Posterior subependymal germinal matrix hemorrhage as a mild form of hemorrhage in extremely preterm infants: neurodevelopmental outcomes at corrected ages of 18-24 months.

IF 2.4 3区医学 Q2 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

Ultrasonography Pub Date : 2024-09-25 DOI:10.14366/usg.24110

Jae Mo Koo, So-Young Yoo, Ji Hye Kim, Ji Eun Park, Sun-Young Baek, Tae Yeon Jeon

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引用次数: 0

Abstract

Purpose: This study aimed to explore the effects of both the presence and size of posterior subependymal germinal matrix hemorrhage (PS-GMH), considered a mild form of hemorrhage, on the neurodevelopmental outcomes of extremely preterm infants.

Methods: A retrospective analysis was conducted on 221 extremely preterm infants, assessing their initial and term-equivalent age (TEA) cranial ultrasound (cUS) examinations from 2016 to 2021. Infants were classified based on the presence and size (small/large) of PS-GMH. Neurodevelopmental outcomes at corrected ages of 18-24 months were analyzed in 135 infants.

Results: PS-GMH was identified in 86.9% (192/221) of the infants, with 13.5% (26/192) exhibiting large PS-GMH. Among the 135 infants who were followed up, those with PS-GMH were found to have younger gestational ages (P<0.001) and a higher incidence of maternal chorioamnionitis (P=0.016) than those without PS-GMH. Significant differences were observed in the incidence of grade II intraventricular hemorrhage (IVH) on initial cUS (P=0.003) and ventriculomegaly at TEA cUS (P=0.026) across the groups with no PS-GMH, small PS-GMH, and large PS-GMH. The large PS-GMH group exhibited a higher occurrence of grade II IVH than the small PS-GMH group (P=0.006). However, ventriculomegaly incidence did not significantly vary with PS-GMH status. Neurodevelopmental outcomes were also not significantly different across PS-GMH statuses. The adjusted odds ratios for any neurodevelopmental impairment, compared to the no PS-GMH group, were 1.70 (95% confidence interval [CI], 0.40 to 7.26; P=0.471) for all PS-GMH, 1.61 (95% CI, 0.37 to 6.93; P=0.526) for small PS-GMH, and 3.84 (95% CI, 0.62 to 24.00; P=0.150) for large PS-GMH.

Conclusion: PS-GMH was frequently observed in extremely preterm infants; however, it did not independently predict adverse neurodevelopmental outcomes.

查看原文本刊更多论文

极早产儿后枕叶下胚芽基质出血是一种轻度出血：18-24 个月矫正后的神经发育结果。

目的：本研究旨在探讨被视为轻度出血的后脐下胚芽基质出血（PS-GMH）的存在和大小对极早产儿神经发育结果的影响：研究人员对221名极度早产儿进行了回顾性分析，评估了他们在2016年至2021年期间的初次和足月等龄（TEA）头颅超声（cUS）检查结果。根据PS-GMH的存在和大小（小/大）对婴儿进行分类。对135名婴儿在18-24个月校正年龄时的神经发育结果进行了分析：结果：86.9%（192/221）的婴儿发现了 PS-GMH，其中 13.5%（26/192）的婴儿表现为 PS-GMH 较大。在接受随访的 135 名婴儿中，与无 PS-GMH 的婴儿相比，有 PS-GMH 的婴儿胎龄更小（P<0.001），母体绒毛膜羊膜炎的发生率更高（P=0.016）。无 PS-GMH、小 PS-GMH 和大 PS-GMH 组的初始 cUS II 级脑室内出血（IVH）发生率（P=0.003）和 TEA cUS 脑室肿大发生率（P=0.026）存在显著差异。大 PS-GMH 组的 II 级 IVH 发生率高于小 PS-GMH 组（P=0.006）。然而，脑室肥大的发生率并不因PS-GMH状态的不同而显著变化。不同PS-GMH状态下的神经发育结果也无明显差异。与无PS-GMH组相比，所有PS-GMH组出现任何神经发育障碍的调整后几率为1.70（95%置信区间[CI]，0.40至7.26；P=0.471），小PS-GMH组为1.61（95% CI，0.37至6.93；P=0.526），大PS-GMH组为3.84（95% CI，0.62至24.00；P=0.150）：结论：在极早产儿中经常观察到 PS-GMH，但它并不能独立预测不良的神经发育结局。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Ultrasonography Medicine-Radiology, Nuclear Medicine and Imaging

CiteScore

5.10

自引率

6.50%

发文量

审稿时长

15 weeks

期刊介绍： Ultrasonography, the official English-language journal of the Korean Society of Ultrasound in Medicine (KSUM), is an international peer-reviewed academic journal dedicated to practice, research, technology, and education dealing with medical ultrasound. It is renamed from the Journal of Korean Society of Ultrasound in Medicine in January 2014, and published four times per year: January 1, April 1, July 1, and October 1. Original articles, technical notes, topical reviews, perspectives, pictorial essays, and timely editorial materials are published in Ultrasonography covering state-of-the-art content. Ultrasonography aims to provide updated information on new diagnostic concepts and technical developments, including experimental animal studies using new equipment in addition to well-designed reviews of contemporary issues in patient care. Along with running KSUM Open, the annual international congress of KSUM, Ultrasonography also serves as a medium for cooperation among physicians and specialists from around the world who are focusing on various ultrasound technology and disease problems and relevant basic science.