Biological Psychiatry-Cognitive Neuroscience and Neuroimaging最新文献

{"title":"Abnormal Scanning Patterns Based on Eye Movement Entropy in Early Psychosis","authors":"Dan Zhang ,&nbsp;Chunyan Ma ,&nbsp;Lihua Xu ,&nbsp;Xu Liu ,&nbsp;Huiru Cui ,&nbsp;Yanyan Wei ,&nbsp;Wensi Zheng ,&nbsp;Yawen Hong ,&nbsp;Yuou Xie ,&nbsp;Zhenying Qian ,&nbsp;Yegang Hu ,&nbsp;Yingying Tang ,&nbsp;Chunbo Li ,&nbsp;Zhi Liu ,&nbsp;Tao Chen ,&nbsp;Haichun Liu ,&nbsp;Tianhong Zhang ,&nbsp;Jijun Wang","doi":"10.1016/j.bpsc.2024.06.003","DOIUrl":"10.1016/j.bpsc.2024.06.003","url":null,"abstract":"<div><h3>Background</h3><div>Restricted scan path mode is hypothesized to explain abnormal scanning patterns in patients with schizophrenia. Here, we calculated entropy scores (drawing on gaze data to measure the statistical randomness of eye movements) to quantify how strategical and random participants were when processing image stimuli.</div></div><div><h3>Methods</h3><div>Eighty-six patients with first-episode schizophrenia (FES), 124 individuals at clinical high risk (CHR) for psychosis, and 115 healthy control participants (HCs) completed an eye-tracking examination while freely viewing 35 static images (each presented for 10 seconds) and cognitive assessments. We compared group differences in the overall entropy score, as well as entropy scores under various conditions. We also investigated the correlations between entropy scores and symptoms and cognitive function.</div></div><div><h3>Results</h3><div>Increased overall entropy scores were noted in the FES and CHR groups compared with the HC group, and these differences were already apparent within 0 to 2.5 seconds. In addition, the CHR group exhibited higher entropy than the HC group when viewing low-meaning images. Moreover, the entropy within 0 to 2.5 seconds showed significant correlations with negative symptoms in the FES group, attention/vigilance scores in the CHR group, and speed of processing and attention/vigilance scores across all 3 groups.</div></div><div><h3>Conclusions</h3><div>The results indicate that individuals with FES and those at CHR scanned pictures more randomly and less strategically than HCs. These patterns also correlated with clinical symptoms and neurocognition. The current study highlights the potential of the eye movement entropy measure as a neurophysiological marker for early psychosis.</div></div>","PeriodicalId":54231,"journal":{"name":"Biological Psychiatry-Cognitive Neuroscience and Neuroimaging","volume":"10 7","pages":"Pages 718-725"},"PeriodicalIF":5.7,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141443938","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Delusional Unreality and Predictive Processing","authors":"Santiago Castiello ,&nbsp;Rosa Rossi-Goldthorpe ,&nbsp;Siyan Fan ,&nbsp;Joshua Kenney ,&nbsp;James A. Waltz ,&nbsp;Molly Erickson ,&nbsp;Sonia Bansal ,&nbsp;James M. Gold ,&nbsp;Philip R. Corlett","doi":"10.1016/j.bpsc.2024.12.006","DOIUrl":"10.1016/j.bpsc.2024.12.006","url":null,"abstract":"<div><h3>Background</h3><div>Phenomenological psychopathologists have recently highlighted how people with delusions experience multiple realities (delusional and nondelusional) and have suggested that this double bookkeeping cannot be explained via predictive processing. Here, we present data from Kamin blocking and extinction learning that show how predictive processing might, in principle, explain a pervasive sense of dual reality.</div></div><div><h3>Methods</h3><div>This cross-sectional study involved 3 participant groups: patients with schizophrenia (SZ) (<em>n</em> = 42), healthy participants with elevated esoteric beliefs (EEBs) (clairaudient psychics) (<em>n</em> = 31), and healthy control participants (HCs) with neither illness nor significant delusional ideation (<em>n</em> = 62). We examined belief formation using a Kamin blocking causal learning task with extinction and delusions with the 40-item Peters Delusion Inventory, specifically the unreality item “Do things around you ever feel unreal, as though it was all part of an experiment?” as a proxy for unreality experiences and beliefs. A clinician also assessed symptoms with a structured clinical interview.</div></div><div><h3>Results</h3><div>Some people with SZ did not report a sense of unreality, and some people with elevated esoteric beliefs (but no psychotic illness) reported unreality experiences. No HCs reported them (despite reporting other delusion-like beliefs). Unreality experiences in clinical delusions and nonclinical delusion-like beliefs were associated with different types of aberrant prediction error processing.</div></div><div><h3>Conclusions</h3><div>These data suggest how predictive processing may explain the sense of unreality. They indicate that different prediction error dysfunctions are associated with delusions with different contents. In this case, we have used predictive processing to address a salient issue raised by our phenomenological colleagues, namely the impact of psychosis on experiences of and beliefs about reality.</div></div>","PeriodicalId":54231,"journal":{"name":"Biological Psychiatry-Cognitive Neuroscience and Neuroimaging","volume":"10 7","pages":"Pages 709-717"},"PeriodicalIF":5.7,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142878938","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"It’s About Time: Why We Need to Consider Temporal Drift When Developing and Implementing Clinical Prediction Models","authors":"Yanakan Logeswaran ,&nbsp;Dominic Oliver","doi":"10.1016/j.bpsc.2025.05.003","DOIUrl":"10.1016/j.bpsc.2025.05.003","url":null,"abstract":"","PeriodicalId":54231,"journal":{"name":"Biological Psychiatry-Cognitive Neuroscience and Neuroimaging","volume":"10 7","pages":"Pages 677-678"},"PeriodicalIF":5.7,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144535622","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gamma Oscillations and Excitation/Inhibition Imbalance: Parallel Effects of NMDA Receptor Antagonism and Psychosis","authors":"Brian J. Roach ,&nbsp;Judith M. Ford ,&nbsp;Spero Nicholas ,&nbsp;Jamie M. Ferri ,&nbsp;Handan Gunduz-Bruce ,&nbsp;John H. Krystal ,&nbsp;Judith Jaeger ,&nbsp;Daniel H. Mathalon","doi":"10.1016/j.bpsc.2025.01.008","DOIUrl":"10.1016/j.bpsc.2025.01.008","url":null,"abstract":"<div><h3>Background</h3><div>Auditory steady-state response (ASSR) abnormalities in the 40-Hz (gamma band) frequency have been observed in schizophrenia and in rodent studies of NMDA receptor (NMDAR) hypofunction. However, the extent to which 40-Hz ASSR abnormalities in schizophrenia resemble deficits in 40-Hz ASSR induced by acute administration of ketamine, an NMDAR antagonist, is not yet known.</div></div><div><h3>Methods</h3><div>To address this knowledge gap, we conducted parallel electroencephalography studies: a crossover, placebo-controlled ketamine drug challenge study with healthy participants (study 1) and a comparison of patients with schizophrenia and healthy control participants (study 2). Time-frequency analysis of the ASSR was used to calculate baseline, broadband gamma power, evoked power, total power, phase-locking factor, and phase-locking angle.</div></div><div><h3>Results</h3><div>Relative to healthy control participants, patients with schizophrenia exhibited increases in prestimulus broadband gamma power and reductions in 40-Hz ASSR evoked power, total power, and phase-locking factor, replicating previous studies. However, we failed to replicate previous findings of 40-Hz ASSR phase delay in schizophrenia. Relative to placebo, ketamine increased prestimulus broadband gamma power; reduced 40-Hz ASSR evoked power, total power, and phase-locking factor; and advanced the phase of the 40-Hz ASSR.</div></div><div><h3>Conclusions</h3><div>Normalized by their respective control groups/conditions, direct comparison of these measures between schizophrenia and ketamine data only revealed significant differences in phase, supporting the role of NMDAR hypofunction in mediating gamma oscillation abnormalities in schizophrenia.</div></div>","PeriodicalId":54231,"journal":{"name":"Biological Psychiatry-Cognitive Neuroscience and Neuroimaging","volume":"10 7","pages":"Pages 681-692"},"PeriodicalIF":5.7,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143017344","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Guide for Authors","authors":"","doi":"10.1016/S2451-9022(25)00182-X","DOIUrl":"10.1016/S2451-9022(25)00182-X","url":null,"abstract":"","PeriodicalId":54231,"journal":{"name":"Biological Psychiatry-Cognitive Neuroscience and Neuroimaging","volume":"10 7","pages":"Pages A5-A10"},"PeriodicalIF":5.7,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144535621","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Normative Modeling of Thalamic Nuclear Volumes and Characterization of Lateralized Volume Alterations in Alzheimer’s Disease Versus Schizophrenia","authors":"Taylor R. Young ,&nbsp;Vinod Jangir Kumar ,&nbsp;Manojkumar Saranathan","doi":"10.1016/j.bpsc.2024.08.006","DOIUrl":"10.1016/j.bpsc.2024.08.006","url":null,"abstract":"<div><h3>Background</h3><div>Thalamic nuclei facilitate a wide range of complex behaviors, emotions, and cognition and have been implicated in neuropsychiatric disorders including Alzheimer’s disease (AD) and schizophrenia (SCZ). The aim of this work was to establish novel normative models of thalamic nuclear volumes and their laterality indices and investigate their changes in SCZ and AD.</div></div><div><h3>Methods</h3><div>Volumes of bilateral whole thalami and 10 thalamic nuclei were generated from T1 magnetic resonance imaging data using a state-of-the-art novel segmentation method in healthy control participants (<em>n</em> = 2374) and participants with early mild cognitive impairment (<em>n</em> = 211), late mild cognitive impairment (<em>n</em> = 113), AD (<em>n</em> = 88), and SCZ (<em>n</em> = 168). Normative models for each nucleus were generated from healthy control participants while controlling for sex, intracranial volume, and site. Extreme <em>z</em>-score deviations (|<em>z</em>| &gt; 1.96) and <em>z-</em>score distributions were compared across phenotypes. <em>z</em> Scores were associated with clinical descriptors.</div></div><div><h3>Results</h3><div>Increased infranormal and decreased supranormal <em>z</em> scores were observed in SCZ and AD. <em>z</em> Score shifts representing reduced volumes were observed in most nuclei in SCZ and AD, with strong overlap in the bilateral pulvinar, medial dorsal, and centromedian nuclei. Shifts were larger in AD, with evidence of a left-sided preference in early mild cognitive impairment while a predilection for right thalamic nuclei was observed in SCZ. The right medial dorsal nucleus was associated with disorganized thought and daily auditory verbal hallucinations.</div></div><div><h3>Conclusions</h3><div>In AD, thalamic nuclei are more severely and symmetrically affected, while in SCZ, the right thalamic nuclei are more affected. We highlight the right medial dorsal nucleus, which may mediate multiple symptoms of SCZ and is affected early in the disease course.</div></div>","PeriodicalId":54231,"journal":{"name":"Biological Psychiatry-Cognitive Neuroscience and Neuroimaging","volume":"10 7","pages":"Pages 726-739"},"PeriodicalIF":5.7,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142057541","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Preliminary Study of Brain Developmental Features of Bipolar Disorder Familial Risk and Subthreshold Symptoms","authors":"Zhongwan Liu ,&nbsp;Weicong Lu ,&nbsp;Wenjin Zou ,&nbsp;Yanling Gao ,&nbsp;Xiaoyue Li ,&nbsp;Guiyun Xu ,&nbsp;Kwok-Fai So ,&nbsp;Roger S. McIntyre ,&nbsp;Kangguang Lin ,&nbsp;Robin Shao","doi":"10.1016/j.bpsc.2024.06.005","DOIUrl":"10.1016/j.bpsc.2024.06.005","url":null,"abstract":"<div><h3>Background</h3><div>Risk for bipolar disorder (BD) is increased among individuals with a family history or subthreshold mood symptoms. However, the brain structural developments associated with these BD risks remain unknown.</div></div><div><h3>Methods</h3><div>This longitudinal cohort study examined the brain gray matter volume (GMV) developmental features of familial and symptomatic risks for BD and their associations with participants’ global function levels. We recruited unaffected BD offspring with (<em>n</em> = 26, 14 female, mean ± SD age = 14.9 ± 2.9 years) or without (<em>n</em> = 35, 19 female, age = 15.3 ± 2.7 years) subthreshold manic or depressive symptoms and unaffected non-BD offspring with (<em>n</em> = 49, 30 female, age = 14.5 ± 2.2 years) or without (<em>n</em> = 68, 37 female, age = 15.0 ± 2.3 years) symptoms. The offspring had no mood disorder diagnosis prior to the study. The average follow-up duration was 2.63 ± 1.63 years.</div></div><div><h3>Results</h3><div>At baseline, we found significant interactive effects of familial risk and subthreshold symptoms that indicated that the symptomatic offspring exhibited markedly large GMV in the brain affective and cognitive circuitries. During follow-up, the combined group of BD offspring (symptomatic and nonsymptomatic) displayed a more accelerated GMV decrease than BD nonoffspring in the hippocampus and anterior cingulate cortex. In contrast, the combined group of symptomatic participants (offspring and nonoffspring) displayed a slower GMV decrease than nonsymptomatic participants in the ventromedial prefrontal cortex. Larger GMV at baseline and accelerated GMV decrease during follow-up prospectively and longitudinally predicted positive global function changes. All results survived multiple testing correction.</div></div><div><h3>Conclusions</h3><div>These findings indicated that familial and symptomatic risks of BD are associated with distinct brain structural developments and unraveled key brain developmental features of particularly vulnerable high-risk individuals to subsequent functional deterioration.</div></div>","PeriodicalId":54231,"journal":{"name":"Biological Psychiatry-Cognitive Neuroscience and Neuroimaging","volume":"10 7","pages":"Pages 769-780"},"PeriodicalIF":5.7,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141443937","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessing Brain Iron and Its Relationship to Cognition and Comorbidity in Children With Attention-Deficit/Hyperactivity Disorder With Quantitative Susceptibility Mapping","authors":"Marcel Schulze ,&nbsp;David Coghill ,&nbsp;Silke Lux ,&nbsp;Alexandra Philipsen ,&nbsp;Tim Silk","doi":"10.1016/j.bpsc.2024.08.015","DOIUrl":"10.1016/j.bpsc.2024.08.015","url":null,"abstract":"<div><h3>Background</h3><div>Quantitative susceptibility mapping is a neuroimaging technique that detects local changes in magnetic susceptibility induced by brain iron. Brain iron and the dopaminergic system are linked because iron is an important cofactor for dopamine synthesis. Attention-deficit/hyperactivity disorder (ADHD) is associated with dysregulation of dopaminergic transmission. Therefore, we applied quantitative susceptibility mapping on subcortical structures to study potential alterations in brain iron and its impact on cognition and mental health in children with ADHD.</div></div><div><h3>Methods</h3><div>Quantitative susceptibility mapping data (3T) of 111 participants (<em>n</em>_ADHD = 58, mean [SD] age = 13.2 [0.63] years; <em>n</em>_Control = 53, mean [SD] age = 13.2 [0.51] years) were analyzed. Subcortical regional brain iron values were extracted. Analysis of variance was used to examine group differences for each region of interest. For dimensional approaches, Pearson correlation analysis was performed across the cohort to examine the association of brain iron with symptoms, mental health, and cognition.</div></div><div><h3>Results</h3><div>No significant differences were found in iron susceptibility between children with ADHD and control children, between children with persistent ADHD and those with remitted ADHD, or between medicated and medication-naïve children. An unexpected finding was that children with an internalizing disorder had significantly higher iron susceptibility, but the result did not survive multiple comparison correction. Higher brain iron was associated with sustained attention, but not inhibition, IQ, or working memory.</div></div><div><h3>Conclusions</h3><div>This is the first study to address brain iron susceptibility and its association with comorbidities and cognition in ADHD. Alterations in brain iron may not fully account for a diagnosis of ADHD but may be an indicator of internalizing problems in children. Alterations in brain iron content in children were linked to detrimental sustained attention and may represent developmental variation in cognition.</div></div>","PeriodicalId":54231,"journal":{"name":"Biological Psychiatry-Cognitive Neuroscience and Neuroimaging","volume":"10 6","pages":"Pages 597-606"},"PeriodicalIF":5.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142115864","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Guide for Authors","authors":"","doi":"10.1016/S2451-9022(25)00150-8","DOIUrl":"10.1016/S2451-9022(25)00150-8","url":null,"abstract":"","PeriodicalId":54231,"journal":{"name":"Biological Psychiatry-Cognitive Neuroscience and Neuroimaging","volume":"10 6","pages":"Pages A5-A10"},"PeriodicalIF":5.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144212686","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Deep Learning–Derived Transdiagnostic Signature Indexing Hypoarousal and Impulse Control: Implications for Treatment Prediction in Psychiatric Disorders","authors":"Hannah Meijs ,&nbsp;Jurjen J. Luykx ,&nbsp;Nikita van der Vinne ,&nbsp;Rien Breteler ,&nbsp;Evian Gordon ,&nbsp;Alexander T. Sack ,&nbsp;Hanneke van Dijk ,&nbsp;Martijn Arns","doi":"10.1016/j.bpsc.2024.07.027","DOIUrl":"10.1016/j.bpsc.2024.07.027","url":null,"abstract":"<div><h3>Background</h3><div>Psychiatric disorders are traditionally classified within diagnostic categories, but this approach has limitations. The Research Domain Criteria (RDoC) constitute a research classification system for psychiatric disorders based on dimensions within domains that cut across these psychiatric diagnoses. The overall aim of RDoC is to better understand mental illness in terms of dysfunction in fundamental neurobiological and behavioral systems, leading to better diagnosis, prevention, and treatment.</div></div><div><h3>Methods</h3><div>A unique electroencephalographic feature, referred to as spindling excessive beta, has been studied in relation to impulse control and sleep as part of the arousal/regulatory system RDoC domain. Here, we studied electroencephalographic frontal beta activity as a potential transdiagnostic biomarker capable of diagnosing and predicting impulse control and sleep problems.</div></div><div><h3>Results</h3><div>We showed in the first dataset (<em>n</em> = 3279) that the probability of having spindling excessive beta, classified by a deep learning algorithm, was associated with poor sleep maintenance and low daytime impulse control. Furthermore, in 2 additional, independent datasets (iSPOT-A [International Study to Predict Optimized Treatment in ADHD], <em>n</em> = 336; iSPOT-D [International Study to Predict Optimized Treatment in Depression], <em>n</em> = 1008), we revealed that conventional frontocentral beta power and/or spindling excessive beta probability, referred to as Brainmarker-III, is associated with a diagnosis of attention-deficit/hyperactivity disorder, with remission to methylphenidate in children with attention-deficit/hyperactivity disorder in a sex-specific manner, and with remission to antidepressant medication in adults with major depressive disorder in a drug-specific manner.</div></div><div><h3>Conclusion</h3><div>Our results demonstrate the value of the RDoC approach in psychiatry research for the discovery of biomarkers with diagnostic and treatment prediction capacities.</div></div>","PeriodicalId":54231,"journal":{"name":"Biological Psychiatry-Cognitive Neuroscience and Neuroimaging","volume":"10 6","pages":"Pages 587-596"},"PeriodicalIF":5.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141984157","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}