Practical Radiation Oncology最新文献

{"title":"In Regard to Mechalakos et al.","authors":"Hinpetch Daungsupawong PhD, Viroj Wiwanitkit MD","doi":"10.1016/j.prro.2024.11.013","DOIUrl":"10.1016/j.prro.2024.11.013","url":null,"abstract":"","PeriodicalId":54245,"journal":{"name":"Practical Radiation Oncology","volume":"15 3","pages":"Page 308"},"PeriodicalIF":3.4,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143906894","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In Regard to Alcorn and Baldoni","authors":"Dimitri Alex Dimitroyannis PhD, MBA","doi":"10.1016/j.prro.2024.10.016","DOIUrl":"10.1016/j.prro.2024.10.016","url":null,"abstract":"","PeriodicalId":54245,"journal":{"name":"Practical Radiation Oncology","volume":"15 3","pages":"Page e304"},"PeriodicalIF":3.4,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143906879","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In Reply to Dimitroyannis","authors":"Sara Alcorn MD, MPH, PhD , Tracy Balboni MD, MPH","doi":"10.1016/j.prro.2024.12.010","DOIUrl":"10.1016/j.prro.2024.12.010","url":null,"abstract":"","PeriodicalId":54245,"journal":{"name":"Practical Radiation Oncology","volume":"15 3","pages":"Pages e305-e306"},"PeriodicalIF":3.4,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143906880","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Radiosurgery Society Working Groups on GRID, LATTICE, Microbeam, and FLASH Radiotherapies: Advancements Symposium and Subsequent Progress Made","authors":"James W. Snider MD ,&nbsp;Nina A. Mayr MD ,&nbsp;Jason Molitoris MD, PhD ,&nbsp;Arpit M. Chhabra MD ,&nbsp;Sina Mossahebi PhD ,&nbsp;Robert Griffin PhD ,&nbsp;Majid Mohiuddin MD ,&nbsp;Hualin Zhang PhD ,&nbsp;Beatriz Amendola MD ,&nbsp;Slavisa Tubin MD ,&nbsp;Minglei Kang PhD ,&nbsp;Charles Limoli PhD ,&nbsp;Kimberly Marter CMD ,&nbsp;Naipy Perez MS ,&nbsp;Gwendolyn O. Rustin BS ,&nbsp;Anand Mahadevan MD ,&nbsp;C. Norman Coleman MD ,&nbsp;Mansoor Ahmed PhD ,&nbsp;Charles B. Simone II MD","doi":"10.1016/j.prro.2024.09.015","DOIUrl":"10.1016/j.prro.2024.09.015","url":null,"abstract":"<div><h3>Purpose</h3><div>Since the inaugural workshop “Understanding High-Dose, Ultra-High Dose Rate and Spatially Fractionated Radiotherapy.” hosted by the National Cancer Institute and sponsored by the Radiosurgery Society (RSS), growing collaborations and investigations have ensued among experts, practitioners, and researchers. The RSS GRID, LATTICE, Microbeam and FLASH (GLMF) Working Groups were formed as a framework for these efforts and have focused on advancing the understanding of the biology, technical/physical parameters, trial design, and clinical practice of these new radiation therapy modalities.</div></div><div><h3>Methods and Materials</h3><div>In view of the steadily increasing clinical interest in Spatially Fractionated Radiotherapy (SFRT) and FLASH, a full-day symposium entitled “Advancements in GRID, LATTICE, and FLASH Radiotherapy Symposium” was established in 2022 that immediately preceded the RSS scientific meeting. This well-attended symposium focused on clinical, technical, and physics approaches for SFRT, and closely examining relevant radiobiological underpinnings. Practical clinical trial development was a highlighted discussion. An additional section reviewed proton therapy and other particle-based techniques for the delivery of GRID and LATTICE therapy. A treatment planning and delivery tutorial for GRID, LATTICE, and proton GRID/LATTICE was directed toward the real-world considerations for the development of new clinical GRID or LATTICE programs. An overall similar approach was applied to the discussion of FLASH. This report summarizes the content of the first GLMF Symposium and related work of the RSS GLMF Working Groups in the field of heterogeneous and ultrahigh dose rate irradiation, over approximately 2 years.</div></div><div><h3>Results</h3><div>The GLMF Working Groups have continued to expand in membership and attendance, and several resultant trial concepts, research efforts, academic discussions, and peer-reviewed publications have followed as the number of institutions and practitioners using SFRT and FLASH continues to grow.</div></div><div><h3>Conclusions</h3><div>The GLMF Working Groups and the RSS continue to demonstrate excellent progress in proliferating use of and improving understanding of SFRT and ultrahigh dose rate radiation therapy techniques.</div></div>","PeriodicalId":54245,"journal":{"name":"Practical Radiation Oncology","volume":"15 3","pages":"Pages 300-307"},"PeriodicalIF":3.4,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142512857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hesed","authors":"Edward G. Shaw MD, MA","doi":"10.1016/j.prro.2025.01.001","DOIUrl":"10.1016/j.prro.2025.01.001","url":null,"abstract":"","PeriodicalId":54245,"journal":{"name":"Practical Radiation Oncology","volume":"15 3","pages":"Pages 225-227"},"PeriodicalIF":3.4,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143906966","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prospective Evaluation of Supplemental External Beam Radiation Therapy With Palladium-103 Prostate Brachytherapy: Long-Term Results of the 44/20/0 Trials","authors":"Martin T. King MD, PhD ,&nbsp;Gregory S. Merrick MD ,&nbsp;Robert W. Galbreath PhD ,&nbsp;Ryan Fiano PhD ,&nbsp;Wayne M. Butler PhD ,&nbsp;Kent E. Wallner MD ,&nbsp;Peter F. Orio DO, MS","doi":"10.1016/j.prro.2024.10.005","DOIUrl":"10.1016/j.prro.2024.10.005","url":null,"abstract":"<div><h3>Purpose</h3><div>The 44/20 and 20/0 randomized trials evaluated whether different external beam radiation therapy (EBRT) dosing regimens prior to brachytherapy affected biochemical failure (BF). We report long-term outcomes of both trials and evaluate whether biological equivalent dose (BED) was associated with reduced BF in the combined trial cohort.</div></div><div><h3>Methods and Materials</h3><div>Both trials enrolled patients with clinical T1c to T2b, Gleason scores 7 to 9, and/or a pretreatment prostate-specific antigen (PSA) 10 to 20 ng/mL disease. The 44/20 trial randomized patients to 44 Gy EBRT with 90 Gy palladium (Pd)-103 versus 20 Gy EBRT with 115 Gy Pd-103. The subsequent 20/0 trial randomized patients to the 20 Gy arm versus monotherapeutic 125 Gy Pd-103. For each trial, univariate Fine–Gray analysis evaluated whether the treatment arm was associated with BF for the entire cohort and the unfavorable intermediate-risk (UIR) subgroup. For the combined trial cohort, multivariate Fine–Gray analysis evaluated whether BED was associated with BF while adjusting for clinical factors.</div></div><div><h3>Results</h3><div>There were 247 analyzable patients in the 44/20 trial. At a median follow-up of 13.7 years, there were no differences in BF for the entire cohort (subdistribution hazard ratio [sHR] 0.99; 95% CI, 0.43, 2.276; <em>P</em> = .97) or the UIR subgroup (sHR 0.72; 95% CI, 0.25, 2.08; <em>P</em> = .55). There were 383 analyzable patients in the 20/0 trial. At a median follow-up of 10.4 years, there were no differences in BF for the entire cohort (sHR 0.42; 95% CI, 0.13-1.80; <em>P</em> = .15) or the UIR subgroup (sHR 0.81; 95% CI, 0.16-4.03; <em>P</em> = .80). For the combined cohort (630 patients), BED was not associated with BF (1.00; 95% CI, 0.98-1.02; <em>P</em> = .88) on multivariate analyses while adjusting for androgen deprivation therapy utilization, 4-tiered National Comprehensive Cancer Network category, and year of treatment.</div></div><div><h3>Conclusions</h3><div>Brachytherapy monotherapy should be a standard-of-care treatment for clinically localized, intermediate-risk prostate cancer, including UIR disease.</div></div>","PeriodicalId":54245,"journal":{"name":"Practical Radiation Oncology","volume":"15 3","pages":"Pages e276-e285"},"PeriodicalIF":3.4,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142512854","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anesthetic Considerations for Gynecologic High Dose Rate Brachytherapy","authors":"Jill S. Remick MD ,&nbsp;Emma C. Fields MD ,&nbsp;Binoy P. Bhatt MD","doi":"10.1016/j.prro.2024.12.009","DOIUrl":"10.1016/j.prro.2024.12.009","url":null,"abstract":"","PeriodicalId":54245,"journal":{"name":"Practical Radiation Oncology","volume":"15 3","pages":"Pages 277-283"},"PeriodicalIF":3.4,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142973265","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Radiation Therapy for Dupuytren Contracture","authors":"Michael J. Yunes MD","doi":"10.1016/j.prro.2024.11.010","DOIUrl":"10.1016/j.prro.2024.11.010","url":null,"abstract":"","PeriodicalId":54245,"journal":{"name":"Practical Radiation Oncology","volume":"15 3","pages":"Pages 248-252"},"PeriodicalIF":3.4,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143016268","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Partially Ablative Body Radiation Therapy: A Widely Applicable Planning Technique for Palliation of Locally Advanced Unresectable Tumors","authors":"David Jong BAppSc (MedRad) ,&nbsp;Mark Burns MARadTherPrac ,&nbsp;Sarat Chander MBBS, FRANZCR ,&nbsp;Therese Chesson BAppSc (MedRad) ,&nbsp;Siena Williams BAppSc (MedRad) ,&nbsp;Adam U. Yeo PhD, QMP","doi":"10.1016/j.prro.2024.09.010","DOIUrl":"10.1016/j.prro.2024.09.010","url":null,"abstract":"<div><div>Patients with locally advanced, bulky, and unresectable tumors frequently exhibit frailty and endure symptomatic burdens arising from the mass effect of their tumors. Conservative approaches may often fail to provide symptomatic benefits in relatively radioresistant, slower-growing tumors such as sarcomas. A novel technique termed partially ablative body radiation therapy (PABR) administers a highly centralized ablative dose through the utilization of a simultaneous integrated boost while delivering a low and safe palliative dose to the peripheral regions of tumors. The purpose of this paper was to describe a widely applicable radiation therapy protocol in detail for the PABR technique, of which clinical results are available in previous work.⁷ In summary, a PABR prescription of 20 Gy in 5 fractions is applied to the planning target volume and is planned for 95% of the volume to be covered by 95% of the prescribed dose. A dose of 50 Gy is planned to the boost target volume, with an allowed maximum dose of up to 65 to 70 Gy, using volumetric modulated arc therapy. Daily Cone-Beam Computed Tomography images are used for delivery verification and imaging study. The centrally located volume exceeding 50 Gy effectively achieved the desired outcomes of symptom relief and tumor size reduction. The PABR approach is widely accessible and can be readily implemented in a routine clinical setting to address a pressing need for the challenging palliative patient cohort.</div></div>","PeriodicalId":54245,"journal":{"name":"Practical Radiation Oncology","volume":"15 3","pages":"Pages 284-289"},"PeriodicalIF":3.4,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142407140","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In Reply to Daungsupawong and Wiwanitkit","authors":"James G. Mechalakos PhD,&nbsp;Yu-Chi Hu PhD,&nbsp;Licheng Kuo MS,&nbsp;Lei Zhang PhD,&nbsp;Niral Shah MS,&nbsp;Ase Ballangrud PhD,&nbsp;Laura Cervino PhD,&nbsp;Ellen Yorke PhD,&nbsp;Yilin Liu PhD,&nbsp;Pengpeng Zhang PhD","doi":"10.1016/j.prro.2025.01.017","DOIUrl":"10.1016/j.prro.2025.01.017","url":null,"abstract":"","PeriodicalId":54245,"journal":{"name":"Practical Radiation Oncology","volume":"15 3","pages":"Pages e307-e308"},"PeriodicalIF":3.4,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143907012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}