Ultrasonography最新文献

{"title":"Histopathologic determinants of shear-wave elastography stiffness in soft-tissue sarcomas.","authors":"Jiwoo Park, Sang Kyum Kim, Seung Hyun Kim, Seok Hahn, Young Han Lee","doi":"10.14366/usg.25268","DOIUrl":"10.14366/usg.25268","url":null,"abstract":"<p><strong>Purpose: </strong>This study aimed to evaluate shear-wave elastography (SWE)-derived stiffness values and key histopathologic features of soft-tissue sarcomas and to assess the potential diagnostic value of SWE for differentiating sarcomas from non-sarcoma soft-tissue lesions.</p><p><strong>Methods: </strong>This retrospective study included 49 consecutive patients with clinically suspected soft-tissue tumors who underwent conventional ultrasonography (US) and SWE between April 2024 and March 2025. Quantitative SWE parameters, including mean and maximum stiffness values in kilopascals, were measured from at least four acquisitions for each lesion. Histopathologic grade was determined using the Fédération Nationale des Centres de Lutte Contre le Cancer (FNCLCC) system, and key histopathologic features relevant to SWE interpretation were assessed, including tumor necrosis, mitotic count, cellularity, and extent of myxoid stroma. Associations between SWE-derived stiffness values and histopathologic features were evaluated as the primary analysis, and diagnostic performance for sarcoma discrimination was evaluated as a secondary analysis. A P&lt;0.05 was considered to indicate statistical significance.</p><p><strong>Results: </strong>Microscopic necrosis was the only histopathologic feature significantly associated with SWE-derived stiffness; sarcomas without necrosis showed higher stiffness values than those with necrosis (P&lt;0.05). SWE stiffness values showed a nonlinear relationship with FNCLCC grade, increasing from grade 1 to grade 2 and then decreasing in grade 3 sarcomas. Conventional US showed high sensitivity (84.4%) but low specificity (35.3%) for sarcoma discrimination, whereas SWE-derived stiffness showed low sensitivity (21.9%-31.3%) but relatively high specificity (82.4%-88.2%).</p><p><strong>Conclusion: </strong>SWE-derived stiffness appears to be affected by intratumoral heterogeneity, particularly microscopic necrosis, which may help explain its nonlinear relationship with histologic grade. Although SWE alone showed limited sensitivity for sarcoma discrimination, its relatively high specificity may complement conventional US when markedly elevated stiffness is present.</p>","PeriodicalId":54227,"journal":{"name":"Ultrasonography","volume":"45 5","pages":"450-459"},"PeriodicalIF":2.4,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13620274/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148882476","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pelvic pain of venous origin: diagnostic insights from transvaginal ultrasonography.","authors":"Francine Freitas Fernandes, Isabela Rodrigues Tavares, Manuella Brandão Barreto Silva, Joana Storino, Fanilda Souto Barros, Nathalia Cardoso Oliveira, Dionésio Oliveira Coelho, Paulo Sérgio Cossi, Edward Araujo Júnior, Gustavo Yano Callado, Alexandre Freitas Teixeira Fernandes, Luciana Pardini Chamie","doi":"10.14366/usg.25270","DOIUrl":"10.14366/usg.25270","url":null,"abstract":"<p><p>Chronic pelvic pain is a common clinical condition among women and accounts for up to 15% of gynecological consultations. Pelvic pain of venous origin is one of the main gynecological causes of chronic pelvic pain, accounting for 16%-31% of cases. Several imaging modalities can be used to evaluate pelvic venous disorders; among them, ultrasonography is a first-line method because it provides real-time anatomical and functional assessment of the pelvic veins. This article reviews pelvic venous anatomy, etiopathogenic mechanisms, clinical manifestations, and imaging findings associated with pelvic venous disorders. Using illustrative cases, this review emphasizes the role of transvaginal ultrasound in detecting pelvic varices, venous insufficiency, and morphological and functional abnormalities, thereby supporting accurate diagnosis and appropriate management.</p>","PeriodicalId":54227,"journal":{"name":"Ultrasonography","volume":"45 4","pages":"325-341"},"PeriodicalIF":2.4,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13554645/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148392483","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"BI-RADS v2025 for breast ultrasound: key updates and Asian perspectives.","authors":"Hongping Song, Rui Shu, Takayoshi Uematsu, Woo Kyung Moon","doi":"10.14366/usg.26107","DOIUrl":"10.14366/usg.26107","url":null,"abstract":"<p><p>Breast ultrasound plays an increasingly important role in breast cancer detection, diagnosis, and management, particularly in regions where mammographic sensitivity is reduced by dense breast tissue. Although the Breast Imaging Reporting and Data System (BI-RADS) lexicon, developed by the American College of Radiology, provides a standardized framework for ultrasound interpretation, its terminology and conceptual structure continue to evolve in response to advances in imaging technology, changes in screening paradigms, and ongoing refinement of diagnostic and therapeutic approaches. This review summarizes the key ultrasound-related updates in BI-RADS v2025, with particular emphasis on the glandular tissue component, non-mass lesions, and structured lymph node assessment, and discusses their clinical implications in settings where breast ultrasound plays a central role in screening and diagnostic pathways, especially in Asia.</p>","PeriodicalId":54227,"journal":{"name":"Ultrasonography","volume":"45 4","pages":"311-324"},"PeriodicalIF":2.4,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13554624/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148392507","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sonographic identification of the tendinous septum of the semispinalis capitis muscle.","authors":"Muhammed Oğuz, Burak Tayyip Dede, Bülent Alyanak, Fatih Bağcıer, Mustafa Turgut Yıldızgören","doi":"10.14366/usg.25274","DOIUrl":"10.14366/usg.25274","url":null,"abstract":"","PeriodicalId":54227,"journal":{"name":"Ultrasonography","volume":"45 4","pages":"419-421"},"PeriodicalIF":2.4,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13554578/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148392512","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Two-dimensional elastography and dispersion slope for allograft evaluation after pediatric liver transplantation.","authors":"Jeong Min Song, In Hye Song, Hee Mang Yoon, Pyeong Hwa Kim, Ah Young Jung, Jin Seong Lee, Jung-Man Namgoong, Seak Hee Oh, Kyung Mo Kim, Young Ah Cho, Teresa Victoria","doi":"10.14366/usg.25237","DOIUrl":"10.14366/usg.25237","url":null,"abstract":"<p><strong>Purpose: </strong>This study evaluated the diagnostic performance of two-dimensional shear-wave elastography (2D SWE) for assessing allograft pathology in pediatric liver transplantation (LT) recipients, with subgroup analyses according to sonographic approach and age group. Additionally, the present study aimed to identify factors associated with SWE-derived parameters.</p><p><strong>Methods: </strong>This study retrospectively analyzed pediatric LT recipients who had received a left lobe or left lateral segment graft during childhood and underwent paired 2D SWE and liver biopsy. Associations between elasticity and dispersion slope measurements and clinicopathologic parameters were evaluated using univariable and multivariable regression analyses. Subgroup analyses were performed according to sonographic approach and age group. Diagnostic performance was assessed using receiver operating characteristic analysis.</p><p><strong>Results: </strong>A total of 108 patients (median age, 13.4 years; 47 males) were included. Elasticity measured using the intercostal approach in patients aged ≥13 years showed significant associations with METAVIR (Meta-analysis of Histological Data in Viral Hepatitis) fibrosis grade, necroinflammatory activity grade, liver allograft fibrosis score, and rejection activity index score. In multivariable analysis incorporating clinical parameters, METAVIR fibrosis grade remained the only independent predictor of intercostal elasticity in this age group (coefficient, 2.17; P&lt;0.001). Intercostal elasticity demonstrated excellent diagnostic performance for distinguishing F0-F2 from F3-F4 fibrosis (area under the curve [AUC], 0.95; P&lt;0.001; cut-off, 11.0 kPa) and good performance for distinguishing F0-F1 from F2-F4 fibrosis (AUC, 0.83; P&lt;0.001; cut-off, 7.2 kPa). In contrast, subcostal measurements and dispersion slope showed no significant association with any pathologic parameter.</p><p><strong>Conclusion: </strong>Intercostal elasticity demonstrated diagnostic value for predicting graft fibrosis in pediatric LT recipients aged ≥13 years who received left lobe or left lateral segment grafts. Among the evaluated clinicopathologic parameters, METAVIR fibrosis grade was the only independent predictor of elasticity in this subgroup.</p>","PeriodicalId":54227,"journal":{"name":"Ultrasonography","volume":"45 4","pages":"381-392"},"PeriodicalIF":2.4,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13554677/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148392426","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Early ultrasound markers for predicting the transition from acute kidney injury to chronic kidney disease and treatment response in a murine model.","authors":"Min Hoan Moon, Jeonghwan Lee, Chang Kyu Sung, Jung Pyo Lee, Myoung Seok Lee","doi":"10.14366/usg.26139","DOIUrl":"10.14366/usg.26139","url":null,"abstract":"<p><strong>Purpose: </strong>This study evaluated the feasibility of ultrasound (US) parameters for predicting the transition from acute kidney injury (AKI) to chronic kidney disease (CKD) and assessing the therapeutic response to 17-DMAG, a fibrosis-mitigating agent, in a murine unilateral ischemia-reperfusion injury (UIRI) model.</p><p><strong>Methods: </strong>Male C57BL/6 mice were assigned to sham (n=16) or UIRI (n=24) groups, with half of the UIRI mice receiving 17-DMAG (20 mg/kg intraperitoneally, three times weekly). Serial US examinations were performed on postoperative days (PODs) 3 and 8 to evaluate morphological parameters (kidney size and parenchymal thickness [PT]), vascular parameters (resistive index [RI] and vascular index [VI] derived from microvascular imaging [MVI]), and tissue stiffness assessed by shear-wave speed (SWS). Pathologic fibrosis was defined as a Sirius red-positive area &gt;4%. Diagnostic performance was evaluated using receiver operating characteristic (ROC) curve analysis.</p><p><strong>Results: </strong>At the early stage (POD 3), vascular parameters (VI and RI) demonstrated high diagnostic performance for predicting fibrosis progression (area under the receiver operating characteristic curve, 0.948 and 0.890, respectively), with VI serving as the only significant predictor of early treatment response to 17-DMAG. At POD 8, all parameters showed significant diagnostic performance for predicting fibrosis progression. However, for treatment response, only kidney size, PT, and RI demonstrated significant ROC performance, whereas VI and SWS did not reach statistical significance. These findings reflect the temporal transition from early functional microvascular compromise to established structural remodeling and parenchymal atrophy.</p><p><strong>Conclusion: </strong>RI and VI are promising noninvasive surrogate markers for predicting the AKI-to-CKD transition, and VI may be useful for assessing early responses to 17-DMAG treatment. Whereas conventional US parameters identify late-stage structural remodeling, MVI provides a critical diagnostic window during the acute phase by detecting early microvascular compromise. These findings highlight the potential utility of MVI for real-time monitoring of AKI progression and anti-fibrotic treatment responses in clinical practice.</p>","PeriodicalId":54227,"journal":{"name":"Ultrasonography","volume":"45 4","pages":"359-368"},"PeriodicalIF":2.4,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13564347/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148392420","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A new single-sagittal-plane deep learning approach for continuous bladder volume monitoring: a feasibility study.","authors":"Junhwan Kwon, Ilseob Song, Sangeun Park, Jongsoo Lee, Yangmo Yoo","doi":"10.14366/usg.25258","DOIUrl":"10.14366/usg.25258","url":null,"abstract":"<p><strong>Purpose: </strong>Conventional ultrasound-based bladder volumetry multiplies three orthogonal diameters and applies a heuristic shape coefficient. This approach requires near-simultaneous transverse and sagittal imaging and is vulnerable to interplane misregistration and coefficient-dependent bias. This study evaluated whether a single sagittal B-mode image can provide accurate, patient-specific bladder volume estimation by leveraging sagittal morphology, perivesical echotexture, and latent image features associated with overall bladder geometry.</p><p><strong>Methods: </strong>In this Institutional Review Board-approved, single-center study, participants were scanned in the supine position, and bladder volume was referenced to immediate Foley catheter drainage. Segmentation masks were independently annotated by two sonographers and adjudicated by a urologist. Maximum sagittal length was extracted using OpenCV and included as an auxiliary scalar input. A single-stage deep learning model was developed that receives one sagittal B-mode image and its expert-annotated segmentation mask as input. The model used a lightweight convolutional neural network backbone with integrated self-attention to capture global echotextural cues. Performance on a held-out test set (n=53) was assessed using linear regression, Bland-Altman analysis, mean absolute error, and mean absolute percentage error.</p><p><strong>Results: </strong>The model demonstrated a strong correlation with catheter-derived volumes (R²=0.87). Bland-Altman analysis showed a mean bias of -3.96±48.44 mL, with limits of agreement from -98.90 to +90.98 mL. Stratified error analysis showed a mean absolute error of 14.15 mL for volumes of 0-100 mL and a mean absolute percentage error of 16.64% for volumes ≥100 mL. Attention maps emphasized the bladder wall and perivesical soft tissues, suggesting reliance on contextual echotexture.</p><p><strong>Conclusion: </strong>A deep learning framework using a single sagittal plane estimated bladder volume with accuracy approaching that of two-plane techniques while simplifying image acquisition and eliminating reliance on fixed shape coefficients.</p>","PeriodicalId":54227,"journal":{"name":"Ultrasonography","volume":"45 4","pages":"393-401"},"PeriodicalIF":2.4,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13554572/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148392505","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ultrasound-based follow-up of low-suspicion thyroid nodules with cytopathologic confirmation: is nodule growth associated with malignancy?","authors":"Myoung Kyoung Kim, Haejung Kim, Soo Yeon Hahn, Jung Hee Shin","doi":"10.14366/usg.25198","DOIUrl":"10.14366/usg.25198","url":null,"abstract":"<p><strong>Purpose: </strong>This study aimed to evaluate the clinical utility of different ultrasound-based methods for assessing growth in low-suspicion thyroid nodules and to determine whether significant nodule growth (SNG) is associated with malignancy or thyroid neoplasm, as well as its implications for follow-up intervals.</p><p><strong>Methods: </strong>In this retrospective study, 309 patients with 334 low-suspicion thyroid nodules were analyzed. All nodules underwent at least three ultrasound examinations over ≥1 year and had cytopathologic confirmation. SNG was defined using three criteria: diameter-based criterion (DBC; ≥20% increase in at least two diameters with a minimum increase of ≥2 mm), volume-based criterion (VBC; ≥50% increase in volume), and change in the longest diameter alone (≥20% and ≥2 mm increase). Statistical associations between SNG and malignancy or thyroid neoplasm were evaluated using odds ratios (ORs).</p><p><strong>Results: </strong>Nodule growth was common, occurring in 57.8% of nodules according to DBC or VBC and in 51.5% based on the longest diameter, with substantial concordance between methods (κ=0.68). The median time to SNG was 2.9 years for DBC or VBC and 2.6 years for the longest diameter. SNG was not significantly associated with malignancy (OR, 1.19; 95% confidence interval [CI], 0.69 to 2.06) or thyroid neoplasm (OR, 1.05; 95% CI, 0.59 to 1.88).</p><p><strong>Conclusion: </strong>Among cytopathologically confirmed low-suspicion thyroid nodules, SNG was not associated with malignancy or thyroid neoplasm. Measurement of the longest diameter alone provided a practical alternative to more complex growth assessment methods. Given that the median time to SNG exceeded 2.6 years, current ultrasound follow-up intervals for low-suspicion nodules may warrant cautious reconsideration.</p>","PeriodicalId":54227,"journal":{"name":"Ultrasonography","volume":"45 4","pages":"351-358"},"PeriodicalIF":2.4,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13554628/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148392596","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quantitative ultrasound attenuation imaging outperforms B-mode scoring for assessing hepatic steatosis.","authors":"Sadanobu Ogawa, Takashi Kumada, Tatsuya Gotoh, Fumihiko Niwa, Hidenori Toyoda, Tomoyuki Akita, Junko Tanaka, Masahito Shimizu","doi":"10.14366/usg.26105","DOIUrl":"10.14366/usg.26105","url":null,"abstract":"<p><strong>Purpose: </strong>Accurate quantification of hepatic fat is essential for the management of metabolic dysfunction-associated steatotic liver disease; however, area under the receiver operating characteristic curve analysis is suboptimal for ordinal outcomes such as steatosis grade. This study compared the improved attenuation parameter (iATT) and the Hamaguchi score for hepatic steatosis assessment using the Obuchowski measure.</p><p><strong>Methods: </strong>This prospective study enrolled 605 patients with chronic liver disease who underwent iATT measurement, Hamaguchi scoring, and magnetic resonance imaging-derived proton density fat fraction (MRI-PDFF) assessment between April 2021 and March 2024. iATT was measured using the ARIETTA 850 ultrasound system, whereas the Hamaguchi score was determined through blinded assessment of standardized images for hepatorenal contrast, liver brightness, deep attenuation, and vessel blurring. MRI-PDFF served as the reference standard, with thresholds defined as S0 (&lt;5.2%), S1 (5.2% to &lt;11.3%), S2 (11.3% to &lt;17.1%), and S3 (≥17.1%). Diagnostic accuracy was evaluated using the Obuchowski measure, which weights pairwise comparisons across disease stages.</p><p><strong>Results: </strong>Both methods showed strong correlations with MRI-PDFF (iATT: ρ=0.814; Hamaguchi score: ρ=0.799; P=0.533) and demonstrated excellent diagnostic performance. The Obuchowski measure was significantly higher for iATT than for the Hamaguchi score at S1 (0.921 vs. 0.875, P&lt;0.001), S2 (0.931 vs. 0.892, P&lt;0.001), and S3 (0.911 vs. 0.870, P&lt;0.001). iATT performed significantly better in patients with body mass index (BMI) &lt;30 kg/m², whereas the Hamaguchi score showed relatively better performance for detecting S1 steatosis in patients with obesity (BMI ≥30 kg/m²).</p><p><strong>Conclusion: </strong>The Obuchowski measure demonstrated that iATT provided significantly better ordinal discriminatory performance than the Hamaguchi score for the assessment of hepatic steatosis.</p>","PeriodicalId":54227,"journal":{"name":"Ultrasonography","volume":"45 4","pages":"369-380"},"PeriodicalIF":2.4,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13554635/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148392480","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of an annotation-free artificial intelligence system for simultaneous detection and diagnosis on breast ultrasonography: a multireader, multicase study across diverse healthcare professionals.","authors":"Hasang Park, Kyunghwa Han, Hye Won Kim, Won Hwa Kim, Jaeil Kim, Jung Hyun Yoon","doi":"10.14366/usg.26033","DOIUrl":"10.14366/usg.26033","url":null,"abstract":"<p><strong>Purpose: </strong>This study aimed to evaluate how a deep learning-based artificial intelligence (AI) system that provides automatic lesion detection and diagnosis affects the diagnostic performance of readers from diverse professional backgrounds.</p><p><strong>Methods: </strong>A total of 1,000 breast ultrasound (US) images (500 malignant, 250 benign, and 250 negative) were independently reviewed by 15 readers (six radiologists, three surgeons, three physicians, and three radiographers) in two sessions: session 1 without AI assistance and session 2 with AI assistance following a 2-week washout period. Reader performance across sessions was compared using the area under the localization receiver operating characteristic curve (AULROC), sensitivity, specificity, and accuracy.</p><p><strong>Results: </strong>With AI assistance, the reader-averaged AULROC increased significantly from 0.864 (95% confidence interval [CI], 0.831 to 0.898) to 0.910 (95% CI, 0.888 to 0.931) (P=0.002). The standalone AI achieved an AULROC of 0.909 (95% CI, 0.889 to 0.930). Radiographers demonstrated a significant increase in AULROC, from 0.868 (95% CI, 0.840 to 0.897) to 0.922 (95% CI, 0.908 to 0.936) (P=0.032). Across all readers, sensitivity increased from 85.3% to 95.0% and accuracy from 82.3% to 85.7% (both P&lt;0.001). Specificity did not change significantly among radiologists or surgeons (P=0.089 and P=0.955, respectively) but decreased among physicians (82.3% vs. 75.7%, P&lt;0.001) and radiographers (81.7% vs. 76.7%, P&lt;0.001). Radiologists without fellowship training or with &lt;8 years of experience showed significantly improved sensitivity and accuracy, accompanied by decreased specificity after AI assistance (all P&lt;0.05).</p><p><strong>Conclusion: </strong>AI assistance significantly increased the average diagnostic performance of readers in breast US interpretation. Among less experienced professionals and radiologists, improvements in sensitivity and accuracy were accompanied by decreased specificity.</p>","PeriodicalId":54227,"journal":{"name":"Ultrasonography","volume":"45 4","pages":"342-350"},"PeriodicalIF":2.4,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13554587/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148392486","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}