Prof Leonardo Trasande MD , Aleksandra Buha Đorđević PhD , Marina Olga Fernandez PhD
{"title":"The effects of plastic exposures on children's health and urgent opportunities for prevention","authors":"Prof Leonardo Trasande MD , Aleksandra Buha Đorđević PhD , Marina Olga Fernandez PhD","doi":"10.1016/S2352-4642(25)00212-3","DOIUrl":"10.1016/S2352-4642(25)00212-3","url":null,"abstract":"<div><div>Children face an urgent threat in the form of hazards posed by plastics in the environment. Despite robust and rapidly accumulating evidence on the effects of plastic on children's health, plastic presents a paradox for child health providers: while plastic is a vehicle for so many interventions, robust evidence from laboratory and human studies show that chemicals used to produce plastics contribute to chronic conditions in multiple organ systems and disrupt hormone function, and exposure to plastic-derived toxins is associated with adverse birth outcomes, metabolic conditions, neurodevelopmental disease and disability, and reproductive conditions. Evidence-based, safe, simple, and low-cost steps exist for child health providers in primary care to help families limit children's exposure to plastic-derived toxins. Health-care providers also have a crucial opportunity to protect the health and wellbeing of future generations of children by supporting local and global campaigns for governments, industries, and the general public to reduce the accumulation of plastics in the environment and minimise the use of plastics within health-care systems.</div></div>","PeriodicalId":54238,"journal":{"name":"Lancet Child & Adolescent Health","volume":"9 11","pages":"Pages 796-807"},"PeriodicalIF":15.5,"publicationDate":"2025-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145134140","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nicolas A Menzies PhD , Tyler S Brown MD , Jeffrey W Imai-Eaton PhD , Prof Peter J Dodd PhD , Prof Ted Cohen MD DrPH , Leonardo Martinez PhD
{"title":"Potential paediatric tuberculosis incidence and deaths resulting from interruption in programmes supported by international health aid, 2025–34: a mathematical modelling study","authors":"Nicolas A Menzies PhD , Tyler S Brown MD , Jeffrey W Imai-Eaton PhD , Prof Peter J Dodd PhD , Prof Ted Cohen MD DrPH , Leonardo Martinez PhD","doi":"10.1016/S2352-4642(25)00218-4","DOIUrl":"10.1016/S2352-4642(25)00218-4","url":null,"abstract":"<div><h3>Background</h3><div>Children are at increased risk of developing and dying from tuberculosis. We aimed to estimate the additional paediatric tuberculosis deaths that could occur over 2025–34 if programmes supported by US bilateral health aid and The Global Fund to Fight AIDS, Tuberculosis, and Malaria are discontinued.</div></div><div><h3>Methods</h3><div>For this modelling study we collated data on funding sources for tuberculosis and HIV programmes in low-income and middle-income countries and constructed scenarios representing reductions in health aid from 2025. Using calibrated transmission-dynamic models of tuberculosis and HIV for 130 countries, we projected the discontinuation of tuberculosis and HIV treatment services under several funding reduction scenarios, and how this would affect paediatric (ages 0–14 years) tuberculosis exposure and treatment access. We projected paediatric tuberculosis incidence and mortality over 2025–34 to calculate the impact of funding reductions.</div></div><div><h3>Findings</h3><div>Compared to maintenance of pre-2025 service levels, withdrawal of services currently supported by US bilateral health aid is projected to result in an additional 2·5 million (95% uncertainty interval [UI] 1·8–3·3) paediatric tuberculosis cases and 340 000 (240 000–460 000) tuberculosis deaths over 2025–34. Withdrawal of US support to The Global Fund and reductions in non-US contributions are projected to result in an additional 8·9 million (95% UI 6·9–11·5) paediatric tuberculosis cases and 1·5 million (1·1–2·0) tuberculosis deaths, more than double the number of paediatric tuberculosis deaths expected with continued service levels (1·10 million [0·89–1·38]). Impacts were greatest in the WHO African and South-East Asia regions. Restoration of services in 2026 was projected to lead to a substantially smaller number of additional deaths (39 000 [95% UI 29 000–51 000]).</div></div><div><h3>Interpretation</h3><div>Without actions to restore discontinued services, cuts to health aid for tuberculosis and HIV programmes could result in millions of additional childhood tuberculosis cases and deaths in low-income and middle-income countries over the next decade.</div></div><div><h3>Funding</h3><div>None.</div></div>","PeriodicalId":54238,"journal":{"name":"Lancet Child & Adolescent Health","volume":"9 11","pages":"Pages 787-795"},"PeriodicalIF":15.5,"publicationDate":"2025-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145071298","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Beyond sepsis awareness: why some children still fall through the cracks","authors":"Akash Deep , Melissa Mead","doi":"10.1016/S2352-4642(25)00273-1","DOIUrl":"10.1016/S2352-4642(25)00273-1","url":null,"abstract":"","PeriodicalId":54238,"journal":{"name":"Lancet Child & Adolescent Health","volume":"9 11","pages":"Pages 764-765"},"PeriodicalIF":15.5,"publicationDate":"2025-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145058950","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Prof Morris Gordon PhD , Jip Groen MD , Vasiliki Sinopoulou RD , Ashish Chogle MD , Prof Carlo di Lorenzo MD , Miguel Saps MD , Merit M Tabbers PhD , Prof Marc A Benninga PhD
{"title":"European and North American guidelines for treating irritable bowel syndrome and functional abdominal pain in childhood: a guide for health-care professionals","authors":"Prof Morris Gordon PhD , Jip Groen MD , Vasiliki Sinopoulou RD , Ashish Chogle MD , Prof Carlo di Lorenzo MD , Miguel Saps MD , Merit M Tabbers PhD , Prof Marc A Benninga PhD","doi":"10.1016/S2352-4642(25)00209-3","DOIUrl":"10.1016/S2352-4642(25)00209-3","url":null,"abstract":"<div><div>Abdominal pain-related disorders of gut–brain interaction (AP-DGBI; including irritable bowel syndrome, functional abdominal pain—not otherwise specified, abdominal migraine, and functional dyspepsia) are very common among children and adolescents worldwide. Two of these disorders, irritable bowel syndrome and functional abdominal pain–not otherwise specified, have high rates of school absenteeism, psychological comorbidities, and chronicity into adulthood. A wide range of psychosocial, dietary, and pharmacological treatments have been explored for treatment of irritable bowel syndrome and functional abdominal pain—not otherwise specified in children. However, the evidence remains broad but shallow, limiting certainty about the effectiveness of specific therapies. This Health Policy translates the new evidence-based treatment guidelines for irritable bowel syndrome and functional abdominal pain–not otherwise specified produced by the European and North American societies for Paediatric Gastroenterology, Hepatology, and Nutrition into practical guidance for general paediatricians and primary care providers. This Health Policy aims to empower clinicians at all levels of care to make informed, evidence-based decisions through a shared decision-making approach tailored to the management of children with irritable bowel syndrome and functional abdominal pain–not otherwise specified.</div></div>","PeriodicalId":54238,"journal":{"name":"Lancet Child & Adolescent Health","volume":"9 11","pages":"Pages 808-816"},"PeriodicalIF":15.5,"publicationDate":"2025-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145043755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Ayodele Faleye: building a subspecialty in Africa's largest nation","authors":"Ray Cavanaugh","doi":"10.1016/S2352-4642(25)00217-2","DOIUrl":"10.1016/S2352-4642(25)00217-2","url":null,"abstract":"","PeriodicalId":54238,"journal":{"name":"Lancet Child & Adolescent Health","volume":"9 10","pages":"Page 696"},"PeriodicalIF":15.5,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144932494","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}