Pulmonology最新文献

{"title":"Reallocation time of accelerometer-measured movement behaviours, genetic susceptibility, and incident chronic obstructive pulmonary disease.","authors":"Darui Gao, Wenya Zhang, Yanyu Zhang, Mengmeng Ji, Xiaobo Han, Jie Liang, Yang Pan, Fanfan Zheng, Lixin Xie, Wuxiang Xie","doi":"10.1080/25310429.2026.2649099","DOIUrl":"https://doi.org/10.1080/25310429.2026.2649099","url":null,"abstract":"<p><strong>Introduction: </strong>Little is known about the associations between reallocating time from one movement behaviour to another within 24 h with the risk of chronic obstructive pulmonary disease (COPD), particularly in the context of genetics.</p><p><strong>Methods: </strong>This study included 87 656 participants from the UK Biobank with valid wrist-worn accelerometer data and without prevalent COPD for the primary analysis. The isotemporal substitution model was used to evaluate the potential impact on COPD incidence of replacing one behaviour with an equivalent duration of another.</p><p><strong>Results: </strong>Our study showed that replacing 1 h/day of sleep, sedentary behaviours (SB), or light-intensity physical activity (LIPA) with an equal amount of time spent in moderate-to-vigorous physical activity (MVPA) was associated with 40%, 43%, and 39% lower risk of incident COPD, respectively. Stratified by genetic risk, within each subgroup, the inverse relationship between replacing sleep, SB, and LIPA with MVPA and COPD remained significant. In the joint association analysis of genetic susceptibility and MVPA duration with COPD, participants with intermediate and low genetic predisposition plus low MVPA duration were significantly associated with a 1.72- (95% CI: 1.32-2.24) and 1.39- (95% CI: 1.04-1.87) fold higher risk of incident COPD, respectively, compared to those with a high genetic predisposition and high MVPA duration.</p><p><strong>Conclusion: </strong>Irrespective of genetic susceptibility, substituting MVPA for other movement behaviours was associated with a lower risk of incident COPD. More MVPA involvement seemed to be able to mitigate the genetic risk of COPD.</p>","PeriodicalId":54237,"journal":{"name":"Pulmonology","volume":"32 1","pages":"2649099"},"PeriodicalIF":6.4,"publicationDate":"2026-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147629339","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Plasma proteomic signatures linking preserved ratio impaired spirometry to cardiometabolic diseases and multimorbidity: A longitudinal cohort study.","authors":"Li He, Ce Liu, Hao Zhao, Zhaoru Yang, Zelin Lei, Wentao Lei, Bin Luo","doi":"10.1080/25310429.2026.2650733","DOIUrl":"https://doi.org/10.1080/25310429.2026.2650733","url":null,"abstract":"<p><strong>Background: </strong>Preserved ratio impaired spirometry (PRISm), defined by reduced FEV1 with preserved FEV1/FVC ratio, has been linked to cardiometabolic diseases (CMDs), but underlying mechanisms remain unclear. This study aims to identify plasma proteomic signatures linking PRISm to type 2 diabetes (T2D), ischaemic heart disease (IHD), stroke, first cardiometabolic disease (FCMD), and cardiometabolic multimorbidity (CMM).</p><p><strong>Methods: </strong>We conducted plasma proteomic profiling of 2 911 proteins in 32 689 UK Biobank participants with a median follow-up of 14.37 years. Machine learning algorithms were employed to identify protein signatures associated with PRISm. Causal mediation analyses were performed to quantify the mediating effects of identified proteins on the associations between PRISm and cardiometabolic outcomes. Combined protein-covariate models were developed to assess predictive performance.</p><p><strong>Results: </strong>We identified a 29-protein signature associated with PRISm. Outcome-specific analyses revealed 29 proteins for T2D, 26 for IHD, 13 for stroke, 29 for FCMD, and 27 for CMM, with 14 proteins showing consistent associations across all outcomes. Combined protein-covariate models significantly improved prediction over covariates alone (AUCs: T2D, 0.83; IHD, 0.72; stroke, 0.75; FCMD, 0.76; CMM, 0.79). Mediation analyses demonstrated that IGSF3 mediated 19.5% of the PRISm-T2D association, 12.8% for FCMD, and 11.3% for CMM, while GDF15 mediated 12.1% for IHD and 13.1% for stroke. These proteins converged on inflammatory signalling, extracellular matrix remodelling, and metabolic pathways.</p><p><strong>Conclusions: </strong>The identified protein signatures offer promising biomarkers for risk prediction, enabling early identification of high-risk individuals with PRISm and informing targeted preventive strategies for cardiometabolic complications.</p>","PeriodicalId":54237,"journal":{"name":"Pulmonology","volume":"32 1","pages":"2650733"},"PeriodicalIF":6.4,"publicationDate":"2026-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147629310","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence of preserved ratio impaired spirometry: A systematic review and meta-analysis.","authors":"Yiting Li, Peng Zhang, Yan Wang, Baichuan Xu, Tao Chen, Yang Xie","doi":"10.1080/25310429.2026.2637311","DOIUrl":"10.1080/25310429.2026.2637311","url":null,"abstract":"<p><strong>Objective: </strong>To summarise the prevalence of preserved ratio impaired spirometry (PRISm), intending to inform prevention strategies and clinical management.</p><p><strong>Methods: </strong>We systematically searched PubMed, Embase, Web of Science, and the Cochrane Library databases for cohort studies investigating the prevalence of PRISm. The quality of included studies was assessed with appropriate tools for evaluating risk of bias in prevalence studies. Publication bias was assessed using funnel plots and Egger's test.</p><p><strong>Results: </strong>After deduplication, 24 of the 33 initially eligible studies were included in the meta-analysis. The pooled prevalence of PRISm was 10% (95% CI: 0.08, 0.12). Smoking was a significant risk factor for PRISm, while no significant association was found with respiratory symptoms. PRISm was significantly associated with comorbidities including hypertension, diabetes, cardiovascular disease, and stroke. Moreover, individuals with PRISm had higher all-cause mortality (OR 1.84, 95% CI: 0.99, 3.41) and cardiovascular mortality (OR 1.82, 95% CI: 1.35, 2.44). Lung function trajectories were heterogeneous, with 10-50% reverting to normal, 20-60% remaining stable, and 6-53% progressing to chronic obstructive pulmonary disease (COPD).</p><p><strong>Conclusions: </strong>PRISm is associated with a high prevalence, smoking, cardiometabolic comorbidities, increased all-cause and cardiovascular mortality, and heterogeneous lung function trajectories, underscoring its clinical importance beyond COPD.</p>","PeriodicalId":54237,"journal":{"name":"Pulmonology","volume":"32 1","pages":"2637311"},"PeriodicalIF":6.4,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147348665","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence, type, and clinical implications of CFTR variants in bronchiectasis.","authors":"Andrea Gramegna, Lucia Allavena, Gianfranco Alicandro, Elisa Canella, Mattia Nigro, Chiara Premuda, Margherita Ori, Martina Santambrogio, Luigi Porcaro, Daniele Prati, Luca Valenti, Stefano Aliberti, Francesco Blasi","doi":"10.1080/25310429.2025.2588945","DOIUrl":"10.1080/25310429.2025.2588945","url":null,"abstract":"<p><strong>Background and objective: </strong>Bronchiectasis is a chronic lung condition characterised by persistent respiratory symptoms and permanent bronchial dilation. CFTR variants are commonly reported in patients with bronchiectasis with unclear clinical implications.This study aims to investigate the prevalence of CFTR variants in people with bronchiectasis and their association with clinical characteristics.</p><p><strong>Methods: </strong>Patients were recruited from two centres in Milan, Italy and screened for CFTR variants. The prevalence of CFTR variants in people with bronchiectasis was compared to that of a control group of healthy blood donors. Sweat chloride levels, pulmonary function tests, airway microbiology, disease severity and respiratory symptoms were compared between CFTR variant carriers and non-carriers.</p><p><strong>Results: </strong>The study included 454 adults with bronchiectasis and 250 individuals in the control group. Among those with bronchiectasis, 178 individuals (39.2%) carried at least one CFTR variant, with 41 (9.0%) identified as having a CF-causing variant. This prevalence was higher than that observed in the control group (<i>n</i> = 10, 4%). The odds ratio of carrying a CF-causing variant among bronchiectasis patients was 2.83 (95% CI: 1.39-5.79, <i>p</i> = 0.004). No significant association was found between CFTR carrier status and clinical outcomes.</p><p><strong>Conclusions: </strong>CFTR variants are frequently observed in patients with bronchiectasis, although they are not associated with increased disease severity.</p>","PeriodicalId":54237,"journal":{"name":"Pulmonology","volume":"32 1","pages":"2588945"},"PeriodicalIF":6.4,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145960821","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter to the editor: Effect of exercise training on modulating the TH17/TREG imbalance in individuals with severe COPD: A randomised controlled trial.","authors":"Anchal Thakur, Kanika Bhatia, Nikita Vaid","doi":"10.1080/25310429.2026.2620227","DOIUrl":"https://doi.org/10.1080/25310429.2026.2620227","url":null,"abstract":"","PeriodicalId":54237,"journal":{"name":"Pulmonology","volume":"32 1","pages":"2620227"},"PeriodicalIF":6.4,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146020361","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"American College of Chest Physicians algorithm for lung resective surgery: Real-life validation.","authors":"Luis Puente-Maestu, Paola Benedetti, Julia Garcia de Pedro, Javier García, Christian Castro, Ignacio Garutti, Carlos Simon","doi":"10.1080/25310429.2026.2625574","DOIUrl":"https://doi.org/10.1080/25310429.2026.2625574","url":null,"abstract":"<p><strong>Rationale: </strong>The preoperative evaluation of candidates for resective surgery has been addressed in several guidelines, the most recent is the American College of Chest Physicians (ACCP) algorithm; however, validating information in routine clinical practice is scant.</p><p><strong>Methods: </strong>This is a retrospective cohort study based on an ongoing registry of candidates for thoracic surgery that began in 2011; therefore, relevant data were prospectively collected. This study is based on patients who operated from January 2011 to 16 December 2023. The last survival update was done on 16 March 2024.</p><p><strong>Results: </strong>Overall, postoperative mortality increased from 3.1% at 30 days to 5.5% at 90 days. Factors associated with mortality included age, predicted-postoperative (PPO) FEV₁, PPO-DLco, intermediate ACCP risk and pneumonectomy. Video-assisted thoracic surgery (VATS) reduced risk. When adjusted for covariates, independent risk factors were age, ACCP intermediate risk and pneumonectomy. Thirty-day mortality: age >70 years OR = 7.5 (95% CI 2.1-26.6), ACCP intermediate risk = 5.6 (1.2-25.8) and pneumonectomy = 6.5 (1.7-24.8); 60-day mortality: age >70 = 10.5 (3.0-37.1), ACCP intermediate risk = 4.5 (1.22-16.33) and pneumonectomy = 8.2 (2.2-29.3); 90-day mortality, age >70 = 6.5 (1.1-24.8), ACCP intermediate risk = 8.2 (2.3-29.26), pneumonectomy = 8.1 (2.78-24.3).</p><p><strong>Conclusions: </strong>The ACCP algorithm remains a valid tool for the assessment of fitness for anatomical lung resection. Our data support some reworking of the algorithm (i.e. considering age >70 years and pneumonectomy in the decision algorithm as intermediate-risk determinants). Mortality continues to increase from 30 to 90 days with higher risk, and this should be considered in the risk/benefit analysis of therapeutic alternatives.</p>","PeriodicalId":54237,"journal":{"name":"Pulmonology","volume":"32 1","pages":"2625574"},"PeriodicalIF":6.4,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146144628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of the performance of the reference equations for single-breath diffusing capacity of the lung for carbon monoxide (DLCOsb) in Latin American populations at different altitudes: A multicentre study.","authors":"Carlos Aguirre-Franco, Ireri Thirion-Romero, Laura Gochicoa-Rangel, Iván Cherrez-Ojeda, Lorena Noriega-Aguirre, Guillermo Adolfo Arbo Oze de Morvil, Sandra González Toledo, Emily Rincon-Alvarez, Luis Torre-Bouscoulet, Cesar Marcelo Delgado Viteri, Luis Giraldo-Cadavid, Nadia Juliana Proaños Jurado","doi":"10.1080/25310429.2026.2638013","DOIUrl":"https://doi.org/10.1080/25310429.2026.2638013","url":null,"abstract":"<p><strong>Introduction: </strong>Altitude, a factor not considered in most reference equations for single-breath diffusing capacity of the lung for carbon monoxide (DLCOsb), plays a crucial role in its assessment. This variable is particularly relevant for Latin American populations residing at different altitudes.</p><p><strong>Methods: </strong>This analytical, prospective, multicentre study was conducted in Latin American adults living at low and high altitudes with normal spirometry. Healthy, asymptomatic subjects were identified through the PLATINO survey. To determine the model with the best performance based on standard estimated error (SEE), predicted DLCOsb values were obtained using the Vásquez García, Crapo, García Rio, and Global Lung Function Initiative (GLI) equations.</p><p><strong>Results: </strong>A total of 269 subjects were included: 90 at low altitude and 179 at high altitude. Women comprised 66.9% (180/269), and the median age was 34 years (IQR 25-51). At both sea level and high altitude, the Vásquez García equation, which includes haemoglobin (Hb), showed the best predictive performance. In both settings, GLI-predicted values were lower than measured values (SEE: 2.158 at low altitude and 5.1 at high altitude).</p><p><strong>Conclusions: </strong>Although with wide limits of agreement for all models, Vázquez-García's equation shows the best performance in the interpretation of DLCOsb in Latin American populations residing at any altitude. Even with adjustments for altitude and Hb, the GLI model underestimates the predicted values of DLCOsb and could require an adjustment factor or inclusion of the altitude variable in the model's new version.</p>","PeriodicalId":54237,"journal":{"name":"Pulmonology","volume":"32 1","pages":"2638013"},"PeriodicalIF":6.4,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147464274","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pulmonary blood volume redistribution in COVID-19 patients of different severity and its predictive value for six-month outcomes in the less pathogenic Omicron variant.","authors":"Ge Hu, Zhenchen Zhu, Zhengsong Pan, Weixiong Tan, Wei Han, Zifeng Wu, Zhen Zhou, Xinlun Tian, Wei Song, Yizhou Yu, Lan Song, Zhengyu Jin","doi":"10.1080/25310429.2025.2607932","DOIUrl":"https://doi.org/10.1080/25310429.2025.2607932","url":null,"abstract":"<p><strong>Background: </strong>The redistribution of pulmonary blood volume (PBV) across COVID-19 severity levels and its prognostic value for the less pathogenic, predominantly upper respiratory tract-infecting Omicron variant remain unclear. This study investigates PBV distribution patterns and validates its predictive utility for Omicron outcomes.</p><p><strong>Methods: </strong>This retrospective study enrolled consecutive patients (November 2022-January 2023) with baseline CT and clinical data, followed for six months. Patients were divided into mild/moderate (MM) and severe/critical (SC) groups according to COVID-19 severity. Pre-trained deep learning algorithms quantified total, lobar, and vessel-size-specific PBV. Adjusted multivariable analyses determined odds ratios (OR) for clinical outcomes, and logistic regression models based on PBV were constructed to predict adverse events.</p><p><strong>Results: </strong>Among 921 patients (61 ± 20 years, 460 men), 755 were in the MM group and 166 in the SC group. Compared to MM patients, SC patients showed significantly lower total PBV (259 mL vs. 239 mL, <i>p</i> = 0.002) and redistribution from lower to upper lobes (upper vs. lower; MM, 21% vs. 23%; SC, 23% vs. 18%) and from small-calibre (≤5 mm², 44% vs. 32%, <i>p</i> < 0.0005) to large-calibre (>10 mm², 39% vs. 51%, <i>p</i> < 0.0005) vessels. PBV (especially in vessels ≤5 mm²) predicted six-month composite outcomes (OR = 4.66, AUC = 0.79, sensitivity = 92%) and mortality (OR = 3.34, AUC = 0.75, sensitivity = 93%) for the Omicron variant with high sensitivity, but at a higher risk threshold (42%) than that reported for more pathogenic variants in previous publications.</p><p><strong>Conclusions: </strong>Severe/critical COVID-19 is associated with reduced PBV and its redistribution across lung regions and vessel sizes. PBV retains predictive value for clinical outcomes in the immune-evasive Omicron variant.</p>","PeriodicalId":54237,"journal":{"name":"Pulmonology","volume":"32 1","pages":"2607932"},"PeriodicalIF":6.4,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145936279","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Global health inequalities in the burden of tuberculosis from 1990 to 2021: Findings from the global burden of disease study 2021.","authors":"Huaiming Zhang, Shihua Shen","doi":"10.1080/25310429.2026.2613995","DOIUrl":"https://doi.org/10.1080/25310429.2026.2613995","url":null,"abstract":"","PeriodicalId":54237,"journal":{"name":"Pulmonology","volume":"32 1","pages":"2613995"},"PeriodicalIF":6.4,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145960813","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Urinary incontinence is common among people attending pulmonary rehabilitation, yet pulmonary rehabilitation has a small effect on urinary symptoms: A multicenter prospective cohort study.","authors":"Francis-Edouard Gravier, Yann Combret, Damien Parrot, Fanny Laporte, Léna Bocquet, Pauline Smondack, Jean-François Muir, Antoine Cuvelier, Fairuz Boujibar, Arnaud Nze Ossima, Clément Médrinal, Guillaume Prieur, Tristan Bonnevie","doi":"10.1080/25310429.2025.2610131","DOIUrl":"10.1080/25310429.2025.2610131","url":null,"abstract":"<p><strong>Introduction: </strong>Urinary incontinence (UI) is common among individuals with chronic respiratory diseases (CRDs) and may limit attendance, completion, and response to pulmonary rehabilitation (PR). This study aims to assess what is the prevalence of UI among individuals attending PR, and how does PR affect UI and other clinical outcomes, and if UI is associated with PR completion and response.</p><p><strong>Methods: </strong>A multicenter prospective cohort study was conducted. UI was assessed using the International Consultation on Incontinence Questionnaire-Urinary Incontinence Short Form (ICIQ-UI-SF) questionnaire before and after an 8-week program. Completion was defined as attending at least 70% of sessions. Response was defined as achieving minimum clinically important differences (MCIDs) in any clinical outcome.</p><p><strong>Results: </strong>Among 341 individuals with CRDs 48% female, mean age of 63 (SD 10)), UI prevalence was 38% (95% CI 32 to 44) and remained unchanged following PR. PR led to a positive effect on urinary symptoms (ICIQ-UI-SF mean change -1.8, 95% CI -2.5 to -1.1), although the magnitude of change was below the established MCID of 4 points. PR also led to a positive improvement on the Saint George's Respiratory Questionnaire total score (-4, 95% CI -7 to -2). The associations between UI and PR completion and response were imprecise due to wide confidence intervals.</p><p><strong>Conclusions: </strong>UI is common among individuals attending PR, yet PR has a small effect on urinary symptoms. Despite this, individuals with UI may still achieve improvements from the program. Our findings suggest that UI should not delay PR initiation but should be screened and managed as part of the multidisciplinary care that defines PR.</p>","PeriodicalId":54237,"journal":{"name":"Pulmonology","volume":"32 1","pages":"2610131"},"PeriodicalIF":6.4,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145901609","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}