Practical Radiation Oncology最新文献

{"title":"Hypofractionated Partial Breast Reirradiation in the Conservative Retreatment of Breast Cancer Local Recurrence","authors":"Maria Cristina Leonardi MD ,&nbsp;Simona Arculeo MD ,&nbsp;Samuele Frassoni MSc ,&nbsp;Maria Alessia Zerella MD ,&nbsp;Marianna Alessandra Gerardi MD ,&nbsp;Cristiana Fodor MSc ,&nbsp;Paolo Veronesi MD ,&nbsp;Viviana Enrica Galimberti MD ,&nbsp;Francesca Magnoni MD ,&nbsp;Ekaterina Milovanova MD ,&nbsp;Damaris Patricia Rojas MD ,&nbsp;Samantha Dicuonzo MD ,&nbsp;Anna Morra MD ,&nbsp;Mattia Zaffaroni MSc ,&nbsp;Maria Giulia Vincini MSc ,&nbsp;Federica Cattani MSc ,&nbsp;Vincenzo Bagnardi PhD ,&nbsp;Roberto Orecchia MD ,&nbsp;Barbara Alicja Jereczek-Fossa MD, PhD","doi":"10.1016/j.prro.2024.07.003","DOIUrl":"10.1016/j.prro.2024.07.003","url":null,"abstract":"<div><h3>Purpose</h3><div>To evaluate the outcome of partial breast reirradiation (re-PBI) with intensity modulated radiation therapy using a hypofractionated scheme for breast cancer (BC) local relapse (LR) operated on with repeat breast-conservative surgery.</div></div><div><h3>Methods and Materials</h3><div>Intensity modulated radiation therapy-based re-PBI was performed using either helical or step-and-shoot modality to deliver 37.05 Gy in 13 fractions in 2.5 weeks. Cumulative incidence of second LR, toxicity, disease-free survival (DFS), BC-specific survival, and overall survival were evaluated.</div></div><div><h3>Results</h3><div>Between May 2012 and May 2021, 70 patients had re-PBI. The median follow-up (FU) was 6.3 years (quartiles 1-3, 4.0-8.1.). The median age at first LR was 62 years. The median primary BC first LR interval was 12.4 years (range, 1.6-26.7 years). Luminal A-like first LR accounted for 41% of the cases, and the median size was 0.8 cm. During FU, 18 (26%) patients showed a subsequent event: 3 second LRs (corresponding to an 8-year cumulative rate of 4%), 3 regional nodal recurrences, 7 distant metastases, and 5 other primary tumors. At 8 years, DFS, BC-specific survival, and overall survival were 76%, 90%, and 90%, respectively. At multivariate analysis, grade 3 and extensive intraductal components were independent predictors for DFS. For 51 and 46 patients, chronic toxicity and cosmesis were evaluated, respectively: 4% had grade 3 fibrosis, and cosmesis was deemed good/excellent in just &gt;60% of the cases.</div></div><div><h3>Conclusions</h3><div>Re-PBI after repeat breast-conservative surgery represents a feasible alternative to mastectomy with regard to local control, showing an acceptable toxicity profile. A long-term FU is crucial to better understand the pattern of relapse and consolidate the position of re-PBI in clinical practice.</div></div>","PeriodicalId":54245,"journal":{"name":"Practical Radiation Oncology","volume":"15 1","pages":"Pages 31-47"},"PeriodicalIF":3.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141789780","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ASTRO Guidelines for Partial Breast Irradiation for Patients With Early-Stage Invasive Breast Cancer: A Disturbing Change of Paradigm for Intraoperative Radiation Therapy. Editorial on Behalf of the International Society of Intraoperative Radiation Therapy Working Group","authors":"Gerd Fastner MD ,&nbsp;Samuel Larsen MD ,&nbsp;Falk Roeder MD ,&nbsp;Maria Cristina Leonardi MD ,&nbsp;Antoine Desmet MD ,&nbsp;John Grecula MD ,&nbsp;Catherine Philippson MD","doi":"10.1016/j.prro.2024.02.010","DOIUrl":"10.1016/j.prro.2024.02.010","url":null,"abstract":"","PeriodicalId":54245,"journal":{"name":"Practical Radiation Oncology","volume":"15 1","pages":"Pages 48-49"},"PeriodicalIF":3.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142958685","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In Regard to Ghirardelli et al","authors":"Jacob Y. Shin MD,&nbsp;Andreas Rimner MD,&nbsp;Charles B. Simone II MD","doi":"10.1016/j.prro.2024.08.009","DOIUrl":"10.1016/j.prro.2024.08.009","url":null,"abstract":"","PeriodicalId":54245,"journal":{"name":"Practical Radiation Oncology","volume":"15 1","pages":"Pages e90-e91"},"PeriodicalIF":3.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142958689","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Survival (Time-To-Event) Curve Names and Endpoints","authors":"Vincent D. Cassidy MD, MBA,&nbsp;Ryan J. Brisson MD,&nbsp;Robert J. Amdur MD","doi":"10.1016/j.prro.2024.08.002","DOIUrl":"10.1016/j.prro.2024.08.002","url":null,"abstract":"<div><div>In oncology, “survival curves” frequently appear in journal articles and meeting presentations. The most common labels on survival curves are overall survival, relapse-free survival, progression-free survival, distant metastasis-free survival, and local and/or regional control. Unfortunately, consistency in the definition of an event differs between authors for the same prescribed survival analyses. Furthermore, the quality of survival curves can be greatly impacted by the methodology used for endpoint selection. This paper will briefly explain widely used names and event endpoints for survival analyses in a way that will help radiation oncologists consistently present and interpret experimental findings that influence clinical practice decisions.</div></div>","PeriodicalId":54245,"journal":{"name":"Practical Radiation Oncology","volume":"15 1","pages":"Pages 25-30"},"PeriodicalIF":3.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142074541","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vulvar Cancer: Histopathologic Considerations and Nuances to Management","authors":"Lindsay Burt MD ,&nbsp;Elke Jarboe MD ,&nbsp;David Gaffney MD, PhD ,&nbsp;Gita Suneja ,&nbsp;Cristina DeCesaris MD ,&nbsp;Sabrina Bedell MD ,&nbsp;Jeffrey Brower MD, PhD","doi":"10.1016/j.prro.2024.07.008","DOIUrl":"10.1016/j.prro.2024.07.008","url":null,"abstract":"<div><div>Vulvar cancer, although rare, poses significant challenges in diagnosis and treatment because of its histopathologic complexities and nuances. This paper reviewed key aspects of the management of vulvar cancer, focusing on histopathologic diagnosis, margin status interpretation, lymph node involvement assessment, and ongoing clinical trials.</div></div>","PeriodicalId":54245,"journal":{"name":"Practical Radiation Oncology","volume":"15 1","pages":"Pages 86-92"},"PeriodicalIF":3.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142114743","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Displacement of the Tongue Base and Soft Palate Because of Breathing Patterns During Radiation Therapy for Head and Neck Cancer","authors":"Hiroaki Ikawa DDS, PhD ,&nbsp;Masashi Koto MD, PhD","doi":"10.1016/j.prro.2024.07.005","DOIUrl":"10.1016/j.prro.2024.07.005","url":null,"abstract":"","PeriodicalId":54245,"journal":{"name":"Practical Radiation Oncology","volume":"15 1","pages":"Pages 1-2"},"PeriodicalIF":3.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141914567","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Erratum to: Gaffney D, Suneja G, Weil C, Creutzberg C. International Federation of Gynecology and Obstetrics Endometrial 2023 Is Better For Radiation Oncology Patients. Pract Radiat Oncol 2024;14(6):574-581.","authors":"","doi":"10.1016/j.prro.2024.11.002","DOIUrl":"10.1016/j.prro.2024.11.002","url":null,"abstract":"","PeriodicalId":54245,"journal":{"name":"Practical Radiation Oncology","volume":"15 1","pages":"Pages e92-e93"},"PeriodicalIF":3.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142774826","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Use of Radiation Therapy in the Management of Vulvar Cancers—Identification and Management of Acute and Late Toxicities","authors":"Cristina DeCesaris MD ,&nbsp;Sabrina Bedell MD ,&nbsp;Kristen Kelley MD ,&nbsp;David Gaffney MD, PhD ,&nbsp;Gita Suneja MD, MS ,&nbsp;Lindsay Burt MD ,&nbsp;Elke Jarboe MD ,&nbsp;Jeffrey Brower MD, PhD","doi":"10.1016/j.prro.2024.08.006","DOIUrl":"10.1016/j.prro.2024.08.006","url":null,"abstract":"<div><div>Radiation therapy plays a critical role in the management of locally advanced vulvar cancers but can lead to a unique spectrum of side effects, with &gt;25% of patients experiencing high-grade toxicities. The treatment phase requires meticulous perineal skincare and may require pharmacologic management of dysuria and cystitis, diarrhea, nausea, and dermatitis/mucositis. The addition of chemotherapy warrants close laboratory monitoring for hematologic and metabolic derangements.</div></div>","PeriodicalId":54245,"journal":{"name":"Practical Radiation Oncology","volume":"15 1","pages":"Pages e57-e62"},"PeriodicalIF":3.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142300802","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In Reply to Fastner et al","authors":"Simona F. Shaitelman MD, EdM ,&nbsp;Alvin R. Cabrera MD ,&nbsp;Kilian E. Salerno MD ,&nbsp;Janice A. Lyons MD","doi":"10.1016/j.prro.2024.11.005","DOIUrl":"10.1016/j.prro.2024.11.005","url":null,"abstract":"","PeriodicalId":54245,"journal":{"name":"Practical Radiation Oncology","volume":"15 1","pages":"Pages 50-53"},"PeriodicalIF":3.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142958692","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relevance of ORATOR Trial Results in a Developing Country Like India","authors":"Sagar Raut MD, DNB ,&nbsp;Sai Kumar Samala MD","doi":"10.1016/j.prro.2024.10.003","DOIUrl":"10.1016/j.prro.2024.10.003","url":null,"abstract":"","PeriodicalId":54245,"journal":{"name":"Practical Radiation Oncology","volume":"15 1","pages":"Pages e88-e89"},"PeriodicalIF":3.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142958697","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}