Allison Landman , Josefine Gibson , Amy L Slogrove
{"title":"Thank you to our peer reviewers and contributors in 2024","authors":"Allison Landman , Josefine Gibson , Amy L Slogrove","doi":"10.1016/S2352-4642(25)00031-8","DOIUrl":"10.1016/S2352-4642(25)00031-8","url":null,"abstract":"","PeriodicalId":54238,"journal":{"name":"Lancet Child & Adolescent Health","volume":"9 3","pages":"Pages 156-157"},"PeriodicalIF":19.9,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143436546","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Anhar Ullah MSc , Raquel Granell PhD , Lesley Lowe PhD , Sara Fontanella PhD , Prof Hasan Arshad DM , Clare S Murray MD , Prof Steve Turner MD , Prof John W Holloway PhD , Prof Angela Simpson PhD , Prof Graham Roberts DM , Gang Wang MD , Prof Jadwiga A Wedzicha MD , Prof Rosa Faner PhD , Hans Jacob L Koefoed MD , Judith M Vonk PhD , Prof Alvar Agusti PhD , Prof Gerard H Koppelman PhD , Prof Erik Melén MD , Prof Adnan Custovic PhD , CADSET Clinical Research Collaboration of the European Respiratory Society
{"title":"Trajectories of airflow limitation from childhood to early adulthood: an analysis of six population-based birth cohorts","authors":"Anhar Ullah MSc , Raquel Granell PhD , Lesley Lowe PhD , Sara Fontanella PhD , Prof Hasan Arshad DM , Clare S Murray MD , Prof Steve Turner MD , Prof John W Holloway PhD , Prof Angela Simpson PhD , Prof Graham Roberts DM , Gang Wang MD , Prof Jadwiga A Wedzicha MD , Prof Rosa Faner PhD , Hans Jacob L Koefoed MD , Judith M Vonk PhD , Prof Alvar Agusti PhD , Prof Gerard H Koppelman PhD , Prof Erik Melén MD , Prof Adnan Custovic PhD , CADSET Clinical Research Collaboration of the European Respiratory Society","doi":"10.1016/S2352-4642(25)00001-X","DOIUrl":"10.1016/S2352-4642(25)00001-X","url":null,"abstract":"<div><h3>Background</h3><div>Lung function during childhood is an important predictor of subsequent health and disease. Understanding patterns of lung function and development of airflow limitation through childhood is necessary to inform lung function trajectories in relation to health and chronic airway disease. We aimed to derive trajectories of airflow limitation from childhood (age 5–8 years) into early adulthood (age 20–26 years) using repeated spirometry data from birth cohorts.</div></div><div><h3>Methods</h3><div>In this study, we drew forced expiratory volume in 1 s (FEV<sub>1</sub>) and forced vital capacity (FVC) data from six population-based birth cohorts: the UK-based Avon Longitudinal Study of Parents and Children (ALSPAC), Isle of Wight cohort (IOW), Manchester Asthma and Allergy Study (MAAS), and Aberdeen Study of Eczema and Asthma (SEATON) as well as the Swedish Child (<em>Barn</em>), Allergy, Milieu, Stockholm, Epidemiological survey (BAMSE) and the Dutch Prevention and Incidence of Asthma and Mite Allergy (PIAMA) cohort. For the discovery analysis, we pooled data from ALSPAC, IOW, MAAS, and BAMSE with spirometry data recorded at middle childhood (age 8–10 years), adolescence (age 15–18 years), and early adulthood (age 20–26 years). For the replication analysis, we pooled middle childhood and adolescence spirometry data from PIAMA and SEATON. We used latent class trajectory modelling to derive trajectory classes based on joint modelling of FEV<sub>1</sub> and FEV<sub>1</sub>/FVC ratio regression residuals ascertained from all age groups. The final model was selected using the lowest Bayesian information criterion. Participants were assigned to the trajectory with the highest posterior probability. Weighted random-effect multinomial logistic regression models were used to investigate factors associated with joining each trajectory, the results of which are reported as relative risk ratios (RRRs) with 95% CIs.</div></div><div><h3>Findings</h3><div>The discovery population included 8114 participants: 4710 from ALSPAC, 808 from IOW, 586 from MAAS, and 2010 from BAMSE and was modelled into one of four lung function trajectories that showed normal airflow (6555 [80·8%] of 8114 people), persistent airflow obstruction (1280 [15·8%]), worsening airflow obstruction (161 [2·0%]), and improved airflow obstruction (118 [1·5%]). Both improvement in and worsening airflow obstruction by early adulthood were seen from all initial severity levels. Whereas improvement in airflow obstruction was more prominent between middle childhood and adolescence (57·8%) than between adolescence and early adulthood (13·4%), worsening airflow obstruction was more prominent between adolescence and early adulthood (61·5%) than between middle childhood and adolescence (32·6%). Among current wheezers, higher BMI was associated with a lower relative risk of joining the trajectory with improvement in airflow obstruction (RRR 0·69 [95% CI 0·49–0·95]), whereas among n","PeriodicalId":54238,"journal":{"name":"Lancet Child & Adolescent Health","volume":"9 3","pages":"Pages 172-183"},"PeriodicalIF":19.9,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143437847","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sabrina H Y Eliason , Anton R Miller , W Ben Gibbard , Gurpreet Salh , Nancy Lanphear
{"title":"An international response to asking difficult FASD questions – Authors' reply","authors":"Sabrina H Y Eliason , Anton R Miller , W Ben Gibbard , Gurpreet Salh , Nancy Lanphear","doi":"10.1016/S2352-4642(24)00339-0","DOIUrl":"10.1016/S2352-4642(24)00339-0","url":null,"abstract":"","PeriodicalId":54238,"journal":{"name":"Lancet Child & Adolescent Health","volume":"9 3","pages":"Page e8"},"PeriodicalIF":19.9,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143437980","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Prof Elizabeth Whittaker PhD , Ruchi Sinha MD , Andrew Riordan MD , Alejandra Alonso MD , Prof Marieke Emonts PhD , Stephen Owens MD , Jonathan Cohen PhD , Sarah Mahoney MD , David Porter PhD , Beatriz Larru PhD , Shelley Segal PhD , Joe Brierley MD
{"title":"Ethical and legal considerations in the care of children and young people with high consequence infectious diseases (HCIDs): an approach to decision making","authors":"Prof Elizabeth Whittaker PhD , Ruchi Sinha MD , Andrew Riordan MD , Alejandra Alonso MD , Prof Marieke Emonts PhD , Stephen Owens MD , Jonathan Cohen PhD , Sarah Mahoney MD , David Porter PhD , Beatriz Larru PhD , Shelley Segal PhD , Joe Brierley MD","doi":"10.1016/S2352-4642(24)00353-5","DOIUrl":"10.1016/S2352-4642(24)00353-5","url":null,"abstract":"<div><div>High consequence infectious diseases (such as Ebola virus or avian influenza) require specialist management with strict isolation to avoid spread to health-care staff and the wider community. These infections present various ethical and legal issues for children and young people. Specific challenges include the impact of isolation on the child and family (potentially without a child's consent), limitations to care due to staff safety considerations, and reduction of resources for other children (due to potential closure of paediatric intensive care unit beds). The complex decision making required in these scenarios needs timely ethical support. As planning for future pandemics accelerates, we suggest that the ethical and legal considerations involved in delivering care to affected children and their families need urgent consideration, and we have highlighted the important areas for focus to provide a route map for this important undertaking.</div></div>","PeriodicalId":54238,"journal":{"name":"Lancet Child & Adolescent Health","volume":"9 3","pages":"Pages 205-210"},"PeriodicalIF":19.9,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143437849","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Toxic air: the biggest environmental killer of children in Europe and Central Asia","authors":"Megan Tatum","doi":"10.1016/S2352-4642(25)00033-1","DOIUrl":"10.1016/S2352-4642(25)00033-1","url":null,"abstract":"","PeriodicalId":54238,"journal":{"name":"Lancet Child & Adolescent Health","volume":"9 3","pages":"Pages 158-159"},"PeriodicalIF":19.9,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143436548","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Iain Hardie PhD , Louise Marryat PhD , Aja Murray PhD , Josiah King PhD , Kenneth Okelo MS , Prof James P Boardman FMedSci , Michael V Lombardo PhD , Prof Sarah J Stock PhD , Prof Rachael Wood PhD , Bonnie Auyeung PhD
{"title":"Early childhood developmental concerns following SARS-CoV-2 infection and COVID-19 vaccination during pregnancy: a Scottish population-level retrospective cohort study","authors":"Iain Hardie PhD , Louise Marryat PhD , Aja Murray PhD , Josiah King PhD , Kenneth Okelo MS , Prof James P Boardman FMedSci , Michael V Lombardo PhD , Prof Sarah J Stock PhD , Prof Rachael Wood PhD , Bonnie Auyeung PhD","doi":"10.1016/S2352-4642(25)00008-2","DOIUrl":"10.1016/S2352-4642(25)00008-2","url":null,"abstract":"<div><h3>Background</h3><div>Understanding the effects of SARS-CoV-2 infection and COVID-19 vaccination during pregnancy can help inform clinical guidance and tackle vaccine hesitancy. We examined relationships between SARS-CoV-2 infection during pregnancy, COVID-19 vaccination during pregnancy, and early child developmental concerns in children aged 13–15 months in Scotland.</div></div><div><h3>Methods</h3><div>We created a large, population-level linked administrative health dataset, combining the COVID-19 in Pregnancy in Scotland (COPS) dataset with age 13–15 month child health review data and other datasets. We included children estimated to have been conceived after May 18, 2020, and born before Sept 30, 2021, and their mothers. We used logistic regression modelling to investigate associations between SARS-CoV-2 infection during pregnancy, COVID-19 vaccination during pregnancy, and developmental concerns (ie, parent or caregiver developmental concerns and health visitor-identified concerns regarding speech–language–communication, problem solving, gross motor, personal–social, and emotional–behavioural development) measured during routine child health reviews at age 13–15 months, including adjustment for confounders and covariates.</div></div><div><h3>Findings</h3><div>A total of 24 919 child–mother pairs (12 752 [51·2%] male children; 12 167 [48·8%] female children) were included. 1631 (6·5%) children were prenatally exposed to SARS-CoV-2 and 4943 (19·8%) to COVID-19 vaccination. We found no associations between SARS-CoV-2 infection during pregnancy and developmental concerns. After confounder and covariate adjustment, COVID-19 vaccination during pregnancy was associated with reduced odds of developmental concerns regarding problem solving (odds ratio 0·78 [95% CI 0·64–0·95]), personal–social (0·76 [0·61–0·95]), and emotional–behavioural (0·67 [0·48–0·92]) development, but had no associations with other developmental concerns.</div></div><div><h3>Interpretation</h3><div>SARS-CoV-2 infections during pregnancy do not appear to be linked to early childhood developmental concerns, and COVID-19 vaccinations during pregnancy appear to be safe from the perspective of early childhood developmental concerns. As some developmental concerns do not become apparent until children are older than 13–15 months, future research should continue to monitor outcomes as children grow and develop.</div></div><div><h3>Funding</h3><div>Economic and Social Research Council.</div></div>","PeriodicalId":54238,"journal":{"name":"Lancet Child & Adolescent Health","volume":"9 3","pages":"Pages 162-171"},"PeriodicalIF":19.9,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143437846","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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