Biological Psychiatry-Cognitive Neuroscience and Neuroimaging最新文献

{"title":"From Tics to Action Timing: Longitudinal Circuit Signatures of Adolescent Tourette Disorder","authors":"Mircea Polosan","doi":"10.1016/j.bpsc.2026.06.006","DOIUrl":"10.1016/j.bpsc.2026.06.006","url":null,"abstract":"","PeriodicalId":54231,"journal":{"name":"Biological Psychiatry-Cognitive Neuroscience and Neuroimaging","volume":"11 8","pages":"Pages 901-902"},"PeriodicalIF":4.9,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148686931","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial Board Page","authors":"","doi":"10.1016/S2451-9022(26)00196-5","DOIUrl":"10.1016/S2451-9022(26)00196-5","url":null,"abstract":"","PeriodicalId":54231,"journal":{"name":"Biological Psychiatry-Cognitive Neuroscience and Neuroimaging","volume":"11 8","pages":"Page A1"},"PeriodicalIF":4.9,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148694696","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Family-Level Brain Pattern Similarities and Their Clinical Significance in Young Offspring of Individuals With Psychotic Disorders","authors":"Halide Bilge Türközer,&nbsp;Carol A. Tamminga,&nbsp;Garrett Fitzmaurice,&nbsp;Manpreet K. Singh,&nbsp;Elena I. Ivleva,&nbsp;Brett A. Clementz,&nbsp;Godfrey D. Pearlson,&nbsp;Sarah Keedy,&nbsp;Elliot S. Gershon,&nbsp;Matcheri S. Keshavan,&nbsp;Dost Öngür","doi":"10.1016/j.bpsc.2026.05.001","DOIUrl":"10.1016/j.bpsc.2026.05.001","url":null,"abstract":"<div><h3>Background</h3><div>Familial high-risk offspring inherently provide an unparalleled opportunity for individual-level risk prediction in psychotic disorders: a personalized forecast of their potential brain pathology should they develop psychosis, based on their own parents’ brain pathology. However, whether brain patterns in offspring resembling those of their affected parents have clinical significance remains unclear. The current study aims to quantify these parent-offspring brain similarities in psychotic disorders and explore their clinical significance.</div></div><div><h3>Methods</h3><div>Using 3T imaging data from the Bipolar-Schizophrenia Network on Intermediate Phenotypes (BSNIP)-1 study, cortical thickness similarities between offspring (ages 15–35 years; <em>N</em> = 73) and their own affected parents with psychosis were quantified using a novel familial vulnerability index (FVI), calculated using regionwise <em>z</em> scores. FVIs were compared with the ENIGMA (Enhancing Neuro Imaging Genetics through Meta Analysis)–derived cortical regional vulnerability index (RVI) in offspring. FVIs and RVIs were examined in offspring with and without psychiatric symptoms and relations to global and cognitive functioning were assessed.</div></div><div><h3>Results</h3><div>Offspring had higher FVIs than RVIs (<em>q</em> &lt; .001, <em>d</em> = 0.78). Offspring with a psychotic disorder (<em>q</em> = .001, <em>d</em> = 2.84) or any other psychiatric diagnosis (<em>q</em> = .02, <em>d</em> = 1.40) had higher FVIs than offspring with no psychiatric diagnosis, while RVIs did not differ between these groups. FVIs, not RVIs, were negatively correlated with global functioning (<em>r</em> = −0.31, <em>q</em> = .047). Neither FVIs nor RVIs were correlated with cognition.</div></div><div><h3>Conclusions</h3><div>This proof-of-concept study demonstrates the clinical significance of FVI in young offspring of individuals with psychotic disorders. Future research on the clinical utility of family-level similarities across modalities holds untapped potential to advance risk and prognostic prediction in families affected by serious mental illness.</div></div>","PeriodicalId":54231,"journal":{"name":"Biological Psychiatry-Cognitive Neuroscience and Neuroimaging","volume":"11 8","pages":"Pages 1007-1016"},"PeriodicalIF":4.9,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147936161","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Limbic-Sensorimotor Tug of War for the Hippocampus: Dynamic Functional Connectivity as a Transdiagnostic Vulnerability Marker in Offspring of Patients With Emotion Dysregulation","authors":"Luigi F. Saccaro,&nbsp;Farnaz Delavari,&nbsp;Ben Meuleman,&nbsp;Nader Perroud,&nbsp;Dimitri Van De Ville,&nbsp;Camille Piguet","doi":"10.1016/j.bpsc.2025.03.007","DOIUrl":"10.1016/j.bpsc.2025.03.007","url":null,"abstract":"<div><h3>Background</h3><div>Emotion dysregulation (ED) is a key transdiagnostic symptom in several psychiatric disorders such as borderline personality disorder, bipolar disorder, and attention-deficit/hyperactivity disorder. These disorders, defined herein as ED disorders (EDDs), share similarities in symptoms, comorbidity, and heritability, emphasizing the importance of a transdiagnostic approach to identify markers of vulnerability to EDDs in high-risk populations, such as the offspring of patients with an EDD (EDDoff). The hippocampus, central to ED, exhibits alterations across EDDs.</div></div><div><h3>Methods</h3><div>We used a state-of-the-art approach (micro-coactivation patterns [μCAPs]) to study the transdiagnostic dynamic functional connectivity (dFC) of hippocampal subregions from resting-state functional magnetic resonance imaging of 201 participants (74 patients with an EDD, 57 EDDoff, 70 healthy control participants). μCAPs provide a data-driven differentiation within the seed region.</div></div><div><h3>Results</h3><div>dFC between the sensorimotor network (SMN) and the hippocampal body was lower in patients with EDDs (false discovery rate [FDR]–corrected <em>p</em> = .0002) and in EDDoff (<em>p</em>_FDR = .01) than in control participants, with EDDoff displaying an intermediate pattern between patients with EDDs and control participants. dFC between the limbic network (LN) and the hippocampal head was higher in patients with EDDs than in control participants (<em>p</em>_FDR = .01) and EDDoff (<em>p</em>_FDR = .01). A negative correlation was found between ED and the SMN (<em>p</em>_FDR = .01), indicating increasing ED with decreasing SMN dFC with the hippocampus.</div></div><div><h3>Conclusions</h3><div>Increased dFC between the hippocampal head and the LN, at the expense of the SMN, may represent a marker of disease in patients with EDDs. Lower dFC between the SMN and the hippocampal body may represent a marker of vulnerability to EDDs in EDDoff that is correlated with ED. Such a transdiagnostic construct represents a clinically relevant target for early interventions aimed at reducing vulnerability to EDDs in high-risk populations.</div></div>","PeriodicalId":54231,"journal":{"name":"Biological Psychiatry-Cognitive Neuroscience and Neuroimaging","volume":"11 8","pages":"Pages 912-922"},"PeriodicalIF":4.9,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143756454","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Erratum to: Longitudinal Associations of Structural and Functional Brain Connectivity With Dimensions of Psychopathology in Adolescence","authors":"","doi":"10.1016/j.bpsc.2026.07.011","DOIUrl":"10.1016/j.bpsc.2026.07.011","url":null,"abstract":"","PeriodicalId":54231,"journal":{"name":"Biological Psychiatry-Cognitive Neuroscience and Neuroimaging","volume":"11 8","pages":"Page 1039"},"PeriodicalIF":4.9,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148686842","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Brain Network Signatures of Heightened Attention From Methamphetamine","authors":"Peter Manza","doi":"10.1016/j.bpsc.2026.06.009","DOIUrl":"10.1016/j.bpsc.2026.06.009","url":null,"abstract":"","PeriodicalId":54231,"journal":{"name":"Biological Psychiatry-Cognitive Neuroscience and Neuroimaging","volume":"11 8","pages":"Pages 897-898"},"PeriodicalIF":4.9,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148686886","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Functional Network Connectivity Deviation Is Associated With Transdiagnostic Symptomatology: Brain Connectivity Links to Transdiagnostic Symptoms","authors":"Josina D. Kist,&nbsp;Charlotte Fraza,&nbsp;Hannah S. Savage,&nbsp;Peter C.R. Mulders,&nbsp;Janna N. Vrijsen,&nbsp;Rose M. Collard,&nbsp;Indira Tendolkar,&nbsp;Philip van Eijndhoven,&nbsp;Andre F. Marquand","doi":"10.1016/j.bpsc.2025.09.014","DOIUrl":"10.1016/j.bpsc.2025.09.014","url":null,"abstract":"<div><h3>Background</h3><div>Large comorbidity and heterogeneity within psychiatric populations have prompted the use of transdiagnostic methods to account for this variability in brain-phenotype associations. Normative modeling offers a way to map individual deviations in brain functioning with respect to a large reference population. This study aims to explore brain-phenotype associations, using normative modeling to compute individual deviation scores of brain functioning, and relating them to different levels of psychopathology in a naturalistic patient sample.</div></div><div><h3>Methods</h3><div>We applied normative modeling to estimate individual deviations in brain functional connectivity in a naturalistic sample (<em>N</em> = 309) comprising both patients and healthy control participants. We examined the association between the resulting neural deviation scores and levels of psychopathology, including traditional diagnostic categories, transdiagnostic symptom profiles, and cognition measures using sparse canonical correlation analysis.</div></div><div><h3>Results</h3><div>We successfully estimated normative models using data from the MIND-Set (Measuring Integrated Novel Dimensions in Neurodevelopmental and Stress-Related Mental Disorders) study and found significantly more extreme deviation scores in the patient as compared with the control population. We found a significant association (<em>R</em>_c = 0.16, <em>R</em>² = 2.56%, <em>p</em> = .021) between neural deviation scores and transdiagnostic symptom profiles, aligning with 4 Research Domain Criteria (RDoC) domains: negative valence, cognition, arousal/inhibition, and social systems.</div></div><div><h3>Conclusions</h3><div>With the use of normative modeling, we were able to detect differences in functional brain connectivity in patients compared with control participants, even in a highly heterogeneous and comorbid patient sample. Additionally, transdiagnostic approaches, such as those embodied in the RDoC framework, are more accurate in uncovering shared neurobiological mechanisms compared with traditional diagnostic categories or cognitive measures.</div></div>","PeriodicalId":54231,"journal":{"name":"Biological Psychiatry-Cognitive Neuroscience and Neuroimaging","volume":"11 8","pages":"Pages 952-962"},"PeriodicalIF":4.9,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145152198","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transdiagnostic Neurobiology of Social Cognition and Individual Variability as Measured by Fractional Amplitude of Low-Frequency Fluctuation in Autism and Schizophrenia Spectrum Disorders","authors":"Soroush Bagheri,&nbsp;Ju-Chi Yu,&nbsp;Julia Gallucci,&nbsp;Vinh Tan,&nbsp;Lindsay D. Oliver,&nbsp;Erin W. Dickie,&nbsp;Ayesha G. Rashidi,&nbsp;George Foussias,&nbsp;Meng-Chuan Lai,&nbsp;Robert W. Buchanan,&nbsp;Anil K. Malhotra,&nbsp;Aristotle N. Voineskos,&nbsp;Stephanie H. Ameis,&nbsp;Colin Hawco","doi":"10.1016/j.bpsc.2025.04.004","DOIUrl":"10.1016/j.bpsc.2025.04.004","url":null,"abstract":"<div><h3>Background</h3><div><span>Fractional amplitude of low-frequency fluctuation (fALFF) is a validated measure of resting-state spontaneous brain activity. Previous fALFF findings in autism and schizophrenia spectrum disorders (SSDs) have been highly heterogeneous. We aimed to use fALFF in a large sample of typically developing control participants (TDCs), autistic participants, and participants with SSDs to explore group differences and relationships with interindividual variability of fALFF maps and </span>social cognition.</div></div><div><h3>Methods</h3><div>fALFF from 495 participants (185 TDCs, 68 with autism, and 242 with SSDs) was computed using functional magnetic resonance imaging as signal power within 2 frequency bands (i.e., slow-4 and slow-5), normalized by the power in the remaining frequency spectrum. Permutation analysis of linear models was used to investigate the relationship of fALFF with diagnostic groups, higher-level social cognition, and lower-level social cognition. Each participant’s average distance of fALFF map to all others was defined as a variability score, with higher scores indicating less typical maps.</div></div><div><h3>Results</h3><div><span>Lower fALFF in the visual and higher fALFF in the frontal regions were found in both participants with SSDs and autistic participants compared with TDCs. Limited differences were observed between autistic participants and participants with SSDs in the cuneus regions only. Associations between slow-4 fALFF and higher-level social cognitive scores across the whole sample were observed in the lateral occipitotemporal and </span>temporoparietal junction. Individual variability within the autism and SSD groups was also significantly higher than within the TDC group.</div></div><div><h3>Conclusions</h3><div>Similar patterns of fALFF and individual variability in autism and SSDs suggest some common neurobiological features across these related heterogeneous conditions.</div></div>","PeriodicalId":54231,"journal":{"name":"Biological Psychiatry-Cognitive Neuroscience and Neuroimaging","volume":"11 8","pages":"Pages 941-951"},"PeriodicalIF":4.9,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144055104","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Disrupted Large-Scale Brain Network Connectivity in Prolonged Grief Disorder: Relationship With Grief-Related Avoidance, Yearning, and Intrusive Thoughts","authors":"Nutta-on P. Blair,&nbsp;Gyujoon Hwang,&nbsp;B. Douglas Ward,&nbsp;Stacy A. Claesges,&nbsp;Abigail R. Webber,&nbsp;Keri R. Hainsworth,&nbsp;Yang Wang,&nbsp;Charles F. Reynolds III,&nbsp;Elliot A. Stein,&nbsp;Joseph S. Goveas","doi":"10.1016/j.bpsc.2025.07.011","DOIUrl":"10.1016/j.bpsc.2025.07.011","url":null,"abstract":"<div><h3>Background</h3><div>Large-scale brain network dysfunctions have been implicated in multiple neuropsychiatric disorders. Disrupted interactions between these networks may similarly underlie key symptoms in prolonged grief disorder (PGD).</div></div><div><h3>Methods</h3><div>In a cross-sectional functional magnetic resonance imaging study, resting-state functional connectivity (rsFC) between large-scale networks was compared in demographic- and time since loss–equated older adults with probable PGD (<em>n</em> = 42) and those with integrated grief (IG) (<em>n</em> = 45). Group independent component analysis revealed multiple networks, 8 of which (salience [SN], default mode [DMN], left and right executive control, ventral attention, dorsal attention, sensorimotor, and visual) were selected for further analyses, with rsFC strength between all network pairs computed. Networks with significant group differences were further assessed using fractional amplitude of low-frequency fluctuations (fALFF) to determine within-network differences. The relationships between connectivity measures and clinical symptoms were explored independently in the PGD and IG groups.</div></div><div><h3>Results</h3><div>Higher rsFC between SN and DMN was observed in the PGD group compared with the IG group (<em>p</em>_{<em>corrected</em>} = .014), which positively correlated with grief severity (<em>p</em>_{<em>corrected</em>} = .04) and grief-related avoidance (<em>p</em>_{<em>corrected</em>} = .04). In the PGD group, higher fALFF was observed in the DMN (<em>p</em>_{<em>uncorrected</em>} = .04), but not the SN. Principal component analysis revealed 4 symptom dimensions, with connectivity between multiple brain networks extending beyond the SN and DMN associated with an intrusive thoughts/yearning/avoidance component.</div></div><div><h3>Conclusions</h3><div>Aberrant connectivity between the SN and DMN appears to be a neurobiological correlate of grief severity and avoidance in PGD. Broader between-network connectivity disruptions correlate with intrusive thoughts, yearning, and avoidance, warranting further investigations into the mechanistic role of brain network dysfunction in PGD.</div></div>","PeriodicalId":54231,"journal":{"name":"Biological Psychiatry-Cognitive Neuroscience and Neuroimaging","volume":"11 8","pages":"Pages 923-931"},"PeriodicalIF":4.9,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144796310","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Improvement in Tics and Motor Impulsivity Is Associated With Functional and Receptor-Enriched Connectivity Changes in Adolescents With Tourette Disorder","authors":"Therese-Marie Sartoris,&nbsp;Cyril Atkinson-Clement,&nbsp;Benoit Béranger,&nbsp;Clement Tarrano,&nbsp;Prasanthi Jegatheesan,&nbsp;Francois Xavier Lejeune,&nbsp;Romain Valabrègue,&nbsp;Andreas Hartmann,&nbsp;Virginie Czernecki,&nbsp;Emmanuel Roze,&nbsp;Marcus Missal,&nbsp;Pierre Pouget,&nbsp;Ceceile Gallea,&nbsp;Yulia Worbe","doi":"10.1016/j.bpsc.2026.03.017","DOIUrl":"10.1016/j.bpsc.2026.03.017","url":null,"abstract":"<div><h3>Background</h3><div>In Tourette disorder (TD), tics are frequently associated with impulsivity, but the mechanisms linking these dimensions and their evolution during adolescence remain unclear. We combined behavioral, clinical, and receptor-enriched analysis of functional connectivity by targets (REACT) functional connectivity imaging to examine tic severity and impulsivity over time in adolescents with TD.</div></div><div><h3>Methods</h3><div>A total of 64 adolescents with TD and 56 healthy control participants completed a saccadic motor waiting impulsivity (WI) task and resting-state functional magnetic resonance imaging at baseline. Participants with TD were reassessed 15 months later. REACT was used to examine dopamine transporter (DAT)– and serotonin 1B (5-HT_1B) receptor–weighted functional connectivity within frontostriatal motor and limbic networks. Longitudinal analyses focused on within-TD changes and their associations with clinical measures.</div></div><div><h3>Results</h3><div>Behaviorally, no differences emerged between groups, but in the TD group, higher WI was associated with greater global tic severity (Yale Global Tic Severity Scale [YGTSS/100]). Longitudinally, both tics (YGTSS/50 and 100) and WI improved significantly. Compared with controls, adolescents with TD showed higher functional connectivity between the caudate and the anterior cingulate cortex (ACC) on the left. Longitudinally, tic reduction (YGTSS/50) was linked to increased connectivity between the nucleus accumbens (NAcc) and the ventral tegmental area on the left; reduced WI correlated with higher left caudate–subgenual ACC and bilateral putamen–supplementary motor area (SMA) connectivity. In patients with TD versus controls, REACT showed elevated DAT-weighted connectivity between the NAcc and SMA and 5-HT_1B–weighted connectivity between the raphe and the SMA. Longitudinally in TD, while 5-HT_1B–weighted connectivity declined, DAT-weighted connectivity remained stable.</div></div><div><h3>Conclusions</h3><div>Changes in motor and limbic frontostriatal functional connectivity were associated with longitudinal improvements in tics and WI in adolescents with TD.</div></div>","PeriodicalId":54231,"journal":{"name":"Biological Psychiatry-Cognitive Neuroscience and Neuroimaging","volume":"11 8","pages":"Pages 1017-1025"},"PeriodicalIF":4.9,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147617207","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}