Translational Medicine at UniSa最新文献_第5页

Effects of Polyurethane Foam Dressings as an Add-on Therapy in the Management of Digital Ulcers in Scleroderma Patients. 聚氨酯泡沫敷料在硬皮病患者手指溃疡治疗中的附加治疗效果。

IF 1.5

Translational Medicine at UniSa Pub Date : 2020-05-31 eCollection Date: 2020-05-01

F W Rossi, F Rivellese, F Napolitano, F Mosella, C Selleri, N Montuori, A de Paulis

{"title":"Effects of Polyurethane Foam Dressings as an Add-on Therapy in the Management of Digital Ulcers in Scleroderma Patients.","authors":"F W Rossi, F Rivellese, F Napolitano, F Mosella, C Selleri, N Montuori, A de Paulis","doi":"","DOIUrl":"","url":null,"abstract":"Digital ulcers (DUs) represent a severe and common complication occurring in patients affected by Systemic Sclerosis (SSc), with a consistent impact on the quality of life and often resulting in longer hospitalization than unaffected patients. Conventional treatment of SSc ulcers consists of both topical and systemic (oral or intravenous) pharmacological therapies. Several surgical options are also available, but there is overall a lack of official guidelines or recommendations. The aim of this study was to evaluate the efficacy of a novel local therapy based on polyurethane foam dressings, namely the Highly Hydrophilic Polyurethane Foam (HPF), in addition to the conventional pharmacological treatment, in a cohort of 41 SSc patients with at least one active ulcer. Our results showed that the addition of HPF to the conventional treatment based on systemic drugs induced i) a significant reduction in the number of active DUs (p=0.0034); ii) a significant reduction of the mean duration of ulcer-related hospitalization as compared with standard therapy (p=0.0001); iii) a significant improvement of patients' Quality of Life, as evaluated through the Scleroderma Health Assessment Questionnaire (SHAQ) (p=0.00011). Therefore, in our experience, the combined management of DUs can improve both the onset of new DUs and DU's healing thus leading to a better outcome.","PeriodicalId":54170,"journal":{"name":"Translational Medicine at UniSa","volume":"22 ","pages":"10-14"},"PeriodicalIF":1.5,"publicationDate":"2020-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7265916/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38036749","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Papillary Thyroid Carcinoma in Paediatric Age. 小儿年龄甲状腺乳头状癌。

IF 1.5

Translational Medicine at UniSa Pub Date : 2020-05-31 eCollection Date: 2020-05-01

A Garzi, M Prestipino, E Calabrò, R M Di Crescenzo, M S Rubino

{"title":"Papillary Thyroid Carcinoma in Paediatric Age.","authors":"A Garzi, M Prestipino, E Calabrò, R M Di Crescenzo, M S Rubino","doi":"","DOIUrl":"","url":null,"abstract":"In children, differentiated thyroid carcinoma is a rare condition. Early diagnosis is not always easy, because of the lack of clinical symptoms, but it has a pivotal role in performing a correct therapeutic process. The study describes three cases of papillary thyroid carcinoma. None of the three patients had a positive familiarity or exposure to risk factors. In two cases, the tumor occurred as a non-injurious swelling in the anterior cervical region, in the other case it occurred with a latero-cervical lymphadenopathy that had been persistent for a year. In the first two patients we made a certain diagnosis by the needle aspiration of the thyroid nodule; in the other case the diagnosis was made by surgical exeresis and histological analysis of the lymph nodes. We also performed blood chemistry and hormonal tests, neck ultrasound, chest x-ray. The three children underwent total thyroidectomy and two of them also underwent right-sided cervical lymph node exeresis because there was the presence of metastasis. In our experience, the best therapeutic strategy for children with differentiated thyroid carcinoma is the total thyroidectomy, followed or not by latero-cervical lymph node exeresis and radioiodiotherapy. The removal of the whole gland reduces the risk of relapse.","PeriodicalId":54170,"journal":{"name":"Translational Medicine at UniSa","volume":"22 ","pages":"28-32"},"PeriodicalIF":1.5,"publicationDate":"2020-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7265913/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38036753","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dietary Restriction for The Treatment of Meniere's Disease. 饮食限制治疗梅尼埃病。

IF 1.5

Translational Medicine at UniSa Pub Date : 2020-05-31 eCollection Date: 2020-05-01

P De Luca, C Cassandro, M Ralli, F M Gioacchini, R Turchetta, M P Orlando, I Iaccarino, M Cavaliere, E Cassandro, A Scarpa

引用次数: 0

Mozart's or Ambient Music do not Affect Autoalgometric Pain Threshold. 莫扎特或环境音乐不影响疼痛阈值。

IF 1.5

Translational Medicine at UniSa Pub Date : 2020-05-31 eCollection Date: 2020-05-01

N Vecchione, L Lorusso, A Viggiano

{"title":"Mozart's or Ambient Music do not Affect Autoalgometric Pain Threshold.","authors":"N Vecchione, L Lorusso, A Viggiano","doi":"","DOIUrl":"","url":null,"abstract":"Nowadays, researchers and clinicians are increasingly interested in alternative non-pharmacological treatments, and music therapy seems to have additional and powerful effects on different pathologies and pain. However, since pain is a subjective perception, it is difficult to evaluate if and which effect music has on it. In this study, a new device and method have been introduced to objectively estimate pain threshold and its changes related to external stimuli. The above-mentioned device, called autoalgometer, allows to evaluate pain threshold changes while listening to music or other sounds. In this experiment, the pain threshold was evaluated in twenty-seven volunteers after listening to one out of three different soundtracks: white noise, Mozart's sonata K448 or Brian Eno's ambient music. Compared to staying in silence, listening to the recordings had no significant effect on pain threshold, and the results did not show any significant difference between the experimental groups. Probably, the positive effect of music described in other studies can be ascribed to a psychological effect, meaning that music can improve subjective mood and, thus, modify pain perception.","PeriodicalId":54170,"journal":{"name":"Translational Medicine at UniSa","volume":"22 ","pages":"1-4"},"PeriodicalIF":1.5,"publicationDate":"2020-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7265910/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38035805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pleomorphic Adenoma of the Parotid Gland and Ipsilateral Thyroid Incidentaloma: Report of A Rare Case With Review of Literature. 腮腺多形性腺瘤及同侧甲状腺偶发瘤1例报告并文献复习。

IF 1.5

Translational Medicine at UniSa Pub Date : 2020-05-31 eCollection Date: 2020-05-01

F Candelori, A Minni, A Greco, A Scarpa, C Cassandro, M Cavaliere, M Bisognox, E Cassandro, M de Vincentiis, M Ralli

{"title":"Pleomorphic Adenoma of the Parotid Gland and Ipsilateral Thyroid Incidentaloma: Report of A Rare Case With Review of Literature.","authors":"F Candelori, A Minni, A Greco, A Scarpa, C Cassandro, M Cavaliere, M Bisognox, E Cassandro, M de Vincentiis, M Ralli","doi":"","DOIUrl":"","url":null,"abstract":"Background: Pleomorphic adenomas are benign tumors of the salivary glands that mainly affect the lower pole of the superficial lobe of the parotid gland. The term \"pleomorphic\" refers to the epithelial and connective origin of the mass. The clinical presentation is typically that of asymptomatic swelling which increases in volume. Therapy consists in surgical removal of the tumor mass by parotidectomy with nerve preservation.Case details: This clinical case describes an interesting case of pleomorphic adenoma of the parotid gland in a 62-year-old patient. The patient presented with a long history of an asymptomatic mildly worsening swelling of the left parotid region. The peculiarity of the clinical case is the dimension of the adenoma (9x5x9 cm) and the presence of a thyroid incidentaloma (TI), consisting of a thyroid multinodular goiter composed of nodules, the largest of which measured 8 cm in diameter. This mass dislocated the laryngotracheal axis, compressed the larynx and caused the reduction of the respiratory space, making orotracheal intubation difficult and determining the need to perform a tracheotomy.Conclusion: Benign pleomorphic adenomas can potentially reach large sizes if untreated. Socio-economic problems may be the reason for late diagnosis.","PeriodicalId":54170,"journal":{"name":"Translational Medicine at UniSa","volume":"22 ","pages":"15-18"},"PeriodicalIF":1.5,"publicationDate":"2020-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7265912/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38036750","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Trends in Pediatric Surgery in the New Millennium. 新千年儿科外科的发展趋势。

IF 1.5

Translational Medicine at UniSa Pub Date : 2020-05-31 eCollection Date: 2020-05-01

A Garzi, M S Rubino

引用次数: 0

Prevention of Diabetic Foot Ulcer: A Neglected Opportunity. 预防糖尿病足溃疡:一个被忽视的机会。

IF 1.5

Translational Medicine at UniSa Pub Date : 2020-05-31 eCollection Date: 2020-05-01

C Miranda, R Da Ros

引用次数: 0

Complications of the "Nuss Procedure" In Pectus Excavatum. 漏斗胸“Nuss手术”的并发症。

IF 1.5

Translational Medicine at UniSa Pub Date : 2020-05-31 eCollection Date: 2020-05-01

A Garzi, M Prestipino, M S Rubino, R M Di Crescenzo, E Calabrò

{"title":"Complications of the \"Nuss Procedure\" In Pectus Excavatum.","authors":"A Garzi, M Prestipino, M S Rubino, R M Di Crescenzo, E Calabrò","doi":"","DOIUrl":"","url":null,"abstract":"During the pediatric age range, one the most frequent deformities of the chest wall are Pectus Excavatum (PE). Currently the treatment of choice for PE is surgical intervention following the Nuss procedure. In this study, we present a description of the complications associated with surgical treatment of PE with the Nuss technique, in patients with symmetrical or asymmetrical deformity, in different stages of disease severity. The study was conducted in collaboration with the Pediatric Hospital \"Istituto G. Gaslini\" of Genoa. We analyzed a cohort of 402 patients (334 males and 68 females), who underwent corrective surgery between 2005 and 2018. Within this group of patients, we observed 82 cases with complications (20.39%), 20 of which were intraoperative (4.98%) and 62 post-operative (15.42%). For the evaluation of complications, this group was arbitrarily divided into patients with symmetric and asymmetric Pectus and in patients with mild, moderate and severe Pectus using Haller's index. Although a small group of patients presented complications, overall results from data analysis show that the Nuss technique represents the preferred surgical procedure for the treatment of PE, in agreement with literature. Furthermore, in our results show no correlation between asymmetry or severity of PE with complication related to the surgery.","PeriodicalId":54170,"journal":{"name":"Translational Medicine at UniSa","volume":"22 ","pages":"24-27"},"PeriodicalIF":1.5,"publicationDate":"2020-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7265919/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38036752","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Minimally Invasive Treatment of Urolithiasis in Children: Evaluation of the Use of Flexible Ureterorenoscopy and Laser Lithotripsy. 儿童尿石症的微创治疗:软性输尿管镜和激光碎石术的应用评价。

IF 1.5

Translational Medicine at UniSa Pub Date : 2020-05-31 eCollection Date: 2020-05-01

A Garzi, M Prestipino, E Calabrò, R M Di Crescenzo, M S Rubino

{"title":"Minimally Invasive Treatment of Urolithiasis in Children: Evaluation of the Use of Flexible Ureterorenoscopy and Laser Lithotripsy.","authors":"A Garzi, M Prestipino, E Calabrò, R M Di Crescenzo, M S Rubino","doi":"","DOIUrl":"","url":null,"abstract":"Urolithiasis is a multifactorial disease; in recent years, its incidence has gradually increased in pediatric age. Among the factors involved in urolithiasis pathophysiology, urinary tract anomalies and metabolic diseases are the most relevant, although ethnicity and environmental factors may have an important role. The advances in technology and miniaturization of endoscopic devices have permitted the use of Retrograde Intrarenal Surgery (RIRS) to treat kidney and ureteral stones. Nowadays, flexible ureterorenoscopy and laser lithotripsy, which are techniques that have been applied in the management of adult upper urinary tract disorders, are also used in children as a minimally invasive treatment of urolithiasis with encouraging, effective and safe results. The Authors report a retrospective review of their record of cases considering 21 pediatric urolithiasis treatment procedures performed between October 2017 and April 2019 in a total of 17 patients (10 males and 7 females). Six procedures involved the use of the flexible ureterorenoscope (FURS) while in 15 procedures the application of the laser fiber was used (FURSL). A case of laser lithotripsy for bladder stone was included. The average age of patients was 10.5 years (2-18 years). The renal pelvis dilatation pretreatment was evaluated in post-operative follow-up. From the evaluation of the sample in analysis, the use of RIRS has good results in the treatment of paediatric urolithiasis, emerging as a valid option in the management of the paediatric population in terms of efficacy and safety, with an improvement in patient outcomes.","PeriodicalId":54170,"journal":{"name":"Translational Medicine at UniSa","volume":"22 ","pages":"46-49"},"PeriodicalIF":1.5,"publicationDate":"2020-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7265911/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38032070","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sub-Clinical Effects of Chronic Noise Exposure on Vestibular System. 慢性噪声暴露对前庭系统的亚临床影响。

IF 1.5

Translational Medicine at UniSa Pub Date : 2020-05-31 eCollection Date: 2020-05-01

P Viola, A Scarpa, D Pisani, C Petrolo, T Aragona, L Spadera, P De Luca, F M Gioacchini, M Ralli, E Cassandro, C Cassandro, G Chiarella

{"title":"Sub-Clinical Effects of Chronic Noise Exposure on Vestibular System.","authors":"P Viola, A Scarpa, D Pisani, C Petrolo, T Aragona, L Spadera, P De Luca, F M Gioacchini, M Ralli, E Cassandro, C Cassandro, G Chiarella","doi":"","DOIUrl":"","url":null,"abstract":"Aim: to investigate the effect of chronic noise exposure on vestibular function of subjects without clinical evidence of vestibular disorders and with documented cochlear damage from noise.Subjects and methods: 25 patients with chronic noise-induced hearing loss (NIHL) and without vestibular complaints (group A) and 25 matched controls with sensorineural hearing loss without noise exposure (group B), underwent audiological and vestibular test including caloric and cervical vestibular-evoked myogenic potentials tests (cVEMPs).Results: In subjects chronically exposed to noise, similarly to that of the auditory threshold, an increase in the evocation threshold of VEMPs has been documented, statistically significant (p<0,05) and independent of the performance of the auditory threshold. p1-n1 amplitude values showed a significant difference between group A and group B. No significant difference for p1-n1 latencies between the two groups was found.Conclusion: We have documented the possibility of vestibular lesion, along with cochlear damage, related to chronic acoustic trauma.","PeriodicalId":54170,"journal":{"name":"Translational Medicine at UniSa","volume":"22 ","pages":"19-23"},"PeriodicalIF":1.5,"publicationDate":"2020-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7265918/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38036751","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0