Ultrasonography最新文献

{"title":"Ultrasonography in evolution: current position and priorities for global expansion.","authors":"Jung-Eun Cheon","doi":"10.14366/usg.25140","DOIUrl":"10.14366/usg.25140","url":null,"abstract":"","PeriodicalId":54227,"journal":{"name":"Ultrasonography","volume":" ","pages":"305-307"},"PeriodicalIF":2.5,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12457926/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144876767","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison between vibration-controlled transient elastography and point shear wave elastography for assessment of hepatic fibrosis based on magnetic resonance elastography.","authors":"Tatsuya Gotoh, Takashi Kumada, Sadanobu Ogawa, Fumihiko Niwa, Hidenori Toyoda, Tomoyuki Akita, Junko Tanaka, Masahito Shimizu","doi":"10.14366/usg.25090","DOIUrl":"https://doi.org/10.14366/usg.25090","url":null,"abstract":"<p><strong>Purpose: </strong>This study prospectively compared the diagnostic accuracy of vibration-controlled transient elastography (VCTE) and point shear wave elastography (pSWE) in the assessment of liver fibrosis, versus a reference standard of magnetic resonance elastography (MRE).</p><p><strong>Methods: </strong>This study prospectively enrolled patients with chronic liver disease, who underwent pSWE, VCTE, and MRE. Fibrosis was staged based on liver stiffness (LS) values measured using MRE: F0 (&lt;2.61 kPa), F1 (≥2.61 to &lt;2.97 kPa), F2 (≥2.97 to &lt;3.62 kPa), F3 (≥3.62 to &lt;4.69 kPa), and F4 (≥4.69 kPa). Each modality was performed independently, and the results were blinded to minimize bias. Diagnostic performance was assessed using the Pearson correlation coefficient (CC), Lin concordance correlation coefficient (CCC), area under the receiver operating characteristic curve (AUROC), Obuchowski index, integrated discrimination improvement (IDI), and net reclassification improvement (NRI).</p><p><strong>Results: </strong>In total, 251 patients (median age, 64 years; 97 women) were evaluated. Both pSWE (CC, 0.838; CCC, 0.825) and VCTE (CC, 0.803; CCC, 0.784) demonstrated strong correlations with MRE, with no statistically significant differences. AUROC values for diagnosing fibrosis stage were comparable between pSWE and VCTE. Based on the Obuchowski index, pSWE provided closer agreement with MRE in detecting ≥F1, ≥F2, and ≥F4. Analyses of IDI and NRI also displayed significantly better agreement between pSWE and MRE in detecting ≥F1, ≥F2, and ≥F4 (NRI: P&lt;0.001; IDI: F1 and F2, P&lt;0.001; F4, P=0.002).</p><p><strong>Conclusion: </strong>pSWE demonstrated closer alignment than VCTE with LS values measured by MRE, suggesting the potential of pSWE for noninvasively assessing liver fibrosis.</p>","PeriodicalId":54227,"journal":{"name":"Ultrasonography","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145281793","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Modulation of cell viability, apoptosis, and autophagy in pancreatic cancer cells using therapeutic ultrasound with microbubbles and gemcitabine.","authors":"Seunghyeon Roh, Jae Young Lee, Eun-Joo Park, Yuri Cheon, Yun Deok Ahn","doi":"10.14366/usg.25084","DOIUrl":"https://doi.org/10.14366/usg.25084","url":null,"abstract":"<p><strong>Purpose: </strong>This study aimed to investigate the effects of therapeutic ultrasound (TUS) combined with microbubbles and gemcitabine on cell viability, apoptosis, and autophagy in pancreatic cancer cells. The goal was to elucidate the cell death mechanisms by which TUS enhances drug delivery and therapeutic efficacy.</p><p><strong>Methods: </strong>Human pancreatic ductal adenocarcinoma CFPAC-1 cells were treated with varying TUS intensities (0.29 MPa/continuous wave, 0.42 MPa/50% duty cycle, and 0.86 MPa/10% duty cycle), microbubble volumes (0, 10, and 50 μL), and gemcitabine concentrations (0 μg/mL and 2 μg/mL). Cell viability was assessed by MTT assay, apoptosis by annexin V/propidium iodide staining and flow cytometry, and autophagy by an autophagy detection kit. Statistical analyses included three-way analysis of variance and post hoc Tukey honestly significant difference tests to evaluate the effects and interactions of treatment variables.</p><p><strong>Results: </strong>TUS combined with microbubbles and gemcitabine significantly reduced cell viability, induced apoptosis, and modulated autophagy in pancreatic cancer cells. Higher ultrasound intensities (with lower duty cycles) and increased microbubble volumes further enhanced these effects. Autophagy activation varied across treatment conditions. Under certain parameters, autophagy exhibited dose-dependent suppression with higher-intensity TUS, thereby promoting apoptosis-mediated cell death.</p><p><strong>Conclusion: </strong>TUS combined with microbubbles and gemcitabine synergistically induces cell death in pancreatic cancer cells through mechanical bioeffects and enhanced drug delivery, mediated by both apoptosis induction and autophagy modulation. These findings highlight a promising strategy for improving pancreatic cancer treatment outcomes, warranting further in vivo and clinical studies to optimize parameters and assess translational potential.</p>","PeriodicalId":54227,"journal":{"name":"Ultrasonography","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145187520","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Feasibility of high-resolution flow-mediated dilation using a 24-MHz probe to assess endothelial dysfunction: comparison of hypertensive and normotensive groups.","authors":"Yinping Wang, Zhengqiu Zhu, Xuehui Ma, Bixiao Shen, Chong Zou, Hui Gao, Ping Dai, Yiyun Wu, Hui Huang","doi":"10.14366/usg.25095","DOIUrl":"https://doi.org/10.14366/usg.25095","url":null,"abstract":"<p><strong>Purpose: </strong>This study investigated differences in endothelial cell dysfunction (ECD) and vascular response between hypertensive (HT) and non-hypertensive (NHT) individuals, as evaluated by high-resolution flow-mediated dilation (hrFMD) using a 24-MHz ultrasound probe.</p><p><strong>Methods: </strong>The study included 31 participants in the HT group and 29 in the NHT group. Clinical data, laboratory findings, and carotid intima-media thickness (cIMT) were measured, as were brachial artery systolic and diastolic diameters at baseline and 30, 60, and 120 seconds after a 5-minute cuff occlusion. Based on these measurements, systolic (TER&lt;sub&gt;S&lt;/sub&gt;) and diastolic (TER&lt;sub&gt;D&lt;/sub&gt;) traditional expansion ratios (TER), as well as a new expansion ratio (NER), were calculated for each post-occlusion time point. Differences, correlations, and multivariable logistic regression analyses were used to evaluate associations between ECD and hrFMD indices, with odds ratios (ORs) and 95% confidence intervals (CIs) reported.</p><p><strong>Results: </strong>At 60 seconds, NER and TER values in the HT group were significantly lower than in the NHT group. Most participants in the NHT (22/29, 75.8%) and HT (21/31, 67.7%) groups exhibited peak vasodilation at NER&lt;sub&gt;60&lt;/sub&gt;. NER&lt;sub&gt;60&lt;/sub&gt; was negatively correlated with age (r=-0.603, P&lt;0.001), cIMT (r=-0.328, P=0.011), and systolic blood pressure (r=-0.277, P=0.032). NER&lt;sub&gt;60&lt;/sub&gt; was associated with hypertension-related ECD independently of major cardiovascular risk factors (OR, 0.025; 95% CI, 0.002 to 0.316; P=0.004).</p><p><strong>Conclusion: </strong>In hrFMD, NER&lt;sub&gt;60&lt;/sub&gt; was significantly lower in HT than in NHT participants and may represent a surrogate marker for impaired vascular reactivity associated with hypertension. However, its role in the direct detection of ECD requires further validation against established physiological criteria.</p>","PeriodicalId":54227,"journal":{"name":"Ultrasonography","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145132759","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ductal abnormalities as primary findings on breast ultrasonography: a literature review and proposed classification.","authors":"Ken Oba, Hiroko Tsunoda, Woo Kyung Moon","doi":"10.14366/usg.25048","DOIUrl":"10.14366/usg.25048","url":null,"abstract":"<p><p>Ductal abnormalities, such as dilated ducts with intraductal lesions, are frequently the primary ultrasound findings prompting biopsy and resulting in the early diagnosis of breast cancer or high-risk lesions. However, the Breast Imaging Reporting and Data System (BI-RADS) ultrasound lexicon provides limited guidance on these findings, categorizing them merely as associated features. To address this limitation, this review presents a critical analysis of existing literature and proposes a new classification encompassing three distinct subtypes: dilated ducts alone, dilated ducts with intraductal echoes, and intraductal masses. Additionally, an interpretation algorithm is introduced that incorporates lesion size and suspicious ultrasound features to guide BI-RADS assessment. This structured approach aims to standardize terminology, improve diagnostic accuracy, and promote consistent management of ductal abnormalities, especially in asymptomatic women.</p>","PeriodicalId":54227,"journal":{"name":"Ultrasonography","volume":" ","pages":"245-259"},"PeriodicalIF":2.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12242359/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144327744","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of physical properties and image quality of a breast tissue phantom with glycerol-enhanced polyvinyl chloride plastisol for ultrasound imaging.","authors":"Aditya Prayugo Hariyanto, Anggraini Dwi Sensusiati, Suprijanto, Mohamed Aminah, Sook Sam Leong, Freddy Haryanto, Kwan Hoong Ng, Endarko","doi":"10.14366/usg.24096","DOIUrl":"10.14366/usg.24096","url":null,"abstract":"<p><strong>Purpose: </strong>This study aimed to fabricate and evaluate breast tissue-equivalent phantoms with varying glycerol concentrations, focusing on their physical properties (density, elasticity, and acoustic parameters) and ultrasound image quality metrics, including echogenicity and lesion geometric accuracy.</p><p><strong>Methods: </strong>Four phantom types were fabricated, each consisting of a polyvinyl chloride: dioctyl phthalate: glycerol mixture at varying ratios: 7%:93%:0% (background phantom A); 7%:88%:5% (background phantom B); 7%:83%:10% (background phantom C); and 7%:78%:15% (background phantom D). The phantoms contained spherical lesions (0.85, 1.10, and 1.45 cm) composed of gypsum, silicone rubber, and graphite. Physical properties such as density, elasticity, speed of sound, and acoustic impedance were measured for each phantom. Ultrasound image quality was assessed using signal-to-noise ratio, contrast-to-noise ratio, and geometric accuracy metrics.</p><p><strong>Results: </strong>Background phantoms with higher glycerol concentrations demonstrated increases in density (1.012 to 1.073 g/cm3), elasticity (6.340 to 10.458 kPa), speed of sound (1,532.68±16.35 to 1,578.28±15.63 m/s), and acoustic impedance ([1.55±0.030 to 1.69±0.014]×106 kg/m2/s). Lesion size variation was less than 6.43%, indicating high geometric accuracy. Phantoms B, C, and D exhibited better echogenicity and clearer image contrast compared to phantom A, which showed an anechoic pattern.</p><p><strong>Conclusion: </strong>Background phantom B demonstrated equivalence to breast tissue, and adding a specific concentration of glycerol allowed the mimicry of acoustic properties of target tissues, thereby improving image quality. This phantom can enhance ultrasound diagnostic skills and provide a cost-effective, self-build option suitable for medical training.</p>","PeriodicalId":54227,"journal":{"name":"Ultrasonography","volume":" ","pages":"260-273"},"PeriodicalIF":2.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12242360/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144267899","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Plaque biomarkers from high-frame rate vector flow imaging and shear wave elastography in mild carotid stenosis.","authors":"Man Zhao, Jing Chen, Shiyao Gu, Haoqing Hu, Luni Zhang, Rong Wu, Caixia Jia","doi":"10.14366/usg.25031","DOIUrl":"10.14366/usg.25031","url":null,"abstract":"<p><strong>Purpose: </strong>This study aimed to investigate the association of carotid plaque biomechanical parameters and elasticity-measured using high-frame rate vector flow imaging (VFI) and shear wave elastography (SWE)-with the occurrence of ipsilateral ischemic stroke in patients with mild stenosis.</p><p><strong>Methods: </strong>The study included 122 patients with mild carotid stenosis involving a single plaque between September 2023 and April 2024 who underwent B-mode ultrasound, high-frame rate VFI, and SWE examinations. Based on head computed tomography or magnetic resonance imaging findings, participants were classified as symptomatic (with ipsilateral ischemic lesions) or asymptomatic. Wall shear stress, oscillatory shear index, and turbulence (Tur) index were quantified on both downstream and upstream plaque surfaces, and the Young modulus (YM) was measured for distinct plaque regions. Multivariate logistic regression models were employed to evaluate correlations between these imaging-derived parameters and ipsilateral ischemic stroke.</p><p><strong>Results: </strong>A higher Tur index on the plaque's downstream surface and a lower mean YM within the plaque were significantly associated with ipsilateral ischemic stroke in patients with mild carotid stenosis. Moreover, the combined use of high-frame rate VFI and SWE demonstrated superior predictive performance for stroke risk compared with either modality alone.</p><p><strong>Conclusion: </strong>High-frame rate VFI and SWE enable detection of biomechanical features and stiffness in high-risk plaques among patients with mild carotid stenosis. Their combined application may yield valuable non-invasive biomarkers for stratifying stroke risk in this population.</p>","PeriodicalId":54227,"journal":{"name":"Ultrasonography","volume":" ","pages":"274-284"},"PeriodicalIF":2.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12242361/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144267901","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intraoperative sonography using high-frequency transducer during living Donor liver transplantation with modified right-lobe graft.","authors":"Jin Sil Kim, Kyoung Won Kim, Eun Sun Choi, Gi-Won Song","doi":"10.14366/usg.25047","DOIUrl":"10.14366/usg.25047","url":null,"abstract":"<p><p>This study highlights the role of intraoperative sonography (IOS) using a high-frequency transducer in living donor liver transplantation (LDLT) with modified right-lobe grafts. IOS is pivotal for the real-time assessment of vascular patency and anastomotic integrity, providing crucial insights into hepatic artery, portal vein, and hepatic vein configurations. The technique's high spatial resolution allows for the early detection of potential vascular complications, which are significant predictors of postoperative outcomes. Through detailed illustrations of vascular anastomoses and hemodynamics, this article discusses technical and anatomical considerations of IOS and demonstrates its effectiveness in screening and managing vascular complications in LDLT, thereby enhancing surgical precision and patient safety.</p>","PeriodicalId":54227,"journal":{"name":"Ultrasonography","volume":" ","pages":"294-303"},"PeriodicalIF":2.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12242362/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144303576","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inconclusive cytology results of fine-needle aspiration for thyroid nodules: the importance of strict guideline implementation.","authors":"Sangwoo Cho, Kyunghwa Han, Jung Hyun Yoon, Vivian Youngjean Park, Miribi Rho, Jiyoung Yoon, Jin Young Kwak","doi":"10.14366/usg.24216","DOIUrl":"10.14366/usg.24216","url":null,"abstract":"<p><strong>Purpose: </strong>This study investigated whether strict adherence to the Korean Thyroid Imaging Reporting and Data System (K-TIRADS) biopsy indications could reduce inconclusive cytology results and evaluated associated clinical factors.</p><p><strong>Methods: </strong>This retrospective study included 2,440 nodules from 2,256 patients who underwent initial fine-needle aspiration (FNA) for thyroid nodules from January to December 2022. Inconclusive specimens were defined as Bethesda categories I and III, while conclusive specimens comprised Bethesda categories II, IV, V, and VI. Nodules smaller than the K-TIRADS biopsy threshold were considered FNA not-indicated nodules. Clinical factors included patient age, sex, ultrasound features, nodule size, number of needle passes, and operator experience. Univariate and multivariate logistic regression analyses were performed to assess the associations between clinical factors and inconclusive results.</p><p><strong>Results: </strong>Among 2,440 nodules, 900 yielded initial inconclusive biopsy results, while 1,540 provided conclusive results. Independent predictors of inconclusive biopsy results included FNA not-indicated nodules, nodules sized 0 to 5 mm, operator experience of less than 1 year, older age, and K-TIRADS category 4 (P<0.001, P=0.006, P=0.003, P=0.001, and P<0.001, respectively). Among K-TIRADS category 4 nodules, the presence of suspicious ultrasound characteristics was negatively associated with inconclusive biopsy results (P=0.004).</p><p><strong>Conclusion: </strong>FNA not-indicated nodules, nodule size of 0 to 5 mm, operator experience of less than 1 year, older age, and K-TIRADS category 4 were factors associated with inconclusive biopsy results. Strict adherence to the K-TIRADS biopsy indications may reduce inconclusive cytology results.</p>","PeriodicalId":54227,"journal":{"name":"Ultrasonography","volume":" ","pages":"285-293"},"PeriodicalIF":2.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12242358/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144267900","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ultrasound evaluation of clinical mimics of deep vein thrombosis: essential insights for radiologists in interpretation.","authors":"Dongsuk Im, Lyo Min Kwon, Sun Young Park, Min Su Park, Won Ju Hong","doi":"10.14366/usg.24120","DOIUrl":"10.14366/usg.24120","url":null,"abstract":"<p><p>Ultrasonography (US) is a sensitive and radiation-free technique for diagnosing deep vein thrombosis (DVT). Therefore, when DVT is clinically suspected but not detected on US, radiologists should consider a range of alternative differential diagnoses. This review article presents the imaging findings of clinical conditions that mimic DVT, which can be distinguished using a multimodal radiologic approach. Additionally, DVT mimics can be categorized into two groups based on whether a flat or normal waveform is observed on Doppler US. This article details the imaging findings and clinical presentations of DVT mimics, organized by these classifications. This information may help radiologists make more accurate diagnoses, enabling patients to receive appropriate treatment in a timely manner.</p>","PeriodicalId":54227,"journal":{"name":"Ultrasonography","volume":" ","pages":"171-188"},"PeriodicalIF":2.4,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12081133/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143025758","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}