2,"publicationDate":"2026-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13245446/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148254435","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Door-to-unload time and mortality in patients with ST-segment elevation myocardial infarction complicated by cardiogenic shock.","authors":"Shin Nagai, Toru Kondo, Shingo Kazama, Asuka Nozaki, Takahiro Imaizumi, Shotaro Komeyama, Chiaki Mizuno, Ryota Ito, Hiroaki Hiraiwa, Ryota Morimoto, Yasunari Hayashi, Tomo Yoshizumi, Masato Mutsuga, Toyoaki Murohara, On Behalf Of The J-Pvad Investigators","doi":"10.4244/EIJ-D-25-01369","DOIUrl":"10.4244/EIJ-D-25-01369","url":null,"abstract":"<p><strong>Background: </strong>Microaxial flow pumps (mAFPs) provide left ventricular unloading and haemodynamic stabilisation, with evidence suggesting a survival benefit in patients with ST-segment elevation myocardial infarction (STEMI) complicated by cardiogenic shock (CS). The prognostic impact of early mAFP placement after hospital arrival remains unclear. Aims: We aimed to investigate the association between door-to-unload time and in-hospital mortality in patients with STEMI-CS. Methods: We analysed data from the Japan Registry for Percutaneous Ventricular Assist Devices, including consecutive patients with STEMI-CS who underwent mAFP placement between February 2020 and December 2023. The primary outcome was in-hospital mortality. Results: Among 1,783 patients, the median door-to-unload time was 99 min. The overall in-hospital mortality rate was 39.2%, and this increased with longer door-to-unload times: 32.9% (≤60 min), 33.0% (61-90 min), 40.1% (91-150 min), and 48.3% (>150 min). Using a 90 min cutoff, delayed placement (>90 min) was associated with higher mortality (adjusted odds ratio 1.56, 95% confidence interval: 1.26-1.95). A restricted cubic spline model showed that mortality remained stable when placement was within 90 min, followed by an increase. When stratified by no prior mechanical circulatory support and prior venoarterial extracorporeal membrane oxygenation (VA-ECMO) only, the patients with prior VA-ECMO only had more severe baseline characteristics and higher mortality; however, the association of longer door-to-unload time with higher mortality was consistent. Predictors of delayed mAFP placement included older age, lower institutional volume, higher heart rate, higher creatinine levels, prior use of an intra-aortic balloon pump or VA-ECMO, and percutaneous coronary intervention before mAFP placement. Conclusions: A shorter door-to-unload time, particularly within 90 min, is associated with better survival in patients with STEMI-CS.</p>","PeriodicalId":54378,"journal":{"name":"Eurointervention","volume":"22 12","pages":"e678-e689"},"PeriodicalIF":9.2,"publicationDate":"2026-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13245458/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148254334","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}