Pulmonology最新文献

{"title":"Multidisciplinary virtual management of pulmonary nodules","authors":"D. Polanco ,&nbsp;J. González ,&nbsp;E. Gracia-Lavedan ,&nbsp;L. Pinilla ,&nbsp;R. Plana ,&nbsp;M. Molina ,&nbsp;M. Pardina ,&nbsp;F. Barbé","doi":"10.1016/j.pulmoe.2021.12.003","DOIUrl":"10.1016/j.pulmoe.2021.12.003","url":null,"abstract":"<div><h3>Introduction and objectives</h3><p>Multidisciplinary nodule clinics provide high-quality care and favor adherence to guidelines. Virtual care has shown savings benefits along with patient satisfaction. Our aim is to describe the first year of operation of a multidisciplinary virtual lung nodule clinic, the population evaluated and issued decisions. Secondarily, among discharged patients, we aimed to analyze their follow-up prior to the existence of our consultation, evaluating its adherence to guidelines.</p></div><div><h3>Materials and methods</h3><p>Observational study including all patients evaluated at the Virtual Lung Nodule Clinic (VLNC) (March 2018- March 2019). Clinical and radiological data were recorded. Recommendations, based on 2017 Fleischner Society guidelines, were categorized into follow-up, discharge or referral to lung cancer consultation. Discharged patients were classified according to adherence to guidelines of their previous management, into adequate, prolonged and non-indicated follow-up.</p></div><div><h3>Results</h3><p>A total of 365 patients (58.9% men; median age 64.0 years) were included. Sixty-four percent had smoking history and 23% had chronic obstructive pulmonary disease (COPD). Most nodules were solid (87.4%) and multiple (57.5%). The median diameter was 6.00 mm. 43.8% of patients were discharged following first VLNC evaluation. Among them, 27.5% had received appropriate follow-up, but 66.9% had received poor management. Patients with prolonged follow-up (33.1%) were older (67.0 vs 60.5 years) and had larger nodules (6.00 mm vs 5.00). Non-indicated follow-up patients (33.8%) were more non-smokers (77.8% vs 31.8%) and presented smaller nodules (4.00 vs 5.00 mm).</p></div><div><h3>Conclusions</h3><p>During its first year of operation, the VLNC has evaluated a population with a relevant risk profile for lung cancer development, management of which should be cautious and adhere to guidelines. After the first VLNC assessment, approximately one-half of this population was discharged. It was noticeable that previous follow-up of discharged patients was found poorly adherent to guidelines, with a marked tendency to overmanagement.</p></div>","PeriodicalId":54237,"journal":{"name":"Pulmonology","volume":null,"pages":null},"PeriodicalIF":11.7,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2531043722000010/pdfft?md5=a36cd1d9941ab4bc906fd3f88feed186&pid=1-s2.0-S2531043722000010-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39885426","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lung cancer and breast metastasis: A rare and atypical presentation","authors":"H. Guedes ,&nbsp;A. Barroso ,&nbsp;D. João ,&nbsp;A. Furtado ,&nbsp;T. Costa","doi":"10.1016/j.pulmoe.2023.08.001","DOIUrl":"10.1016/j.pulmoe.2023.08.001","url":null,"abstract":"","PeriodicalId":54237,"journal":{"name":"Pulmonology","volume":null,"pages":null},"PeriodicalIF":11.7,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2531043723001563/pdfft?md5=85f8003cc3389293cffc2bfa2b494edc&pid=1-s2.0-S2531043723001563-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41147164","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pulmonary capillary hemangiomatosis/veno-occlusive disease diagnosed by transbronchial cryobiopsy","authors":"Venerino Poletti ,&nbsp;Davide Femia ,&nbsp;Simone Petrarulo ,&nbsp;Alessandro Marinelli ,&nbsp;Claudia Ravaglia ,&nbsp;Sara Piciucchi","doi":"10.1016/j.pulmoe.2023.08.009","DOIUrl":"10.1016/j.pulmoe.2023.08.009","url":null,"abstract":"","PeriodicalId":54237,"journal":{"name":"Pulmonology","volume":null,"pages":null},"PeriodicalIF":11.7,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2531043723001629/pdfft?md5=a7b51197975a582cd01773a20487d0ed&pid=1-s2.0-S2531043723001629-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41174813","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Differential immunohistochemical expression of hTERT in lung cancer patients with and without idiopathic pulmonary fibrosis","authors":"G. Gomatou ,&nbsp;C. Masaoutis ,&nbsp;I. Vamvakaris ,&nbsp;E. Kotteas ,&nbsp;E. Bouros ,&nbsp;V. Tzilas ,&nbsp;D. Bouros","doi":"10.1016/j.pulmoe.2021.12.001","DOIUrl":"10.1016/j.pulmoe.2021.12.001","url":null,"abstract":"<div><h3>Background</h3><p>Human telomerase reverse transcriptase (hTERT) is the catalytic subunit of telomerase enzyme, which adds nucleotides to telomeres and counteracts their length shortening. The development of a telomere maintenance mechanism represents a hallmark of cancer. On the other hand, idiopathic pulmonary fibrosis (IPF) is associated with mutations in telomerase genes and shorter telomeres. IPF is frequently complicated with lung cancer.</p></div><div><h3>Aim</h3><p>To investigate the expression of hTERT in lung cancer with co-existing IPF and to compare with lung cancer without fibrosis.</p></div><div><h3>Methods</h3><p>Diagnostic lung cancerous biopsies were retrieved from 18 patients with lung cancer and concomitant IPF, as well as 18 age and gender matched controls with lung cancer without pulmonary fibrosis. The expression of hTERT was studied with immunohistochemistry. ImajeJ software was used to quantitate subcellular stain intensity. Immunohistochemical investigation of two senescence-associated markers, p16 and p21, was also performed in all 36 cases.</p></div><div><h3>Results</h3><p>Both groups highly expressed hTERT, without significant difference (100% vs 95%, <em>p</em> = 0.521). Evaluation of p16 and p21 immunostaining revealed negative to minimal immunoreactivity in both groups. hTERT localization exhibited higher median nuclear intensity in the group of lung cancer with IPF (0.62 vs 0.45, <em>p</em> = 0.016), while cytoplasmic intensity did not differ significantly (0.17 vs 0.15, <em>p</em> = 0.463). Higher median nuclear intensity was also correlated with small cell lung cancer subtype in the whole study sample (0.69 vs 0.45, <em>p</em> = 0.09).</p></div><div><h3>Conclusion</h3><p>hTERT is highly expressed in lung cancer with concomitant IPF, but with differential localization compared to lung cancer without IPF, implying differences in pathogenicity and requiring further investigation.</p></div>","PeriodicalId":54237,"journal":{"name":"Pulmonology","volume":null,"pages":null},"PeriodicalIF":11.7,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2531043722000022/pdfft?md5=8a09591d52fcb237ae8928f3ee271925&pid=1-s2.0-S2531043722000022-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39913432","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Issue 4-Impact of air pollution on COVID-19 mortality and morbidity: An epidemiological and mechanistic review.","authors":"Hasan Bayram, N. Konyalilar, Muge Akpinar Elci, Hadi Rajabi, G. Tuşe Aksoy, Deniz Mortazavi, Ö. Kayalar, Öner Dikensoy, Luis Taborda-Barata, Giovanni Viegi","doi":"10.1016/j.pulmoe.2024.04.005","DOIUrl":"https://doi.org/10.1016/j.pulmoe.2024.04.005","url":null,"abstract":"","PeriodicalId":54237,"journal":{"name":"Pulmonology","volume":null,"pages":null},"PeriodicalIF":11.7,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141042612","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Main bronchus fistula: An open window to the lung parenchyma","authors":"N. Faria,&nbsp;M. Sucena,&nbsp;J. Gomes","doi":"10.1016/j.pulmoe.2023.07.007","DOIUrl":"10.1016/j.pulmoe.2023.07.007","url":null,"abstract":"","PeriodicalId":54237,"journal":{"name":"Pulmonology","volume":null,"pages":null},"PeriodicalIF":11.7,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2531043723001332/pdfft?md5=212f344ffa54d02a1b9c1c377d958f99&pid=1-s2.0-S2531043723001332-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10540116","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"COPD phenotypes by computed tomography and ventilatory response to exercise","authors":"S. Rodrigues Sousa,&nbsp;J. Nunes Caldeira,&nbsp;C. Rodrigues","doi":"10.1016/j.pulmoe.2022.01.002","DOIUrl":"10.1016/j.pulmoe.2022.01.002","url":null,"abstract":"<div><h3>Introduction</h3><p>Computed tomographic (CT) phenotypic patterns of chronic obstructive pulmonary disease (COPD) identify different clinical features of disease. The impact of these variables on the physiological response to exercise has been the focus of a great deal of research as it allows more individualized clinical approaches. The aim of our study was to evaluate the relationships between CT phenotyping of subjects with COPD and the ventilatory response during cardiopulmonary exercise testing (CPET).</p></div><div><h3>Methods</h3><p>Subjects with COPD were classified into four phenotypes based on CT metrics of emphysema (low attenuation area less than a threshold of -950 Hounsfield [%LAA-950]) and airwall thickness (bronchial wall area percentage [%WA]).</p></div><div><h3>Results</h3><p>Eighty COPD patients (78.8% males, median age 65±11.3 years) were enrolled in the study. Based on CT phenotype, 25 (31.3%) patients were classified as normal, 27 (33.8%) air dominant, 17 (21.3%) emphysema dominant and 11 (13.8%) mixed type. The emphysema and mixed phenotypes showed the highest ventilatory equivalent for carbon dioxide (V_E/VCO₂) and V_E/VCO₂ slope (<em>p</em>&lt;0,05). In all phenotypes, %LAA was positive correlated with V_E/VCO₂ and V_E/VCO₂ slope (<em>r</em> = 0.437, <em>p</em> = 0.006 and <em>r</em> = 0.503, <em>p</em>&lt;0.001, respectively). %WA also showed a positive correlation with V_E/VCO₂ and V_E/VCO₂ slope (<em>r</em> = 0.541, <em>p</em>&lt;0.001 and <em>r</em> = 0.299, <em>p</em> = 0.033, respectively). In multivariate regression models, after adjustment for age, BMI, sex and FEV1, %LAA was the only independent predictor of V_E/VCO₂ and V_E/VCO₂ slope (β 0.343, SE 0.147, 95% CI 0.009/0.610, <em>p</em> = 0.044 and β 0.496, SE 0.081, 95% CI 0.130/0.455, <em>p</em> = 0.001, respectively).</p></div><div><h3>Conclusion</h3><p>Emphysema (%LAA) and airways metrics (%WA) had strong relationships with the different characteristics of ventilatory response to exercise in subjects with mild to moderate COPD. In particular, %LAA seemed to play an important role as an independent predictor of V_E/VCO₂ and V_E/VCO₂ slope. These results suggested that CT phenotyping may help predicting ventilatory response to exercise in subjects with COPD.</p></div>","PeriodicalId":54237,"journal":{"name":"Pulmonology","volume":null,"pages":null},"PeriodicalIF":11.7,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2531043722000083/pdfft?md5=2fea1ac8ec093582b12dc93b9172cb6a&pid=1-s2.0-S2531043722000083-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39592489","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Personalised follow-up and management schema for patients with screen-detected pulmonary nodules: A dynamic modelling study.","authors":"Z. Wang, F. Xue, X. Sui, W. Han, W. Song, J. Jiang","doi":"10.1016/j.pulmoe.2024.02.010","DOIUrl":"https://doi.org/10.1016/j.pulmoe.2024.02.010","url":null,"abstract":"","PeriodicalId":54237,"journal":{"name":"Pulmonology","volume":null,"pages":null},"PeriodicalIF":11.7,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140778022","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between lung function and dyspnoea and its variation in the multinational Burden of Obstructive Lung Disease (BOLD) study.","authors":"A. Müller, E.F. Wouters, P. Koul, T. Welte, I. Harrabi, A. Rashid, L. Loh, M. Al Ghobain, A. Elsony, R. Ahmed, J. Potts, K. Mortimer, F. Rodrigues, S. N. Paraguas, S. Juvekar, D. Agarwal, D. Obaseki, T. Gislason, T. Seemungal, A. A. Nafees, C. Jenkins, H.B. Dias, F. Franssen, M. Studnicka, C. Janson, H. Cherkaski, M. El Biaze, P. A. Mahesh, J. Cardoso, P. Burney, S. Hartl, D. Janssen, A. Amaral","doi":"10.1016/j.pulmoe.2024.03.005","DOIUrl":"https://doi.org/10.1016/j.pulmoe.2024.03.005","url":null,"abstract":"","PeriodicalId":54237,"journal":{"name":"Pulmonology","volume":null,"pages":null},"PeriodicalIF":11.7,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140768120","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Low tumor interleukin-1β expression predicts a limited effect of adjuvant platinum-based chemotherapy for patients with completely resected lung adenocarcinoma: An identification and validation study.","authors":"S. Safi, J. Krzykalla, H. Hoffmann, A. Benner, H. Bischoff, M. Eichhorn, M. Kriegsmann, I. Poschke, F. Stögbauer, L. Umansky, C. Mogler, W. Weichert, H. Winter, P. Beckhove, T. Muley","doi":"10.1016/j.pulmoe.2024.03.003","DOIUrl":"https://doi.org/10.1016/j.pulmoe.2024.03.003","url":null,"abstract":"","PeriodicalId":54237,"journal":{"name":"Pulmonology","volume":null,"pages":null},"PeriodicalIF":11.7,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140765758","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}