Biological Psychiatry-Cognitive Neuroscience and Neuroimaging最新文献

{"title":"Subscribers' Page","authors":"","doi":"10.1016/S2451-9022(26)00197-7","DOIUrl":"10.1016/S2451-9022(26)00197-7","url":null,"abstract":"","PeriodicalId":54231,"journal":{"name":"Biological Psychiatry-Cognitive Neuroscience and Neuroimaging","volume":"11 8","pages":"Page A2"},"PeriodicalIF":4.9,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148694692","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Longitudinal Associations of Structural and Functional Brain Connectivity With Dimensions of Psychopathology in Adolescence","authors":"Lucy Vanes,&nbsp;Divyangana Rakesh,&nbsp;Tobias Banaschewski,&nbsp;Arun L.W. Bokde,&nbsp;Sylvane Desrivières,&nbsp;Herta Flor,&nbsp;Hugh Garavan,&nbsp;Penny Gowland,&nbsp;Antoine Grigis,&nbsp;Andreas Heinz,&nbsp;Herve Lemaitre,&nbsp;Jean-Luc Martinot,&nbsp;Marie-Laure Paillère Martinot,&nbsp;Eric Artiges,&nbsp;Frauke Nees,&nbsp;Dimitri Papadopoulos Orfanos,&nbsp;Luise Poustka,&nbsp;Michael N. Smolka,&nbsp;Sarah Hohmann,&nbsp;Nathalie Holz,&nbsp;Christine Macare","doi":"10.1016/j.bpsc.2025.09.015","DOIUrl":"10.1016/j.bpsc.2025.09.015","url":null,"abstract":"<div><h3>Background</h3><div>Adolescence is a critical period of neurodevelopment marked by ongoing maturation of structural and functional brain connectivity. Simultaneously, this period is associated with an increase in mental health problems, spanning from subclinical symptoms to diagnosable disorders.</div></div><div><h3>Methods</h3><div>This study investigated longitudinal associations between psychopathology dimensions and voxelwise brain measures related to connectivity across 3 time points (ages 14, 19, and 23) in more than 1500 participants using the IMAGEN dataset. White matter (WM) microstructure was indexed using diffusion metrics quantified along the WM skeleton (<em>N</em> = 1736), while functional connectivity was captured as voxelwise degree centrality (DC) derived from resting-state functional imaging (<em>N</em> = 1510).</div></div><div><h3>Results</h3><div>Development of WM microstructure was selectively linked to externalizing (but not internalizing) symptoms. Here, higher externalizing symptoms were associated with widespread reductions in fractional anisotropy (FA) across the WM skeleton as well as accelerated decreases in FA in the corticospinal tract over time. In contrast, functional DC was developmentally associated with general, rather than specific, psychopathology in frontal and temporal regions. An increase in total difficulties over time was associated with developmental decrease in DC in bilateral superior frontal gyri. In addition, a positive association between total difficulties and DC in left inferior temporal gyrus was observed in younger, but not older, adolescents or young adults.</div></div><div><h3>Conclusions</h3><div>These findings highlight the dynamic interplay between brain connectivity development and psychopathology in adolescence, with potential implications for identifying neural markers of risk and resilience during sensitive windows of development.</div></div>","PeriodicalId":54231,"journal":{"name":"Biological Psychiatry-Cognitive Neuroscience and Neuroimaging","volume":"11 8","pages":"Pages 963-975"},"PeriodicalIF":4.9,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145180767","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations Between Youth Marijuana and Alcohol Use, Neurocognitive Performance, and Triple-Network Resting-State Connectivity","authors":"Sophia H. Blyth,&nbsp;Lauren D. Hill,&nbsp;Anna Huang,&nbsp;Neil D. Woodward,&nbsp;Baxter P. Rogers,&nbsp;Simon Vandekar,&nbsp;Heather Burrell Ward","doi":"10.1016/j.bpsc.2025.12.014","DOIUrl":"10.1016/j.bpsc.2025.12.014","url":null,"abstract":"<div><h3>Background</h3><div>Adolescent substance use is associated with increased risk of suicide, overdose, and executive dysfunction. Alcohol and marijuana are the two most-used substances among young people. Substance use is associated with dysfunctional resting-state network connectivity between the default mode network (DMN), executive control network (ECN), and salience network (SN) and executive dysfunction. There is limited research on triple-network connectivity (DMN, ECN, SN) in adolescents who use substances.</div></div><div><h3>Methods</h3><div>In typically developing youth from the Philadelphia Neurodevelopmental Cohort (PNC), regression models were used to examine relationships between alcohol and marijuana use and triple-network connectivity (<em>n</em> = 520), while adjusting for age, sex, maternal education, and head motion. In individuals with neurocognitive and substance use data (<em>n</em> = 4197), regression models were used to examine relationships with executive control.</div></div><div><h3>Results</h3><div>Alcohol use was not associated with any connectivity measures after false discovery rate correction. Higher marijuana use was associated with higher DMN-ECN connectivity (<em>F</em>_2,507 = 5.08, <em>p</em> = .0066, <em>q</em> = .039). Higher alcohol use was associated with better working memory (<em>p</em> = .020), mental flexibility (<em>p</em> &lt; .0001), attention (<em>p</em> = .019), and executive efficiency (<em>p</em> = .0015) and accuracy (<em>p</em> = .00044), which may have been due to other socioeconomic factors. Marijuana use was not associated with neurocognitive performance.</div></div><div><h3>Conclusions</h3><div>In typically developing youth, marijuana use was associated with DMN-ECN connectivity, while alcohol use was associated with neurocognitive performance. Future research should use interventions targeting the DMN, ECN, and SN to interrogate relationships between connectivity, cognitive performance, and substance use.</div></div>","PeriodicalId":54231,"journal":{"name":"Biological Psychiatry-Cognitive Neuroscience and Neuroimaging","volume":"11 8","pages":"Pages 987-995"},"PeriodicalIF":4.9,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12906899/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145992143","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cannabis and Tobacco Co-Use Is Associated With Impaired Neurocognitive Performance in Individuals at Clinical High Risk for Psychosis","authors":"Daniel Bello,&nbsp;Jillian G. Connolly,&nbsp;Jean Addington,&nbsp;Carrie E. Bearden,&nbsp;Kristin Cadenhead,&nbsp;Tyrone D. Cannon,&nbsp;Barbara Cornblatt,&nbsp;Matcheri Keshavan,&nbsp;Daniel H. Mathalon,&nbsp;Diana O. Perkins,&nbsp;Larry Seidman,&nbsp;William S. Stone,&nbsp;Ming T. Tsuang,&nbsp;Elaine F. Walker,&nbsp;Scott Woods,&nbsp;Roscoe O. Brady Jr.,&nbsp;Ricardo E. Carrión,&nbsp;Heather Burrell Ward","doi":"10.1016/j.bpsc.2026.03.021","DOIUrl":"10.1016/j.bpsc.2026.03.021","url":null,"abstract":"<div><h3>Background</h3><div>Cannabis use is highly prevalent among people with psychotic disorders. While there is some indication that cannabis use exacerbates psychosis symptoms, its neurocognitive effects remain unclear. Co-use of cannabis and tobacco is increasing in the general population, but little is known about its effects in people with psychosis or those at risk for developing a psychotic disorder, including its effects on cognitive performance.</div></div><div><h3>Methods</h3><div>We analyzed data from NAPLS2 (North American Prodrome Longitudinal Study 2), a multisite prospective study of individuals at clinical high risk for psychosis (CHR-P) and healthy control participants. Cognitive performance was assessed using the MATRICS Consensus Cognitive Battery and the Seidman Auditory Continuous Performance Task. We examined differences in cognitive performance across 6 study groups: 1) CHR-P tobacco use, 2) CHR-P cannabis use, 3) CHR-P co-use, 4) CHR-P with neither tobacco nor cannabis use, 5) CHR-P with no substance use, and 6) healthy control.</div></div><div><h3>Results</h3><div>Among 1012 participants (734 CHR-P, 278 healthy control), co-use of cannabis and tobacco was associated with lower global cognitive performance and lower working memory, verbal learning, and attentional performance compared with healthy control participants. CHR-P individuals who did not use substances also had lower cognitive performance across multiple measures, including global cognition, working memory, verbal learning, visual learning, and attentional performance. The CHR-P non–substance use group also had the lowest social functioning.</div></div><div><h3>Conclusions</h3><div>Cannabis and tobacco co-use is associated with lower neurocognitive performance, which may explain the mixed associations between cannabis use and cognitive performance in previous literature.</div></div>","PeriodicalId":54231,"journal":{"name":"Biological Psychiatry-Cognitive Neuroscience and Neuroimaging","volume":"11 8","pages":"Pages 996-1006"},"PeriodicalIF":4.9,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147719053","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Guide for Authors","authors":"","doi":"10.1016/S2451-9022(26)00199-0","DOIUrl":"10.1016/S2451-9022(26)00199-0","url":null,"abstract":"","PeriodicalId":54231,"journal":{"name":"Biological Psychiatry-Cognitive Neuroscience and Neuroimaging","volume":"11 8","pages":"Pages A6-A12"},"PeriodicalIF":4.9,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148694694","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Resting-State Neural Signatures of Moral Injury: Associations With Rumination","authors":"Travis M. Fulton,&nbsp;Alfonsina Guelfo,&nbsp;Aziz Elbasheir,&nbsp;Timothy J. McDermott,&nbsp;Jiwon Lee,&nbsp;Vishwadeep Ahluwalia,&nbsp;Timothy D. Ely,&nbsp;Emma C. Lathan,&nbsp;Negar Fani","doi":"10.1016/j.bpsc.2025.08.001","DOIUrl":"10.1016/j.bpsc.2025.08.001","url":null,"abstract":"<div><h3>Background</h3><div>Moral injury (MI) is a condition that may emerge following a violation of an individual’s moral code. MI leads to significant functional impairment in many trauma-exposed civilians, with rumination proposed as a mechanism of action. Little is known about the neuropathophysiology of different MI dimensions, including MI related to transgressions caused by the self or others. We examined links between facets of MI, resting-state amplitude of low-frequency fluctuations (ALFF), and rumination in trauma-exposed civilians.</div></div><div><h3>Methods</h3><div>Sixty adults (ages 18–56 years; 51 female) completed measures of MI (Moral Injury Exposure and Symptom Scale for Civilians [MIESS-C]), rumination (Response Styles Questionnaire), and resting-state functional magnetic resonance imaging. Voxelwise linear regression on ALFF was performed with rumination and MIESS-C–derived self-, other-, and betrayal-related MI as regressors.</div></div><div><h3>Results</h3><div>Betrayal-related MI associated with higher ALFF in the bilateral precuneus and left medial prefrontal cortex (mPFC). Other-related MI was associated with lower ALFF in the left dorsolateral PFC and insula (voxelwise <em>p</em> &lt; .001, cluster false discovery rate–corrected <em>p</em> &lt; .05). Rumination severity was positively associated with betrayal-related ALFF clusters in the bilateral precuneus (<em>r</em> = 0.32, <em>p</em> = .012) and left mPFC (<em>r</em> = 0.31, <em>p</em> = .017).</div></div><div><h3>Conclusions</h3><div>Results revealed distinct neural signatures of MI, with betrayal-related MI associated with greater ALFF in default mode network regions and this activation related to rumination severity. Other-related MI was linked to diminished activation in cognitive control and interoceptive network regions, which may reflect physiological withdrawal. These signatures are attractive candidate neuromodulatory targets.</div></div>","PeriodicalId":54231,"journal":{"name":"Biological Psychiatry-Cognitive Neuroscience and Neuroimaging","volume":"11 8","pages":"Pages 932-940"},"PeriodicalIF":4.9,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144877240","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genetically Informed Disassortative Brain Morphometric Similarities Revealing Suicide Risk in Bipolar Disorder","authors":"Ting Wang,&nbsp;Li Xue,&nbsp;Zhongpeng Dai,&nbsp;Junneng Shao,&nbsp;Wei Zhang,&nbsp;Rui Yan,&nbsp;Zhilu Chen,&nbsp;Tingting Xiong,&nbsp;Zhijian Yao,&nbsp;Qing Lu","doi":"10.1016/j.bpsc.2025.04.011","DOIUrl":"10.1016/j.bpsc.2025.04.011","url":null,"abstract":"<div><h3>Background</h3><div>Cortical structure alterations in bipolar disorder (BD) have consistently been reported in association with suicide with high heritability. Currently, the multifaceted genetic landscape responsible for replicable neuroanatomical alterations with suicidal effects is poorly explored but could help develop personalized risk assessments in clinics.</div></div><div><h3>Methods</h3><div>Anatomically informed suicidal effects quantified with morphometric similarity network (MSN) upon structural magnetic resonance imaging were evaluated in 2 independent BD cohorts that consisted of patients with suicide attempt (SA) and without SA (NSA) (discovery: 63 BD-SAs and 72 BD-NSAs with 6 potential suicide-related single nucleotide polymorphisms [SNPs] examined in 46 BD-SAs and 55 BD-NSAs; replication: 23 BD-SAs and 23 BD-NSAs) and 119 healthy control participants. In the discovery study, transcriptomic and neurotransmitter correlates of suicide-relevant MSN deficits were examined by partial least squares regression using the Allen Human Brain Atlas and dominance analysis on 9 distinct neurotransmitter systems. Molecularly informed MSN deficits were orthogonally validated by estimating genetic risks from targeted SNP genotyping using a multilevel mediation analysis. A reproducible pattern of genetically decoding suicide-relevant MSN changes was validated in the replication study.</div></div><div><h3>Results</h3><div>The μ opioid receptor was consistently suggested to be responsible for reproducible suicide-relevant MSN alterations identified in entorhinal and left lateral occipital cortices. MSN deficits of the entorhinal cortex positively mediated the effects of genetic risks of <em>OPRM1</em> on SA (portion mediated = 61.3%; β = 6.99 × 10⁻²; <em>p</em> = .02; 95% CI, 3.34 × 10⁻² to 0.11).</div></div><div><h3>Conclusions</h3><div>Abnormal cytoarchitecture communities, especially maladaptive changes in neuronal communication between the entorhinal cortex and the reward circuit regulated by opioid receptors and reflected by enhanced morphometric similarities could mediate the effect on increased suicidal tendencies involved in <em>OPRM1</em> gene variants in BD.</div></div>","PeriodicalId":54231,"journal":{"name":"Biological Psychiatry-Cognitive Neuroscience and Neuroimaging","volume":"11 8","pages":"Pages 1026-1038"},"PeriodicalIF":4.9,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144002177","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inter-network Effective Connectivity During an Emotional Working Memory Task in Two Independent Samples of Young Adults","authors":"Renata Rozovsky,&nbsp;Michele Bertocci,&nbsp;Vaibhav Diwadkar,&nbsp;Richelle S. Stiffler,&nbsp;Genna Bebko,&nbsp;Alexander S. Skeba,&nbsp;Haris Aslam,&nbsp;Mary L. Phillips","doi":"10.1016/j.bpsc.2025.01.006","DOIUrl":"10.1016/j.bpsc.2025.01.006","url":null,"abstract":"<div><h3>Background</h3><div>Effective connectivity (EC) analysis provides valuable insights into the directionality of neural interactions, which are crucial for understanding the mechanisms underlying cognitive and emotional regulation in depressive and anxiety disorders. In this study, we examined EC within key neural networks during working memory (WM) and emotional regulation (ER) tasks in young adults, both healthy individuals and those seeking help from mental health professionals for emotional distress.</div></div><div><h3>Methods</h3><div><span>Dynamic causal modeling was used to analyze EC in 2 independent samples (</span><em>n</em> = 97 and <em>n</em><span><span> = 94). Participants performed an emotional n-back task to assess EC across the central executive network (CEN), default mode network (DMN), salience network (SN), and </span>face processing network. Group-level parametric empirical Bayes analyses were conducted to examine EC patterns, with subanalyses comparing individuals with and without depression and anxiety.</span></div></div><div><h3>Results</h3><div>Consistent patterns of positive (posterior probability &gt; .95) DMN→CEN and DMN→SN EC were observed in both samples, predominantly in low and high WM conditions without ER. However, individuals without depressive or anxiety disorders exhibited a significantly greater number of preserved connections that were replicated across both samples.</div></div><div><h3>Conclusions</h3><div>This study highlights the different patterns of DMN→CEN EC in conditions with high and low WM loads with and without ER, suggesting that in higher WM loads with ER, the integration of the DMN with the CEN is reduced to facilitate successful cognitive task performance. The findings also suggest that DMN→CEN and DMN→SN EC are significantly reduced in depressive and anxiety disorders, highlighting this pattern of reduced EC as a potential neural marker of these disorders.</div></div>","PeriodicalId":54231,"journal":{"name":"Biological Psychiatry-Cognitive Neuroscience and Neuroimaging","volume":"11 8","pages":"Pages 903-911"},"PeriodicalIF":4.9,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142980884","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Individual-Specific Neural Subspaces Reveal Reward Dysregulation and State Transition Vulnerabilities in Internet Gaming Disorder","authors":"Min Wang,&nbsp;Ningning Zeng,&nbsp;Hui Zheng,&nbsp;Shaoyu Cui,&nbsp;Xuefeng Xu,&nbsp;Xin Luo,&nbsp;Guang-Heng Dong","doi":"10.1016/j.bpsc.2025.08.011","DOIUrl":"10.1016/j.bpsc.2025.08.011","url":null,"abstract":"<div><h3>Background</h3><div>Internet gaming disorder (IGD) is a clinically heterogeneous condition, yet the underlying neurobiological subtypes remain to be elucidated. Investigating subpatterns of spontaneous neural activity and state switching from individual to group patterns may provide deeper insights into the etiology of IGD.</div></div><div><h3>Methods</h3><div>Resting-state functional magnetic resonance imaging data were collected from 519 participants (257 with IGD, 262 recreational game users [RGUs]). The fractional amplitude of low-frequency fluctuations was computed to assess spontaneous neural activity. Nonnegative matrix factorization was used to extract features that were predictive of addiction severity. Network control theory (NCT) was utilized to quantify the energy required for brain state transitions.</div></div><div><h3>Results</h3><div>Compared with RGUs, participants with IGD exhibited heightened activity in brain patterns (involving the basal ganglia and thalamic regions) associated with reward processing. The individual weight of this pattern was positively associated with addiction severity, and the spatial intensity was negatively correlated with the density of serotonin 1A (5-HT_1A) receptors. Furthermore, NCT analysis demonstrated that transitioning to a high-craving state required less control energy than transitioning to other states.</div></div><div><h3>Conclusions</h3><div>Although neural activity varies among individuals with IGD, the homogeneity can be embedded in reward processing-related brain areas. Reduction in 5-HT_1A receptor density may be a substrate for this pattern. Individuals with IGD transition more readily to high-craving states than to other states. These results elucidate neural mechanisms underlying IGD and highlight the importance of individualized approaches to treating the disorder.</div></div>","PeriodicalId":54231,"journal":{"name":"Biological Psychiatry-Cognitive Neuroscience and Neuroimaging","volume":"11 7","pages":"Pages 833-842"},"PeriodicalIF":4.9,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145006955","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Functional Connectivity Patterns in Preadolescents With Generalized Anxiety Disorder: Considering Heterogeneity Over Time, Symptoms, and Comorbidity","authors":"Michal Assaf,&nbsp;Gretchen Diefenbach","doi":"10.1016/j.bpsc.2026.05.007","DOIUrl":"10.1016/j.bpsc.2026.05.007","url":null,"abstract":"","PeriodicalId":54231,"journal":{"name":"Biological Psychiatry-Cognitive Neuroscience and Neuroimaging","volume":"11 7","pages":"Pages 763-764"},"PeriodicalIF":4.9,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148400309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}