Washout-parametric imaging with Sonazoid for enhanced differentiation of focal liver lesions.

IF 2.4 3区医学 Q2 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

Ultrasonography Pub Date : 2024-11-01 Epub Date: 2024-08-05 DOI:10.14366/usg.24100

Tatsuya Kakegawa, Katsutoshi Sugimoto, Naohisa Kamiyama, Hiroshi Hashimoto, Hiroshi Takahashi, Takuya Wada, Yu Yoshimasu, Hirohito Takeuchi, Ryohei Nakayama, Kentaro Sakamaki, Takao Itoi

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引用次数: 0

Abstract

Purpose: The study aimed to compare the diagnostic performance of washout-parametric imaging (WOPI) with that of conventional contrast-enhanced ultrasound (cCEUS) in differentiating focal liver lesions (FLLs).

Methods: A total of 181 FLLs were imaged with contrast-enhanced ultrasound using Sonazoid, and the recordings were captured for 10 minutes in a prospective setting. WOPI was constructed from three images, depicting the arterial phase (peak enhancement), the early portal venous phase (1-minute post-injection), and the vasculo-Kupffer phase (5 or 10 minutes post-injection). The intensity variations in these images were color-coded and superimposed to produce a single image representing the washout timing across the lesions. From the 181 FLLs, 30 hepatocellular carcinomas (HCCs), 30 non-HCC malignancies, and 30 benign lesions were randomly selected for an observer study. Both techniques (cCEUS and WOPI) were evaluated by four off-site readers. They classified each lesion as benign or malignant using a continuous rating scale, with the endpoints representing "definitely benign" and "definitely malignant." The diagnostic performance of cCEUS and WOPI was compared using the area under the receiver operating characteristic curve (AUC) with the DeLong test. Interobserver agreement was assessed using the intraclass correlation coefficient (ICC).

Results: The difference in average AUC values between WOPI and cCEUS was 0.0062 (95% confidence interval, -0.0161 to 0.0285), indicating no significant difference between techniques. The interobserver agreement was higher for WOPI (ICC, 0.77) than cCEUS (ICC, 0.67).

Conclusion: The diagnostic performance of WOPI is comparable to that of cCEUS in differentiating FLLs, with superior interobserver agreement.

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利用 Sonazoid 进行冲洗参数成像，增强肝脏病灶的分辨能力。

目的：该研究旨在比较冲洗参数成像（WOPI）与传统对比增强超声波（cCEUS）在区分肝脏局灶性病变（FLLs）方面的诊断性能：方法：使用 Sonazoid 对 181 个 FLL 进行了造影剂增强超声成像，并在前瞻性环境中采集了 10 分钟的记录。WOPI 由三幅图像组成，分别描述动脉期（峰值增强）、门静脉早期（注射后 1 分钟）和血管-Kupffer 期（注射后 5 或 10 分钟）。对这些图像的强度变化进行颜色编码和叠加，以生成代表整个病灶冲洗时间的单一图像。从 181 个 FLL 中随机抽取 30 个肝细胞癌 (HCC)、30 个非 HCC 恶性肿瘤和 30 个良性病变进行观察研究。两种技术（cCEUS 和 WOPI）均由四名场外读片员进行评估。他们采用连续评分法对每个病变进行良性或恶性分类，终点代表 "肯定是良性 "和 "肯定是恶性"。cCEUS 和 WOPI 的诊断性能使用接收器操作特征曲线下面积 (AUC) 和 DeLong 检验进行比较。使用类内相关系数（ICC）评估观察者之间的一致性：结果：WOPI 和 cCEUS 的平均 AUC 值相差 0.0062（95% 置信区间，-0.0161 至 0.0285），表明两种技术之间没有显著差异。WOPI的观察者间一致性（ICC，0.77）高于cCEUS（ICC，0.67）：结论：在鉴别 FLL 方面，WOPI 的诊断性能与 cCEUS 相当，但观察者之间的一致性更高。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Ultrasonography Medicine-Radiology, Nuclear Medicine and Imaging

CiteScore

5.10

自引率

6.50%

发文量

审稿时长

15 weeks

期刊介绍： Ultrasonography, the official English-language journal of the Korean Society of Ultrasound in Medicine (KSUM), is an international peer-reviewed academic journal dedicated to practice, research, technology, and education dealing with medical ultrasound. It is renamed from the Journal of Korean Society of Ultrasound in Medicine in January 2014, and published four times per year: January 1, April 1, July 1, and October 1. Original articles, technical notes, topical reviews, perspectives, pictorial essays, and timely editorial materials are published in Ultrasonography covering state-of-the-art content. Ultrasonography aims to provide updated information on new diagnostic concepts and technical developments, including experimental animal studies using new equipment in addition to well-designed reviews of contemporary issues in patient care. Along with running KSUM Open, the annual international congress of KSUM, Ultrasonography also serves as a medium for cooperation among physicians and specialists from around the world who are focusing on various ultrasound technology and disease problems and relevant basic science.