Pulmonology最新文献

{"title":"Correspondence: 'CFTR variants in bronchiectasis'.","authors":"Yuanli Yang","doi":"10.1080/25310429.2026.2632449","DOIUrl":"10.1080/25310429.2026.2632449","url":null,"abstract":"","PeriodicalId":54237,"journal":{"name":"Pulmonology","volume":"32 1","pages":"2632449"},"PeriodicalIF":5.3,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146203718","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Blood eosinopenia (≤30/µL) as an early predictor of respiratory failure in community-acquired pneumonia: A prospective multicentre study.","authors":"Barbara Christine Weckler, Roman Martin, Max Kutzinski, Wilhelm Bertrams, Anna Lena Jung, Hendrik Pott, Katrin Laakmann, Leon Schulte, Peter Ahnert, Dominik Heider, Stephan Ringshandl, Christian Seidemann, Norbert Suttorp, Martin Witzenrath, Christian Wildberg, Mareike Lehmann, Gernot Rohde, Timm Greulich, Claus Franz Vogelmeier, Bernd Schmeck","doi":"10.1080/25310429.2025.2611215","DOIUrl":"10.1080/25310429.2025.2611215","url":null,"abstract":"<p><strong>Introduction and objectives: </strong>Lower blood eosinophil counts have been associated with increased mechanical ventilation rates in patients with community-acquired pneumonia (CAP). However, the optimal eosinophil count threshold for identifying CAP patients at high risk of respiratory failure remains undefined. This study aimed to establish an optimal admission eosinophil count as a prognostic biomarker for respiratory failure in CAP.</p><p><strong>Methods: </strong>This prospective, multicentre cohort study (PROGRESS) enrolled adult patients (≥18 years) hospitalised with community-acquired pneumonia (CAP). A receiver operating characteristic curve analysis with Youden's index was applied to identify the optimal eosinophil threshold for predicting mechanical ventilation. Associations were adjusted for corticosteroid use using multivariable regression. Additional outcomes - ICU admission and hospital length of stay - were compared between patients above and below the optimal eosinophil count threshold.</p><p><strong>Results: </strong>An eosinophil count threshold of ≤30/µL was optimal for predicting mechanical ventilation. Patients with eosinophil counts ≤30/µL experienced significantly higher mechanical ventilation rates (15.5% versus 7.3%; <i>p</i> < 0.0001; RR 2.12, 95% CI 1.61-2.80), regardless of glucocorticoid treatment. They also exhibited higher ICU admission rates (23.1% versus 10.9%; <i>p</i> < 0.0001; RR 2.11, 95% CI 1.70-2.63) and longer hospital stays among survivors (median 8.0 versus 7.0 days; <i>p</i> < 0.0001).</p><p><strong>Conclusions: </strong>Admission eosinopenia (≤30 µL) is a robust, easily measured biomarker that predicts respiratory failure in hospitalised CAP. It supports early risk stratification and may guide timely escalation of care.</p>","PeriodicalId":54237,"journal":{"name":"Pulmonology","volume":"32 1","pages":"2611215"},"PeriodicalIF":6.4,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145936319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter to Editor: Beyond pulmonary rehabilitation: Can the PICk UP programme fill the gap? A randomised trial in COPD.","authors":"Anchal Thakur, Kanika Bhatia","doi":"10.1080/25310429.2025.2612382","DOIUrl":"10.1080/25310429.2025.2612382","url":null,"abstract":"","PeriodicalId":54237,"journal":{"name":"Pulmonology","volume":"32 1","pages":"2612382"},"PeriodicalIF":5.3,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145901578","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter to editor - Impact of an early follow-up visit on adherence and adherence trajectories after initiation of continuous positive airway pressure therapy for obstructive sleep apnea.","authors":"Rana Dey, Suman Pradhan, Sunita Sharma","doi":"10.1080/25310429.2026.2673638","DOIUrl":"10.1080/25310429.2026.2673638","url":null,"abstract":"","PeriodicalId":54237,"journal":{"name":"Pulmonology","volume":"32 1","pages":"2673638"},"PeriodicalIF":5.3,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147965418","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fatigue in bronchiectasis: An under-recognised treatable trait.","authors":"Akhil Sawant","doi":"10.1080/25310429.2026.2734660","DOIUrl":"https://doi.org/10.1080/25310429.2026.2734660","url":null,"abstract":"","PeriodicalId":54237,"journal":{"name":"Pulmonology","volume":"32 1","pages":"2734660"},"PeriodicalIF":5.3,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148992528","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effectiveness of self-management digital interventions in improving health-related outcomes in patients with chronic obstructive pulmonary disease: An umbrella review.","authors":"Ricardo Salgado, Hugo Fernandes, Véronique de Goumoëns, Blanche Kiszio, Patrício Costa, Philippe Delmas, José Miguel Padilha","doi":"10.1080/25310429.2026.2684901","DOIUrl":"10.1080/25310429.2026.2684901","url":null,"abstract":"<p><strong>Background: </strong>Chronic obstructive pulmonary disease (COPD) is a leading cause of morbidity and mortality. Self-management interventions improve health outcomes but suffer from limited accessibility and sustainability. The usage of digital interventions may offer scalable alternatives.</p><p><strong>Research question: </strong>What is the effectiveness of self-management digital interventions in improving health-related outcomes among adults with COPD?</p><p><strong>Methods: </strong>This umbrella review followed the JBI methodology and was registered in PROSPERO (CRD42024517476). A systematic search across multiple databases was conducted to identify relevant systematic reviews published in any language from database inception to February 2024. Effect sizes and confidence intervals reported in the included reviews were converted into equivalent odds ratios (eORs) to enable standardised comparisons across outcomes.</p><p><strong>Results: </strong>Thirteen systematic reviews (15 363 participants) were included, of which 11 reported meta-analyses and two provided narrative syntheses only. Self-management digital interventions improved physical activity (eOR 2·34 [95% CI 1·14-4·80]), quality of life (eOR 2·02 [1·41-2·90]), lung function (eOR 2·60 [1·04-6·50]), adherence (eOR 5·04 [2·14-11·87]), anxiety (eOR 1·43 [1·15-1·76]), and depression (eOR 1·30 [1·05-1·60]). Effects were inconclusive for dyspnoea, physical capacity, sedentary time, emergency visits, and mortality. Heterogeneity was substantial across most outcomes. The certainty of evidence according to the GRADE approach ranged from very low to moderate.</p><p><strong>Conclusion: </strong>Self-management digital interventions appear effective in improving several key outcomes in COPD management. Future research should prioritise standardised methodologies and long-term evaluations to strengthen the evidence base.</p>","PeriodicalId":54237,"journal":{"name":"Pulmonology","volume":"32 1","pages":"2684901"},"PeriodicalIF":5.3,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148551417","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of exposure to second-hand tobacco smoke (SHS) using questionnaires in Portugal and Brazil: A qualitative study.","authors":"Ana Teijeiro, Mónica Pérez-Ríos, Julia Rey-Brandariz, Ana Blanco-Ferreiro, Sofia Ravara","doi":"10.1080/25310429.2026.2717024","DOIUrl":"https://doi.org/10.1080/25310429.2026.2717024","url":null,"abstract":"<p><p>This study aimed to identify the key concepts involved in designing epidemiological surveys to estimate the prevalence of second-hand tobacco smoke (SHS) exposure in Portugal and Brazil. A two-round Delphi study was conducted. Firstly, a group of experts was asked for their opinions on the relevance of various concepts (exposure scenarios, recall, time, environmental context, exposure intensity, and relationship to smoking) and domains. Based on their responses, a new questionnaire was developed. The experts ranked the importance of different questions. A thematic analysis was carried out. The experts considered it important to evaluate SHS exposure in general, as well as in specific settings, such as the home, workplace, public and private transport (with or without children), and leisure settings. They reported that recalling the number of hours of exposure spent indoors and outdoors on working and non-working days, and in the last month, provided a more detailed assessment. They also stated that exposure intensity should be assessed either by the presence and number of smokers or by the perception of a smoke-heavy environment. Differences in responses according to the country in which experts reside were minimal. The researchers provided clear, precise, and consistent recommendations for collecting comparable data across studies to enact smoke-free policies. This reinforces the feasibility of using standardised questionnaires to evaluate SHS exposure across countries.</p>","PeriodicalId":54237,"journal":{"name":"Pulmonology","volume":"32 1","pages":"2717024"},"PeriodicalIF":5.3,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148801555","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Stable lung function, but how stable? Methodological and clinical questions in defining asthma remission.","authors":"Shaveta Mala, Shalom Akhai","doi":"10.1080/25310429.2026.2743959","DOIUrl":"https://doi.org/10.1080/25310429.2026.2743959","url":null,"abstract":"","PeriodicalId":54237,"journal":{"name":"Pulmonology","volume":"32 1","pages":"2743959"},"PeriodicalIF":5.3,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149129140","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of anti-tuberculosis drugs on the pharmacokinetics and pharmacodynamics of novel antidiabetic drugs: A scoping review.","authors":"David S Gomes, Joana Lourenço, Maria J Moura, Mariana Vieira, João Pedro Ramos, Marina Pinheiro, Raquel Duarte","doi":"10.1080/25310429.2026.2640663","DOIUrl":"10.1080/25310429.2026.2640663","url":null,"abstract":"<p><strong>Background: </strong>The co-occurrence of tuberculosis (TB) and diabetes mellitus (DM) presents a growing public global health concern. Managing DM during anti-TB therapy is challenging due to potential drug-drug interactions, especially with rifamycin (RIF).</p><p><strong>Research question: </strong>Assess the effects of anti-TB drugs on the pharmacokinetics and pharmacodynamics of novel antidiabetic agents, including DPP-4 inhibitors (DPP4i), SGLT-2 inhibitors (SGLT2i) and GLP-1 receptor agonists (GLP-1a).</p><p><strong>Study design and methods: </strong>A PRISMA-ScR-based scoping review was conducted among four databases.</p><p><strong>Results: </strong>Ten studies involving 307 participants were included. RIF significantly reduced the plasma exposure of DPP4i (saxagliptin, gemigliptin, evogliptin) and canagliflozin, while other SGLT2i (dapagliflozin, empagliflozin, ertugliflozin) were minimally affected. No direct data was available for GLP-1a. Adverse events were rare in healthy participants but more frequent in elderly patients with poorly controlled DM. Linezolid and dapagliflozin co-administration may lead to severe pancytopenia.</p><p><strong>Discussion: </strong>RIF co-administration with gemigliptin, evogliptin and canagliflozin requires caution and potential requiring dose adjustments, while saxagliptin, dapagliflozin, ertugliflozin and empagliflozin appear safer alternatives. Haematologic monitoring is recommended when combining linezolid and dapagliflozin. However, current evidence remains limited by small sample sizes, single-dose designs, inclusion of mainly healthy participants, and lack of data on GLP-1a or other anti-TB agents. The limited inclusion of DM patients with TB, restricted to one study with latent TB infection, further reduces generalisability. We developed a clinical decision algorithm to support co-treatment in TB - DM cases, but further dedicated studies are warranted to guide optimal co-treatment.</p>","PeriodicalId":54237,"journal":{"name":"Pulmonology","volume":"32 1","pages":"2640663"},"PeriodicalIF":5.3,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147390466","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optimizing EBUS-Guided mediastinal biopsy strategies: Considerations beyond diagnostic yield.","authors":"Weikai Dong, Qing Shao, Qiang Wang","doi":"10.1080/25310429.2026.2649664","DOIUrl":"https://doi.org/10.1080/25310429.2026.2649664","url":null,"abstract":"","PeriodicalId":54237,"journal":{"name":"Pulmonology","volume":"32 1","pages":"2649664"},"PeriodicalIF":6.4,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147576532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}