Biological Psychiatry-Cognitive Neuroscience and Neuroimaging最新文献

{"title":"Guide for Authors","authors":"","doi":"10.1016/S2451-9022(24)00365-3","DOIUrl":"10.1016/S2451-9022(24)00365-3","url":null,"abstract":"","PeriodicalId":54231,"journal":{"name":"Biological Psychiatry-Cognitive Neuroscience and Neuroimaging","volume":"10 1","pages":"Pages A5-A10"},"PeriodicalIF":5.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143164481","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Neural Signature for Reappraisal as an Emotion Regulation Strategy: Relationship to Stress-Related Suicidal Ideation and Negative Affect in Major Depression","authors":"Sarah Herzog ,&nbsp;Noam Schneck ,&nbsp;Hanga Galfalvy ,&nbsp;Tse Hwei-Choo ,&nbsp;Mike Schmidt ,&nbsp;Christina A. Michel ,&nbsp;M. Elizabeth Sublette ,&nbsp;Ainsley Burke ,&nbsp;Kevin Ochsner ,&nbsp;J. John Mann ,&nbsp;Maria A. Oquendo ,&nbsp;Barbara H. Stanley","doi":"10.1016/j.bpsc.2024.08.011","DOIUrl":"10.1016/j.bpsc.2024.08.011","url":null,"abstract":"<div><h3>Background</h3><div>Impaired emotion regulation (ER) contributes to major depression and suicidal ideation and behavior. ER is typically studied by explicitly directing participants to regulate, but this may not capture spontaneous tendencies of individuals with depression to engage ER in daily life.</div></div><div><h3>Methods</h3><div>In 82 participants with major depressive disorder, we examined the relationship of spontaneous engagement of ER to real-world responses to stress. We used a machine learning–derived neural signature reflecting neural systems that underlie cognitive reappraisal (an ER strategy) to identify reappraisal-related activity while participants recalled negative autobiographical memories under the following conditions: 1) unstructured recall; 2) distanced recall, a form of reappraisal; and 3) immersed recall (comparison condition). Participants also completed a week of ecological momentary assessment measuring daily stressors, suicidal ideation, and negative affect.</div></div><div><h3>Results</h3><div>Higher reappraisal signature output for the unstructured period, a proxy for the spontaneous tendency to engage ER, was associated with greater increases in suicidal ideation following stressors (<em>b</em> = 0.083, <em>p</em> = .041). Higher signature output for distanced recall, a proxy for the capacity to engage ER when directed, was associated with lower negative affect following stressors (<em>b</em> = −0.085, <em>p</em> = .029). Output for the immerse period was not associated with ecological momentary assessment outcomes.</div></div><div><h3>Conclusions</h3><div>Findings suggest that in major depressive disorder, the spontaneous tendency to react to negative memories with attempts to reappraise may indicate greater reactivity to negative cues, while intact capacity to use reappraisal when directed may be associated with more adaptive responses to stress. These data have implications for understanding stress-related increases in suicide risk in depression.</div></div>","PeriodicalId":54231,"journal":{"name":"Biological Psychiatry-Cognitive Neuroscience and Neuroimaging","volume":"10 1","pages":"Pages 94-102"},"PeriodicalIF":5.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142094291","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"History of Peripartum Depression Moderates the Association Between Estradiol Polygenic Risk Scores and Basal Ganglia Volumes in Major Depressive Disorder","authors":"Yasmin A. Harrington ,&nbsp;Marco Paolini ,&nbsp;Lidia Fortaner-Uyà ,&nbsp;Melania Maccario ,&nbsp;Elisa M.T. Melloni ,&nbsp;Sara Poletti ,&nbsp;Cristina Lorenzi ,&nbsp;Raffaella Zanardi ,&nbsp;Cristina Colombo ,&nbsp;Francesco Benedetti","doi":"10.1016/j.bpsc.2024.09.011","DOIUrl":"10.1016/j.bpsc.2024.09.011","url":null,"abstract":"<div><h3>Background</h3><div>The neurobiological differences between women who have experienced a peripartum episode and those who have only had episodes outside of this period are not well understood.</div></div><div><h3>Methods</h3><div>Sixty-four parous female patients with major depressive disorder who had either a positive (<em>n</em> = 30) or negative (<em>n</em> = 34) history of peripartum depression (PPD) underwent magnetic resonance imaging acquisition to obtain structural brain images. An independent 2-sample <em>t</em> test comparing patients with and without a history of PPD was performed using voxel-based morphometry analysis. Additionally, polygenic risk scores for estradiol were calculated, and a moderation analysis was conducted between 3 estradiol polygenic risk scores and PPD history status on extracted cluster volumes using IBM SPSS PROCESS macro.</div></div><div><h3>Results</h3><div>The voxel-based morphometry analysis identified larger gray matter volumes in bilateral clusters encompassing the putamen, pallidum, caudate, and thalamus in patients with a PPD history than in patients without a history. The moderation analysis identified a significant interaction effect between 2 estradiol polygenic risk scores and PPD history on gray matter cluster volumes, with a positive effect in women with PPD and a negative effect in women with no history of PPD.</div></div><div><h3>Conclusions</h3><div>Our findings demonstrate that women who have experienced a peripartum episode are neurobiologically distinct from women who have no history of PPD in a cluster within the basal ganglia, an area important for motivation, decision making, and emotional processing. Furthermore, we show that the genetic load for estradiol has a differing effect in this area based on PPD status, which supports the claim that PPD is associated with sensitivity to sex steroid hormones.</div></div>","PeriodicalId":54231,"journal":{"name":"Biological Psychiatry-Cognitive Neuroscience and Neuroimaging","volume":"10 1","pages":"Pages 7-16"},"PeriodicalIF":5.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142373755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neural Signature of Reappraisal: Tendency Versus Capacity","authors":"Agnieszka Zuberer","doi":"10.1016/j.bpsc.2024.11.016","DOIUrl":"10.1016/j.bpsc.2024.11.016","url":null,"abstract":"","PeriodicalId":54231,"journal":{"name":"Biological Psychiatry-Cognitive Neuroscience and Neuroimaging","volume":"10 1","pages":"Pages 5-6"},"PeriodicalIF":5.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142960128","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Spatiotemporal Eye Movement Dynamics Reveal Altered Face Prioritization in Early Visual Processing Among Autistic Children","authors":"Jason W. Griffin ,&nbsp;Adam Naples ,&nbsp;Raphael Bernier ,&nbsp;Katarzyna Chawarska ,&nbsp;Geraldine Dawson ,&nbsp;James Dziura ,&nbsp;Susan Faja ,&nbsp;Shafali Jeste ,&nbsp;Natalia Kleinhans ,&nbsp;Catherine Sugar ,&nbsp;Sara Jane Webb ,&nbsp;Frederick Shic ,&nbsp;James C. McPartland ,&nbsp;Autism Biomarkers Consortium for Clinical Trials","doi":"10.1016/j.bpsc.2024.08.017","DOIUrl":"10.1016/j.bpsc.2024.08.017","url":null,"abstract":"<div><h3>Background</h3><div>Reduced social attention—looking at faces—is one of the most common manifestations of social difficulty in autism that is central to social development. Although reduced social attention is well characterized in autism, qualitative differences in how social attention unfolds across time remains unknown.</div></div><div><h3>Methods</h3><div>We used a computational modeling (i.e., hidden Markov modeling) approach to assess and compare the spatiotemporal dynamics of social attention in a large, well-characterized sample of children with autism (<em>n</em> = 280) and neurotypical children (<em>n</em> = 119) (ages 6–11) who completed 3 social eye-tracking assays at 3 longitudinal time points (baseline, 6 weeks, 24 weeks).</div></div><div><h3>Results</h3><div>Our analysis supported the existence of 2 common eye movement patterns that emerged across 3 eye-tracking assays. A focused pattern was characterized by small face regions of interest, which had high a probability of capturing fixations early in visual processing. In contrast, an exploratory pattern was characterized by larger face regions of interest, with a lower initial probability of fixation and more nonsocial regions of interest. In the context of social perception, children with autism showed significantly more exploratory eye movement patterns than neurotypical children across all social perception assays and all 3 longitudinal time points. Eye movement patterns were associated with clinical features of autism, including adaptive function, face recognition, and autism symptom severity.</div></div><div><h3>Conclusions</h3><div>Decreased likelihood of precisely looking at faces early in social visual processing may be an important feature of autism that is associated with autism-related symptomology and may reflect less visual sensitivity to face information.</div></div>","PeriodicalId":54231,"journal":{"name":"Biological Psychiatry-Cognitive Neuroscience and Neuroimaging","volume":"10 1","pages":"Pages 45-57"},"PeriodicalIF":5.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142142042","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Subscribers' Page","authors":"","doi":"10.1016/S2451-9022(24)00362-8","DOIUrl":"10.1016/S2451-9022(24)00362-8","url":null,"abstract":"","PeriodicalId":54231,"journal":{"name":"Biological Psychiatry-Cognitive Neuroscience and Neuroimaging","volume":"10 1","pages":"Page A2"},"PeriodicalIF":5.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143164484","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Leveraging Distributed Brain Signal at Rest to Predict Internalizing Symptoms in Youth: Deriving a Polyneuro Risk Score From the ABCD Study Cohort","authors":"Dakota Kliamovich ,&nbsp;Oscar Miranda-Dominguez ,&nbsp;Nora Byington ,&nbsp;Abigail V. Espinoza ,&nbsp;Arturo Lopez Flores ,&nbsp;Damien A. Fair ,&nbsp;Bonnie J. Nagel","doi":"10.1016/j.bpsc.2024.07.026","DOIUrl":"10.1016/j.bpsc.2024.07.026","url":null,"abstract":"<div><h3>Background</h3><div>The prevalence of internalizing psychopathology rises precipitously from early to mid-adolescence, yet the underlying neural phenotypes that give rise to depression and anxiety during this developmental period remain unclear.</div></div><div><h3>Methods</h3><div>Youths from the Adolescent Brain Cognitive Development (ABCD) Study (ages 9–10 years at baseline) with a resting-state functional magnetic resonance imaging scan and mental health data were eligible for inclusion. Internalizing subscale scores from the Brief Problem Monitor-Youth Form were combined across 2 years of follow-up to generate a cumulative measure of internalizing symptoms. The total sample (<em>N</em> = 6521) was split into a large discovery dataset and a smaller validation dataset. Brain-behavior associations of resting-state functional connectivity with internalizing symptoms were estimated in the discovery dataset. The weighted contributions of each functional connection were aggregated using multivariate statistics to generate a polyneuro risk score (PNRS). The predictive power of the PNRS was evaluated in the validation dataset.</div></div><div><h3>Results</h3><div>The PNRS explained 10.73% of the observed variance in internalizing symptom scores in the validation dataset. Model performance peaked when the top 2% functional connections identified in the discovery dataset (ranked by absolute <em>β</em> weight) were retained. The resting-state functional connectivity networks that were implicated most prominently were the default mode, dorsal attention, and cingulo-parietal networks. These findings were significant (<em>p</em> &lt; 1 × 10⁻⁶) as accounted for by permutation testing (<em>n</em> = 7000).</div></div><div><h3>Conclusions</h3><div>These results suggest that the neural phenotype associated with internalizing symptoms during adolescence is functionally distributed. The PNRS approach is a novel method for capturing relationships between resting-state functional connectivity and behavior.</div></div>","PeriodicalId":54231,"journal":{"name":"Biological Psychiatry-Cognitive Neuroscience and Neuroimaging","volume":"10 1","pages":"Pages 58-67"},"PeriodicalIF":5.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141914860","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Reward Positivity Mediates the Association Between Adverse Childhood Experiences and Anhedonia in Young Adults With Drug-Naïve Major Depressive Disorder","authors":"Ciqing Bao ,&nbsp;Qiaoyang Zhang ,&nbsp;Haowen Zou ,&nbsp;Chen He ,&nbsp;Rui Yan ,&nbsp;Lingling Hua ,&nbsp;Qing Lu ,&nbsp;Zhijian Yao","doi":"10.1016/j.bpsc.2024.08.014","DOIUrl":"10.1016/j.bpsc.2024.08.014","url":null,"abstract":"<div><h3>Background</h3><div>Current clinical studies have indicated that major depressive disorder (MDD) concurrent with adverse childhood experiences (ACEs) is associated with greater anhedonia. However, little is known about whether the change in reward sensitivity among young individuals with MDD and ACEs is related to anhedonia.</div></div><div><h3>Methods</h3><div>We evaluated anhedonia and ACEs in 86 patients with MDD (31 with no or 1 ACE and 55 with 2 or more ACEs) and 44 healthy control participants. Then, participants completed the Iowa Gambling Task during electroencephalography to measure the reward positivity (RewP) and its difference (ΔRewP; gains minus losses). Furthermore, we constructed a mediation model to assess whether aberrant ΔRewP mediated the relationship between ACEs and anhedonia.</div></div><div><h3>Results</h3><div>Compared with healthy control participants and MDD patients with no or 1 ACE, MDD patients with 2 or more ACEs had the most severe symptoms of anhedonia and impaired decision making and showed significantly reduced reward sensitivity (most blunted ΔRewP). More importantly, ΔRewP mediated the relationship between ACEs and anhedonia in MDD.</div></div><div><h3>Conclusions</h3><div>We found that the ΔRewP partially mediated the association between ACEs and anhedonia in patients with MDD, which provides evidence for the neurobiological basis of abnormal changes in the reward system in MDD individuals with early adverse experiences.</div></div>","PeriodicalId":54231,"journal":{"name":"Biological Psychiatry-Cognitive Neuroscience and Neuroimaging","volume":"10 1","pages":"Pages 17-25"},"PeriodicalIF":5.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142115865","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"New Approaches to Eye-Tracking Analysis in Autism Research","authors":"Terje Falck-Ytter","doi":"10.1016/j.bpsc.2024.11.009","DOIUrl":"10.1016/j.bpsc.2024.11.009","url":null,"abstract":"","PeriodicalId":54231,"journal":{"name":"Biological Psychiatry-Cognitive Neuroscience and Neuroimaging","volume":"10 1","pages":"Pages 3-4"},"PeriodicalIF":5.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142960131","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Navigating Exploitative Traps: Unveiling the Uncontrollable Reward Seeking of Individuals With Internet Gaming Disorder","authors":"Lin Zuo ,&nbsp;Kedan Ai ,&nbsp;Weili Liu ,&nbsp;Bensheng Qiu ,&nbsp;Rui Tang ,&nbsp;Jiaxin Fu ,&nbsp;Ping Yang ,&nbsp;Zhuo Kong ,&nbsp;Hongwen Song ,&nbsp;Xiaoyu Zhu ,&nbsp;Xiaochu Zhang","doi":"10.1016/j.bpsc.2024.05.005","DOIUrl":"10.1016/j.bpsc.2024.05.005","url":null,"abstract":"<div><h3>Background</h3><div>Internet gaming disorder (IGD) involves an imbalance in the brain’s dual system, characterized by heightened reward seeking and diminished cognitive control, which lead to decision-making challenges. The exploration-exploitation strategy is key to decision making, but how IGD affects this process is unclear.</div></div><div><h3>Methods</h3><div>To investigate the impact of IGD on decision making, a modified version of the 2-armed bandit task was employed. Participants included 41 individuals with IGD and 44 healthy control individuals. The study assessed the strategies used by participants in the task, particularly focusing on the exploitation-exploration strategy. Additionally, functional magnetic resonance imaging was used to examine brain activation patterns during decision-making and estimation phases.</div></div><div><h3>Results</h3><div>The study found that individuals with IGD demonstrated greater reliance on exploitative strategies in decision making due to their elevated value-seeking tendencies and decreased cognitive control. Individuals with IGD also displayed heightened activation in the presupplementary motor area and the ventral striatum compared with the healthy control group in both decision-making and estimation phases. Meanwhile, the prefrontal cortex showed more inhibition in individuals with IGD than in the healthy control group during exploitative strategies. This inhibition decreased as cognitive control diminished.</div></div><div><h3>Conclusions</h3><div>The imbalance in the development of the dual system in individuals with IGD may lead to an overreliance on exploitative strategies. This imbalance, marked by increased reward seeking and reduced cognitive control, contributes to difficulties in decision making and value-related behavioral processes in individuals with IGD.</div></div>","PeriodicalId":54231,"journal":{"name":"Biological Psychiatry-Cognitive Neuroscience and Neuroimaging","volume":"10 1","pages":"Pages 26-36"},"PeriodicalIF":5.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141262977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}