Pulmonology最新文献

{"title":"Reallocation time of accelerometer-measured movement behaviours, genetic susceptibility, and incident chronic obstructive pulmonary disease.","authors":"Darui Gao, Wenya Zhang, Yanyu Zhang, Mengmeng Ji, Xiaobo Han, Jie Liang, Yang Pan, Fanfan Zheng, Lixin Xie, Wuxiang Xie","doi":"10.1080/25310429.2026.2649099","DOIUrl":"10.1080/25310429.2026.2649099","url":null,"abstract":"<p><strong>Introduction: </strong>Little is known about the associations between reallocating time from one movement behaviour to another within 24 h with the risk of chronic obstructive pulmonary disease (COPD), particularly in the context of genetics.</p><p><strong>Methods: </strong>This study included 87 656 participants from the UK Biobank with valid wrist-worn accelerometer data and without prevalent COPD for the primary analysis. The isotemporal substitution model was used to evaluate the potential impact on COPD incidence of replacing one behaviour with an equivalent duration of another.</p><p><strong>Results: </strong>Our study showed that replacing 1 h/day of sleep, sedentary behaviours (SB), or light-intensity physical activity (LIPA) with an equal amount of time spent in moderate-to-vigorous physical activity (MVPA) was associated with 40%, 43%, and 39% lower risk of incident COPD, respectively. Stratified by genetic risk, within each subgroup, the inverse relationship between replacing sleep, SB, and LIPA with MVPA and COPD remained significant. In the joint association analysis of genetic susceptibility and MVPA duration with COPD, participants with intermediate and low genetic predisposition plus low MVPA duration were significantly associated with a 1.72- (95% CI: 1.32-2.24) and 1.39- (95% CI: 1.04-1.87) fold higher risk of incident COPD, respectively, compared to those with a high genetic predisposition and high MVPA duration.</p><p><strong>Conclusion: </strong>Irrespective of genetic susceptibility, substituting MVPA for other movement behaviours was associated with a lower risk of incident COPD. More MVPA involvement seemed to be able to mitigate the genetic risk of COPD.</p>","PeriodicalId":54237,"journal":{"name":"Pulmonology","volume":"32 1","pages":"2649099"},"PeriodicalIF":5.3,"publicationDate":"2026-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147629339","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Measurement properties of the Canadian occupational performance measure and the pulmonary functional status and dyspnea questionnaire-modified version in interstitial lung disease.","authors":"Cíntia Dias, Raquel Marinho, José Joaquim Alvarelhão, Eduarda Tinoco, Tiago Alfaro, Vânia Fernandes, Sérgio Campainha, Chris Burtin, Alda Marques","doi":"10.1080/25310429.2026.2740362","DOIUrl":"https://doi.org/10.1080/25310429.2026.2740362","url":null,"abstract":"<p><strong>Background: </strong>Measurement properties of patient-reported outcome measures assessing functional performance and activity limitations in interstitial lung disease (ILD) are often unknown.</p><p><strong>Research question: </strong>To evaluate the reliability and validity of the Canadian Occupational Performance Measure (COPM) and the Pulmonary Functional Status and Dyspnea Questionnaire-Modified version (PFSDQ-M) in European Portuguese among people with ILD, and to explore differences between fibrotic and non-fibrotic ILD.</p><p><strong>Study design and methods: </strong>Cross-sectional study. Internal consistency (Cronbach's α), test-retest/intra-rater and inter-rater reliability assessed using intraclass correlation coefficients [ICC_2,1[95%CI]], standard error of measurement (SEM), minimal detectable change at 95% confidence level (MDC₉₅) and Bland-Altman analysis, and floor/ceiling effects were evaluated. Construct validity was explored with correlations: convergent validity with the LCADL, CIS-8, 6MWT and 1-minSTS, only for PFSDQ-M; divergent validity with age and lung function for both instruments. Subgroup analyses compared fibrotic and non-fibrotic ILD.</p><p><strong>Results: </strong>A total of 334 participants were included. The COPM showed moderate test-retest/intra-rater and inter-rater reliability (ICC2,1 = 0.68[0.57-0.77]-0.72[0.63-0.80]), with SEM = 1.08-1.42 and MDC95 = 3.00-3.94, and no floor/ceiling effects. The PFSDQ-M demonstrated excellent internal consistency (α = 0.90-0.96) and good test-retest and inter-rater reliability (ICC2,1 = 0.80[0.74-0.85]-0.92[0.89-0.94]), with SEM = 15.80 and MDC₉₅ = 43.80 for total score. Bland-Altman analysis showed no systematic bias for the COPM and a small bias for the PFSDQ-M test-retest. Moderate-to-strong correlations with LCADL/CIS-8 and weak-to-moderate with 6MWT/1-minSTS supported convergent validity for PFSDQ-M. Negligible-to-weak correlations with age and lung function for COPM and PFSDQ-M supported divergent validity. Subgroup results were similar.</p><p><strong>Conclusion: </strong>The European Portuguese COPM and PFSDQ-M demonstrated reliability. The COPM showed evidence of divergent validity, whereas the PFSDQ-M demonstrated both convergent and divergent validity. These findings support their use for assessing functional performance in people with ILD.</p>","PeriodicalId":54237,"journal":{"name":"Pulmonology","volume":"32 1","pages":"2740362"},"PeriodicalIF":5.3,"publicationDate":"2026-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149118338","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Brain iron deposition mediates cognitive impairment in COPD: A possible imaging marker linking systemic inflammation to neurodegeneration.","authors":"Qian Chen, Tianlu Teng, Wenyu Zhou, Yu Zhang, Jingting Sun, Ziyi Jing, Ling Wang, Xuejing Li, Lucas Becker, Huan Ye, Zhenghan Yang, Hongjiang Wei, Zhenchang Wang","doi":"10.1080/25310429.2026.2704429","DOIUrl":"https://doi.org/10.1080/25310429.2026.2704429","url":null,"abstract":"<p><strong>Background: </strong>Cognitive impairment is a relatively prevalent comorbidity in chronic obstructive pulmonary disease (COPD), yet its neuropathological mechanism remains poorly understood.</p><p><strong>Methods: </strong>We enrolled 48 stable COPD patients, categorized into cognitively normal (CogN, <i>n</i> = 22) and impaired (Cog, <i>n</i> = 26) groups based on Montreal Cognitive Assessment (MoCA) scores, along with 34 matched healthy controls. All participants underwent 3T MRI with quantitative susceptibility mapping (QSM) to quantify regional brain iron content. Group comparisons of whole-brain and region-of-interest susceptibility were performed. Mediation analysis was then used to test whether specific brain iron deposition mediates the relationship of both COPD status and peripheral inflammatory markers with cognitive performance.</p><p><strong>Results: </strong>Cog patients showed increased total iron in the right cerebellum crus I, while CogN patients exhibited higher paramagnetic susceptibility (χpara) in the left orbitofrontal cortex (OFC), right precentral gyrus, and right brainstem. χ_para in the left OFC and right brainstem were positively correlated with total MoCA, abstraction, and orientation scores. Mediation analysis demonstrated that χpara of the left OFC mediated the effects of both COPD status and systemic neutrophil counts on impaired abstraction. Additionally, right brainstem χ_para mediated the relationship between COPD and deficits in orientation.</p><p><strong>Conclusions: </strong>COPD patients with cognitive impairment exhibited distinct patterns of brain iron deposition. Importantly, deposition in several key regions served as a potential mediator, linking both COPD and systemic inflammation to specific cognitive deficits. These preliminary findings suggest a possible association between brain iron accumulation and cognitive impairment in COPD, offering candidate neuroimaging markers for early identification.  .</p>","PeriodicalId":54237,"journal":{"name":"Pulmonology","volume":"32 1","pages":"2704429"},"PeriodicalIF":5.3,"publicationDate":"2026-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148474204","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Plasma proteomic signatures linking preserved ratio impaired spirometry to cardiometabolic diseases and multimorbidity: A longitudinal cohort study.","authors":"Li He, Ce Liu, Hao Zhao, Zhaoru Yang, Zelin Lei, Wentao Lei, Bin Luo","doi":"10.1080/25310429.2026.2650733","DOIUrl":"10.1080/25310429.2026.2650733","url":null,"abstract":"<p><strong>Background: </strong>Preserved ratio impaired spirometry (PRISm), defined by reduced FEV1 with preserved FEV1/FVC ratio, has been linked to cardiometabolic diseases (CMDs), but underlying mechanisms remain unclear. This study aims to identify plasma proteomic signatures linking PRISm to type 2 diabetes (T2D), ischaemic heart disease (IHD), stroke, first cardiometabolic disease (FCMD), and cardiometabolic multimorbidity (CMM).</p><p><strong>Methods: </strong>We conducted plasma proteomic profiling of 2 911 proteins in 32 689 UK Biobank participants with a median follow-up of 14.37 years. Machine learning algorithms were employed to identify protein signatures associated with PRISm. Causal mediation analyses were performed to quantify the mediating effects of identified proteins on the associations between PRISm and cardiometabolic outcomes. Combined protein-covariate models were developed to assess predictive performance.</p><p><strong>Results: </strong>We identified a 29-protein signature associated with PRISm. Outcome-specific analyses revealed 29 proteins for T2D, 26 for IHD, 13 for stroke, 29 for FCMD, and 27 for CMM, with 14 proteins showing consistent associations across all outcomes. Combined protein-covariate models significantly improved prediction over covariates alone (AUCs: T2D, 0.83; IHD, 0.72; stroke, 0.75; FCMD, 0.76; CMM, 0.79). Mediation analyses demonstrated that IGSF3 mediated 19.5% of the PRISm-T2D association, 12.8% for FCMD, and 11.3% for CMM, while GDF15 mediated 12.1% for IHD and 13.1% for stroke. These proteins converged on inflammatory signalling, extracellular matrix remodelling, and metabolic pathways.</p><p><strong>Conclusions: </strong>The identified protein signatures offer promising biomarkers for risk prediction, enabling early identification of high-risk individuals with PRISm and informing targeted preventive strategies for cardiometabolic complications.</p>","PeriodicalId":54237,"journal":{"name":"Pulmonology","volume":"32 1","pages":"2650733"},"PeriodicalIF":5.3,"publicationDate":"2026-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147629310","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence, type, and clinical implications of CFTR variants in bronchiectasis.","authors":"Andrea Gramegna, Lucia Allavena, Gianfranco Alicandro, Elisa Canella, Mattia Nigro, Chiara Premuda, Margherita Ori, Martina Santambrogio, Luigi Porcaro, Daniele Prati, Luca Valenti, Stefano Aliberti, Francesco Blasi","doi":"10.1080/25310429.2025.2588945","DOIUrl":"10.1080/25310429.2025.2588945","url":null,"abstract":"<p><strong>Background and objective: </strong>Bronchiectasis is a chronic lung condition characterised by persistent respiratory symptoms and permanent bronchial dilation. CFTR variants are commonly reported in patients with bronchiectasis with unclear clinical implications.This study aims to investigate the prevalence of CFTR variants in people with bronchiectasis and their association with clinical characteristics.</p><p><strong>Methods: </strong>Patients were recruited from two centres in Milan, Italy and screened for CFTR variants. The prevalence of CFTR variants in people with bronchiectasis was compared to that of a control group of healthy blood donors. Sweat chloride levels, pulmonary function tests, airway microbiology, disease severity and respiratory symptoms were compared between CFTR variant carriers and non-carriers.</p><p><strong>Results: </strong>The study included 454 adults with bronchiectasis and 250 individuals in the control group. Among those with bronchiectasis, 178 individuals (39.2%) carried at least one CFTR variant, with 41 (9.0%) identified as having a CF-causing variant. This prevalence was higher than that observed in the control group (<i>n</i> = 10, 4%). The odds ratio of carrying a CF-causing variant among bronchiectasis patients was 2.83 (95% CI: 1.39-5.79, <i>p</i> = 0.004). No significant association was found between CFTR carrier status and clinical outcomes.</p><p><strong>Conclusions: </strong>CFTR variants are frequently observed in patients with bronchiectasis, although they are not associated with increased disease severity.</p>","PeriodicalId":54237,"journal":{"name":"Pulmonology","volume":"32 1","pages":"2588945"},"PeriodicalIF":6.4,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145960821","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"American College of Chest Physicians algorithm for lung resective surgery: Real-life validation.","authors":"Luis Puente-Maestu, Paola Benedetti, Julia Garcia de Pedro, Javier García, Christian Castro, Ignacio Garutti, Carlos Simon","doi":"10.1080/25310429.2026.2625574","DOIUrl":"10.1080/25310429.2026.2625574","url":null,"abstract":"<p><strong>Rationale: </strong>The preoperative evaluation of candidates for resective surgery has been addressed in several guidelines, the most recent is the American College of Chest Physicians (ACCP) algorithm; however, validating information in routine clinical practice is scant.</p><p><strong>Methods: </strong>This is a retrospective cohort study based on an ongoing registry of candidates for thoracic surgery that began in 2011; therefore, relevant data were prospectively collected. This study is based on patients who operated from January 2011 to 16 December 2023. The last survival update was done on 16 March 2024.</p><p><strong>Results: </strong>Overall, postoperative mortality increased from 3.1% at 30 days to 5.5% at 90 days. Factors associated with mortality included age, predicted-postoperative (PPO) FEV₁, PPO-DLco, intermediate ACCP risk and pneumonectomy. Video-assisted thoracic surgery (VATS) reduced risk. When adjusted for covariates, independent risk factors were age, ACCP intermediate risk and pneumonectomy. Thirty-day mortality: age >70 years OR = 7.5 (95% CI 2.1-26.6), ACCP intermediate risk = 5.6 (1.2-25.8) and pneumonectomy = 6.5 (1.7-24.8); 60-day mortality: age >70 = 10.5 (3.0-37.1), ACCP intermediate risk = 4.5 (1.22-16.33) and pneumonectomy = 8.2 (2.2-29.3); 90-day mortality, age >70 = 6.5 (1.1-24.8), ACCP intermediate risk = 8.2 (2.3-29.26), pneumonectomy = 8.1 (2.78-24.3).</p><p><strong>Conclusions: </strong>The ACCP algorithm remains a valid tool for the assessment of fitness for anatomical lung resection. Our data support some reworking of the algorithm (i.e. considering age >70 years and pneumonectomy in the decision algorithm as intermediate-risk determinants). Mortality continues to increase from 30 to 90 days with higher risk, and this should be considered in the risk/benefit analysis of therapeutic alternatives.</p>","PeriodicalId":54237,"journal":{"name":"Pulmonology","volume":"32 1","pages":"2625574"},"PeriodicalIF":5.3,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146144628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inhaled 3% hypertonic saline is associated with improved symptoms and microbiological stabilisation in antibiotic-naïve nontuberculous mycobacterial lung disease: A prospective study.","authors":"I-Hua Chen, Jia-Yih Feng, Chin-Chung Shu, Chih-Jung Chang, Yen-Han Tseng, Ping-Huai Wang, Sheng-Wei Pan","doi":"10.1080/25310429.2026.2704386","DOIUrl":"https://doi.org/10.1080/25310429.2026.2704386","url":null,"abstract":"<p><strong>Background: </strong>Evidence for hypertonic saline (HS) in nontuberculous mycobacterial lung disease (NTM-LD) remains limited, particularly during watchful waiting when non-antibiotic strategies are needed. We evaluated inhaled 3% HS as a potential adjunct in antibiotic-naïve NTM-LD.</p><p><strong>Methods: </strong>In this prospective cohort study, antibiotic-naïve NTM-LD patients were enrolled between September 2024 and December 2025. Patients receiving daily inhaled 3% HS were compared with contemporaneous controls. Symptom burden (visual analog scale, 0-60) and sputum smear status at month 3 were analysed using generalised estimating equations. <i>In vitro</i> experiments assessed HS effects on <i>Mycobacterium abscessus</i> growth and macrophage function, including intracellular bacterial burden, viability, phagocytosis, and pro-inflammatory gene expression.</p><p><strong>Results: </strong>Among 45 patients (HS: <i>n</i> = 22; control: <i>n</i> = 23), 3% HS was associated with a significant reduction in symptom burden from baseline (coefficient -4.40, 95% CI -6.43 to -2.37; <i>p</i> < 0.001) and a lower odds of sputum smear positivity at month 3 (odds ratio 0.15, 95% CI 0.03-0.64; <i>p</i> = 0.011) in adjusted analyses. <i>In vitro</i>, HS inhibited extracellular <i>M. abscessus</i> growth in a concentration-dependent manner. Pretreatment of macrophages with 3% HS reduced intracellular <i>M. abscessus</i> burden by 51% (<i>p</i> = 0.021) without impairing viability or phagocytosis, while upregulating pro-inflammatory gene expression, including TNF-α (<i>p</i> = 0.004), IL-6 (<i>p</i> = 0.030), and IL-1β (<i>p</i> = 0.058).</p><p><strong>Conclusions: </strong>In antibiotic-naïve NTM-LD, inhaled 3% HS was associated with improved symptom burden and reduced progression to sputum smear positivity. Complementary in vitro findings support both direct antimycobacterial effects and enhanced macrophage-mediated control, supporting HS as a biologically active adjunct during conservative management of NTM-LD.</p>","PeriodicalId":54237,"journal":{"name":"Pulmonology","volume":"32 1","pages":"2704386"},"PeriodicalIF":5.3,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148521274","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence of preserved ratio impaired spirometry: A systematic review and meta-analysis.","authors":"Yiting Li, Peng Zhang, Yan Wang, Baichuan Xu, Tao Chen, Yang Xie","doi":"10.1080/25310429.2026.2637311","DOIUrl":"10.1080/25310429.2026.2637311","url":null,"abstract":"<p><strong>Objective: </strong>To summarise the prevalence of preserved ratio impaired spirometry (PRISm), intending to inform prevention strategies and clinical management.</p><p><strong>Methods: </strong>We systematically searched PubMed, Embase, Web of Science, and the Cochrane Library databases for cohort studies investigating the prevalence of PRISm. The quality of included studies was assessed with appropriate tools for evaluating risk of bias in prevalence studies. Publication bias was assessed using funnel plots and Egger's test.</p><p><strong>Results: </strong>After deduplication, 24 of the 33 initially eligible studies were included in the meta-analysis. The pooled prevalence of PRISm was 10% (95% CI: 0.08, 0.12). Smoking was a significant risk factor for PRISm, while no significant association was found with respiratory symptoms. PRISm was significantly associated with comorbidities including hypertension, diabetes, cardiovascular disease, and stroke. Moreover, individuals with PRISm had higher all-cause mortality (OR 1.84, 95% CI: 0.99, 3.41) and cardiovascular mortality (OR 1.82, 95% CI: 1.35, 2.44). Lung function trajectories were heterogeneous, with 10-50% reverting to normal, 20-60% remaining stable, and 6-53% progressing to chronic obstructive pulmonary disease (COPD).</p><p><strong>Conclusions: </strong>PRISm is associated with a high prevalence, smoking, cardiometabolic comorbidities, increased all-cause and cardiovascular mortality, and heterogeneous lung function trajectories, underscoring its clinical importance beyond COPD.</p>","PeriodicalId":54237,"journal":{"name":"Pulmonology","volume":"32 1","pages":"2637311"},"PeriodicalIF":5.3,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147348665","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Commentary on 'The effects of asymmetrical versus symmetrical high-flow nasal cannula on respiratory muscle activity in acute hypoxaemic respiratory failure and chronic obstructive pulmonary disease: A randomised crossover study'.","authors":"Gourab Deb, Suman Pradhan, Sunita Sharma","doi":"10.1080/25310429.2026.2710580","DOIUrl":"https://doi.org/10.1080/25310429.2026.2710580","url":null,"abstract":"","PeriodicalId":54237,"journal":{"name":"Pulmonology","volume":"32 1","pages":"2710580"},"PeriodicalIF":5.3,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148714601","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of the performance of the reference equations for single-breath diffusing capacity of the lung for carbon monoxide (DLCOsb) in Latin American populations at different altitudes: A multicentre study.","authors":"Carlos Aguirre-Franco, Ireri Thirion-Romero, Laura Gochicoa-Rangel, Iván Cherrez-Ojeda, Lorena Noriega-Aguirre, Guillermo Adolfo Arbo Oze de Morvil, Sandra González Toledo, Emily Rincon-Alvarez, Luis Torre-Bouscoulet, Cesar Marcelo Delgado Viteri, Luis Giraldo-Cadavid, Nadia Juliana Proaños Jurado","doi":"10.1080/25310429.2026.2638013","DOIUrl":"10.1080/25310429.2026.2638013","url":null,"abstract":"<p><strong>Introduction: </strong>Altitude, a factor not considered in most reference equations for single-breath diffusing capacity of the lung for carbon monoxide (DLCOsb), plays a crucial role in its assessment. This variable is particularly relevant for Latin American populations residing at different altitudes.</p><p><strong>Methods: </strong>This analytical, prospective, multicentre study was conducted in Latin American adults living at low and high altitudes with normal spirometry. Healthy, asymptomatic subjects were identified through the PLATINO survey. To determine the model with the best performance based on standard estimated error (SEE), predicted DLCOsb values were obtained using the Vásquez García, Crapo, García Rio, and Global Lung Function Initiative (GLI) equations.</p><p><strong>Results: </strong>A total of 269 subjects were included: 90 at low altitude and 179 at high altitude. Women comprised 66.9% (180/269), and the median age was 34 years (IQR 25-51). At both sea level and high altitude, the Vásquez García equation, which includes haemoglobin (Hb), showed the best predictive performance. In both settings, GLI-predicted values were lower than measured values (SEE: 2.158 at low altitude and 5.1 at high altitude).</p><p><strong>Conclusions: </strong>Although with wide limits of agreement for all models, Vázquez-García's equation shows the best performance in the interpretation of DLCOsb in Latin American populations residing at any altitude. Even with adjustments for altitude and Hb, the GLI model underestimates the predicted values of DLCOsb and could require an adjustment factor or inclusion of the altitude variable in the model's new version.</p>","PeriodicalId":54237,"journal":{"name":"Pulmonology","volume":"32 1","pages":"2638013"},"PeriodicalIF":5.3,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147464274","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}