Pulmonology最新文献_第10页

Associations of serum sclerostin levels with body composition, pulmonary function, and exacerbations in COPD patients 慢性阻塞性肺病患者血清硬骨素水平与身体组成、肺功能和病情恶化的关系。

IF 10.4 2区医学

Pulmonology Pub Date : 2024-11-01 DOI: 10.1016/j.pulmoe.2022.06.003

{"title":"Associations of serum sclerostin levels with body composition, pulmonary function, and exacerbations in COPD patients","authors":"","doi":"10.1016/j.pulmoe.2022.06.003","DOIUrl":"10.1016/j.pulmoe.2022.06.003","url":null,"abstract":"<div><h3>Background</h3><div>In COPD, the bronchial epithelium shows a pathologically activated Wnt pathway. Sclerostin (SOST) is a secreted glycoprotein that is associated with bone metabolism and blocks the Wnt pathway. We hypothesized that low sclerostin levels might be associated with lung function and COPD exacerbations in patients.</div></div><div><h3>Methods</h3><div>We studied 139 outpatients with stable COPD and normal kidney function. We assessed the serum levels of SOST and bone metabolism parameters, body composition, clinical characteristics and lung function at baseline. We followed the patients prospectively for 12 months after enrolment. Moderate exacerbations and hospital admissions were recorded during follow-up.</div></div><div><h3>Results</h3><div>The serum SOST levels were 23.98±7.6 pmol/l (men: 25.5±7.7 pmol/l, women: 20.3±5.9 pmol/l (<em>p</em> < 0.001)). SOST showed correlations with age (<em>r</em> = 0.36), FFMI (<em>r</em> = 0.38), FEV1 (<em>r</em> = 0.27), DLCO (<em>r</em> = 0.39), 6MWD (<em>r</em> = 0.19) and CAT (<em>r</em> = -0.24). In multivariate linear regression analysis, only age (beta=0.264) and FFMI (beta=1.241) remained significant. SOST showed a significant negative correlation with serum phosphorus (<em>r</em> = -0.29). Cox proportional risk analysis indicated that patients in the lower tertile of SOST levels were at higher risk of moderate COPD exacerbation (HR 2.015, CI95% 1.136–3.577, <em>p</em> = 0.017) and hospital admission due to COPD (HR 5.142, CI95% 1.380–19.158, <em>p</em> = 0.015) than the rest of the patients.</div></div><div><h3>Conclusions</h3><div>SOST levels are associated with body composition and lung function in patients with COPD. Furthermore, lower SOST levels predict a higher risk of exacerbations and hospitalization.</div></div>","PeriodicalId":54237,"journal":{"name":"Pulmonology","volume":"30 6","pages":"Pages 512-521"},"PeriodicalIF":10.4,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40611190","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Brompton breathing pattern assessment tool (BPAT): Portuguese translation and cultural adaptation 布朗普顿呼吸模式评估工具（BPAT）：葡萄牙语翻译和文化适应。

IF 10.4 2区医学

Pulmonology Pub Date : 2024-11-01 DOI: 10.1016/j.pulmoe.2024.01.006

引用次数: 0

Malignant pulmonary epithelioid hemangioendothelioma masquerading as lung adenocarcinoma: A possible radiological and pathological diagnostic pitfall 伪装成肺腺癌的恶性肺上皮样血管内皮瘤：一个可能的放射学和病理学诊断陷阱。

IF 10.4 2区医学

Pulmonology Pub Date : 2024-11-01 DOI: 10.1016/j.pulmoe.2024.04.007

引用次数: 0

An extremely rare case of Langerhans cell hyperplasia in the thymus 一例极为罕见的胸腺朗格汉斯细胞增生症。

IF 10.4 2区医学

Pulmonology Pub Date : 2024-11-01 DOI: 10.1016/j.pulmoe.2024.04.002

引用次数: 0

Delays have dangerous ends: Tuberculosis diagnosis delay in Portugal, a qualitative study 拖延会带来危险的结局：葡萄牙结核病诊断延误的定性研究。

IF 10.4 2区医学

Pulmonology Pub Date : 2024-11-01 DOI: 10.1016/j.pulmoe.2024.02.006

引用次数: 0

Recommendations for the implementation of a national lung cancer screening program in Portugal—A consensus statement 关于在葡萄牙实施全国肺癌筛查计划的建议--共识声明。

IF 10.4 2区医学

Pulmonology Pub Date : 2024-11-01 DOI: 10.1016/j.pulmoe.2024.04.003

M.G.O. Fernandes , M. Dias , R. Santos , S. Ravara , P. Fernandes , J. Firmino-Machado , J.P. Antunes , O. Fernandes , A. Madureira , V. Hespanhol , C. Rodrigues , C.A. Vicente , S. Alves , G. Mendes , R. Ilgenfritz , B.S. Pinto , J. Alves , I. Saraiva , C. Bárbara , M.A. Cipriano , A. Morais

{"title":"Recommendations for the implementation of a national lung cancer screening program in Portugal—A consensus statement","authors":"M.G.O. Fernandes , M. Dias , R. Santos , S. Ravara , P. Fernandes , J. Firmino-Machado , J.P. Antunes , O. Fernandes , A. Madureira , V. Hespanhol , C. Rodrigues , C.A. Vicente , S. Alves , G. Mendes , R. Ilgenfritz , B.S. Pinto , J. Alves , I. Saraiva , C. Bárbara , M.A. Cipriano , A. Morais","doi":"10.1016/j.pulmoe.2024.04.003","DOIUrl":"10.1016/j.pulmoe.2024.04.003","url":null,"abstract":"<div><div>Lung cancer (LC) is a leading cause of cancer-related mortality worldwide. Lung Cancer Screening (LCS) programs that use low-dose computed tomography (LDCT) have been shown to reduce LC mortality by up to 25 % and are considered cost-effective. The European Health Union has encouraged its Member States to explore the feasibility of LCS implementation in their respective countries.</div><div>The task force conducted a comprehensive literature review and engaged in extensive discussions to provide recommendations.</div><div>These recommendations encompass the essential components required to initiate pilot LCS programs following the guidelines established by the World Health Organization. They were tailored to align with the specific context of the Portuguese healthcare system. The document addresses critical aspects, including the eligible population, methods for issuing invitations, radiological prerequisites, procedures for reporting results, referral processes, diagnostic strategies, program implementation, and ongoing monitoring. Furthermore, the task force emphasized that pairing LCS with evidence-based smoking cessation should be the standard of care for a high-quality screening program. This document also identifies areas for further research.</div><div>These recommendations aim to guarantee that the implementation of a Portuguese LCS program ensures high-quality standards, consistency, and uniformity across centres.</div></div>","PeriodicalId":54237,"journal":{"name":"Pulmonology","volume":"30 6","pages":"Pages 625-635"},"PeriodicalIF":10.4,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141903524","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Obstructive Sleep Apnoea (OSA) and early atherosclerosis: The role of microbiota and EVs 阻塞性睡眠呼吸暂停（OSA）与早期动脉粥样硬化：微生物群和 EVs 的作用

IF 10.4 2区医学

Pulmonology Pub Date : 2024-11-01 DOI: 10.1016/j.pulmoe.2023.11.011

引用次数: 0

Single breath nitrogen test as predictor of lung function decline and COPD over an 8-year follow-up 单次呼气含氮量测试作为肺功能下降和慢性阻塞性肺病的预测指标，随访 8 年。

IF 10.4 2区医学

Pulmonology Pub Date : 2024-11-01 DOI: 10.1016/j.pulmoe.2022.09.001

{"title":"Single breath nitrogen test as predictor of lung function decline and COPD over an 8-year follow-up","authors":"","doi":"10.1016/j.pulmoe.2022.09.001","DOIUrl":"10.1016/j.pulmoe.2022.09.001","url":null,"abstract":"<div><h3>Background</h3><div>The single breath nitrogen (SBN<sub>2</sub>) test was proposed for early detection of “small airways disease” in the seventies. Few longitudinal studies have subsequently evaluated the relationships between SBN<sub>2</sub> test measurements and lung function decline or COPD incidence.</div></div><div><h3>Aim</h3><div>This study evaluates whether SBN<sub>2</sub> test abnormalities may be significant predictors of lung function decline and COPD incidence over an 8-year follow-up.</div></div><div><h3>Study Design and Methods</h3><div>In this longitudinal study, 907 adults (20+ years old; 56% males) from the prospective Po River Delta epidemiological study underwent SBN<sub>2</sub> test at baseline and spirometry testing at both baseline and follow-up 8-year apart. Multinomial and multiple regression models were used to assess associations of SBN<sub>2</sub> indexes and rates of FEV<sub>1</sub> decline or risk of COPD incidence over time, after adjusting for sex, height and baseline age, FEV<sub>1</sub> and smoking status. COPD was defined according to either GOLD or ATS-ERS criteria.</div></div><div><h3>Results</h3><div>Among SBN<sub>2</sub> indexes, only the slope of alveolar plateau (N<sub>2</sub>-slope) was significantly associated with rates of FEV<sub>1</sub> decline (7.93 mL/year for a one-unit change in N<sub>2</sub>-slope, p<0.0001), and with an increased risk of developing COPD as defined by GOLD (RR 1.81, 95%CI 1.29-2.52, mild; RR 2.78, 95%CI 1.70-4.53, moderate or severe obstruction) and ATS-ERS criteria (RR 1.62, 95%CI 1.14-2.29, mild; RR 3.40, 95%CI 1.72-6.73, moderate or severe obstruction).</div></div><div><h3>Conclusion</h3><div>In this population-based study, N<sub>2</sub>-slope from SBN<sub>2</sub> test is a significant predictor of lung function decline and COPD incidence over an 8-year follow-up, confirming the role of the “small airways disease” in the natural history of COPD.</div></div>","PeriodicalId":54237,"journal":{"name":"Pulmonology","volume":"30 6","pages":"Pages 546-554"},"PeriodicalIF":10.4,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33497589","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Intensity of exercise in people with COPD enrolled in community-based physical activities 参加社区体育活动的COPD患者的运动强度。

IF 10.4 2区医学

Pulmonology Pub Date : 2024-11-01 DOI: 10.1016/j.pulmoe.2023.11.001

引用次数: 0

Unraveling the resurgence of pertussis: Insights into epidemiology and global health strategies 揭示百日咳卷土重来的原因：流行病学和全球健康战略的启示。

IF 10.4 2区医学

Pulmonology Pub Date : 2024-11-01 DOI: 10.1016/j.pulmoe.2024.04.009

引用次数: 0