UltrasonographyPub Date : 2024-09-01Epub Date: 2024-06-23DOI: 10.14366/usg.24102
Min Jeong Cho, Jee Won Chai, Dong Hyun Kim, Hyo Jin Kim, Jiwoon Seo
{"title":"Ultrasonographic differential diagnosis of medial elbow pain.","authors":"Min Jeong Cho, Jee Won Chai, Dong Hyun Kim, Hyo Jin Kim, Jiwoon Seo","doi":"10.14366/usg.24102","DOIUrl":"10.14366/usg.24102","url":null,"abstract":"<p><p>Medial elbow pain is a common musculoskeletal problem among individuals engaging in repetitive activities. Medial epicondylitis is the predominant cause of this pain. However, other potential causes must be considered as part of the differential diagnosis. This article discusses several etiologies of medial elbow pain, including medial epicondylitis, ulnar neuropathy, snapping triceps syndrome, ulnar collateral ligament injury, medial antebrachial cutaneous neuropathy, and diseases of the elbow joint, with an emphasis on ultrasound (US) findings. Awareness of possible diagnoses and their US features can assist radiologists in establishing a comprehensive diagnosis for medial elbow pain.</p>","PeriodicalId":54227,"journal":{"name":"Ultrasonography","volume":" ","pages":"299-313"},"PeriodicalIF":2.4,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11374584/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141861610","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
UltrasonographyPub Date : 2024-07-01Epub Date: 2024-05-31DOI: 10.14366/usg.24059
Ji Youn Park, Jae Yong Jeon, Seungwoo Cha
{"title":"Ultrasonographic features of the skin and subcutis: correlations with the severity of breast cancer-related lymphedema.","authors":"Ji Youn Park, Jae Yong Jeon, Seungwoo Cha","doi":"10.14366/usg.24059","DOIUrl":"10.14366/usg.24059","url":null,"abstract":"<p><strong>Purpose: </strong>Assessing the severity of breast cancer-related lymphedema (BCRL) requires various clinical tools, yet no standardized methodology is available. Ultrasonography shows promise for diagnosing lymphedema and evaluating its severity. This study explored the clinical utility of ultrasonography in patients with BCRL.</p><p><strong>Methods: </strong>In this retrospective cross-sectional study, patients with unilateral BCRL were examined. The analyzed data included demographics, lymphedema location, International Society of Lymphology (ISL) stage, surgical history, treatment regimens, and arm circumference. Skin, subcutis, and muscle thicknesses were assessed ultrasonographically at predetermined sites, and the percentage of excess thickness was calculated. Multivariate logistic regression analysis was employed to identify associations between ultrasonographic measurements and advanced lymphedema (ISL 2 or 3). The Lymphedema Quality of Life arm questionnaire was used to evaluate patient-reported outcomes regarding lymphedema and their correlations with ultrasonographic findings.</p><p><strong>Results: </strong>Among 118 patients, 71 were classified as ISL 0-1 and 47 as ISL 2-3. Patients with advanced lymphedema were older, had higher nodal stages, underwent more axillary lymph node dissections, and had higher rates of dominant-arm lymphedema. Multivariate logistic regression revealed significant associations of greater skin thickness (adjusted odds ratio [OR], 4.634; 95% confidence interval [CI], 1.233 to 17.419), subcutis thickness (adjusted OR, 7.741; 95% CI, 1.649 to 36.347), and subcutis echogenicity (adjusted OR, 4.860; 95% CI, 1.517 to 15.566) with advanced lymphedema. Furthermore, greater skin thickness (P=0.016) and subcutis echogenicity (P=0.023) were correlated with appearance-related discomfort.</p><p><strong>Conclusion: </strong>Ultrasonographic measurements were significantly associated with advanced lymphedema in BCRL. Ultrasonography represents a valuable diagnostic and severity assessment tool for lymphedema.</p>","PeriodicalId":54227,"journal":{"name":"Ultrasonography","volume":" ","pages":"284-293"},"PeriodicalIF":2.4,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11222127/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141332452","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
UltrasonographyPub Date : 2024-07-01Epub Date: 2024-05-29DOI: 10.14366/usg.24040
Jeung Hui Pyo, Soo Jin Cho, Sung Chul Choi, Jae Hwan Jee, Jeeyeong Yun, Jeong Ah Hwang, Goeun Park, Kyunga Kim, Wonseok Kang, Mira Kang, Young Hye Byun
{"title":"Diagnostic performance of quantitative ultrasonography for hepatic steatosis in a health screening program: a prospective single-center study.","authors":"Jeung Hui Pyo, Soo Jin Cho, Sung Chul Choi, Jae Hwan Jee, Jeeyeong Yun, Jeong Ah Hwang, Goeun Park, Kyunga Kim, Wonseok Kang, Mira Kang, Young Hye Byun","doi":"10.14366/usg.24040","DOIUrl":"10.14366/usg.24040","url":null,"abstract":"<p><strong>Purpose: </strong>This study compared the diagnostic performance of quantitative ultrasonography (QUS) with that of conventional ultrasonography (US) in assessing hepatic steatosis among individuals undergoing health screening using magnetic resonance imaging-derived proton density fat fraction (MRI-PDFF) as the reference standard.</p><p><strong>Methods: </strong>This single-center prospective study enrolled 427 participants who underwent abdominal MRI and US. Measurements included the attenuation coefficient in tissue attenuation imaging (TAI) and the scatter-distribution coefficient in tissue scatter-distribution imaging (TSI). The correlation between QUS and MRI-PDFF was evaluated. The diagnostic capabilities of QUS, conventional B-mode US, and their combined models for detecting hepatic fat content of ≥5% (MRI-PDFF ≥5%) and ≥10% (MRI-PDFF ≥10%) were compared by analyzing the areas under the receiver operating characteristic curves. Additionally, clinical risk factors influencing the diagnostic performance of QUS were identified using multivariate linear regression analyses.</p><p><strong>Results: </strong>TAI and TSI were strongly correlated with MRI-PDFF (r=0.759 and r=0.802, respectively; both P<0.001) and demonstrated good diagnostic performance in detecting and grading hepatic steatosis. The combination of QUS and B-mode US resulted in the highest areas under the ROC curve (AUCs) (0.947 and 0.975 for detecting hepatic fat content of ≥5% and ≥10%, respectively; both P<0.05), compared to TAI, TSI, or B-mode US alone (AUCs: 0.887, 0.910, 0.878 for ≥5% and 0.951, 0.922, 0.875 for ≥10%, respectively). The independent determinants of QUS included skinliver capsule distance (β=7.134), hepatic fibrosis (β=4.808), alanine aminotransferase (β=0.202), triglyceride levels (β=0.027), and diabetes mellitus (β=3.710).</p><p><strong>Conclusion: </strong>QUS is a useful and effective screening tool for detecting and grading hepatic steatosis during health checkups.</p>","PeriodicalId":54227,"journal":{"name":"Ultrasonography","volume":" ","pages":"250-262"},"PeriodicalIF":2.4,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11222130/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141428292","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Arterial stiffness in subclinical atherosclerosis quantified with ultrafast pulse wave velocity measurements: a comparison with a healthy population using propensity score matching.","authors":"Xuezhong Jiang, Weiming Ge, Hui Huang, Yating Li, Xiaojing Liu, Huiyan Pang, Rui He, Hui Wang, Zhengqiu Zhu, Ping He, Yinping Wang, Xuehui Ma, Airong Ren, Bixiao Shen, Meijuan Wang","doi":"10.14366/usg.24045","DOIUrl":"10.14366/usg.24045","url":null,"abstract":"<p><strong>Purpose: </strong>This study aimed to evaluate changes in ultrafast pulse wave velocity (ufPWV) in individuals with arterial stiffness and subclinical atherosclerosis (subAS), and to provide cutoff values.</p><p><strong>Methods: </strong>This retrospective study recruited 231 participants, including 67 patients with subAS. The pulse wave velocity was measured at the beginning and end of systole (PWV-BS and PWVES, respectively) using ultrafast ultrasonography to assess arterial stiffness. The right and left common carotid arteries were measured separately, and laboratory metabolic parameters were also collected. Participants were balanced between groups using propensity score matching (PSM) at a 1:1 ratio, adjusting for age, sex, and waist-to-hip ratio as potential confounders. Cutoff values of ufPWV for monitoring subAS were determined via receiver operating characteristic (ROC) curve analysis.</p><p><strong>Results: </strong>PWV-ES, unlike PWV-BS, was higher in the subAS subgroup than in the subAS-free group after PSM (all P<0.05). For each 1 m/s increase in left, right, and bilateral mean PWV-ES, the risk of subAS increased by 23% (95% confidence interval [CI], 1.04 to 1.46), 26% (95% CI, 1.07 to 1.52), and 38% (95% CI, 1.12 to 1.72), respectively. According to ROC analyses, predictive potential was found for left PWV-ES (cutoff value=7.910 m/s, P=0.002), right PWV-ES (cutoff value=6.615 m/s, P=0.003), and bilateral mean PWV-ES (cutoff value=7.415 m/s, P<0.001), but not for PWV-BS (all P>0.05).</p><p><strong>Conclusion: </strong>PWV-ES measured using ultrafast ultrasonography was significantly higher in individuals with subAS than in those without. Specific PWV-ES cutoff values showed potential for predicting an increased risk of subAS.</p>","PeriodicalId":54227,"journal":{"name":"Ultrasonography","volume":"43 4","pages":"263-271"},"PeriodicalIF":2.4,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11222132/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141499641","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
UltrasonographyPub Date : 2024-07-01Epub Date: 2024-05-27DOI: 10.14366/usg.23229
Seong Sook Hong, Sung Hwan Bae, Jiyoung Hwang, Eun Ji Lee
{"title":"Transperineal versus transrectal prostate fiducial insertion in radiation treatment of prostate cancer: a systematic review and meta-analysis.","authors":"Seong Sook Hong, Sung Hwan Bae, Jiyoung Hwang, Eun Ji Lee","doi":"10.14366/usg.23229","DOIUrl":"10.14366/usg.23229","url":null,"abstract":"<p><strong>Purpose: </strong>To provide more accurate and definitive conclusions regarding the clinical and technical complications associated with the transperineal (TP) and transrectal (TR) approaches, a comprehensive review of observational studies and randomized controlled trials was conducted. This systematic review covered all eligible studies to facilitate a thorough comparison of complications linked to the two fiducial marker insertion methods, TP and TR.</p><p><strong>Methods: </strong>A comprehensive search of the literature was conducted, encompassing databases such as PubMed, Embase, and the Cochrane Library, up to July 7, 2023. The relative risk and 95% confidence interval were utilized to evaluate the diagnosis and complication rates.</p><p><strong>Results: </strong>The final selection for the methodological quality analysis included 13 observational studies that utilized TP and TR gold fiducial insertion approaches. The meta-analysis revealed significantly lower risks of urinary tract infections (UTI) and rectal bleeding with the TP approach.</p><p><strong>Conclusion: </strong>The use of both TP and TR techniques for placing gold seed fiducial markers has proven to be an effective, safe, and well-tolerated method for image-guided radiation therapy in prostate cancer patients. A significant benefit of the TP technique is its ability to avoid rectal puncture, thereby reducing the risk of UTIs. Although the incidence of UTIs and rectal bleeding associated with the TR method is relatively low, these complications can disrupt patient wellbeing and potentially cause delays in treatment.</p>","PeriodicalId":54227,"journal":{"name":"Ultrasonography","volume":" ","pages":"229-237"},"PeriodicalIF":2.4,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11222131/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141428293","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
UltrasonographyPub Date : 2024-07-01Epub Date: 2024-05-29DOI: 10.14366/usg.24046
Jung Joo Hong, Hyun Jeong Park, Eun Sun Lee, Min Ju Kim
{"title":"Severity of hyperechoic pancreas on preoperative ultrasonography: high potential as a clinically useful predictor of a postoperative pancreatic fistula.","authors":"Jung Joo Hong, Hyun Jeong Park, Eun Sun Lee, Min Ju Kim","doi":"10.14366/usg.24046","DOIUrl":"10.14366/usg.24046","url":null,"abstract":"<p><strong>Purpose: </strong>This study aimed to evaluate the effectiveness of using the severity of hyperechoic pancreas (HP) observed on preoperative ultrasonography (US) as a predictor of clinically relevant postoperative pancreatic fistula (CR-POPF).</p><p><strong>Methods: </strong>A retrospective study was conducted with 94 patients who underwent pancreatectomy between April 2006 and March 2021. The severity of HP on US was classified into two categories (normal to mild vs. moderate to severe [obvious HP]). Multiple preoperative and intraoperative parameters were analyzed to predict CR-POPF.</p><p><strong>Results: </strong>Out of the 94 patients, CR-POPF occurred in 21 (22%) patients, and obvious HP was observed in 30 (32%). Univariate analysis revealed that moderate to severe HP (obvious HP) was significantly associated with an increased incidence of CR-POPF (P<0.001). Factors such as the absence of pancreatitis, a small main pancreatic duct (<3 mm), intraoperative soft pancreas, increased body mass index, and lower pancreatic attenuation and attenuation index were also associated with CR-POPF (all P<0.05). Multivariate analysis showed that obvious HP and soft pancreatic texture were independent predictors of CR-POPF, with odds ratios of 11.53 (P=0.001) and 14.12 (P=0.003), respectively. The combination of obvious HP and soft pancreatic texture provided the most accurate prediction for CR-POPF.</p><p><strong>Conclusion: </strong>The severity of HP, as observed on preoperative US, was significantly associated with CR-POPF. Severe HP may serve as a clinically useful predictor of POPF, especially when evaluated alongside the intraoperative pancreatic texture.</p>","PeriodicalId":54227,"journal":{"name":"Ultrasonography","volume":" ","pages":"272-283"},"PeriodicalIF":2.4,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11222128/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141332451","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
UltrasonographyPub Date : 2024-07-01Epub Date: 2024-05-23DOI: 10.14366/usg.24086
Bülent Alyanak, Burak Tayyip Dede, Mustafa Hüseyin Temel, Mustafa Turgut Yıldızgören, Fatih Bağcıer
{"title":"Casting light on the overlooked trigger point of the interosseous muscles in metatarsalgia: insights and treatment strategies.","authors":"Bülent Alyanak, Burak Tayyip Dede, Mustafa Hüseyin Temel, Mustafa Turgut Yıldızgören, Fatih Bağcıer","doi":"10.14366/usg.24086","DOIUrl":"10.14366/usg.24086","url":null,"abstract":"","PeriodicalId":54227,"journal":{"name":"Ultrasonography","volume":" ","pages":"294-296"},"PeriodicalIF":2.4,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11222126/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141302012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
UltrasonographyPub Date : 2024-05-01Epub Date: 2024-02-14DOI: 10.14366/usg.23211
Tiago Neto, Johanna Johannsson, Ricardo J Andrade
{"title":"Using ultrasound shear wave elastography to characterize peripheral nerve mechanics: a systematic review on the normative reference values in healthy individuals.","authors":"Tiago Neto, Johanna Johannsson, Ricardo J Andrade","doi":"10.14366/usg.23211","DOIUrl":"10.14366/usg.23211","url":null,"abstract":"<p><p>Ultrasound shear wave elastography (SWE) is an emerging non-invasive imaging technique for peripheral nerve evaluation. Shear wave velocity (SWV), a surrogate measure of stiffness, holds promise as a biomarker for various peripheral nerve disorders. However, to maximize its clinical and biomechanical value, it is important to fully understand the factors that influence nerve SWV measurements. This systematic review aimed to identify the normal range of SWV for healthy sciatic and tibial nerves and to reveal the factors potentially affecting nerve SWV. An electronic search yielded 17 studies eligible for inclusion, involving 548 healthy individuals (age range, 17 to 72 years). Despite very good reliability metrics, the reported SWV values differed considerably across studies for the sciatic (1.9-9.9 m/s) and tibial (2.3-9.1 m/s) nerves. Factors such as measurement proximity to joint regions, limb postures inducing nerve axial stretching, and transducer alignment with nerve fiber orientation were associated with increased SWV. These findings suggest regional-specific nerve mechanical properties, non-linear elastic behaviour, and marked mechanical anisotropy. The impact of age and sex remains unclear and warrants further investigation. These results emphasize the importance of considering these factors when assessing and interpreting nerve SWE. While increased SWV has been linked to pathological changes affecting nerve tissue mechanics, the significant variability observed in healthy nerves highlights the need for standardized SWE assessment protocols. Developing guidelines for enhanced clinical utility and achieving a comprehensive understanding of the factors that influence nerve SWE assessments are critical in advancing the field.</p>","PeriodicalId":54227,"journal":{"name":"Ultrasonography","volume":" ","pages":"169-178"},"PeriodicalIF":3.1,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11079506/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140307809","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Man Zhao, Luni Zhang, Jing Chen, Shiyao Gu, Rong Wu, Caixia Jia
{"title":"Associations between carotid plaque shape, biomechanical parameters, and ischemic stroke in mild carotid stenosis with a single plaque.","authors":"Man Zhao, Luni Zhang, Jing Chen, Shiyao Gu, Rong Wu, Caixia Jia","doi":"10.14366/usg.24019","DOIUrl":"https://doi.org/10.14366/usg.24019","url":null,"abstract":"This cross-sectional cohort-comparison observational study investigated the value of high-frame-rate vector flow (V Flow) imaging for evaluating differences in carotid plaque shape and biomechanical parameters in patients with mild stenosis according to a recent history of ipsilateral ischemic stroke.","PeriodicalId":54227,"journal":{"name":"Ultrasonography","volume":"17 1","pages":""},"PeriodicalIF":3.1,"publicationDate":"2024-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140635828","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
UltrasonographyPub Date : 2024-04-01Epub Date: 2024-01-27DOI: 10.14366/usg.23227
Iraklis Perysinakis, Evangelia E Vassalou
{"title":"Non-traumatic lower abdominal pain: ultrasonographic and clinical differential diagnosis.","authors":"Iraklis Perysinakis, Evangelia E Vassalou","doi":"10.14366/usg.23227","DOIUrl":"10.14366/usg.23227","url":null,"abstract":"<p><p>Lower abdominal pain is frequently reported and has a diverse differential diagnosis. In cases with atypical presentation and nonspecific findings, further imaging evaluation is required to confirm the clinical suspicion and to distinguish between self-limiting disorders and those requiring immediate intervention. In line with European guidelines, transabdominal ultrasonography is recommended as a first-line imaging modality for clinically suspected acute appendicitis and acute diverticulitis, which respectively represent the predominant causes of right and left lower quadrant abdominal pain. It is similarly the preferred method for evaluating suspected obstetric/gynecologic and genitourinary diseases. Computed tomography is utilized as a secondary option when ultrasonography results are inconclusive. This pictorial essay illustrates the sonographic features of the most common conditions associated with lower abdominal pain and outlines the clinical characteristics of each entity.</p>","PeriodicalId":54227,"journal":{"name":"Ultrasonography","volume":"43 2","pages":"151-168"},"PeriodicalIF":3.1,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10915120/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140040845","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}