{"title":"Luregn Schlapbach: advocating for children with sepsis","authors":"Talha Burki","doi":"10.1016/S2352-4642(24)00206-2","DOIUrl":"10.1016/S2352-4642(24)00206-2","url":null,"abstract":"","PeriodicalId":54238,"journal":{"name":"Lancet Child & Adolescent Health","volume":"8 9","pages":"Page 621"},"PeriodicalIF":19.9,"publicationDate":"2024-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141979706","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Alya Al Sager MSc , Prof Sherryl H Goodman PhD , Joshua Jeong ScD , Paul A Bain PhD , Marilyn N Ahun PhD
{"title":"Effects of multi-component parenting and parental mental health interventions on early childhood development and parent outcomes: a systematic review and meta-analysis","authors":"Alya Al Sager MSc , Prof Sherryl H Goodman PhD , Joshua Jeong ScD , Paul A Bain PhD , Marilyn N Ahun PhD","doi":"10.1016/S2352-4642(24)00134-2","DOIUrl":"10.1016/S2352-4642(24)00134-2","url":null,"abstract":"<div><h3>Background</h3><p>Interventions supporting parents of young children often target parenting or parental mental health separately. Multi-component parenting and parental mental health interventions have the potential to improve parenting practices, mental health, and early childhood development. We aimed to examine their impact on child and parent outcomes.</p></div><div><h3>Methods</h3><p>In this systematic review and meta-analysis, we searched MEDLINE, Embase, Web of Science Core Collection, APA PsycINFO, CINAHL Complete, the Cochrane Central Register of Controlled Trials, and the Global Health Database from inception to Jan 23, 2024. Eligible studies were randomised controlled trials of interventions explicitly targeting parenting behaviours and parental mental health antenatally or in children's first 3 years of life. Screening, extraction, and quality assessment were done independently by two authors. Primary outcomes were cognitive and social–emotional functioning in children and depressive symptoms in parents, meta-analysed as standardised mean differences (SMDs), relative to control. This study is registered with PROSPERO, CRD42022302848.</p></div><div><h3>Findings</h3><p>We found 5843 records. After screening 2636 (45·1%) titles and abstracts, we manually identified and screened three additional articles and excluded 2177 records. After screening 462 full-length articles, 25 articles, representing a sample size of 8520 children and caregivers, were included. At baseline, mean caregiver age was 27·7 years (SD 5·9) and mean child age (excluding those enrolled during pregnancy) was 14·4 months (8·0). Interventions lasted a mean of 14 months (SD 11) and used a mean of 3·7 behaviour change techniques (2·0). Most interventions dedicated more time to parenting behaviours than to parental mental health. We found significant intervention effects on children's cognitive (SMD 0·19 [95% CI 0·04 to 0·34]; <em>I</em><sup>2</sup>=69%) and social–emotional (0·26 [0·17 to 0·34]; <em>I</em><sup>2</sup>=47%) outcomes but not on depressive symptoms in female caregivers (–0·18 [–0·36 to 0·002]; <em>I</em><sup>2</sup>=86%) relative to control conditions. Risk of bias across studies was moderate, and we found heterogeneity across results.</p></div><div><h3>Interpretation</h3><p>Multi-component parenting and mental health interventions had a positive effect on child cognitive and social–emotional outcomes, but not on depressive symptoms in parents, suggesting that other factors might contribute to positive ECD outcomes. Interventions might lack adequate focus on mental health to make a discernible impact, highlighting a need for future studies to differentiate and assess contributions of parenting and mental health components to understand independent and collective effects on family outcomes.</p></div><div><h3>Funding</h3><p>Canadian Institutes of Health Research.</p></div>","PeriodicalId":54238,"journal":{"name":"Lancet Child & Adolescent Health","volume":"8 9","pages":"Pages 656-669"},"PeriodicalIF":19.9,"publicationDate":"2024-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141979677","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Starting with empirical oral antibiotics for paediatric bone and joint infections","authors":"Jason G Newland","doi":"10.1016/S2352-4642(24)00191-3","DOIUrl":"10.1016/S2352-4642(24)00191-3","url":null,"abstract":"","PeriodicalId":54238,"journal":{"name":"Lancet Child & Adolescent Health","volume":"8 9","pages":"Pages 612-613"},"PeriodicalIF":19.9,"publicationDate":"2024-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141979682","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jasmine Eve Ong , Penelope Wong , Jasper Chua , Annika See , Rowalt Alibudbud
{"title":"Achievement goals and adolescent mental health in individualist versus collectivist cultures","authors":"Jasmine Eve Ong , Penelope Wong , Jasper Chua , Annika See , Rowalt Alibudbud","doi":"10.1016/S2352-4642(24)00170-6","DOIUrl":"10.1016/S2352-4642(24)00170-6","url":null,"abstract":"","PeriodicalId":54238,"journal":{"name":"Lancet Child & Adolescent Health","volume":"8 9","pages":"Page e7"},"PeriodicalIF":19.9,"publicationDate":"2024-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141979636","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Daniela C de Souza MD PhD , Raina Paul MD , Rebeca Mozun MD PhD , Jhuma Sankar MD , Roberto Jabornisky MD , Emma Lim MD , Amanda Harley PhD , Samirah Al Amri MD , Maha Aljuaid MD , Suyun Qian MD , Prof Luregn J Schlapbach MD PhD , Andrew Argent MD , Niranjan Kissoon MBBS
{"title":"Quality improvement programmes in paediatric sepsis from a global perspective","authors":"Daniela C de Souza MD PhD , Raina Paul MD , Rebeca Mozun MD PhD , Jhuma Sankar MD , Roberto Jabornisky MD , Emma Lim MD , Amanda Harley PhD , Samirah Al Amri MD , Maha Aljuaid MD , Suyun Qian MD , Prof Luregn J Schlapbach MD PhD , Andrew Argent MD , Niranjan Kissoon MBBS","doi":"10.1016/S2352-4642(24)00142-1","DOIUrl":"10.1016/S2352-4642(24)00142-1","url":null,"abstract":"<div><p>Sepsis is a major contributor to poor child health outcomes around the world. The high morbidity, mortality, and societal cost associated with paediatric sepsis render it a global health priority, as summarised in Paper 1 of this Series. Sepsis is characterised by a dysregulated host response to infection that manifests as organ failure, and children are uniquely susceptible to sepsis, as discussed in Paper 2. The focus of this third Series paper is quality improvement in paediatric sepsis. The 2017 WHO resolution on sepsis outlined key aims to reduce the burden of sepsis. As of 2024, only a small number of countries have implemented systematic, paediatric-focused quality improvement programmes to raise sepsis awareness, enhance recognition of sepsis, promote timely treatment, and provide long-term support for paediatric sepsis survivors. We examine programme successes and systematic barriers to quality improvement targeting paediatric sepsis. We highlight the need for programme design to consider the entire patient journey, starting with prevention, caregiver awareness, recognition at home, education of the health-care workforce, development of health-care systems, and establishment of long-term family and survivor support extending beyond the intensive care unit. Building on lessons learnt from existing quality improvement programmes, we outline implementation strategies and measures to enable benchmarking. Ultimately, quality improvement on a global scale can only be accelerated through a global learning platform focusing on paediatric sepsis.</p></div>","PeriodicalId":54238,"journal":{"name":"Lancet Child & Adolescent Health","volume":"8 9","pages":"Pages 695-706"},"PeriodicalIF":19.9,"publicationDate":"2024-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141979678","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
R Scott Watson MD MPH , Enitan D Carrol MD MBChB , Michael J Carter MRCPCH DPhil , Niranjan Kissoon MBBS , Suchitra Ranjit MD FCCM , Prof Luregn J Schlapbach MD PhD
{"title":"The burden and contemporary epidemiology of sepsis in children","authors":"R Scott Watson MD MPH , Enitan D Carrol MD MBChB , Michael J Carter MRCPCH DPhil , Niranjan Kissoon MBBS , Suchitra Ranjit MD FCCM , Prof Luregn J Schlapbach MD PhD","doi":"10.1016/S2352-4642(24)00140-8","DOIUrl":"10.1016/S2352-4642(24)00140-8","url":null,"abstract":"<div><p>Sepsis is a dysregulated host response to infection that leads to life-threatening organ dysfunction. Half of the 50 million people affected by sepsis globally every year are neonates and children younger than 19 years. This burden on the paediatric population translates into a disproportionate impact on global child health in terms of years of life lost, morbidity, and lost opportunities for children to reach their developmental potential. This Series on paediatric sepsis presents the current state of diagnosis and treatment of sepsis in children, and maps the challenges in alleviating the burden on children, their families, and society. Drawing on diverse experience and multidisciplinary expertise, we offer a roadmap to improving outcomes for children with sepsis. This first paper of the Series is a narrative review of the burden of paediatric sepsis from low-income to high-income settings. Advances towards improved operationalisation of paediatric sepsis across all age groups have facilitated more standardised assessment of the Global Burden of Disease estimates of the impact of sepsis on child health, and these estimates are expected to gain further precision with the roll out of the new Phoenix criteria for sepsis. Sepsis remains one of the leading causes of childhood morbidity and mortality, with immense direct and indirect societal costs. Although substantial regional differences persist in relation to incidence, microbiological epidemiology, and outcomes, these cannot be explained by differences in income level alone. Recent insights into post-discharge sequelae after paediatric sepsis, ranging from late mortality and persistent neurodevelopmental impairment to reduced health-related quality of life, show how common post-sepsis syndrome is in children. Targeting sepsis as a key contributor to poor health outcomes in children is therefore an essential component of efforts to meet the Sustainable Development Goals.</p></div>","PeriodicalId":54238,"journal":{"name":"Lancet Child & Adolescent Health","volume":"8 9","pages":"Pages 670-681"},"PeriodicalIF":19.9,"publicationDate":"2024-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2352464224001408/pdfft?md5=e73d3b088ad5162dd9687577b54fdb1c&pid=1-s2.0-S2352464224001408-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141979680","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Renz C W Klomberg , Nicholas M Croft , Lissy de Ridder
{"title":"Rare and severe adverse events in children with inflammatory bowel disease - Authors' reply","authors":"Renz C W Klomberg , Nicholas M Croft , Lissy de Ridder","doi":"10.1016/S2352-4642(24)00197-4","DOIUrl":"10.1016/S2352-4642(24)00197-4","url":null,"abstract":"","PeriodicalId":54238,"journal":{"name":"Lancet Child & Adolescent Health","volume":"8 9","pages":"Pages e9-e10"},"PeriodicalIF":19.9,"publicationDate":"2024-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141979871","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Advancing neonatal phototherapy after 70 years of global impact","authors":"Daniele De Luca , Vinod K Bhutani","doi":"10.1016/S2352-4642(24)00195-0","DOIUrl":"10.1016/S2352-4642(24)00195-0","url":null,"abstract":"","PeriodicalId":54238,"journal":{"name":"Lancet Child & Adolescent Health","volume":"8 11","pages":"Pages 778-780"},"PeriodicalIF":19.9,"publicationDate":"2024-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141918472","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}