Pulmonology最新文献

{"title":"Pulmonary capillary hemangiomatosis/veno-occlusive disease diagnosed by transbronchial cryobiopsy","authors":"Venerino Poletti , Davide Femia , Simone Petrarulo , Alessandro Marinelli , Claudia Ravaglia , Sara Piciucchi","doi":"10.1016/j.pulmoe.2023.08.009","DOIUrl":"10.1016/j.pulmoe.2023.08.009","url":null,"abstract":"","PeriodicalId":54237,"journal":{"name":"Pulmonology","volume":"30 3","pages":"Pages 310-312"},"PeriodicalIF":11.7,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2531043723001629/pdfft?md5=a7b51197975a582cd01773a20487d0ed&pid=1-s2.0-S2531043723001629-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41174813","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lung cancer and breast metastasis: A rare and atypical presentation","authors":"H. Guedes , A. Barroso , D. João , A. Furtado , T. Costa","doi":"10.1016/j.pulmoe.2023.08.001","DOIUrl":"10.1016/j.pulmoe.2023.08.001","url":null,"abstract":"","PeriodicalId":54237,"journal":{"name":"Pulmonology","volume":"30 3","pages":"Pages 305-306"},"PeriodicalIF":11.7,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2531043723001563/pdfft?md5=85f8003cc3389293cffc2bfa2b494edc&pid=1-s2.0-S2531043723001563-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41147164","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Differential immunohistochemical expression of hTERT in lung cancer patients with and without idiopathic pulmonary fibrosis","authors":"G. Gomatou ,&nbsp;C. Masaoutis ,&nbsp;I. Vamvakaris ,&nbsp;E. Kotteas ,&nbsp;E. Bouros ,&nbsp;V. Tzilas ,&nbsp;D. Bouros","doi":"10.1016/j.pulmoe.2021.12.001","DOIUrl":"10.1016/j.pulmoe.2021.12.001","url":null,"abstract":"<div><h3>Background</h3><p>Human telomerase reverse transcriptase (hTERT) is the catalytic subunit of telomerase enzyme, which adds nucleotides to telomeres and counteracts their length shortening. The development of a telomere maintenance mechanism represents a hallmark of cancer. On the other hand, idiopathic pulmonary fibrosis (IPF) is associated with mutations in telomerase genes and shorter telomeres. IPF is frequently complicated with lung cancer.</p></div><div><h3>Aim</h3><p>To investigate the expression of hTERT in lung cancer with co-existing IPF and to compare with lung cancer without fibrosis.</p></div><div><h3>Methods</h3><p>Diagnostic lung cancerous biopsies were retrieved from 18 patients with lung cancer and concomitant IPF, as well as 18 age and gender matched controls with lung cancer without pulmonary fibrosis. The expression of hTERT was studied with immunohistochemistry. ImajeJ software was used to quantitate subcellular stain intensity. Immunohistochemical investigation of two senescence-associated markers, p16 and p21, was also performed in all 36 cases.</p></div><div><h3>Results</h3><p>Both groups highly expressed hTERT, without significant difference (100% vs 95%, <em>p</em> = 0.521). Evaluation of p16 and p21 immunostaining revealed negative to minimal immunoreactivity in both groups. hTERT localization exhibited higher median nuclear intensity in the group of lung cancer with IPF (0.62 vs 0.45, <em>p</em> = 0.016), while cytoplasmic intensity did not differ significantly (0.17 vs 0.15, <em>p</em> = 0.463). Higher median nuclear intensity was also correlated with small cell lung cancer subtype in the whole study sample (0.69 vs 0.45, <em>p</em> = 0.09).</p></div><div><h3>Conclusion</h3><p>hTERT is highly expressed in lung cancer with concomitant IPF, but with differential localization compared to lung cancer without IPF, implying differences in pathogenicity and requiring further investigation.</p></div>","PeriodicalId":54237,"journal":{"name":"Pulmonology","volume":"30 3","pages":"Pages 214-221"},"PeriodicalIF":11.7,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2531043722000022/pdfft?md5=8a09591d52fcb237ae8928f3ee271925&pid=1-s2.0-S2531043722000022-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39913432","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Main bronchus fistula: An open window to the lung parenchyma","authors":"N. Faria,&nbsp;M. Sucena,&nbsp;J. Gomes","doi":"10.1016/j.pulmoe.2023.07.007","DOIUrl":"10.1016/j.pulmoe.2023.07.007","url":null,"abstract":"","PeriodicalId":54237,"journal":{"name":"Pulmonology","volume":"30 3","pages":"Pages 317-318"},"PeriodicalIF":11.7,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2531043723001332/pdfft?md5=212f344ffa54d02a1b9c1c377d958f99&pid=1-s2.0-S2531043723001332-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10540116","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"COPD phenotypes by computed tomography and ventilatory response to exercise","authors":"S. Rodrigues Sousa,&nbsp;J. Nunes Caldeira,&nbsp;C. Rodrigues","doi":"10.1016/j.pulmoe.2022.01.002","DOIUrl":"10.1016/j.pulmoe.2022.01.002","url":null,"abstract":"<div><h3>Introduction</h3><p>Computed tomographic (CT) phenotypic patterns of chronic obstructive pulmonary disease (COPD) identify different clinical features of disease. The impact of these variables on the physiological response to exercise has been the focus of a great deal of research as it allows more individualized clinical approaches. The aim of our study was to evaluate the relationships between CT phenotyping of subjects with COPD and the ventilatory response during cardiopulmonary exercise testing (CPET).</p></div><div><h3>Methods</h3><p>Subjects with COPD were classified into four phenotypes based on CT metrics of emphysema (low attenuation area less than a threshold of -950 Hounsfield [%LAA-950]) and airwall thickness (bronchial wall area percentage [%WA]).</p></div><div><h3>Results</h3><p>Eighty COPD patients (78.8% males, median age 65±11.3 years) were enrolled in the study. Based on CT phenotype, 25 (31.3%) patients were classified as normal, 27 (33.8%) air dominant, 17 (21.3%) emphysema dominant and 11 (13.8%) mixed type. The emphysema and mixed phenotypes showed the highest ventilatory equivalent for carbon dioxide (V_E/VCO₂) and V_E/VCO₂ slope (<em>p</em>&lt;0,05). In all phenotypes, %LAA was positive correlated with V_E/VCO₂ and V_E/VCO₂ slope (<em>r</em> = 0.437, <em>p</em> = 0.006 and <em>r</em> = 0.503, <em>p</em>&lt;0.001, respectively). %WA also showed a positive correlation with V_E/VCO₂ and V_E/VCO₂ slope (<em>r</em> = 0.541, <em>p</em>&lt;0.001 and <em>r</em> = 0.299, <em>p</em> = 0.033, respectively). In multivariate regression models, after adjustment for age, BMI, sex and FEV1, %LAA was the only independent predictor of V_E/VCO₂ and V_E/VCO₂ slope (β 0.343, SE 0.147, 95% CI 0.009/0.610, <em>p</em> = 0.044 and β 0.496, SE 0.081, 95% CI 0.130/0.455, <em>p</em> = 0.001, respectively).</p></div><div><h3>Conclusion</h3><p>Emphysema (%LAA) and airways metrics (%WA) had strong relationships with the different characteristics of ventilatory response to exercise in subjects with mild to moderate COPD. In particular, %LAA seemed to play an important role as an independent predictor of V_E/VCO₂ and V_E/VCO₂ slope. These results suggested that CT phenotyping may help predicting ventilatory response to exercise in subjects with COPD.</p></div>","PeriodicalId":54237,"journal":{"name":"Pulmonology","volume":"30 3","pages":"Pages 222-229"},"PeriodicalIF":11.7,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2531043722000083/pdfft?md5=2fea1ac8ec093582b12dc93b9172cb6a&pid=1-s2.0-S2531043722000083-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39592489","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Phenotyping exercise limitation of patients with Interstitial Fibrosing Lung Disease: the importance of exercise hemodynamics","authors":"E. Panagiotidou ,&nbsp;A. Βoutou ,&nbsp;E. Fouka ,&nbsp;D. Papakosta ,&nbsp;E. Chatzopoulos ,&nbsp;E. Sourla ,&nbsp;A. Markopoulou ,&nbsp;I. Kioumis ,&nbsp;I. Stanopoulos ,&nbsp;G. Pitsiou","doi":"10.1016/j.pulmoe.2022.03.012","DOIUrl":"10.1016/j.pulmoe.2022.03.012","url":null,"abstract":"&lt;div&gt;&lt;h3&gt;Introduction and objective&lt;/h3&gt;&lt;p&gt;Left-heart dysfunction and pulmonary vasculopathy are increasingly recognized as contributing factors of exercise capacity limitation in interstitial fibrosing lung disease (IFLD). Moreover, the clinical significance of exercise pulmonary hypertension (ePH) in pulmonary and cardiac diseases has been documented, representing a risk factor for decreased exercise capacity and survival, progression to resting pulmonary hypertension (PH) and overall clinical worsening.&lt;/p&gt;&lt;p&gt;We conducted a prospective study aiming at: (a) assessing the prevalence of PH and ePH in a cohort of 40 functionally limited patients with IFLD, (b) determining the post-capillary (postC) or pre-capillary (preC) etiology of either PH or ePH in this cohort, and (c) examining the correlations between invasively and non-invasively measured exercise variables among hemodynamic groups.&lt;/p&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Patients and methods&lt;/h3&gt;&lt;p&gt;40 IFLD patients underwent cardiopulmonary evaluation, including: clinical examination, lung function tests, 6-minute walking test, heart ultrasonography, cardiopulmonary exercise test and, finally, right heart catheterization (RHC). Resting hemodynamic evaluation was followed by the exercise protocol proposed by Herve et al, using a bedside cycle ergometer in the supine position. Abnormal elevation of mean pulmonary artery pressure (mPAP) above 30mmHg during exercise, with respect to abnormal elevation of cardiac output (CO) below 10 L/min (mPAP–CO ratio ⩾3 mmHg·min·L&lt;sup&gt;−1&lt;/sup&gt;) was used to define ePH (Herve et al, 2015). Secondary hemodynamic evaluation involved detection of abnormal pulmonary arterial wedge pressure (PAWP) increase at peak exercise in relation to CO. Specifically, ΔPAWP/ΔCO &gt;2 mmHg/L per minute determined an abnormal PAWP elevation (Bentley et al, 2020).&lt;/p&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Results&lt;/h3&gt;&lt;p&gt;Among the 40-patient cohort, 25% presented postC PH, 37.5% preC PH, 27.5% ePH, with the remaining 10% recording normal hemodynamics. PAWP evaluation during exercise revealed a postC etiology in 4 out of the 11 patients presenting ePH, and a postC etiology in 6 out of the 15 patients presenting resting preC PH. Mean values of non-invasive variables did not display statistically significant differences among hemodynamic groups, except for: diffusing capacity for carbon monoxide (DLCO), carbon monoxide transfer coefficient (KCO) and the ratio of functional vital capacity to DLCO (FVC%/DLCO%), which were lower in both ePH and PH groups (&lt;em&gt;p&lt;/em&gt; &lt; 0.05). Resting values of CO, cardiac index (CI), stroke volume (SV) and pulmonary vascular compliance (PVC) were significantly impaired in ePH, preC-PH and postC-PH groups when compared to the normal group.&lt;/p&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Conclusions&lt;/h3&gt;&lt;p&gt;Both PH and ePH were highly prevalent within the IFLD patient group, suggesting that RHC should be offered more frequently in functionally limited patients. Diffusion capacity markers must thus guide decision making, in para","PeriodicalId":54237,"journal":{"name":"Pulmonology","volume":"30 2","pages":"Pages 104-112"},"PeriodicalIF":11.7,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2531043722001052/pdfft?md5=f9b8adb1e540e5e0e9a6842374b108d2&pid=1-s2.0-S2531043722001052-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80070575","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Postural lung volume reduction, expiratory flow limitation, and orthopnoea in diaphragmatic weakness: Preliminary observations","authors":"S. Redolfi ,&nbsp;C. Straus ,&nbsp;V. Ninane ,&nbsp;T. Similowski","doi":"10.1016/j.pulmoe.2023.08.007","DOIUrl":"10.1016/j.pulmoe.2023.08.007","url":null,"abstract":"","PeriodicalId":54237,"journal":{"name":"Pulmonology","volume":"30 2","pages":"Pages 188-191"},"PeriodicalIF":11.7,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2531043723001605/pdfft?md5=6308d24ce544412691c2b47560c78bae&pid=1-s2.0-S2531043723001605-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41123508","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Subpleural curvilinear lines as an early indicator of silicosis in artificial stone workers","authors":"C.H. Chen ,&nbsp;P.J. Tsai ,&nbsp;W.W. Chang ,&nbsp;C.Y. Chen ,&nbsp;C.Y. Chen ,&nbsp;Y.L. Guo","doi":"10.1016/j.pulmoe.2023.08.006","DOIUrl":"10.1016/j.pulmoe.2023.08.006","url":null,"abstract":"","PeriodicalId":54237,"journal":{"name":"Pulmonology","volume":"30 2","pages":"Pages 174-176"},"PeriodicalIF":11.7,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2531043723001551/pdfft?md5=008c60a84f443b269105c7cb70bc451d&pid=1-s2.0-S2531043723001551-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41149291","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Thoracic endometriosis presenting as diffuse cystic lung disease: a rare case report","authors":"G. das Posses Bridi ,&nbsp;M.R. de Oliveira ,&nbsp;C.R.R. Carvalho ,&nbsp;E.C.T. do Nascimento ,&nbsp;B.G. Baldi","doi":"10.1016/j.pulmoe.2023.04.005","DOIUrl":"10.1016/j.pulmoe.2023.04.005","url":null,"abstract":"","PeriodicalId":54237,"journal":{"name":"Pulmonology","volume":"30 2","pages":"Pages 195-197"},"PeriodicalIF":11.7,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2531043723000867/pdfft?md5=cd7cf33ec34de554ad42e374f6049e5e&pid=1-s2.0-S2531043723000867-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9491537","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Open-source, low-cost App-driven Internet of Things approach to facilitate respiratory oscillometry at home and in developing countries","authors":"J.-E. González ,&nbsp;M.A. Rodríguez ,&nbsp;E. Caballero ,&nbsp;A. Pardo ,&nbsp;S. Marco ,&nbsp;R. Farré","doi":"10.1016/j.pulmoe.2023.10.004","DOIUrl":"10.1016/j.pulmoe.2023.10.004","url":null,"abstract":"","PeriodicalId":54237,"journal":{"name":"Pulmonology","volume":"30 2","pages":"Pages 180-183"},"PeriodicalIF":11.7,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2531043723001939/pdfft?md5=32f7ee620f505cfca9149b8e0e6790ce&pid=1-s2.0-S2531043723001939-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134650525","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}