Lancet Child & Adolescent Health最新文献

{"title":"Achievement goals and adolescent depression: implications for school-based interventions","authors":"Sophie H Li , Aliza Werner-Seidler","doi":"10.1016/S2352-4642(24)00100-7","DOIUrl":"10.1016/S2352-4642(24)00100-7","url":null,"abstract":"","PeriodicalId":54238,"journal":{"name":"Lancet Child & Adolescent Health","volume":"8 6","pages":"Pages 387-388"},"PeriodicalIF":36.4,"publicationDate":"2024-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140791575","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-term neurocognitive, psychosocial, and physical outcomes after prenatal exposure to radiotherapy: a multicentre cohort study of the International Network on Cancer, Infertility, and Pregnancy","authors":"Indra A Van Assche MSc , Kristel Van Calsteren PhD , Jurgen Lemiere PhD , Jana Hohmann MSc , Jeroen Blommaert PhD , Evangeline A Huis in 't Veld MSc , Elyce Cardonick MD , Charlotte LeJeune MD , Nelleke P B Ottevanger PhD , Prof Els P O Witteveen PhD , Martine van Grotel PhD , Prof Marry M van den Heuvel-Eibrink PhD , Prof Lieven Lagae PhD , Maarten Lambrecht PhD , Prof Frédéric Amant PhD","doi":"10.1016/S2352-4642(24)00075-0","DOIUrl":"10.1016/S2352-4642(24)00075-0","url":null,"abstract":"<div><h3>Background</h3><p>The main data available on the safety of radiation during pregnancy originate from animal studies and from studies of survivors of atomic or nuclear disasters. The effect of radiotherapy to treat maternal cancer on fetal development is uncertain. This report presents a unique cohort and aims to determine the long-term neurocognitive, psychosocial and physical outcomes of offspring of mothers treated with radiotherapy during pregnancy.</p></div><div><h3>Methods</h3><p>In this international, multicentre, mixed retrospective–prospective cohort study, we recruited participants between Aug 5, 2006, and Aug 24, 2023, aged between 1·5 and 46 years, at three referral centres in Belgium, the Netherlands, and the USA. Participants were eligible if they were born from mothers treated with radiotherapy during pregnancy. Fetal radiation doses were obtained from medical records and participants were followed up at predefined ages (1·5, 3, 6, 9, 12, 15, and 18 years) and 5-yearly in adulthood, based on age at enrolment, using a neurocognitive test battery (measuring intelligence, attention, and memory), parent-reported executive function and psychosocial questionnaires, and a medical assessment. Results were compared with test-specific normative data. Linear regression models investigated associations between radiotherapy factors (fetal radiation dose, gestational age at the start and end of radiotherapy, and radiotherapy duration) and outcomes.</p></div><div><h3>Findings</h3><p>68 maternal cases of radiotherapy during pregnancy were registered by the three participating centres, of which 61 resulted in a livebirth and were therefore eligible to participate in the child follow-up study. After excluding those who did not give consent, 43 participants born from 42 mothers treated with radiotherapy during pregnancy were included in the study (median age at first assessment 3 years [IQR 2–11]; median age at last assessment 12 years [9–18]; median number of assessments two [1–4]). 18 (42%) of the included participants were female and 25 (58%) male, and 37 (86%) were of White ethnicity. Mean neurocognitive outcomes of the entire cohort were within normal ranges. No associations were found with fetal radiation dose or timing of radiotherapy during pregnancy. Six (16%) of 38 participants with neurocognitive outcomes scored lower than one SD on at least one neurocognitive outcome, three (7%) reported chronic medical conditions (spasmophilia, spastic diplegia, and IgG deficiency), and three (7%) were diagnosed with attention-deficit hyperactivity disorder (of whom two scored lower on attention). Of ten (23%) participants with lower neurocognitive score(s), a chronic medical condition, or attention-deficit hyperactivity disorder, eight were born preterm. The remaining 33 (77%) participants showed no neurocognitive, psychosocial, or chronic physical problems.</p></div><div><h3>Interpretation</h3><p>We show on average normal neurocognitive, psycho","PeriodicalId":54238,"journal":{"name":"Lancet Child & Adolescent Health","volume":"8 6","pages":"Pages 433-442"},"PeriodicalIF":36.4,"publicationDate":"2024-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140632157","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Determinants of lung function development from birth to age 5 years: an interrupted time series analysis of a South African birth cohort","authors":"Carlyle McCready MSc ,&nbsp;Prof Heather J Zar PhD ,&nbsp;Shaakira Chaya MD ,&nbsp;Carvern Jacobs MSc ,&nbsp;Lesley Workman MPH ,&nbsp;Prof Zoltan Hantos PhD ,&nbsp;Prof Graham L Hall PhD ,&nbsp;Prof Peter D Sly PhD ,&nbsp;Prof Mark P Nicol PhD ,&nbsp;Prof Dan J Stein PhD ,&nbsp;Anhar Ullah MSc ,&nbsp;Prof Adnan Custovic PhD ,&nbsp;Prof Francesca Little PhD ,&nbsp;Diane M Gray PhD","doi":"10.1016/S2352-4642(24)00072-5","DOIUrl":"10.1016/S2352-4642(24)00072-5","url":null,"abstract":"<div><h3>Background</h3><p>Early life is a key period that determines long-term health. Lung development in childhood predicts lung function attained in adulthood and morbidity and mortality across the life course. We aimed to assess the effect of early-life lower respiratory tract infection (LRTI) and associated risk factors on lung development from birth to school age in a South African birth cohort.</p></div><div><h3>Methods</h3><p>We prospectively followed children enrolled in a population-based cohort from birth (between March 5, 2012 and March 31, 2015) to age 5 years with annual lung function assessment. Data on multiple early-life exposures, including LRTI, were collected. The effect of early-life risk factors on lung function development from birth to age 5 years was assessed using the Generalised Additive Models for Location, Scale and Shape and Interrupted Time Series approach.</p></div><div><h3>Findings</h3><p>966 children (475 [49·2%] female, 491 [50·8%] male) had lung function measured with oscillometry, tidal flow volume loops, and multiple breath washout. LRTI occurred in 484 (50·1%) children, with a median of 2·0 LRTI episodes (IQR 1·0–3·0) per child. LRTI was independently associated with altered lung function, as evidenced by lower compliance (0·959 [95% CI 0·941–0·978]), higher resistance (1·028 [1·016–1·041]), and higher respiratory rate (1·018 [1·063–1·029]) over 5 years. Additional impact on lung function parameters occurred with each subsequent LRTI. Respiratory syncytial virus (RSV) LRTI was associated with lower expiratory flow ratio (0·97 [0·95–0·99]) compared with non-RSV LRTI. Maternal factors including allergy, smoking, and HIV infection were also associated with altered lung development, as was preterm birth, low birthweight, female sex, and coming from a less wealthy household.</p></div><div><h3>Interpretation</h3><p>Public health interventions targeting LRTI prevention, with RSV a priority, are vital, particularly in low-income and middle-income settings.</p></div><div><h3>Funding</h3><p>UK Medical Research Council Grant, The Wellcome Trust, The Bill &amp; Melinda Gates Foundation, US National Institutes of Health Human Heredity and Health in Africa, South African Medical Research Council, Hungarian Scientific Research Fund, and European Respiratory Society.</p></div>","PeriodicalId":54238,"journal":{"name":"Lancet Child & Adolescent Health","volume":"8 6","pages":"Pages 400-412"},"PeriodicalIF":36.4,"publicationDate":"2024-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2352464224000725/pdfft?md5=c8391ce1701999eb83cd9bc36b9550a9&pid=1-s2.0-S2352464224000725-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140777616","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lung function trajectories and determinants in early life","authors":"Sophie Yammine ,&nbsp;Philipp Latzin","doi":"10.1016/S2352-4642(24)00081-6","DOIUrl":"10.1016/S2352-4642(24)00081-6","url":null,"abstract":"","PeriodicalId":54238,"journal":{"name":"Lancet Child & Adolescent Health","volume":"8 6","pages":"Pages 386-387"},"PeriodicalIF":36.4,"publicationDate":"2024-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140770056","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Re-integrating Africa's street children","authors":"John Agaba","doi":"10.1016/S2352-4642(24)00103-2","DOIUrl":"10.1016/S2352-4642(24)00103-2","url":null,"abstract":"","PeriodicalId":54238,"journal":{"name":"Lancet Child & Adolescent Health","volume":"8 6","pages":"Pages 394-395"},"PeriodicalIF":36.4,"publicationDate":"2024-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140765520","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PECARN prediction rules for CT imaging of children presenting to the emergency department with blunt abdominal or minor head trauma: a multicentre prospective validation study","authors":"Prof James F Holmes MD ,&nbsp;Prof Kenneth Yen MD ,&nbsp;Irma T Ugalde MD ,&nbsp;Prof Paul Ishimine MD ,&nbsp;Pradip P Chaudhari MD ,&nbsp;Nisa Atigapramoj MD ,&nbsp;Prof Mohamed Badawy MD ,&nbsp;Prof Kevan A McCarten-Gibbs MD ,&nbsp;Donovan Nielsen BA ,&nbsp;Allyson C Sage MPH ,&nbsp;Grant Tatro MD ,&nbsp;Prof Jeffrey S Upperman MD ,&nbsp;Prof P David Adelson MD ,&nbsp;Prof Daniel J Tancredi PhD ,&nbsp;Prof Nathan Kuppermann MD","doi":"10.1016/S2352-4642(24)00029-4","DOIUrl":"https://doi.org/10.1016/S2352-4642(24)00029-4","url":null,"abstract":"&lt;div&gt;&lt;h3&gt;Background&lt;/h3&gt;&lt;p&gt;The intra-abdominal injury and traumatic brain injury prediction rules derived by the Pediatric Emergency Care Applied Research Network (PECARN) were designed to reduce inappropriate use of CT in children with abdominal and head trauma, respectively. We aimed to validate these prediction rules for children presenting to emergency departments with blunt abdominal or minor head trauma.&lt;/p&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Methods&lt;/h3&gt;&lt;p&gt;For this prospective validation study, we enrolled children and adolescents younger than 18 years presenting to six emergency departments in Sacramento (CA), Dallas (TX), Houston (TX), San Diego (CA), Los Angeles (CA), and Oakland (CA), USA between Dec 27, 2016, and Sept 1, 2021. We excluded patients who were pregnant or had pre-existing neurological disorders preventing examination, penetrating trauma, injuries more than 24 h before arrival, CT or MRI before transfer, or high suspicion of non-accidental trauma. Children presenting with blunt abdominal trauma were enrolled into an abdominal trauma cohort, and children with minor head trauma were enrolled into one of two age-segregated minor head trauma cohorts (younger than 2 years &lt;em&gt;vs&lt;/em&gt; aged 2 years and older). Enrolled children were clinically examined in the emergency department, and CT scans were obtained at the attending clinician's discretion. All enrolled children were evaluated against the variables of the pertinent PECARN prediction rule before CT results were seen. The primary outcome of interest in the abdominal trauma cohort was intra-abdominal injury undergoing acute intervention (therapeutic laparotomy, angiographic embolisation, blood transfusion, intravenous fluid for ≥2 days for pancreatic or gastrointestinal injuries, or death from intra-abdominal injury). In the age-segregated minor head trauma cohorts, the primary outcome of interest was clinically important traumatic brain injury (neurosurgery, intubation for &gt;24 h for traumatic brain injury, or hospital admission ≥2 nights for ongoing symptoms and CT-confirmed traumatic brain injury; or death from traumatic brain injury).&lt;/p&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Findings&lt;/h3&gt;&lt;p&gt;7542 children with blunt abdominal trauma and 19 999 children with minor head trauma were enrolled. The intra-abdominal injury rule had a sensitivity of 100·0% (95% CI 98·0–100·0; correct test for 145 of 145 patients with intra-abdominal injury undergoing acute intervention) and a negative predictive value (NPV) of 100·0% (95% CI 99·9–100·0; correct test for 3488 of 3488 patients without intra-abdominal injuries undergoing acute intervention). The traumatic brain injury rule for children younger than 2 years had a sensitivity of 100·0% (93·1–100·0; 42 of 42) for clinically important traumatic brain injuries and an NPV of 100·0%; 99·9–100·0; 2940 of 2940), whereas the traumatic brain injury rule for children aged 2 years and older had a sensitivity of 98·8% (95·8–99·9; 168 of 170) and an NPV of 100·0% (99·9–100·0; 6015 of 6017)","PeriodicalId":54238,"journal":{"name":"Lancet Child & Adolescent Health","volume":"8 5","pages":"Pages 339-347"},"PeriodicalIF":36.4,"publicationDate":"2024-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140543254","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A renewed commitment to intersectoral action for child and adolescent health","authors":"Jennifer Thorley","doi":"10.1016/S2352-4642(24)00082-8","DOIUrl":"https://doi.org/10.1016/S2352-4642(24)00082-8","url":null,"abstract":"","PeriodicalId":54238,"journal":{"name":"Lancet Child & Adolescent Health","volume":"8 5","pages":"Pages 320-321"},"PeriodicalIF":36.4,"publicationDate":"2024-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140544012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Limiting radiation exposure when evaluating injured children","authors":"Shannon N Acker ,&nbsp;Katrina Weaver","doi":"10.1016/S2352-4642(24)00085-3","DOIUrl":"https://doi.org/10.1016/S2352-4642(24)00085-3","url":null,"abstract":"","PeriodicalId":54238,"journal":{"name":"Lancet Child & Adolescent Health","volume":"8 5","pages":"Pages 312-313"},"PeriodicalIF":36.4,"publicationDate":"2024-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140543255","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Death by accident: the curse of mobility","authors":"Dominik Mautner","doi":"10.1016/S2352-4642(24)00083-X","DOIUrl":"https://doi.org/10.1016/S2352-4642(24)00083-X","url":null,"abstract":"","PeriodicalId":54238,"journal":{"name":"Lancet Child & Adolescent Health","volume":"8 5","pages":"Pages 323-324"},"PeriodicalIF":36.4,"publicationDate":"2024-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140544013","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Extreme or pathological demand avoidance: prioritising research to understand the prevalence and cause","authors":"Christopher Gillberg ,&nbsp;Ylva Larsson ,&nbsp;Eva Billstedt","doi":"10.1016/S2352-4642(24)00057-9","DOIUrl":"10.1016/S2352-4642(24)00057-9","url":null,"abstract":"","PeriodicalId":54238,"journal":{"name":"Lancet Child & Adolescent Health","volume":"8 7","pages":"Pages 471-473"},"PeriodicalIF":36.4,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140873370","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}