Eurointervention最新文献

{"title":"Coronary sinus narrowing for the treatment of refractory angina: one-year results of the REDUCER-I study.","authors":"Stefan Verheye, Tim P van de Hoef, Ranil de Silva, Jan-Peter van Kuijk, Jonathan Byrne, Matteo Montorfano, Eva Buschmann, Matthias Dupont, Axel Linke, Tiffany Patterson, Nick E J West, Shmuel Banai","doi":"10.4244/EIJ-D-24-01123","DOIUrl":"10.4244/EIJ-D-24-01123","url":null,"abstract":"","PeriodicalId":54378,"journal":{"name":"Eurointervention","volume":"21 15","pages":"e879-e881"},"PeriodicalIF":9.5,"publicationDate":"2025-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12319574/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144800938","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transcatheter valve repair of tricuspid regurgitation: 1-year outcomes from the TriCLASP study.","authors":"Stephan Baldus, Harald Lapp, Niklas Schofer, Tobias Geisler, Tobias Kister, Peter Lüdike, Tienush Rassaf, Jörg Hausleiter, Kai Friedrichs, Christian Frerker, Edith Lubos, Mirjam Kessler, Konstantinos Spargias, Thomas Schmitz, Georg Nickenig, Fabien Praz, Sergio Berti, Claudia Walther, Dennis Mehrkens, Bjorn Goebel, Daniel Kalbacher, Monika Zdanyte, Maximilian von Roeder, Amir Mahabadi, Ludwig Weckbach, Maria Ivannikova, Christoph Marquetand, Inge Dotz, Matthias Gröger, Michael Chrissoheris, Mareike Eißmann, Johanna Vogelhuber, Nicolas Brugger, Andreina D'Agostino, Manuela Kroll, Claire B Ren, Philipp Lurz, On Behalf Of The TriCLASP Study Investigators","doi":"10.4244/EIJ-D-24-01174","DOIUrl":"10.4244/EIJ-D-24-01174","url":null,"abstract":"<p><strong>Background: </strong>Patients with tricuspid regurgitation (TR) are at high risk for morbidity and mortality, with poorer outcomes associated with increasing TR severity. Tricuspid transcatheter edge-to-edge repair (T-TEER) has emerged as a promising treatment option.</p><p><strong>Aims: </strong>TriCLASP is a prospective, single-arm, European post-market study evaluating the safety and effectiveness of T-TEER with the PASCAL system to treat patients with ≥severe TR.</p><p><strong>Methods: </strong>The TriCLASP study enrolled 300 patients to evaluate the safety and performance of T-TEER. Major adverse events (MAE), reduction in TR grade, and clinical, functional, and quality-of-life outcomes were assessed at 1 year.</p><p><strong>Results: </strong>Enrolled patients had a mean age of 80.1 years, 52.0% were female, and 75.8% had ≥severe TR. Tricuspid regurgitation was reduced to ≤moderate in 87.7% of patients (p<0.001). The composite MAE rate was 1.7% at 30 days and 12.7% at 1 year. Kaplan-Meier estimates for survival and freedom from heart failure hospitalisation (HFH) were 88.3±1.9% and 83.2±2.3%, respectively. Annualised HFH rates decreased by 72.2% in the 12 months pre- versus post-procedure (p<0.001). Significant functional and quality-of-life improvements were observed from baseline to 1 year, including 74.5% of patients in New York Heart Association Class I/II, a 29.4-metre increase in the 6-minute walk distance, and an 8.3-point increase in the Kansas City Cardiomyopathy Questionnaire score (p<0.001).</p><p><strong>Conclusions: </strong>The 1-year results of the TriCLASP study confirm the safety and effectiveness of T-TEER with the PASCAL system in patients with ≥severe TR. Patients experienced significant TR reduction, low mortality, high freedom from HFH, and significant improvements in symptoms, functional capacity, and quality of life.</p>","PeriodicalId":54378,"journal":{"name":"Eurointervention","volume":"21 15","pages":"e869-e878"},"PeriodicalIF":9.5,"publicationDate":"2025-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12319578/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144800946","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The promise and pitfalls of registries for transcatheter tricuspid valve intervention.","authors":"Rebecca T Hahn","doi":"10.4244/EIJ-E-25-00035","DOIUrl":"10.4244/EIJ-E-25-00035","url":null,"abstract":"","PeriodicalId":54378,"journal":{"name":"Eurointervention","volume":"21 15","pages":"e832-e835"},"PeriodicalIF":9.5,"publicationDate":"2025-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12319573/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144800944","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transcatheter mitral repair in patients with symptomatic moderate functional mitral regurgitation: 1-year outcomes from the MiCLASP study.","authors":"Philipp Lurz, Volker Rudolph, Tienush Rassaf, Peter Luedike, Thomas Schmitz, Tobias Kister, Tobias Geisler, Edith Lubos, Ingo Eitel, Ralph Stephan von Bardeleben, Nedy Brambilla, Sergio Berti, Axel Linke, Bernhard Unsöld, Christian Hengstenberg, Stephan Baldus, Konstantinos Spargias, Georg Nickenig, Paolo Denti, Helge Möllmann, Wolfgang Rottbauer, Fabien Praz, Christian Butter, Markus Reinthaler, Nicolas M Van Mieghem, Frank Edelmann, Martin J Swaans, Adam Witkowski, Mamta H Buch, Tim Seidler, Andrés Iñiguez, Leo Marcoff, Konstantinos Koulogiannis, Jörg Hausleiter, On Behalf Of The MiCLASP Study Investigators","doi":"10.4244/EIJ-D-25-00031","DOIUrl":"10.4244/EIJ-D-25-00031","url":null,"abstract":"<p><strong>Background: </strong>Current clinical guidelines do not recommend mitral transcatheter edge-to-edge repair (M-TEER) for patients with moderate functional mitral regurgitation (FMR), and the implications of M-TEER in this population are not well documented.</p><p><strong>Aims: </strong>We aimed to assess M-TEER outcomes in patients with symptomatic moderate FMR compared to those with FMR ≥3+ who were treated with the PASCAL system in the MiCLASP study.</p><p><strong>Methods: </strong>Patients were stratified by baseline FMR grade (2+ or ≥3+). The echocardiographic core laboratory-assessed mitral regurgitation (MR) reduction, clinical events committee-adjudicated major adverse events (MAE) rate and functional and quality-of-life outcomes were evaluated up to 1 year after M-TEER.</p><p><strong>Results: </strong>Of the 544 (FMR=322; degenerative MR=163; mixed/other=59) enrolled patients, 101 had baseline FMR 2+ and 197 FMR ≥3+. Both groups achieved significant MR reduction at discharge, which was sustained up to 1 year, with 89.8% of patients achieving MR ≤1+ in the FMR 2+ group and 77.8% in the FMR ≥3+ group (all p<0.001 vs baseline). At 1 year, significant improvements (all p<0.001 vs baseline) in functional capacity (New York Heart Association Class I/II: 67.1% FMR 2+; 70.1% FMR ≥3+) and quality of life (change in the Kansas City Cardiomyopathy Questionnaire overall score: +13.9 points FMR 2+; +13.9 points FMR ≥3+) were achieved in both groups, with high survival (90.0% FMR 2+; 84.2% FMR ≥3+; p=0.176) and low MAE rates (13.9% FMR 2+; 18.3% FMR ≥3+; p=0.413).</p><p><strong>Conclusions: </strong>In the MiCLASP study, patients with moderate FMR experienced significant MR reduction at 1 year, resulting in clinical and symptomatic benefits comparable to those with ≥moderate-severe FMR, suggesting that select patients with symptomatic moderate FMR can benefit from M-TEER.</p>","PeriodicalId":54378,"journal":{"name":"Eurointervention","volume":"21 15","pages":"e858-e868"},"PeriodicalIF":9.5,"publicationDate":"2025-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12319577/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144800945","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Coronary sinus Reducer for the treatment of refractory angina: how much more evidence do we need?","authors":"Rasha K Al-Lamee, Michael J Foley","doi":"10.4244/EIJ-E-25-00029","DOIUrl":"10.4244/EIJ-E-25-00029","url":null,"abstract":"","PeriodicalId":54378,"journal":{"name":"Eurointervention","volume":"21 15","pages":"e836-e837"},"PeriodicalIF":9.5,"publicationDate":"2025-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12319570/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144800939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advances in coronary imaging of atherosclerotic plaques.","authors":"Hector M Garcia-Garcia, Jorge Sanz-Sanchez, Natalia Pinilla-Echeverri, Pablo J Blanco, Christos Bourantas, Fernando Alfonso","doi":"10.4244/EIJ-D-24-00387","DOIUrl":"10.4244/EIJ-D-24-00387","url":null,"abstract":"<p><p>Atherosclerosis is a complex disease with multiple factors associated with its progression and complications.Fibroatheroma is a pathological entity which contains abundant lipid, and often, a thin fibrous cap that is the most common underlying cause of acute myocardial infarction. Based on pathological descriptions, we propose a new imaging-based nomenclature indicating high-risk plaque characteristics that can be identified with imaging. Additionally, we review the literature indicating in vivo plaque characterisation as well as outlining the natural history of plaques and, more importantly, its responses to systemic and local therapies. Intravascular imaging has positively impacted how we evaluate atherosclerosis, and it can provide guidance on the use of tailored therapies and the evaluation of their long-term follow-up effects.</p>","PeriodicalId":54378,"journal":{"name":"Eurointervention","volume":"21 14","pages":"e778-e795"},"PeriodicalIF":9.5,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12285404/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144709858","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Validation of the pullback pressure gradient in resting conditions.","authors":"Koshiro Sakai, Jeroen Sonck, Takuya Mizukami, Hitoshi Matsuo, Brian Ko, Divaka Perera, Hirohiko Ando, Simone Biscaglia, Fernando Rivero, Antonio Maria Leone, Liyew Desta, Javier Escaned, Masafumi Nakayama, Daniel Munhoz, Tatyana Storozhenko, Hirofumi Ohashi, Gianluca Campo, Tetsuya Amano, Toshiro Shinke, Ziad Ali, Bernard De Bruyne, Nils P Johnson, Carlos Collet, Allen Jeremias","doi":"10.4244/EIJ-D-25-00025","DOIUrl":"10.4244/EIJ-D-25-00025","url":null,"abstract":"","PeriodicalId":54378,"journal":{"name":"Eurointervention","volume":"21 14","pages":"e820-e823"},"PeriodicalIF":9.5,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12285387/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144709864","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"One-month dual antiplatelet therapy followed by prasugrel monotherapy at a reduced dose: the 4D-ACS randomised trial.","authors":"Youngwoo Jang, Sang-Don Park, Joon Pyo Lee, Seong Huan Choi, Min Gyu Kong, Yoon Sun Won, Minsu Kim, Kyoung Hoon Lee, Seung Hwan Han, Sung Woo Kwon, Jon Suh, Woong Chol Kang","doi":"10.4244/EIJ-D-25-00331","DOIUrl":"10.4244/EIJ-D-25-00331","url":null,"abstract":"<p><strong>Background: </strong>The efficacy and safety of a 1-month prasugrel-based dual antiplatelet therapy (DAPT) strategy followed by reduced-dose prasugrel monotherapy in acute coronary syndrome (ACS) patients treated with drug-coated stents (DCS) have not been studied.</p><p><strong>Aims: </strong>We aimed to evaluate the safety and efficacy of a 1-month prasugrel-based DAPT regimen followed by reduced-dose monotherapy in ACS patients receiving a DCS.</p><p><strong>Methods: </strong>In the multicentre, randomised, open-label trial, 656 ACS patients (age: 60.9±9.7 years; 82.6% male) receiving DCS were randomised to either 1-month DAPT with aspirin 100 mg and prasugrel 10 mg (or 5 mg in patients aged ≥75 years or body weight <60 kg) followed by prasugrel 5 mg monotherapy (1M-DAPT) or 12-month DAPT with aspirin and prasugrel 5 mg (12M-DAPT). The primary endpoint was 12-month net adverse clinical events (NACE), a composite of death, non-fatal myocardial infarction, stroke, ischaemia-driven target vessel revascularisation, and Bleeding Academic Research Consortium Type 2-5 bleeding.</p><p><strong>Results: </strong>NACE occurred in 4.9% of the 1M-DAPT group and 8.8% of the 12M-DAPT group, meeting the criteria for both non-inferiority (non-inferiority margin: 2.0%; absolute difference: -3.9%; 95% confidence interval [CI] for absolute difference: -6.7% to -0.2%; p=0.014) and superiority (hazard ratio [HR] 0.51; 95% CI: 0.27-0.95; p=0.034). Any bleeding occurred in 1.2% vs 5.2% (HR 0.23; p=0.009), and major bleeding occurred in 0.6% vs 4.6% (HR 0.13; p=0.007) in the 1M-DAPT versus 12M-DAPT group, respectively. Ischaemic outcomes were similar.</p><p><strong>Conclusions: </strong>In ACS patients treated with DCS, a 1-month prasugrel-based DAPT strategy followed by prasugrel 5 mg monotherapy reduced NACE by 49%, mainly driven by a 77% reduction of bleeding events without compromising ischaemic safety.</p>","PeriodicalId":54378,"journal":{"name":"Eurointervention","volume":" ","pages":"e796-e809"},"PeriodicalIF":9.5,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12285397/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144112767","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intracoronary nicardipine to induce hyperaemia.","authors":"Michele Mattia Viscusi, Ruiko Seki, Attilio Leone, Dario Tino Bertolone, Takuya Mizukami, Thabo Mahendiran, Marta Belmonte, Jeroen Sonck, Carlos Collet, Bernard De Bruyne","doi":"10.4244/EIJ-D-25-00068","DOIUrl":"10.4244/EIJ-D-25-00068","url":null,"abstract":"","PeriodicalId":54378,"journal":{"name":"Eurointervention","volume":"21 14","pages":"e824-e826"},"PeriodicalIF":9.5,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12285386/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144709861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Supersaturated oxygen therapy to reduce myocardial infarct size: time to pay attention!","authors":"Gregg W Stone, Oludamilola Akinmolayemi","doi":"10.4244/EIJ-E-25-00031","DOIUrl":"10.4244/EIJ-E-25-00031","url":null,"abstract":"","PeriodicalId":54378,"journal":{"name":"Eurointervention","volume":"21 14","pages":"e774-e775"},"PeriodicalIF":9.5,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12285385/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144709862","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}