Eurointervention最新文献

{"title":"Haemorrhagic acute myocardial infarction.","authors":"Ankur Kalra, Rohan Dharmakumar","doi":"10.4244/EIJ-D-26-00478","DOIUrl":"10.4244/EIJ-D-26-00478","url":null,"abstract":"","PeriodicalId":54378,"journal":{"name":"Eurointervention","volume":"22 15","pages":"e805-e807"},"PeriodicalIF":9.2,"publicationDate":"2026-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13404351/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148665248","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"To crack or to ablate? The contemporary calcium dilemma.","authors":"Emanuele Barbato, Emanuele Gallinoro","doi":"10.4244/EIJ-D-26-00622","DOIUrl":"10.4244/EIJ-D-26-00622","url":null,"abstract":"","PeriodicalId":54378,"journal":{"name":"Eurointervention","volume":"22 15","pages":"e800-e801"},"PeriodicalIF":9.2,"publicationDate":"2026-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13404349/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148665228","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Wall shear stress in eruptive versus non-eruptive calcified nodules.","authors":"Diego Gallo, Atomu Tajima, Maurizio Lodi Rizzini, Umberto Morbiducci, Carlos Collet","doi":"10.4244/EIJ-D-26-00088","DOIUrl":"10.4244/EIJ-D-26-00088","url":null,"abstract":"","PeriodicalId":54378,"journal":{"name":"Eurointervention","volume":"22 15","pages":"e832-e833"},"PeriodicalIF":9.2,"publicationDate":"2026-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13404350/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148665316","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Endotype-guided management of ANOCA: are we ready?","authors":"Rocco A Montone","doi":"10.4244/EIJ-D-26-00715","DOIUrl":"10.4244/EIJ-D-26-00715","url":null,"abstract":"","PeriodicalId":54378,"journal":{"name":"Eurointervention","volume":"22 14","pages":"e762-e764"},"PeriodicalIF":9.2,"publicationDate":"2026-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13358693/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148521352","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"P2Y12 inhibitor monotherapy versus dual antiplatelet therapy after complex percutaneous coronary intervention in patients with acute coronary syndromes: a NEO-MINDSET trial substudy.","authors":"Guy F A Prado, Pedro Beraldo de Andrade, Stefano Garzon Dias Lemos, Marcelo Franken, Patricia Oliveira Guimaraes, Caio de Assis Moura Tavares, Fabio Grunspun Pitta, Felipe Mateus Teixeira Bezerra, Willterson Carlos Bandeira, Maria Sanali, Silvia Regina Lamas Assis, Frederico Monfardini, Lailah Cristina de Carvalho Abrão, Rosana Coura Rocha, Fernanda Mangione, Vitor Arantes Pazolini, Adriadne Justi Bertolin, Murillo Antunes, Fabio Serra Silveira, Bruno Ramos Nascimento, Louis N Ohe, Esmeralci Ferreira, Fernanda B A Sampaio, Rogerio Sarmento-Leite, Marco V Wainstein, Cristiano Guedes Bezerra, Jose Airton Arruda, Breno Oliveira Almeida, Valeria Paradies, Jose Mariani Junior, Pedro Alves Lemos Neto","doi":"10.4244/EIJ-D-26-00409","DOIUrl":"10.4244/EIJ-D-26-00409","url":null,"abstract":"<p><strong>Background: </strong>Whether the anatomical complexity of percutaneous coronary intervention (PCI) in patients with acute coronary syndromes (ACS) influences the effects of antiplatelet therapy remains unknown.</p><p><strong>Aims: </strong>We aimed to evaluate the impact of coronary anatomical complexity on clinical outcomes in patients receiving potent P2Y₁₂ inhibitor monotherapy or dual antiplatelet therapy (DAPT).</p><p><strong>Methods: </strong>In the NEO-MINDSET trial, patients with ACS were randomised after successful PCI to 12-month ticagrelor- or prasugrel-based monotherapy or DAPT, initiated within the first 4 days of hospitalisation. The co-primary endpoints were (i) a composite of death, myocardial infarction, urgent target vessel revascularisation, or stroke; and (ii) Bleeding Academic Research Consortium (BARC) Type 2, 3, or 5 bleeding. Complex PCI was defined by one or more of the following criteria: three-vessel PCI, ≥3 treated lesions, ≥3 stents implanted, total stent length >60 mm, two-stent bifurcation, or stenting in the left main coronary artery, in a bypass graft, or in a chronic total occlusion lesion.</p><p><strong>Results: </strong>Of the 3,408 randomised patients with available procedural data, 791 (23.2%) underwent complex PCI. Compared with the non-complex PCI group, patients in the complex PCI group were older (mean age 60.63±10.52 years vs 59.33±10.83 years; p=0.005) and had a higher prevalence of hypertension (67.9% vs 62.9%; p=0.010). Among patients undergoing complex PCI, 1, 2, or ≥3 complexity criteria were present in 45.5% (n=360), 22.5% (n=178), and 32.0% (n=253), respectively. PCI complexity did not significantly modify the treatment effects of monotherapy versus DAPT on the ischaemic co-primary endpoint (p-interaction=0.68). Likewise, PCI complexity did not have an effect on the comparative risk of BARC Type 2, 3, or 5 bleeding between monotherapy versus DAPT.</p><p><strong>Conclusions: </strong>In this post hoc analysis of the NEO-MINDSET trial, PCI complexity did not significantly modify the treatment effects of potent P2Y₁₂ inhibitor monotherapy versus DAPT on the co-primary ischaemic or bleeding outcomes.</p><p><strong>Clinicaltrials: </strong>gov: NCT04360720.</p>","PeriodicalId":54378,"journal":{"name":"Eurointervention","volume":" ","pages":"e765-e772"},"PeriodicalIF":9.2,"publicationDate":"2026-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13358697/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148037664","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Aspirin withdrawal after primary PCI for STEMI: timing matters.","authors":"Valeria Paradies, Giandomenico Mancini","doi":"10.4244/EIJ-E-26-00010","DOIUrl":"10.4244/EIJ-E-26-00010","url":null,"abstract":"","PeriodicalId":54378,"journal":{"name":"Eurointervention","volume":"22 14","pages":"e760-e761"},"PeriodicalIF":9.2,"publicationDate":"2026-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13358691/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148521417","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ticagrelor monotherapy versus dual antiplatelet therapy after primary percutaneous coronary intervention: one-year outcomes of the pilot STOP-IMH randomised trial.","authors":"Bahram Yosofi, Eva C I Woelders, Denise A M Peeters, Clemens von Birgelen, Johannes B van Rees, Antonius A C M Heestermans, Bimmer E P M Claessen, Stijn C H van den Oord, Maurits T Dirksen, Daphne van Vliet, Lara S F Konijnenberg, Aysun Cetinyurek-Yavuz, Niels van Royen, Robert-Jan M van Geuns, Robin Nijveldt, Peter Damman","doi":"10.4244/EIJ-D-26-00421","DOIUrl":"10.4244/EIJ-D-26-00421","url":null,"abstract":"<p><strong>Background: </strong>Ticagrelor monotherapy after a short period of dual antiplatelet therapy (DAPT) has been shown to be safe and effective after percutaneous coronary intervention (PCI), including primary PCI for patients with ST-segment elevation myocardial infarction (STEMI). However, the omission of aspirin could further reduce bleeding risk.</p><p><strong>Aims: </strong>We aimed to assess the impact of ticagrelor monotherapy directly after primary PCI in terms of ischaemic events and to investigate the effect on clinical bleeding events.</p><p><strong>Methods: </strong>In this multicentre, open-label pilot study, 200 STEMI patients were randomised 1:1 to ticagrelor monotherapy versus ticagrelor plus aspirin, directly after primary PCI. Major adverse cardiac and cerebrovascular events (MACCE) and bleeding were assessed at 13 months. The incidence of intramyocardial haemorrhage (IMH) was compared between groups.</p><p><strong>Results: </strong>In the ticagrelor monotherapy group (n=98) and DAPT group (n=101), MACCE occurred in 4.1% versus 4.0%, respectively (hazard ratio [HR] 1.04, 95% confidence interval [CI]: 0.26-4.17). Clinically relevant bleeding was observed in 4.1% versus 10.9% (HR 0.37, 95% CI: 0.12-1.17), and clinically relevant non-access site bleeding in 2.0% versus 9.9% (HR 0.20, 95% CI: 0.04-0.92).</p><p><strong>Conclusions: </strong>While no significant difference in ischaemic events was observed between ticagrelor monotherapy and DAPT in the first 13 months after primary PCI, this pilot study was underpowered to confirm efficacy. In addition, non-access site bleeding events were significantly reduced, and there was a downward trend in all clinical bleeding events. The incidence of IMH was similar between groups. (ClinicalTrials.gov: NCT05986968).</p>","PeriodicalId":54378,"journal":{"name":"Eurointervention","volume":" ","pages":"e773-e783"},"PeriodicalIF":9.2,"publicationDate":"2026-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13358696/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148037606","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Collapse of a new-generation magnesium scaffold.","authors":"Teresa Bastante, Javier Cuesta, Fernando Alfonso","doi":"10.4244/EIJ-D-25-00731","DOIUrl":"10.4244/EIJ-D-25-00731","url":null,"abstract":"","PeriodicalId":54378,"journal":{"name":"Eurointervention","volume":"22 14","pages":"e798-e799"},"PeriodicalIF":9.2,"publicationDate":"2026-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13358699/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148521376","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Endotype-guided medical therapy and symptom response in ANOCA.","authors":"Jacopo Farina, Sant Kumar, Gianluca Campo, Simone Biscaglia, Alberto Sarti, Joan Llevadot-Sesmilo, Valeria Paradies, Gianluca Mincione, Brian Christopher Case, Antonio Maria Leone, Domenico Galante, Andrea Erriquez, Salvatore Brugaletta","doi":"10.4244/EIJ-D-26-00148","DOIUrl":"10.4244/EIJ-D-26-00148","url":null,"abstract":"<p><strong>Background: </strong>Invasive coronary functional testing enables the classification of angina with non-obstructive coronary arteries (ANOCA) into distinct endotypes. However, real-world data linking endotype identification to subsequent pharmacological management and patient-reported symptom outcomes remain limited.</p><p><strong>Aims: </strong>We sought to evaluate the association between coronary endotypes, post-testing pharmacological treatment patterns, and changes in angina-related quality of life in patients with ANOCA in a multicentre real-world registry.</p><p><strong>Methods: </strong>Consecutive ANOCA patients undergoing invasive coronary functional testing were included. Patients were classified into six endotypes using adenosine- and acetylcholine-based testing. Pharmacological therapy was adjusted at the discretion of the treating physician based on the functional test results. The primary endpoint was a clinically meaningful improvement in angina-related health status, defined as a ≥5-point increase in the 7-item Seattle Angina Questionnaire (SAQ-7) summary score, assessed within each endotype.</p><p><strong>Results: </strong>Among 525 patients, endotype distribution was as follows: normal physiology 10.5%, elevated resting coronary blood flow 8.8%, high resistance 13.9%, compensated high resistance 14.9%, epicardial spasm 33.3%, and microvascular spasm 18.7%. After testing, prescription patterns differed across the endotypes, with increased use of beta blockers, ranolazine, and renin-angiotensin-aldosterone system blockers in coronary microvascular dysfunction endotypes and greater use of non-dihydropyridine calcium channel blockers in vasospastic endotypes. At follow-up, a ΔSAQ-7 summary score ≥5 points was observed in elevated resting flow, high-resistance, compensated high-resistance, and epicardial spasm endotypes (all p<0.001) but not in microvascular spasm or normal physiology.</p><p><strong>Conclusions: </strong>In this multicentre real-world registry, invasive coronary endotyping was associated with distinct pharmacological management patterns and differential changes in angina-related quality of life across ANOCA endotypes.</p>","PeriodicalId":54378,"journal":{"name":"Eurointervention","volume":"22 14","pages":"e784-e794"},"PeriodicalIF":9.2,"publicationDate":"2026-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13358701/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148521399","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"When less is no longer more: very early aspirin discontinuation after ACS.","authors":"Raffaele Piccolo, Antonio Pio Vitale","doi":"10.4244/EIJ-D-26-00648","DOIUrl":"10.4244/EIJ-D-26-00648","url":null,"abstract":"","PeriodicalId":54378,"journal":{"name":"Eurointervention","volume":"22 14","pages":"e757-e759"},"PeriodicalIF":9.2,"publicationDate":"2026-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13358694/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148521350","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}