World Allergy Organization Journal最新文献

{"title":"Is there a difference between women and men in chronic spontaneous urticaria? A systematic review on gender and sex differences in CSU patients","authors":"Sarah Preis MD ,&nbsp;Carla Claussen MD ,&nbsp;Stefanie Ziehfreund ,&nbsp;Tilo Biedermann MD ,&nbsp;Sophia Horster MD ,&nbsp;Alexander Zink MD, PhD","doi":"10.1016/j.waojou.2024.100974","DOIUrl":"10.1016/j.waojou.2024.100974","url":null,"abstract":"<div><div>In recent years, there has been a notable surge in interest in gender medicine, with a growing focus on exploring gender and sex differences in skin diseases.</div><div>Although it is noticeable in clinical practice that more women than men present with chronic spontaneous urticaria (CSU) in the outpatient setting, there is currently no systematic review available which addresses gender differences in CSU. PubMed Medline, Web of Science, and Cochrane Central Register of Controlled Trials (CENTRAL) were searched until July 2023. English and German randomized controlled trials, prospective and retrospective cohorts, and case-control studies that examined gender and sex differences in CSU were included. Two authors independently screened the reports for eligibility. One extracted all data, the second double-checked and critically appraised the quality and risk of bias of the studies. Twenty-six reports were included. The article reviewed differences in epidemiology, diagnostics, clinical characteristics, treatment, and quality of life in female and male patients. The findings provide limited data for the substantial impact of gender and sex in CSU patients and reveal major gaps in gender-specific care in dermatology which should be narrowed in the upcoming years to optimize patient-centered, individualized, gender-equal healthcare.</div></div><div><h3>PROSPERO registration</h3><div>CRD42023442958.</div></div>","PeriodicalId":54295,"journal":{"name":"World Allergy Organization Journal","volume":"17 11","pages":"Article 100974"},"PeriodicalIF":3.9,"publicationDate":"2024-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142418144","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role of specific immunoglobulin-E in chronic rhinosinusitis: Its clinical relevance according to nasal challenge test","authors":"Jorge Sánchez MD, MSc, EAC, PhD ,&nbsp;Leidy Álvarez MD, MSc ,&nbsp;Juan Bedoya MD ,&nbsp;Daniel Peñaranda MD, MSc ,&nbsp;Gustavo Vanegas MD ,&nbsp;Carlos Celis MD ,&nbsp;Edison Morales MD ,&nbsp;Elizabeth García MD, EAC ,&nbsp;Augusto Peñaranda MD, MSc","doi":"10.1016/j.waojou.2024.100953","DOIUrl":"10.1016/j.waojou.2024.100953","url":null,"abstract":"<div><h3>Background</h3><div>Guidelines for chronic rhinosinusitis (CRS) propose total IgE and eosinophils as important biomarkers to identify type-2 inflammation. Despite the fact that specific IgE (sIgE) have been identified as a clinical predictor in some type-2 diseases for different clinical outcomes, its role in CRS has yet to be explored in detail.</div></div><div><h3>Objetive</h3><div>To describe systemic and local sIgE in CRS and explore its possible association with clinical outcomes using nasal challenge tests (NCT).</div></div><div><h3>Methods</h3><div>In CRS patients, we measure total IgE, serum sIgE (SsIgE) and nasosinusal sIgE (NsIgE) against 9 allergenic sources; Der p, Der f, Blo t, Can f, Fel d, Per a, grasses, Staphylococcus enterotoxin A, and B. NCT was done using the allergen with the higher sIgE prevalence (Der p).</div></div><div><h3>Results</h3><div>A total of 174 patients were included. Prevalence of SsIgE was 52.8% and NsIgE 46.5%; Der p was the principal allergen for SsIgE and NsIgE. The presence of nasal polyps, asthma comorbidity, NSAID hypersensitivity, and hyposmia, were significantly associated with the presence of SsIgE and NsIgE but not with total IgE. NCT-Der p was performed in 73 CRS patients, being positive in 33 (45.2%). SsIgE have the best diagnostic accuracy (79.4%) to predict NCT results (NsIgE 67.5% total IgE 52%).</div></div><div><h3>Conclusion</h3><div>Specific IgE is a better biomarker in CRS than total IgE. Patients with clinically relevant SsIgE have a pheno-endotype associated with different clinical outcomes. Considering the clinical relevance of SsIgE demonstrated by NCT, interventions like allergen immunotherapy in CRS must be study.</div></div>","PeriodicalId":54295,"journal":{"name":"World Allergy Organization Journal","volume":"17 10","pages":"Article 100953"},"PeriodicalIF":3.9,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142418670","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pollen exposures in pregnancy and early life are associated with childhood asthma incidence","authors":"Rajesh Melaram ,&nbsp;James Adefisoye ,&nbsp;Donald E. Warden ,&nbsp;Stephen Potter ,&nbsp;Hasan Arshad ,&nbsp;Hongmei Zhang","doi":"10.1016/j.waojou.2024.100976","DOIUrl":"10.1016/j.waojou.2024.100976","url":null,"abstract":"<div><h3>Background</h3><div>Pollen exposure is an environmental risk factor for asthma symptoms and allergic reactions in children. The extent to which pollen exposure in pregnancy and the first year of life influences the development of childhood asthma and rhinitis is not fully understood.</div></div><div><h3>Objective</h3><div>We aimed to investigate early life exposures to pollen with childhood asthma and rhinitis at age 6 in a longitudinal birth cohort of the United Kingdom.</div></div><div><h3>Methods</h3><div>In this retrospective cohort study, via logistic regressions, we analyzed the associations between pollen exposures in pregnancy and the first year of life with childhood asthma and rhinitis.</div></div><div><h3>Results</h3><div>Higher pollen exposure accumulated during pregnancy and during the first year of life both associated with an increased odds of asthma at age 6 (OR = 1.14, 95% CI 1.03–1.26, p = 0.01; OR = 1.15, 95% CI 1.03–1.29, p = 0.02, respectively). We did not observe statistically significant associations between early life pollen exposures and the odds of rhinitis at the same age.</div></div><div><h3>Conclusion</h3><div>High pollen exposure during early life (prenatal and postnatal) associated with an increased risk of asthma incidence at age 6. Further studies are desired to validate these findings and to elucidate the mechanisms of early life exposures to pollen on asthma etiology.</div></div>","PeriodicalId":54295,"journal":{"name":"World Allergy Organization Journal","volume":"17 10","pages":"Article 100976"},"PeriodicalIF":3.9,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142418671","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fecal microbiota transplantation alleviates food allergy in neonatal mice via the PD-1/PD-L1 pathway and change of the microbiota composition","authors":"Jinli Huang MD ,&nbsp;Xingzhi Wang MD ,&nbsp;Juan Zhang MD ,&nbsp;Qiuhong Li MD ,&nbsp;Panpan Zhang MD ,&nbsp;Cheng Wu MD ,&nbsp;Yuanyuan Jia MD ,&nbsp;Hui Su PhD ,&nbsp;Xin Sun PhD","doi":"10.1016/j.waojou.2024.100969","DOIUrl":"10.1016/j.waojou.2024.100969","url":null,"abstract":"<div><h3>Background</h3><div>Food allergy (FA) is a common disorder in children and affects the health of children worldwide. The gut microbiota is closely related to the occurrence and development of FA. Fecal microbiota transplantation (FMT) is a way to treat diseases by reconstituting the microbiota; however, the role and mechanisms of FA have not been validated.</div></div><div><h3>Methods</h3><div>In this study, we established an ovalbumin (OVA)-induced juvenile mouse model and used 16S RNA sequencing, pathological histological staining, molecular biology, and flow-through techniques to evaluate the protective effects of FMT treatment on FA and to explore the mechanisms.</div></div><div><h3>Results</h3><div>OVA-induced dysregulation of the gut microbiota led to impaired intestinal function and immune dysregulation in FA mice. FMT treatment improved the structure, diversity, and composition of the gut microbiota and restored it to a near-donor state. FMT treatment reduced levels of Th2-associated inflammatory factors, decreased intestinal tissue inflammation, and reduced IgE production. In addition, FMT reduced the number of mast cells and eosinophils and suppressed OVA-specific antibodies. Further mechanistic studies revealed that FMT treatment induced immune tolerance by inducing the expression of CD103⁺DCs and programmed cell death ligand 1 (PD-L1) in mesenteric lymph nodes and promoting the production of Treg through the programmed cell death protein 1 (PD-1)/PD-L1 pathway. Meanwhile, Th2 cytokines, OVA-specific antibodies, and PD-1/PD-L1 showed a significant correlation with the gut microbiota.</div></div><div><h3>Conclusions</h3><div>FMT could regulate the gut microbiota and Th1/Th2 immune balance and might inhibit FA through the PD-1/PD-L1 pathway, which would provide a new idea for the treatment of FA.</div></div>","PeriodicalId":54295,"journal":{"name":"World Allergy Organization Journal","volume":"17 10","pages":"Article 100969"},"PeriodicalIF":3.9,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142418689","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Time to ACT-UP: Update on precautionary allergen labelling (PAL)","authors":"Paul J. Turner ,&nbsp;Antonio Bognanni ,&nbsp;Stefania Arasi ,&nbsp;Ignacio J. Ansotegui ,&nbsp;Sabine Schnadt ,&nbsp;Sébastien La Vieille ,&nbsp;Jonathan O’B. Hourihane ,&nbsp;Torsten Zuberbier ,&nbsp;Philippe Eigenmann ,&nbsp;Motohiro Ebisawa ,&nbsp;Mario Morais-Almeida ,&nbsp;Julie Barnett ,&nbsp;Bryan Martin ,&nbsp;Linda Monaci ,&nbsp;Graham Roberts ,&nbsp;Gary Wong ,&nbsp;Ruchi Gupta ,&nbsp;Sophia Tsabouri ,&nbsp;Clare Mills ,&nbsp;Simon Brooke-Taylor ,&nbsp;Alessandro Fiocchi","doi":"10.1016/j.waojou.2024.100972","DOIUrl":"10.1016/j.waojou.2024.100972","url":null,"abstract":"<div><h3>Background</h3><div>Precautionary Allergen (“may contain”) Labelling (PAL) is used by industry to communicate potential risk to food-allergic individuals posed by unintended allergen presence (UAP). In 2014, the World Allergy Organization (WAO) highlighted that PAL use was increasing, but often applied inconsistently and without regulation — which reduces its usefulness to consumers with food allergy and those purchasing food for them. WAO proposed the need for a regulated, international framework to underpin application of PAL. In 2019, the World Health Organization (WHO) and the Food and Agriculture Organization (FAO) of the United Nations convened an expert consultation to address the issue of PAL, the outputs of which are now being considered by the Codex Committee on Food Labelling (CCFL).</div></div><div><h3>Objectives</h3><div>To summarise the latest data to inform the application of PAL in a more systematic way, for implementation into global food standards.</div></div><div><h3>Methods</h3><div>A non-systematic review of issues surrounding precautionary labelling and food allergens in pre-packaged products.</div></div><div><h3>Results</h3><div>Approximately, 100 countries around the world have legislation on the declaration of allergenic ingredients. Just a few have legislation on UAP. Given the risks that UAP entails, non-regulated PAL creates inconvenience in real life due to its unequal, difficult interpretation by patients. The attempts made so far to rationalize PAL present lights and shadows.</div></div><div><h3>Conclusions</h3><div>At a time when CCFL is considering the results of the FAO/WHO Expert Consultation 2020–2023, we summarise the prospects to develop an effective and homogeneous legislation at a global level, and the areas of uncertainty that might hinder international agreement on a regulated framework for PAL of food allergens.</div></div>","PeriodicalId":54295,"journal":{"name":"World Allergy Organization Journal","volume":"17 10","pages":"Article 100972"},"PeriodicalIF":3.9,"publicationDate":"2024-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142319758","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Eosinophilic esophagitis and inhalant antigens: Pointing out the roles of allergic rhinitis, immunotherapy and biologic treatment","authors":"Erminia Ridolo MD, PhD ,&nbsp;Francesca Nicoletta MD ,&nbsp;Carlo Lombardi MD ,&nbsp;Giovanni Passalacqua MD ,&nbsp;Gianenrico Senna MD ,&nbsp;Giorgio Walter Canonica MD","doi":"10.1016/j.waojou.2024.100968","DOIUrl":"10.1016/j.waojou.2024.100968","url":null,"abstract":"<div><div>Eosinophilic esophagitis (EoE) and allergic rhinitis (AR) usually represent the latest manifestations of the atopic march, sharing a common type 2 inflammation response. A relevant prevalence of AR in EoE cohorts has been widely confirmed. An increasing literature assessed the involvement of aeroantigens in EoE pathogenesis, focusing foremost on the seasonality of new diagnoses, symptoms, and response to therapy. Unfortunately, no diriment direction has been achieved, probably due to the retrospective design of the studies so far available, which chose surrogate markers of EoE activity (mostly the date of new diagnosis) which may be affected by geographical, logistic and personal factors, probably not dependent by the disease itself. EoE exacerbations reported in the context of the pollen levels (preferably pollen counts) may represent a more reliable marker. AR might promote the onset and the re-exacerbation of EoE through mechanisms that are both local (ie, massive exposure to airborne antigens mediated by post-nasal drip) and systemic (type 2 inflammation). Furthermore, AR may facilitate EoE onset by predisposing to pollen food allergic syndrome (PFAS), and EoE patients with PFAS reported higher rate of AR, thus suggesting a bond among these 3 conditions whose causative relationship have still to be ascertained. In addition, because of its shifting activity from Th2 to Th1 inflammation, several case reports focused on the effect of allergen immunotherapy (AIT) employed to treat AR in EoE patients. Also in this instance, no certainties could be guaranteed, although sublingual immunotherapy (SLIT) is more frequently reported to exacerbate EoE, while SCIT is mostly described as a remission adjuvant. The real life experience reported from our allergy service appears to confirm such hypothesis. Finally, a watchful eye should be reserved to monoclonal antibodies as a potential future option for concomitant EoE and AR. In light of all this, an attentive evaluation of allergic history of EoE patients should be relevant. Future perspectives should be addressed on prospective studies targeted to shed light on causative relations among airborne antigens, AR and EoE, and to viable comprehensive treatments.</div></div>","PeriodicalId":54295,"journal":{"name":"World Allergy Organization Journal","volume":"17 10","pages":"Article 100968"},"PeriodicalIF":3.9,"publicationDate":"2024-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1939455124001005/pdfft?md5=72cc13f072286d806a69f7ae8954a726&pid=1-s2.0-S1939455124001005-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142312085","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Integrated machine learning and bioinformatic analysis of mitochondrial-related signature in chronic rhinosinusitis with nasal polyps","authors":"Bo Yang MMed ,&nbsp;Min Gu MMed ,&nbsp;Chen Hong MMed ,&nbsp;Xin-Yuan Zou MMed ,&nbsp;Jia-Qi Zhang MBBS ,&nbsp;Ye Yuan MBBS ,&nbsp;Chang-Yu Qiu MD, MSc ,&nbsp;Mei-Ping Lu MD, PhD ,&nbsp;Lei Cheng MD, PhD","doi":"10.1016/j.waojou.2024.100964","DOIUrl":"10.1016/j.waojou.2024.100964","url":null,"abstract":"<div><h3>Background</h3><div>Chronic rhinosinusitis with nasal polyps (CRSwNP) is a prevalent inflammatory disorder affecting the upper respiratory tract. Recent studies have indicated an association between CRSwNP and mitochondrial metabolic disorder characterized by impaired metabolic pathways; however, the precise mechanisms remain unclear. This study aims to investigate the mitochondrial-related signature in individuals diagnosed with CRSwNP.</div></div><div><h3>Methods</h3><div>Through the integration of differentially expressed genes (DEGs) with the mitochondrial gene set, differentially expressed mitochondrial-related genes (DEMRGs) were identified. Subsequently, the hub DEMRGs were selected using 4 integrated machine learning algorithms. Immune and mitochondrial characteristics were estimated based on CIBERSORT and ssGSEA algorithms. Bioinformatic findings were confirmed through RT-qPCR, immunohistochemistry, and ELISA for nasal tissues, as well as Western blotting analysis for human nasal epithelial cells (hNECs). The relationship between hub DEMRGs and disease severity was assessed using Spearman correlation analysis.</div></div><div><h3>Results</h3><div>A total of 24 DEMRGs were screened, most of which exhibited lower expression levels in CRSwNP samples. Five hub DEMRGs (<em>ALDH1L1</em>, <em>BCKDHB</em>, <em>CBR3</em>, <em>HMGCS2</em>, and <em>OXR1</em>) were consistently downregulated in both the discovery and validation cohorts. The hub genes showed a high diagnostic performance and were positively correlated with the infiltration of M2 macrophages and resting mast cells. Experimental results confirmed that the 5 genes were downregulated at both the mRNA and protein levels within nasal polyp tissues. Finally, a significant and inverse relationship was identified between the expression levels of these genes and both the Lund-Mackay and Lund-Kennedy scores.</div></div><div><h3>Conclusion</h3><div>Our findings systematically unraveled 5 hub markers correlated with mitochondrial metabolism and immune cell infiltration in CRSwNP, suggesting their potential to be based to design diagnostic and therapeutic strategies for the disease.</div></div>","PeriodicalId":54295,"journal":{"name":"World Allergy Organization Journal","volume":"17 10","pages":"Article 100964"},"PeriodicalIF":3.9,"publicationDate":"2024-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1939455124000954/pdfft?md5=0aa4daa07b7c3b9fd971ce2e75c9690d&pid=1-s2.0-S1939455124000954-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142312084","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inverse association between the molecular spreading of IgE to grass pollen and the IgE response to Dermatophagoides pteronyssinus among children with seasonal allergic rhinitis","authors":"Giulia Brindisi MD, PhD ,&nbsp;Francesca Cipriani MD ,&nbsp;Ekaterina Potapova ,&nbsp;Salvatore Tripodi ,&nbsp;Valentina Panetta ,&nbsp;Roberto Bernardini ,&nbsp;Carlo Caffarelli ,&nbsp;Antonella Casani MD ,&nbsp;Rosa Cervone MD ,&nbsp;Loredana Chini ,&nbsp;Pasquale Comberiati MD ,&nbsp;Giovanna De Castro ,&nbsp;Michele Miraglia Del Giudice ,&nbsp;Iride Dello Iacono ,&nbsp;Andrea Di Rienzo Businco MD ,&nbsp;Stephanie Dramburg MD ,&nbsp;Marcella Gallucci MD ,&nbsp;Arianna Giannetti MD ,&nbsp;Viviana Moschese ,&nbsp;Ifigenia Sfika MD ,&nbsp;Paolo Maria Matricardi PhD","doi":"10.1016/j.waojou.2024.100975","DOIUrl":"10.1016/j.waojou.2024.100975","url":null,"abstract":"<div><h3>Background</h3><div>Seasonal allergic rhinoconjunctivitis (SAR) is a worldwide health problem, especially in Westernized countries. Previous studies of the “Panallergens in Pediatrics” (PAN-PED) cohort found that molecular spreading (ie, the progressive increase in serum specific IgE antibody levels) of the IgE response to the grass pollen, <em>Phleum pratense</em>, molecules is directly associated with polysensitization to pollen in general.</div><div>The research question is aimed at verifying whether this association can also be detected for non-pollen allergens, specifically <em>Dermatophagoides pteronyssinnus</em> (<em>D.pt</em>), to better understand the relationship between a perennial allergen (<em>D.pt</em>) and a seasonal allergen (<em>Phleum pratense</em>).</div><div>To this end, our first objective was to analyze the biobank of the PAN-PED cohort serum by measuring the IgE levels to <em>D.pt</em> and its major recombinant molecules (Der p1, Der p2, Der p23); subsequently we investigated their correlation towards <em>Phleum pratense</em> IgE response, studying also the relationship between the molecular spreading of these 2 different allergens.</div></div><div><h3>Methods</h3><div>Among 1120 patients positive to <em>Phleum pratense</em>, 638 were also sensitized to <em>D.pt</em>. Patients underwent skin prick tests (SPT) for inhalant extracts, and their serum was tested for total IgE (tIgE), and sIgE to pollen and perennial allergens. Considering the molecular allergen detection through the component resolved diagnosis (CRD), out of 638 patients, 146 were further investigated by performing IgE tests of the 3 major D.pt. molecules: Der p1, Der p2, and Der p23.</div></div><div><h3>Results</h3><div>We found that a broader molecular response to <em>Phleum pratense</em> molecules, assessed by CRD, was associated with higher tIgE levels, polysensitization to pollens, and higher IgE levels to pollens, but also to lower IgE levels to <em>D.pt</em> and lower degree of sensitization to rDer p1, r Der p2, and rDer p23. In a multivariate linear model, the number of <em>Phleum pratense</em> molecules recognized by IgE was still inversely associated with the IgE level to <em>D.pt</em> extract.</div></div><div><h3>Conclusions</h3><div>The main finding of this study was the detection of an inverse association, never described in the literature, between the molecular spreading of the IgE response to <em>Phleum pratense</em> and the IgE response to <em>D.pt</em>. This led us to speculate on the etiopathogenetic hypothesis according to which, among the majority of pollen allergic patients, a strong and molecularly diversified IgE response may be limited to pollen allergens and may be preventing or contrasting the development of an equally strong and diversified IgE sensitization to <em>D.pt</em> molecules. The biological mechanisms underlying this phenomenon deserve to be investigated.</div></div>","PeriodicalId":54295,"journal":{"name":"World Allergy Organization Journal","volume":"17 10","pages":"Article 100975"},"PeriodicalIF":3.9,"publicationDate":"2024-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1939455124001078/pdfft?md5=efafb3c2672f9aa2cace5377145e41a1&pid=1-s2.0-S1939455124001078-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142312083","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to “Disease burden and unmet need for acute allergic reactions – A patient perspective” [World Allergy Organ J 17(4) (2024 Apr) 100896]","authors":"Emelie Andersson ,&nbsp;Sofia Löfvendahl ,&nbsp;Sara Olofsson ,&nbsp;Karin Wahlberg ,&nbsp;Leif Bjermer ,&nbsp;Göran Tornling ,&nbsp;Christer Janson ,&nbsp;Jonas Hjelmgren","doi":"10.1016/j.waojou.2024.100973","DOIUrl":"10.1016/j.waojou.2024.100973","url":null,"abstract":"","PeriodicalId":54295,"journal":{"name":"World Allergy Organization Journal","volume":"17 10","pages":"Article 100973"},"PeriodicalIF":3.9,"publicationDate":"2024-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1939455124001054/pdfft?md5=21ec3cfed707143f13d13f6cf80e344c&pid=1-s2.0-S1939455124001054-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142239533","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epinephrine infusion as an adjuvant treatment for breakthrough reactions during desensitization to methotrexate","authors":"Carla Toledo-Salinas MD ,&nbsp;David Alejandro Mendoza-Hernandez MD ,&nbsp;Paul J. Turner MD, PhD","doi":"10.1016/j.waojou.2024.100965","DOIUrl":"10.1016/j.waojou.2024.100965","url":null,"abstract":"","PeriodicalId":54295,"journal":{"name":"World Allergy Organization Journal","volume":"17 10","pages":"Article 100965"},"PeriodicalIF":3.9,"publicationDate":"2024-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1939455124000966/pdfft?md5=a8e47eedf24f8870d55a711132b7ade3&pid=1-s2.0-S1939455124000966-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142239532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}