Lancet Child & Adolescent Health最新文献

{"title":"Assessment, prevention, and management of cardiovascular disease risk factors in children with chronic kidney disease, on dialysis and after transplantation: clinical practice recommendations from the European Society for Paediatric Nephrology","authors":"Prof Stella Stabouli MD PhD ,&nbsp;Prof Manish D Sinha MRCP PhD ,&nbsp;Fabio Paglialonga MD ,&nbsp;Prof Justine Bacchetta MD PhD ,&nbsp;Julie Bernardor MD PhD ,&nbsp;Prof Dorota Drozdz MD ,&nbsp;Prof Ali Düzova MD ,&nbsp;Prof Charles Ferro MD ,&nbsp;Alexander D Lalayiannis FRCPCH PhD ,&nbsp;Prof Anette Melk MD PhD ,&nbsp;Prof Claus Peter Schmitt MD ,&nbsp;Albert Wiegman MD PhD ,&nbsp;Prof Elke Wühl MD ,&nbsp;Prof Burkhard Tönshoff MD ,&nbsp;Prof Rukshana Shroff MD PhD","doi":"10.1016/S2352-4642(25)00334-7","DOIUrl":"10.1016/S2352-4642(25)00334-7","url":null,"abstract":"<div><div>Cardiovascular disease is an important cause of morbidity and the leading cause of death in children with chronic kidney disease. Cardiovascular disease often begins in early chronic kidney disease, progresses rapidly on dialysis, and might only partly attenuate after successful kidney transplantation. Importantly, many cardiovascular disease risk factors are modifiable when detected early and treated appropriately. Despite advances in treatments and dialysis technology, cardiovascular disease continues to cause substantial morbidity and reduced quality of life. Here we present clinical practice points on the assessment, prevention, and management of cardiovascular disease in children with chronic kidney disease, on dialysis, and after transplantation based on the best available evidence and consensus of experts from the European Society for Paediatric Nephrology. Where high-level evidence is lacking, clearly labelled expert opinion is provided and should be adapted to individual patient needs. These guidance points support timely identification and intervention to reduce cardiovascular risk in the paediatric population with chronic kidney disease.</div></div>","PeriodicalId":54238,"journal":{"name":"Lancet Child & Adolescent Health","volume":"10 3","pages":"Pages 216-232"},"PeriodicalIF":15.5,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145611756","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The global need for paediatric palliative care: the evolution of serious health-related suffering in children aged 0–19 years from 1990 to 2023","authors":"Julia Downing PhD ,&nbsp;Prof Felicia Marie Knaul PhD ,&nbsp;Xiaoxiao Jiang Kwete MBBS ,&nbsp;Prof Héctor Arreola-Ornelas MSc ,&nbsp;Nickhill Bhakta MD ,&nbsp;William E Rosa PhD ,&nbsp;Prof Lukas Radbruch MD ,&nbsp;Julia Ambler MBChB Dip Pall Med ,&nbsp;Stephen R Connor PhD ,&nbsp;Jinfeng Ding PhD ,&nbsp;Megan Doherty MMed ,&nbsp;Rui Gong PhD ,&nbsp;Prof Richard Hain MD DPhil ,&nbsp;Rut Kiman MD ,&nbsp;Eric L Krakauer MD PhD ,&nbsp;Michael J McNeil MD ,&nbsp;Oscar Méndez-Carniado BS ,&nbsp;Marina Morais BSc ,&nbsp;Mary Ann Muckaden MD ,&nbsp;Tania Pastrana PD ,&nbsp;Afsan Bhadelia PhD","doi":"10.1016/S2352-4642(25)00338-4","DOIUrl":"10.1016/S2352-4642(25)00338-4","url":null,"abstract":"&lt;div&gt;&lt;h3&gt;Background&lt;/h3&gt;&lt;div&gt;The majority of children needing palliative care globally reside in low-income and middle-income countries (LMICs) with limited or no access to such care, resulting in an excess burden of suffering. We aimed to estimate the global burden of serious health-related suffering (SHS) among children aged 0–19 years from 1990 to 2023, providing a measurement tool essential to respond to the need for more effective palliative care policies and services for children.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Methods&lt;/h3&gt;&lt;div&gt;We generated refined estimates of palliative care need for children aged 0–19 years for a 30-year time series, spanning 1990 to 2023, by extending and applying the SHS methodology originally introduced by &lt;em&gt;The Lancet&lt;/em&gt; Commission on Global Access to Palliative Care and Pain Relief and subsequently updated in 2024. The updated methodology included convening an expert paediatric palliative care panel. First, the panel identified the health conditions specific to children and related parameters for estimation of the total SHS burden in children using epidemiological mortality and prevalence data within the Global Burden of Disease Study 2023 dataset. Second, to estimate the SHS burden among decedents (those who died within the past year) and non-decedents (those who survived but experienced persistent, chronic, or progressive suffering) and quantify the condition-specific palliative care need, for each health condition the panel determined the percentage of deaths or survivors who experienced SHS and thus need palliative care or the ratio of the number of survivors with SHS to the number of deaths.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Findings&lt;/h3&gt;&lt;div&gt;In 2023, about 10·6 million children aged 0–19 years experienced SHS worldwide, with 96% of these children residing in LMICs. The three health conditions accounting for most of the global SHS burden in children were endocrine, metabolic, blood, and immune disorders (51% of SHS in children), premature birth and birth trauma (18%), and injury, poisoning, and external causes (7%). The annual number of children experiencing SHS changed little between 1990 and 2023, but the SHS burden shifted from primarily decedents toward non-decedents, with non-decedents accounting for 59% of the total burden of SHS in children in 1990 to 81% in 2023.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Interpretation&lt;/h3&gt;&lt;div&gt;Our findings underscore the crucial need to expand access to high-quality palliative care services for children and adolescents, particularly in LMICs. Our results also highlight the shift from decedent to non-decedent care needs associated with the substantial morbidity experienced by those living with their disease. Specific health-system policies to respond to the need for increased and higher-quality paediatric palliative care, especially interventions and medicines essential to address the unique palliative care needs of children, must be adequately funded to effectively reduce the avoidable burden of SHS among child","PeriodicalId":54238,"journal":{"name":"Lancet Child & Adolescent Health","volume":"10 3","pages":"Pages 167-178"},"PeriodicalIF":15.5,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146147456","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Thank you to our peer reviewers and contributors in 2025","authors":"Esther Lau ,&nbsp;Josefine Gibson ,&nbsp;Amy L Slogrove","doi":"10.1016/S2352-4642(26)00016-7","DOIUrl":"10.1016/S2352-4642(26)00016-7","url":null,"abstract":"","PeriodicalId":54238,"journal":{"name":"Lancet Child & Adolescent Health","volume":"10 3","pages":"Page 153"},"PeriodicalIF":15.5,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146147459","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Under pressure: the lifelong cardiovascular health of children and youth with primary hypertension","authors":"Rahul Chanchlani MD MSc ,&nbsp;Prof Tammy Brady MD PhD ,&nbsp;Prof Ruan Kruger PhD ,&nbsp;Prof Manish D Sinha MRCP PhD","doi":"10.1016/S2352-4642(25)00302-5","DOIUrl":"10.1016/S2352-4642(25)00302-5","url":null,"abstract":"<div><div>Global cardiovascular health promotion across the lifespan requires a comprehensive approach prioritising early life interventions. Paediatric hypertension is an increasingly recognised public health issue and an important modifiable risk factor for reducing future cardiovascular morbidity and mortality. This Review discusses the epidemiology, risk factors, diagnosis, and management of paediatric hypertension. We highlight the increasing prevalence of paediatric hypertension, its higher rates in low-income and middle-income countries (LMICs), and review its multifactorial causes globally, including genetic, environmental, and lifestyle influences. Barriers to early detection, particularly in LMICs, such as poor awareness of childhood-onset hypertension among families and health-care providers, are elucidated. Studies emphasising the short-term and long-term consequences of paediatric and youth hypertension and evidence-based diagnostic and management strategies, including non-pharmacological and pharmacological interventions, are also discussed. The management of hypertension in youth requires integrating public health strategies with clinical care to establish a robust foundation to improve lifelong health outcomes.</div></div>","PeriodicalId":54238,"journal":{"name":"Lancet Child & Adolescent Health","volume":"10 3","pages":"Pages 203-215"},"PeriodicalIF":15.5,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145784583","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to Lancet Child Adolesc Health 2022; 6: 86–95","authors":"","doi":"10.1016/S2352-4642(26)00017-9","DOIUrl":"10.1016/S2352-4642(26)00017-9","url":null,"abstract":"","PeriodicalId":54238,"journal":{"name":"Lancet Child & Adolescent Health","volume":"10 3","pages":"Page e14"},"PeriodicalIF":15.5,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146147432","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cybervictimisation and mental health conditions in young people: findings from a nationally representative longitudinal cohort","authors":"Frédéric Thériault-Couture PhD ,&nbsp;Flora Blangis PhD ,&nbsp;Niamh Dooley PhD ,&nbsp;Prof Helen L Fisher PhD ,&nbsp;Timothy Matthews PhD ,&nbsp;Prof Candice L Odgers PhD ,&nbsp;Prof Louise Arseneault PhD","doi":"10.1016/S2352-4642(25)00311-6","DOIUrl":"10.1016/S2352-4642(25)00311-6","url":null,"abstract":"&lt;div&gt;&lt;h3&gt;Background&lt;/h3&gt;&lt;div&gt;Cybervictimisation has been linked to poor mental health in young people, but doubts remain about the robustness of this association. We examined mental health outcomes for adolescents who experienced cybervictimisation using a genetically informative longitudinal design to strengthen causal inference by accounting for alternative explanations.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Methods&lt;/h3&gt;&lt;div&gt;We used data from the Environmental Risk (E-Risk) Longitudinal Twin Study, a nationally representative cohort of 2232 British twins born in 1994–95. We included participants who completed interviews assessing cybervictimisation and mulitple offline forms of victimisation since age 12 years, and a range of mental health conditions at age 18 years. Confounders were measured prospectively from ages 5 years to 18 years. Unmeasured confounders including genetic and shared environmental factors were controlled for using discordant twin analyses. People with lived experience were not involved in this study.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Findings&lt;/h3&gt;&lt;div&gt;2066 participants completed assessments at age 18 years, of whom 2063 (99·9%) had data on cybervictimisation. The mean age of the twins at the time of the assessment was 18·4 years (SD 0·4), and 1870 (90·5%) identified as White, 84 (4·1%) as Asian, 40 (1·9%) as Black, eight (0·4%) as mixed race, and 64 (3·1%) as other ethnicities. 419 (20·3%) of 2063 young people reported being moderately or severely cybervictimised between ages 12 years and 18 years, with ten (2·4%) participants reporting online abuse without having experienced offline victimisation. Cybervictimised adolescents were more likely to report generalised anxiety disorder, major depressive disorder, self-harm or suicide attempt, post-traumatic stress disorder, conduct disorder, and psychotic experiences compared with those not cybervictimised. These associations remained after adjusting for confounders, including individual characteristics (sex assigned at birth, minority ethnicity, socioeconomic status, and childhood intelligence quotient), pre-existing vulnerabilities (previous mental health conditions and online and offline victimisation), and concurrent vulnerabilities (problematic digital technology use and loneliness). Offline victimisation accounted for the associations, with modest to substantial attenuation in odds ratios (17·7–28·0% for generalised anxiety disorder and major depressive disorder; 33·5–52·3% for other outcomes). Cybervictimisation was uniquely associated with generalised anxiety disorder independently of genetic and shared environmental factors and offline victimisation (odds ratio 2·14 [95% CI 1·18–3·88]).&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Interpretation&lt;/h3&gt;&lt;div&gt;Amid ongoing policy debates on digital safety and to support targeted intervention strategies, mental health responses to cybervictimisation should consider the broader context of victimisation experienced by young people.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Funding&lt;/h3&gt;&lt;div&gt;UK Medical Resea","PeriodicalId":54238,"journal":{"name":"Lancet Child & Adolescent Health","volume":"10 2","pages":"Pages 94-102"},"PeriodicalIF":15.5,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145728378","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vascular and inflammatory diseases after COVID-19 infection and vaccination in children","authors":"Clare Craig","doi":"10.1016/S2352-4642(25)00386-4","DOIUrl":"10.1016/S2352-4642(25)00386-4","url":null,"abstract":"","PeriodicalId":54238,"journal":{"name":"Lancet Child & Adolescent Health","volume":"10 2","pages":"Pages e5-e6"},"PeriodicalIF":15.5,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145908794","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vascular and inflammatory diseases after COVID-19 infection and vaccination in children","authors":"Pallavi Saxena ,&nbsp;Hans Concin ,&nbsp;Hanno Ulmer","doi":"10.1016/S2352-4642(25)00376-1","DOIUrl":"10.1016/S2352-4642(25)00376-1","url":null,"abstract":"","PeriodicalId":54238,"journal":{"name":"Lancet Child & Adolescent Health","volume":"10 2","pages":"Pages e4-e5"},"PeriodicalIF":15.5,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145908793","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vascular and inflammatory diseases after COVID-19 infection and vaccination in children – Authors' reply","authors":"Angela M Wood ,&nbsp;Alexia Sampri ,&nbsp;Thomas Bolton","doi":"10.1016/S2352-4642(25)00382-7","DOIUrl":"10.1016/S2352-4642(25)00382-7","url":null,"abstract":"","PeriodicalId":54238,"journal":{"name":"Lancet Child & Adolescent Health","volume":"10 2","pages":"Pages e6-e8"},"PeriodicalIF":15.5,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145908795","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chandy John: Using his heart and head for change that matters","authors":"Jules Morgan","doi":"10.1016/S2352-4642(25)00383-9","DOIUrl":"10.1016/S2352-4642(25)00383-9","url":null,"abstract":"","PeriodicalId":54238,"journal":{"name":"Lancet Child & Adolescent Health","volume":"10 2","pages":"Page 80"},"PeriodicalIF":15.5,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145908796","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}