Ultrasonography最新文献

{"title":"Ultrasound shear wave elastography for the assessment of pelvic floor muscle stiffness: technical and analytical challenges in practice.","authors":"Małgorzata Starzec-Proserpio, Guy Cloutier, Nathaly Gaudreault, Nathalie Bureau, Mélanie Morin","doi":"10.14366/usg.26031","DOIUrl":"10.14366/usg.26031","url":null,"abstract":"<p><p>Shear wave elastography (SWE) is an established technique for evaluating thyroid, liver, and breast pathologies. This non-invasive, real-time diagnostic method has also shown value for assessing the mechanical properties of skeletal muscle. However, the specific challenges of pelvic floor evaluation remain insufficiently addressed. Although SWE may appear straightforward, it involves considerable technical and analytical complexity and carries a substantial risk of misinterpretation. This review aims to increase awareness of challenges in SWE image acquisition and analysis, potential pitfalls, common artifacts, and other technical considerations relevant to pelvic floor muscle assessment. By addressing these issues, this review is intended to promote quality and consistency in future SWE research and to highlight areas requiring further investigation.</p>","PeriodicalId":54227,"journal":{"name":"Ultrasonography","volume":"45 4","pages":"402-418"},"PeriodicalIF":2.4,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13554579/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148392501","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Focused ultrasound as a therapeutic adjunct in pancreatic cancer: from thermal and mechanical effects to immune modulation.","authors":"Jae Young Lee, Cyril Lafon, Petros Mouratidis, Timothy Bullock, Joan Vidal-Jove, Jessica Gannon, Eli Vlaisavljevich, Holger Grüll, Tim Meakem, Chrit Moonen","doi":"10.14366/usg.25199","DOIUrl":"10.14366/usg.25199","url":null,"abstract":"<p><p>Pancreatic cancer remains highly lethal, with only limited improvements achieved with surgery, chemotherapy, radiotherapy, or immunotherapy. Focused ultrasound (FUS) offers complementary, noninvasive therapeutic modalities-including thermal ablation, non-ablative mechanical stimulation, and histotripsy-that can debulk tumors, palliate pain, enhance drug delivery through modulation of the dense stromal environment, and stimulate antitumor immunity. Extracorporeal high-intensity focused ultrasound is clinically feasible, while endoscopic and intraoperative approaches aim to overcome anatomical constraints. Preclinical studies demonstrate cavitation-mediated increases in tissue permeability and immune activation, and early clinical trials combining FUS with chemotherapy have reported encouraging signals in response rates and survival outcomes. Ongoing investigations are evaluating synergistic effects with immunotherapies and targeted drug delivery strategies. Key challenges-including the deep anatomical location of the pancreas, its fibrotic microenvironment, and the low immunogenicity of pancreatic tumors-necessitate the standardization of treatment parameters and improvements in image guidance. Overall, FUS represents a promising adjunct within multidisciplinary pancreatic cancer care.</p>","PeriodicalId":54227,"journal":{"name":"Ultrasonography","volume":"45 3","pages":"195-204"},"PeriodicalIF":2.4,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13246840/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148139738","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of triglyceride-driven residual atherosclerotic risk with carotid stiffening assessed using ultrafast ultrasound imaging in individuals with hypertriglyceridemia.","authors":"Ping Dai, Zhengqiu Zhu, Xuezhong Jiang, Hui Gao, Xuehui Ma, Yinping Wang, Bixiao Shen, Chong Zou, Yun Luan, Hui Huang, Weiming Ge","doi":"10.14366/usg.26047","DOIUrl":"10.14366/usg.26047","url":null,"abstract":"<p><strong>Purpose: </strong>Patients with hypertriglyceridemia retain residual atherosclerotic risk despite achieving low-density lipoprotein cholesterol (LDL-C) targets. This study investigated the association of this risk with carotid stiffening assessed by ultrafast pulse wave velocity (ufPWV).</p><p><strong>Methods: </strong>This study included 518 participants who underwent simultaneous ufPWV and carotid intima-media thickness (cIMT) measurements. Participants were stratified by triglyceride (TG) level into TG-optimal, TG-normal, and TG-high groups. Pulse wave velocity (PWV) at the beginning of systole and at the end of systole (PWV-ES) were measured using ufPWV. Participants were also categorized by Framingham risk score (FRS) into low-, intermediate-, and high-risk subgroups and by LDL-C level into normal and high subgroups. Logistic regression analysis was used to evaluate the potential predictive role of increased PWV-ES.</p><p><strong>Results: </strong>In the total population and the normal LDL-C subgroup, both the TG-high and TG-normal groups had higher PWV-ES and cIMT values than the TG-optimal group (all P&lt;0.05). Among participants with normal cIMT (&lt;0.050 cm), PWV-ES effectively differentiated the TG-optimal and TG-high groups (P&lt;0.001), but this difference was not observed when cIMT was ≥0.050 cm. Similarly, PWV-ES differentiated TG groups within the low-risk FRS subgroup (all P&lt;0.01), but not within the intermediate- or high-risk subgroups. Logistic regression showed that increased PWV-ES was independently associated with high TG levels in both the normal LDL-C subgroup (odds ratio [OR], 1.21; P=0.006) and the high LDL-C subgroup (OR, 1.57; P=0.023) after adjustment for LDL-C alone.</p><p><strong>Conclusion: </strong>ufPWV-quantified carotid stiffness is associated with elevated TG-driven residual atherosclerotic risk, independent of LDL-C.</p>","PeriodicalId":54227,"journal":{"name":"Ultrasonography","volume":"45 3","pages":"298-310"},"PeriodicalIF":2.4,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13246877/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148139750","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostic performance of vector flow imaging-derived wall shear stress and radiofrequency echo-tracking-derived arterial stiffness indices in severe carotid stenosis.","authors":"Nezih Yaylı, Atiye Cenay Karabörk Kılıç, Burcu Küçük Biçer, Fatih Öncü, Taylan Altıparmak, Mahi Nur Cerit, Halit Nahit Şendur, Hale Zeynep Batur Çağlayan, Mehmet Koray Akkan, Hüseyin Koray Kılıç, Suna Özhan Oktar, Ahmet Baran Önal, Bijen Nazlıel, Erhan Turgut Ilgıt","doi":"10.14366/usg.25195","DOIUrl":"10.14366/usg.25195","url":null,"abstract":"<p><strong>Purpose: </strong>This study aimed to evaluate the diagnostic performance of vector flow imaging (VFI)-derived hemodynamic parameters and radiofrequency echo-tracking-derived arterial stiffness indices (RF-ASI) for detecting severe carotid artery stenosis.</p><p><strong>Methods: </strong>This prospective, single-center observational study included 90 patients with carotid artery disease examined between May and July 2024. Stenosis severity was categorized as &lt;50%, 50%-69%, and ≥70% according to the Society of Radiologists in Ultrasound (SRU) Doppler criteria. In patients with stenosis ≥50%, severity was confirmed using digital subtraction angiography, computed tomography angiography, or magnetic resonance angiography. At the plaque level, VFI-derived wall shear stress (WSS) and turbulence metrics, as well as RF-ASI, were measured. Correlation analyses, group comparisons, and receiver operating characteristic analysis were performed to evaluate each parameter's ability to detect ≥70% stenosis.</p><p><strong>Results: </strong>Among the 90 patients (mean age, 70.4±8.7 years; 55.6% male), peak-segment mean wall shear stress (WSSmean) demonstrated the strongest correlation with stenosis severity (rₛ=0.87, P&lt;0.001). WSSmean also showed the highest diagnostic performance for detecting ≥70% stenosis (area under the curve, 0.96; 95% confidence interval, 0.92 to 0.99; cutoff, 2.25 Pa), compared with other VFI-derived metrics and RF-ASI. Segmental analysis revealed that WSS values were highest at the plaque peak, whereas turbulence-related metrics were more pronounced in distal segments. In SRU-discordant cases (7 of 90), WSSmean agreed with anatomic imaging-based classification (≥70% vs. &lt;70%) in six of seven lesions.</p><p><strong>Conclusion: </strong>VFI-derived WSSmean demonstrated the highest diagnostic performance for detecting severe (≥70%) carotid stenosis. In contrast, RF-ASI showed limited discriminatory ability and may primarily reflect global arterial stiffness rather than focal plaque severity.</p>","PeriodicalId":54227,"journal":{"name":"Ultrasonography","volume":"45 3","pages":"252-263"},"PeriodicalIF":2.4,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13246891/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148139726","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Perivascular space volume measurement at the inferior basal ganglia on cranial ultrasound in neonates: associations with germinal matrix hemorrhage and brain maturation.","authors":"Se Won Oh, Arum Choi, Dayeon Bak, Jimin Kim, Yoonho Nam, Hyun Gi Kim","doi":"10.14366/usg.25200","DOIUrl":"10.14366/usg.25200","url":null,"abstract":"<p><strong>Purpose: </strong>The aim of this study was to assess the feasibility of cranial ultrasound (CUS)-based perivascular space (PVS) volume quantification in neonates, evaluate its relationship with magnetic resonance imaging (MRI)-based PVS volume measurements, explore associations with germinal matrix hemorrhage (GMH), and examine longitudinal changes with maturation.</p><p><strong>Methods: </strong>This retrospective, single-center study included neonates who underwent CUS with PVS volume measurements at term-equivalent age (TEA) between November 2024 and March 2025. Neonates were grouped into those with GMH and controls. Group differences were analyzed and longitudinal changes of CUS-based PVS according to maturation were evaluated using generalized estimating equations in relation to corrected-gestational age (CGA). In neonates with both CUS and MRI at TEA, corresponding PVS volumes were compared using Spearman correlation and Bland-Altman analysis.</p><p><strong>Results: </strong>A total of 89 neonates were included. Among 19 neonates with GMH (10 males, median [IQR], gestational age [GA]: 260 [247 to 269] days) and 70 controls (46 males, GA: 265 [254 to 274] days), those with GMH had larger CUS-based PVS volumes (0.052 [0.041 to 0.065] cm3 vs. 0.041 [0.030 to 0.054] cm3, P=0.024). Longitudinal analysis revealed increasing CUS-based PVS volume with CGA in both GMH (0.26 mm3/day, P=0.020) and control groups (0.17 mm3/day, P=0.026). CUS-based PVS volume correlated with MRI-based PVS volume (r=0.453, P=0.026) and showed good agreement on Bland-Altman analysis.</p><p><strong>Conclusion: </strong>CUS-based neonatal PVS volume quantification was feasible, correlated with MRI, reflected GMH-related changes, and increased with maturation. CUS-based PVS volume quantification has the potential to serve as a valuable marker of glymphatic function in neonates.</p>","PeriodicalId":54227,"journal":{"name":"Ultrasonography","volume":"45 3","pages":"264-273"},"PeriodicalIF":2.4,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13246933/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148139718","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictors of tumor conspicuity on Kupffer-phase Sonazoid-enhanced ultrasonography in liver tumors: implications for fusion-guided ablation.","authors":"Dae Woong Kim, Jun Hyung Hong, Eun Ju Yoon, Tae-Hoon Kim, Hyung Joong Kim, Young Hoe Hur, Dakyum Shin, Hyun Chul Kim, Sang Gook Song, Jin Woong Kim","doi":"10.14366/usg.26020","DOIUrl":"10.14366/usg.26020","url":null,"abstract":"<p><strong>Purpose: </strong>This study aimed to evaluate the utility of the Kupffer phase in Sonazoid-enhanced ultrasonography (SZUS) for liver tumor ablation and to identify factors influencing tumor conspicuity on the Kupffer phase.</p><p><strong>Methods: </strong>Eighty-one patients with 128 liver tumors (95 hepatocellular carcinomas [HCCs] and 33 non-HCCs) who underwent gadoxetic acid-enhanced magnetic resonance imaging (MRI), B-mode planning ultrasonography (B-US), and SZUS-guided radiofrequency ablation (RFA) were included. Two radiologists scored tumor conspicuity on the hepatobiliary phase (HBP) of MRI, B-US, and the Kupffer phase using a 4-point scale. Tumor echogenicity on B-US was classified as hypoechoic or non-hypoechoic. This study analyzed tumor conspicuity across modalities, correlations between modalities, RFA technical success rates, and predictors of high Kupffer phase conspicuity.</p><p><strong>Results: </strong>The mean tumor diameter was 14.2±7.0 mm, with no differences in size or location between HCCs and non-HCCs. Conspicuity scores on the Kupffer phase were significantly higher than those on B-US for both HCCs (2.87±0.85 vs. 1.79±0.71) and non-HCCs (3.06±0.79 vs. 2.00±0.75) (both P&lt;0.001). The technical success rate of RFA under Kupffer phase guidance was 97.7%. Tumor conspicuity on the Kupffer phase showed a moderate correlation with that on HBP (r=0.436, P&lt;0.001), and this correlation was stronger in non-HCCs (r=0.630, P&lt;0.001). Multivariable analysis identified B-US hypoechogenicity (odds ratio [OR], 1.424; 95% confidence interval [CI], 1.176 to 1.724; P&lt;0.001) and good HBP conspicuity (OR, 1.317; 95% CI, 1.087 to 1.596; P=0.005) as independent predictors of good Kupffer phase conspicuity.</p><p><strong>Conclusion: </strong>B-US hypoechogenicity and good HBP conspicuity are independent predictors of favorable tumor conspicuity on the Kupffer phase. Identifying these features may facilitate optimal patient selection for effective SZUS-guided RFA of tumors that are inconspicuous on B-US.</p>","PeriodicalId":54227,"journal":{"name":"Ultrasonography","volume":"45 3","pages":"286-297"},"PeriodicalIF":2.4,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13246842/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148139793","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Super-resolution contrast-enhanced ultrasound: recent advances.","authors":"Yunlin Huang, Rui Cheng, Ying Wang, Yi Dong, Jeong Min Lee","doi":"10.14366/usg.25238","DOIUrl":"10.14366/usg.25238","url":null,"abstract":"<p><p>Super-resolution (SR) contrast-enhanced ultrasound (CEUS) is a novel sub-diffraction imaging modality that surpasses the diffraction limitations of conventional ultrasound and enables visualization of intricate microvascular architectures. SR CEUS provides improved quantification of hemodynamics and enhanced visualization of microvessels, thereby overcoming several inherent limitations of traditional CEUS. Initially demonstrated for imaging microvessels in the brains of small animals, SR CEUS has subsequently been investigated in multiple fields, including oncology, nephrology, and neurological research, with applications reported in breast cancer, chronic liver disease, and lymph node evaluation. However, clinical translation remains limited by prolonged acquisition times resulting from suboptimal microbubble detectability and the requirement for diluted contrast agents. This review summarizes the technical principles, clinical applications, current limitations, and future directions of SR CEUS from a clinical perspective.</p>","PeriodicalId":54227,"journal":{"name":"Ultrasonography","volume":"45 3","pages":"218-231"},"PeriodicalIF":2.4,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13246927/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148139781","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Non-ablative focused ultrasound induces an adaptive immune response to suppress pancreatic cancer: a preclinical study.","authors":"Eun-Joo Park, Yundeok Ahn, Yuri Cheon, Jae Young Lee","doi":"10.14366/usg.25228","DOIUrl":"10.14366/usg.25228","url":null,"abstract":"<p><strong>Purpose: </strong>This study aimed to investigate whether, and by what mechanisms, focused ultrasound-mediated mechanical stimulation (MS) can induce anti-tumor immunity and elicit an abscopal effect in a pancreatic cancer model.</p><p><strong>Methods: </strong>In study 1, animals bearing unilateral murine pancreatic tumors (Pan02) in the flank were divided into five groups according to the single or combined use of gemcitabine (Gem), thermal ablation, or MS. Study 2 was conducted in mice bearing bilateral flank tumors to evaluate abscopal effects. Tumor growth suppression, tissue damage, expression of tumor growth-inhibitory genes and cytokines, and anti-tumor cytotoxic T lymphocyte responses were analyzed.</p><p><strong>Results: </strong>In study 1, the MS+Gem group exhibited significantly higher levels of interleukin-6, KC-GRO, and tumor necrosis factor-α; higher proportions of CD8+ cells and granzyme B (GrB); and lower Foxp3 expression than the other groups. A significantly higher ratio of CD8+ cells among tumor-infiltrating lymphocytes (TIL) was also observed in the MS+Gem group (P&lt;0.005 at week 2). In study 2, significant growth suppression of the untreated contralateral tumor was observed in the MS+Gem group. Immune analysis of the untreated tumor showed significantly higher proportions of CD8+ cells and GrB, along with a lower proportion of Foxp3+ cells, in the MS+Gem group. The MS+Gem group also demonstrated a higher CD8+/TIL ratio in the untreated tumor.</p><p><strong>Conclusion: </strong>MS+Gem effectively suppressed tumor growth, promoted apoptosis-related factors, and enhanced intratumoral infiltration of cytotoxic T cells in treated tumors. In addition, MS+Gem induced an abscopal effect in untreated tumors, suggesting its potential to mediate systemic anti-tumor immune responses in pancreatic cancer treatment.</p>","PeriodicalId":54227,"journal":{"name":"Ultrasonography","volume":"45 3","pages":"274-285"},"PeriodicalIF":2.4,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13246894/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148139770","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Construction of a nomogram model for predicting benignity and malignancy in adnexal masses.","authors":"Kun Zhang, Lieming Wen, Yuyang Guo, Shan Zhou, Yaqian Fu, Yunxia Huang, Baihua Zhao","doi":"10.14366/usg.25186","DOIUrl":"10.14366/usg.25186","url":null,"abstract":"<p><strong>Purpose: </strong>This study aimed to construct a simple nomogram model to predict the benign or malignant nature of ovarian masses.</p><p><strong>Methods: </strong>A total of 794 patients with ovarian masses from two independent medical centers between 2017 and 2024 were included. Among them, 700 patients from center 1 were randomly divided into training and internal validation datasets, and 94 patients from center 2 comprised the external validation dataset. Clinical information, ultrasound images, and sonographic characteristics were collected for all patients. Independent risk factors were screened and incorporated into the nomogram. The diagnostic performance of the nomogram was compared with that of the Risk of Malignancy Index 4 (RMI4) and Ovarian-Adnexal Reporting and Data System (O-RADS) models.</p><p><strong>Results: </strong>Ultrasound score, menopausal status, maximum tumor diameter, elevated carbohydrate antigen 125, and elevated human epididymis protein 4 were identified as independent risk factors for distinguishing benign from malignant ovarian masses. In the training, internal validation, and external validation datasets, the areas under the receiver operating characteristic curve (AUCs) were 0.912, 0.906, and 0.949, respectively. The corresponding sensitivity values were 79.9%, 71.2%, and 93.3%, and the specificity values were 87.6%, 90.4%, and 86.7%, respectively. Compared with RMI4 and O-RADS, the nomogram demonstrated the highest AUC and greater clinical net benefit.</p><p><strong>Conclusion: </strong>The nomogram is simple to apply and demonstrates significantly higher diagnostic performance than RMI4, while achieving comparable performance to O-RADS. It may serve as a practical and widely applicable tool for predicting the benign or malignant nature of ovarian tumors.</p>","PeriodicalId":54227,"journal":{"name":"Ultrasonography","volume":"45 3","pages":"241-251"},"PeriodicalIF":2.4,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13246879/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148139767","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advantages of thyroid core needle biopsy: an emerging selective first-line biopsy modality.","authors":"Jae Ho Shin, Yeseul Kim, Min Kyoung Lee, Jung Hwan Baek, So Lyung Jung","doi":"10.14366/usg.25201","DOIUrl":"10.14366/usg.25201","url":null,"abstract":"<p><p>Ultrasound-guided fine needle aspiration biopsy (FNAB) for thyroid lesions has proven safe and effective; however, FNAB has limitations, including the frequent occurrence of nondiagnostic and inconclusive results and technical challenges in specific clinical scenarios. To address these limitations, core needle biopsy (CNB) was introduced, and substantial advancements have been made in CNB devices and techniques. Evidence from large patient cohorts indicates that CNB is not only safe and reliable but also provides superior diagnostic accuracy compared with FNAB. This review discusses recent advancements in CNB techniques to optimize tissue sampling, the diagnostic performance of CNB, and patient-centered perspectives, highlighting the potential of CNB as a selective first-line biopsy modality.</p>","PeriodicalId":54227,"journal":{"name":"Ultrasonography","volume":"45 3","pages":"205-217"},"PeriodicalIF":2.4,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13246833/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148139799","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}