Biological Psychiatry-Cognitive Neuroscience and Neuroimaging最新文献

{"title":"Striatal Functional Alterations Link to Distinct Symptomatology Across Mood States in Bipolar Disorder","authors":"","doi":"10.1016/j.bpsc.2024.04.014","DOIUrl":"10.1016/j.bpsc.2024.04.014","url":null,"abstract":"<div><h3>Background</h3><p>As a central hub in cognitive and emotional brain circuits, the striatum is considered likely to be integrally involved in the psychopathology of bipolar disorder (BD). However, it remains unclear how alterations in striatal function contribute to distinct symptomatology of BD during different mood states.</p></div><div><h3>Methods</h3><p>Behavioral assessment (i.e., emotional symptoms and cognitive performance) and neuroimaging data were collected from 125 participants comprising 31 (hypo)manic, 31 depressive, and 31 euthymic patients with BD, and 32 healthy control participants. We compared the functional connectivity (FC) of striatal subregions across BD mood states with healthy control participants and then used a multivariate data-driven approach to explore dimensional associations between striatal connectivity and behavioral performance. Finally, we compared the FC and behavioral composite scores, which reflect the individual weighted representation of the associations, among different mood states.</p></div><div><h3>Results</h3><p><span>Patients in all mood states exhibited increased FC between the bilateral ventral rostral putamen and ventrolateral thalamus. Bipolar (hypo)mania uniquely exhibited increased ventral rostral putamen connectivity and superior </span>ventral striatum connectivity. One latent component was identified, whereby increased FCs of striatal subregions were associated with distinct psychopathological symptomatology (more manic symptoms, elevated positive mood, less depressive symptoms, and worse cognitive performance). Patients with bipolar (hypo)mania had the highest FC and behavioral composite scores while bipolar patients with depression had the lowest scores.</p></div><div><h3>Conclusions</h3><p>Our data demonstrated both trait features of BD and state features specific to bipolar (hypo)mania. The findings underscored the fundamental role of the striatum in the pathophysiological processes underlying specific symptomatology across all mood states.</p></div>","PeriodicalId":54231,"journal":{"name":"Biological Psychiatry-Cognitive Neuroscience and Neuroimaging","volume":"9 8","pages":"Pages 777-785"},"PeriodicalIF":5.7,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140873835","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A New Angle on Transcranial Magnetic Stimulation Coil Orientation: A Targeted Narrative Review","authors":"","doi":"10.1016/j.bpsc.2024.04.018","DOIUrl":"10.1016/j.bpsc.2024.04.018","url":null,"abstract":"<div><p>Transcranial magnetic stimulation (TMS) is used to treat several neuropsychiatric disorders including depression, where it is effective in approximately one half of patients for whom pharmacological approaches have failed. Treatment response is related to stimulation parameters such as the stimulation frequency, pattern, intensity, location, total number of pulses and sessions applied, and target brain network engagement. One critical but underexplored component of the stimulation procedure is the orientation or yaw angle of the commonly used figure-of-eight TMS coil, which is known to impact neuronal response to TMS. However, coil orientation has remained largely unchanged since TMS was first used to treat depression and continues to be based on motor cortex anatomy, which may not be optimal for the dorsolateral prefrontal cortex treatment site. In this targeted narrative review, we evaluate experimental, clinical, and computational evidence indicating that optimizing coil orientation may improve TMS treatment outcomes. The properties of the electric field induced by TMS, the changes to this field caused by the differing conductivities of head tissues, and the interaction between coil orientation and the underlying cortical anatomy are summarized. We describe evidence that the magnitude and site of cortical activation, surrogate markers of TMS dosing and brain network targeting considered central in clinical response to TMS, are influenced by coil orientation. We suggest that coil orientation should be considered when applying therapeutic TMS and propose several approaches to optimizing this potentially important treatment parameter.</p></div>","PeriodicalId":54231,"journal":{"name":"Biological Psychiatry-Cognitive Neuroscience and Neuroimaging","volume":"9 8","pages":"Pages 744-753"},"PeriodicalIF":5.7,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2451902224001204/pdfft?md5=5e9f5e4014fc26be9013b5e0bb4d53c3&pid=1-s2.0-S2451902224001204-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140904550","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bridging Psilocybin-Induced Changes in the Brain’s Dynamic Functional Connectome With an Individual’s Subjective Experience","authors":"S. Parker Singleton ,&nbsp;Amy Kuceyeski","doi":"10.1016/j.bpsc.2024.05.003","DOIUrl":"10.1016/j.bpsc.2024.05.003","url":null,"abstract":"","PeriodicalId":54231,"journal":{"name":"Biological Psychiatry-Cognitive Neuroscience and Neuroimaging","volume":"9 7","pages":"Pages 637-638"},"PeriodicalIF":5.7,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141539009","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sex Differences in Response Inhibition–Related Neural Predictors of Posttraumatic Stress Disorder in Civilians With Recent Trauma","authors":"Bibian Borst ,&nbsp;Tanja Jovanovic ,&nbsp;Stacey L. House ,&nbsp;Steven E. Bruce ,&nbsp;Nathaniel G. Harnett ,&nbsp;Alyssa R. Roeckner ,&nbsp;Timothy D. Ely ,&nbsp;Lauren A.M. Lebois ,&nbsp;Dmitri Young ,&nbsp;Francesca L. Beaudoin ,&nbsp;Xinming An ,&nbsp;Thomas C. Neylan ,&nbsp;Gari D. Clifford ,&nbsp;Sarah D. Linnstaedt ,&nbsp;Laura T. Germine ,&nbsp;Kenneth A. Bollen ,&nbsp;Scott L. Rauch ,&nbsp;John P. Haran ,&nbsp;Alan B. Storrow ,&nbsp;Christopher Lewandowski ,&nbsp;Sanne J.H. van Rooij","doi":"10.1016/j.bpsc.2024.03.002","DOIUrl":"10.1016/j.bpsc.2024.03.002","url":null,"abstract":"<div><h3>Background</h3><p>Females are more likely to develop posttraumatic stress disorder (PTSD) than males. Impaired inhibition has been identified as a mechanism for PTSD development, but studies on potential sex differences in this neurobiological mechanism and how it relates to PTSD severity and progression are relatively rare. Here, we examined sex differences in neural activation during response inhibition and PTSD following recent trauma.</p></div><div><h3>Methods</h3><p>Participants (<em>n</em> = 205, 138 female sex assigned at birth) were recruited from emergency departments within 72 hours of a traumatic event. PTSD symptoms were assessed 2 weeks and 6 months posttrauma. A Go/NoGo task was performed 2 weeks posttrauma in a 3T magnetic resonance imaging scanner to measure neural activity during response inhibition in the ventromedial prefrontal cortex, right inferior frontal gyrus, and bilateral hippocampus. General linear models were used to examine the interaction effect of sex on the relationship between our regions of interest and the whole brain, PTSD symptoms at 6 months, and symptom progression between 2 weeks and 6 months.</p></div><div><h3>Results</h3><p>Lower response inhibition–related ventromedial prefrontal cortex activation 2 weeks posttrauma predicted more PTSD symptoms at 6 months in females but not in males, while greater response inhibition–related right inferior frontal gyrus activation predicted lower PTSD symptom progression in males but not females. Whole-brain interaction effects were observed in the medial temporal gyrus and left precentral gyrus.</p></div><div><h3>Conclusions</h3><p>There are sex differences in the relationship between inhibition-related brain activation and PTSD symptom severity and progression. These findings suggest that sex differences should be assessed in future PTSD studies and reveal potential targets for sex-specific interventions.</p></div>","PeriodicalId":54231,"journal":{"name":"Biological Psychiatry-Cognitive Neuroscience and Neuroimaging","volume":"9 7","pages":"Pages 668-680"},"PeriodicalIF":5.7,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140208480","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prediction of Cognitive Progression Due to Alzheimer's Disease in Normal Participants Based on Individual Default Mode Network Metabolic Connectivity Strength","authors":"Qi Zhang ,&nbsp;Fangjie Li ,&nbsp;Min Wei ,&nbsp;Min Wang ,&nbsp;Luyao Wang ,&nbsp;Ying Han ,&nbsp;Jiehui Jiang ,&nbsp;Alzheimer’s Disease Neuroimaging Initiative","doi":"10.1016/j.bpsc.2024.04.004","DOIUrl":"10.1016/j.bpsc.2024.04.004","url":null,"abstract":"<div><h3>Background</h3><p>Predicting cognitive decline among individuals in the aging population who are already amyloid-β (Aβ) positive or tau positive poses clinical challenges. In Alzheimer's disease research, intra–default mode network (DMN) connections play a pivotal role in diagnosis. In this article, we propose metabolic connectivity within the DMN as a supplementary biomarker to the Aβ, pathological tau, and neurodegeneration framework.</p></div><div><h3>Methods</h3><p>Extracting data from 1292 participants in the Alzheimer’s Disease Neuroimaging Initiative, we collected paired T1-weighted structural magnetic resonance imaging and ¹⁸F-labeled-fluorodeoxyglucose positron emission computed tomography scans. Individual metabolic DMN networks were constructed, and metabolic connectivity (MC) strength in the DMN was assessed. In the cognitively unimpaired group, the Cox model identified cognitively unimpaired (MC+), high-risk participants, with Kaplan-Meier survival analyses and hazard ratios revealing the strength of MC’s predictive performance. Spearman correlation analyses explored relationships between MC strength, and Aβ, pathological tau, neurodegeneration biomarkers, and clinical scales. DMN standard uptake value ratio (SUVR) provided comparative insights in the analyses.</p></div><div><h3>Results</h3><p>Both MC strength and SUVR exhibited gradual declines with cognitive deterioration, displaying significant intergroup differences. Survival analyses indicated enhanced Aβ and tau prediction with both metrics, with MC strength outperforming SUVR. Combined MC strength and Aβ yielded optimal predictive performance (hazard ratio = 9.29), followed by MC strength and tau (hazard ratio = 8.92). Generally, the strength of MC’s correlations with Aβ, pathological tau, and neurodegeneration biomarkers exceeded SUVR.</p></div><div><h3>Conclusions</h3><p>Individuals with normal cognition and disrupted DMN metabolic connectivity face an elevated risk of cognitive decline linked to Aβ that precedes metabolic issues.</p></div>","PeriodicalId":54231,"journal":{"name":"Biological Psychiatry-Cognitive Neuroscience and Neuroimaging","volume":"9 7","pages":"Pages 660-667"},"PeriodicalIF":5.7,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140776825","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Trajectory of Prefrontal GABA Levels in Initially Antipsychotic-Naïve Patients With Psychosis During 2 Years of Treatment and Associations With Striatal Cerebral Blood Flow and Outcome","authors":"Kirsten Borup Bojesen ,&nbsp;Egill Rostrup ,&nbsp;Anne Korning Sigvard ,&nbsp;Mark Mikkelsen ,&nbsp;Richard A.E. Edden ,&nbsp;Bjørn Hylsebeck Ebdrup ,&nbsp;Birte Glenthøj","doi":"10.1016/j.bpsc.2023.12.002","DOIUrl":"10.1016/j.bpsc.2023.12.002","url":null,"abstract":"<div><h3>Background</h3><p>GABAergic (gamma-aminobutyric acidergic) function in the prefrontal cortex seems dysfunctional in patients with first-episode psychosis, but the impact of longer-term treatment and relationship to clinical outcomes and striatal activity are unknown.</p></div><div><h3>Methods</h3><p>A longitudinal study of 39 antipsychotic-naïve and benzodiazepine-free patients with psychosis (22.4 ± 5.4 years, 64% women) and 54 matched healthy control participants (HCs) (22.2 ± 4.3 years, 61% women) who were followed up after 6 weeks (28 patients, 51 HCs), 6 months (17 patients, 47 HCs), and 2 years (21 patients, 43 HCs) was completed. GABA levels in the dorsal anterior cingulate cortex and striatal resting cerebral blood flow were assessed on a 3T magnetic resonance scanner at all visits.</p></div><div><h3>Results</h3><p>GABA levels in the dorsal anterior cingulate cortex were significantly lower in patients at baseline and after 6 weeks but not after 6 months or 2 years. Analyses of groups separately revealed decreased GABA levels after 2 years in HCs but stable levels in patients. Treatment increased striatal resting cerebral blood flow after 6 weeks and 6 months but not after 2 years. GABA levels were negatively associated with striatal resting cerebral blood flow in both groups at all visits. Last, lower baseline GABA levels in patients were related to less functional improvement after 2 years.</p></div><div><h3>Conclusions</h3><p>The findings suggest a different trajectory of GABA levels and striatal perfusion in first-episode patients over 2 years of antipsychotic treatment compared with HCs and indicate a downregulatory role of prefrontal GABAergic function on the striatum. Moreover, abnormally low prefrontal GABA level at illness onset may be a marker for a more severe prognosis.</p></div>","PeriodicalId":54231,"journal":{"name":"Biological Psychiatry-Cognitive Neuroscience and Neuroimaging","volume":"9 7","pages":"Pages 703-713"},"PeriodicalIF":5.7,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2451902223003397/pdfft?md5=83ade5a711308a9869743fb44deb67c7&pid=1-s2.0-S2451902223003397-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139038316","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quantifying Apathy in Late-Life Depression: Unraveling Neurobehavioral Links Through Daily Activity Patterns and Brain Connectivity Analysis","authors":"Jean-Charles Roy ,&nbsp;Renaud Hédouin ,&nbsp;Thomas Desmidt ,&nbsp;Sébastien Dam ,&nbsp;Iris Mirea-Grivel ,&nbsp;Louise Weyl ,&nbsp;Elise Bannier ,&nbsp;Laurent Barantin ,&nbsp;Dominique Drapier ,&nbsp;Jean-Marie Batail ,&nbsp;Renaud David ,&nbsp;Julie Coloigner ,&nbsp;Gabriel H. Robert","doi":"10.1016/j.bpsc.2024.04.002","DOIUrl":"10.1016/j.bpsc.2024.04.002","url":null,"abstract":"<div><h3>Background</h3><p>Better understanding apathy in late-life depression would help improve prediction of poor prognosis of diseases such as dementia. Actimetry provides an objective and ecological measure of apathy from patients’ daily motor activity. We aimed to determine whether patterns of motor activity were associated with apathy and brain connectivity in networks that underlie goal-directed behaviors.</p></div><div><h3>Methods</h3><p>Resting-state functional magnetic resonance imaging and diffusion magnetic resonance imaging were collected from 38 nondemented participants with late-life depression. Apathy was evaluated using the diagnostic criteria for apathy, Apathy Evaluation Scale, and Apathy Motivation Index. Functional principal components (fPCs) of motor activity were derived from actimetry recordings taken for 72 hours. Associations between fPCs and apathy were estimated by linear regression. Subnetworks whose connectivity was significantly associated with fPCs were identified via threshold-free network-based statistics. The relationship between apathy and microstructure metrics was estimated along fibers by diffusion tensor imaging and a multicompartment model called neurite orientation dispersion and density imaging via tractometry.</p></div><div><h3>Results</h3><p>We found 2 fPCs associated with apathy: mean diurnal activity, negatively associated with Apathy Evaluation Scale scores, and an early chronotype, negatively associated with Apathy Motivation Index scores. Mean diurnal activity was associated with increased connectivity in the default mode, cingulo-opercular, and frontoparietal networks, while chronotype was associated with a more heterogeneous connectivity pattern in the same networks. We did not find significant associations between microstructural metrics and fPCs.</p></div><div><h3>Conclusions</h3><p>Our findings suggest that mean diurnal activity and chronotype could provide indirect ambulatory measures of apathy in late-life depression, associated with modified functional connectivity of brain networks that underlie goal-directed behaviors.</p></div>","PeriodicalId":54231,"journal":{"name":"Biological Psychiatry-Cognitive Neuroscience and Neuroimaging","volume":"9 7","pages":"Pages 639-649"},"PeriodicalIF":5.7,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2451902224001022/pdfft?md5=6bab469aaf6a686a3bbd8e21ead7d38c&pid=1-s2.0-S2451902224001022-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140770114","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dynamic Functional Hyperconnectivity After Psilocybin Intake Is Primarily Associated With Oceanic Boundlessness","authors":"Sepehr Mortaheb ,&nbsp;Larry D. Fort ,&nbsp;Natasha L. Mason ,&nbsp;Pablo Mallaroni ,&nbsp;Johannes G. Ramaekers ,&nbsp;Athena Demertzi","doi":"10.1016/j.bpsc.2024.04.001","DOIUrl":"10.1016/j.bpsc.2024.04.001","url":null,"abstract":"<div><h3>Background</h3><p>Psilocybin is a widely studied psychedelic substance that leads to the psychedelic state, a specific altered state of consciousness. To date, the relationship between the psychedelic state’s neurobiological and experiential patterns remains undercharacterized because they are often analyzed separately. We investigated the relationship between neurobiological and experiential patterns after psilocybin by focusing on the link between dynamic cerebral connectivity and retrospective questionnaire assessment.</p></div><div><h3>Methods</h3><p>Healthy participants were randomized to receive either psilocybin (<em>n</em> = 22) or placebo (<em>n</em> = 27) and scanned for 6 minutes in an eyes-open resting state during the peak subjective drug effect (102 minutes posttreatment) in ultrahigh field 7T magnetic resonance imaging. The 5-Dimensional Altered States of Consciousness Rating Scale was administered 360 minutes after drug intake.</p></div><div><h3>Results</h3><p>Under psilocybin, there were alterations across all dimensions of the 5-Dimensional Altered States of Consciousness Rating Scale and widespread increases in averaged brain functional connectivity. Time-varying functional connectivity analysis unveiled a recurrent hyperconnected pattern characterized by low blood oxygen level–dependent signal amplitude, suggesting heightened cortical arousal. In terms of neuroexperiential links, canonical correlation analysis showed higher transition probabilities to the hyperconnected pattern with feelings of oceanic boundlessness and secondly with visionary restructuralization.</p></div><div><h3>Conclusions</h3><p>Psilocybin generates profound alterations at both the brain and the experiential levels. We suggest that the brain’s tendency to enter a hyperconnected-hyperarousal pattern under psilocybin represents the potential to entertain variant mental associations. These findings illuminate the intricate interplay between brain dynamics and subjective experience under psilocybin, thereby providing insights into the neurophysiology and neuroexperiential qualities of the psychedelic state.</p></div>","PeriodicalId":54231,"journal":{"name":"Biological Psychiatry-Cognitive Neuroscience and Neuroimaging","volume":"9 7","pages":"Pages 681-692"},"PeriodicalIF":5.7,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140859315","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of APOE ε4 and Neuropathological Diagnoses on Neuropsychiatric Symptoms: Mediation Analyses and Likely Causation in an Integrated National Alzheimer’s Coordinating Center Database","authors":"Terry E. Goldberg ,&nbsp;D.P. Devanand ,&nbsp;Zhiqian Fang ,&nbsp;Hyun Kim ,&nbsp;Elizabeth Rueppel ,&nbsp;Aren Tucker ,&nbsp;Scott Carlson ,&nbsp;Seonjoo Lee","doi":"10.1016/j.bpsc.2024.01.012","DOIUrl":"10.1016/j.bpsc.2024.01.012","url":null,"abstract":"<div><h3>Background</h3><p>In this study, we sought to identify paths from <em>APOE</em> ε4 to neurobehaviors itemized on a neuropsychiatric inventory (Neuropsychiatric Inventory–Questionnaire [NPI-Q]) that involved neuropathologies associated with <em>APOE</em> ε4 (amyloid, tau, cerebral amyloid angiopathy, and Lewy bodies) or cognition mediators (memory or global cognitive status) as well as direct paths from <em>APOE</em> ε4 to neurobehaviors.</p></div><div><h3>Methods</h3><p>A total of 1199 cases with available neurobehavioral, cognition, and neuropathological data were included. We conducted a series of causal mediation analyses in which <em>APOE</em> ε4 always served as the independent variable, and NPI-Q neurobehavioral items, when included in the mediation analysis, served as the outcome. Neuropathologies or cognition served as mediators.</p></div><div><h3>Results</h3><p>Multiple significant indirect paths from <em>APOE</em> ε4 through neuropathologies to neurobehaviors were identified. More refined analyses indicated that neuritic plaques and Braak stage drove the findings. A significant direct effect of <em>APOE</em> ε4 on memory was also identified. Additionally, Lewy body disease, when treated as an exposure, had a direct effect on hallucinations consistent with features of the disease.</p></div><div><h3>Conclusions</h3><p>We found strong evidence for partial mediation of NPI-Q symptoms by cognition, suggesting that cognitive limitations may have promoted maladaptive behavior. In addition, neuritic amyloid plaque levels and Braak stage, but not diffuse amyloid plaque extent, were key in NPI-Q–mediated associations, suggesting the possibility that synaptic failure plays an important role in multiple neurobehavioral symptoms in dementia, including psychosis. Finally, we found strong evidence that <em>APOE</em> ε4 may have direct effects on cognition when we used verbal episodic memory but not global cognitive status as an outcome.</p></div>","PeriodicalId":54231,"journal":{"name":"Biological Psychiatry-Cognitive Neuroscience and Neuroimaging","volume":"9 7","pages":"Pages 650-659"},"PeriodicalIF":5.7,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139713580","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cognitive Signatures of Depressive and Anhedonic Symptoms and Affective States Using Computational Modeling and Neurocognitive Testing","authors":"Nadja R. Ging-Jehli ,&nbsp;Manuel Kuhn ,&nbsp;Jacob M. Blank ,&nbsp;Pranavan Chanthrakumar ,&nbsp;David C. Steinberger ,&nbsp;Zeyang Yu ,&nbsp;Todd M. Herrington ,&nbsp;Daniel G. Dillon ,&nbsp;Diego A. Pizzagalli ,&nbsp;Michael J. Frank","doi":"10.1016/j.bpsc.2024.02.005","DOIUrl":"10.1016/j.bpsc.2024.02.005","url":null,"abstract":"<div><h3>Background</h3><p>Deeper phenotyping may improve our understanding of depression. Because depression is heterogeneous, extracting cognitive signatures associated with severity of depressive symptoms, anhedonia, and affective states is a promising approach.</p></div><div><h3>Methods</h3><p>Sequential sampling models decomposed behavior from an adaptive approach-avoidance conflict task into computational parameters quantifying latent cognitive signatures. Fifty unselected participants completed clinical scales and the approach-avoidance conflict task by either approaching or avoiding trials offering monetary rewards and electric shocks.</p></div><div><h3>Results</h3><p>Decision dynamics were best captured by a sequential sampling model with linear collapsing boundaries varying by net offer values, and with drift rates varying by trial-specific reward and aversion, reflecting net evidence accumulation toward approach or avoidance. Unlike conventional behavioral measures, these computational parameters revealed distinct associations with self-reported symptoms. Specifically, passive avoidance tendencies, indexed by starting point biases, were associated with greater severity of depressive symptoms (<em>R</em> = 0.34, <em>p</em> = .019) and anhedonia (<em>R</em> = 0.49, <em>p</em> = .001). Depressive symptoms were also associated with slower encoding and response execution, indexed by nondecision time (<em>R</em> = 0.37, <em>p</em> = .011). Higher reward sensitivity for offers with negative net values, indexed by drift rates, was linked to more sadness (<em>R</em> = 0.29, <em>p</em> = .042) and lower positive affect (<em>R</em> = −0.33, <em>p</em> = .022). Conversely, higher aversion sensitivity was associated with more tension (<em>R</em> = 0.33, <em>p</em> = .025). Finally, less cautious response patterns, indexed by boundary separation, were linked to more negative affect (<em>R</em> = −0.40, <em>p</em> = .005).</p></div><div><h3>Conclusions</h3><p>We demonstrated the utility of multidimensional computational phenotyping, which could be applied to clinical samples to improve characterization and treatment selection.</p></div>","PeriodicalId":54231,"journal":{"name":"Biological Psychiatry-Cognitive Neuroscience and Neuroimaging","volume":"9 7","pages":"Pages 726-736"},"PeriodicalIF":5.7,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139944782","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}