Translational Medicine at UniSa最新文献

{"title":"Current Espghan Guidelines for Celiac Disease in Pediatric Age, Tertiary Care Center Experience: A Proposal for Further Simplification","authors":"M. Malamisura, R. Colantuono, V. Salvati, R. Croce, G. D’Adamo, T. Passaro, E. D’Angelo, M. Boffardi, A. Garzi, B. Malamisura","doi":"10.14273/UNISA-2794","DOIUrl":"https://doi.org/10.14273/UNISA-2794","url":null,"abstract":"According to the 2012 ESPGHAN criteria for diagnosis of celiac disease (CD), duodenal biopsy (DB) can be avoided in children with a clear malabsorption syndrome, anti-tissue transglutaminase IgA (tTG2) ≥ 10x the cut-off, anti-endomysium IgA (EMA) and HLA DQ2/DQ8 genes. The aim of this study is to report our experience and evaluate the accuracy of the actual guidelines. Patients and methods This is a retrospective study conducted on all patients diagnosed CD from 2012 to 2018 in our Center. For all patients enrolled were analyzed: data of family history, symptoms, serology, genetics, Marsh grade and follow-up. Results A total of 481 children [mean age 6,4 yrs; F:M= 1.8:1] were included in the study. The mean age of patients who were not subject to DB was lower (4.51 yrs) comparing with patients that received DB (6.48 yrs). Out of the 256 patients with anti-tTG2 ≥ 10 fold, 121 underwent DB because of mild symptoms (84/121) or no symptoms (37/121). In all cases Marsh type 3 was found and HLA haplotypes was compatible with CD diagnosis. Conclusions Our study confirms that the serology has a primary importance to diagnose CD, regardless of the symptoms. These data suggest that biopsy and HLA haplotypes search, in presence of anti-tTG2 IgA ≥ 10x the cut-off, are wasteful and unhelpful for the patients.","PeriodicalId":54170,"journal":{"name":"Translational Medicine at UniSa","volume":null,"pages":null},"PeriodicalIF":1.5,"publicationDate":"2019-01-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42318557","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pediatric Anesthesia.","authors":"S Tesoro, L Marchesini, E De Robertis","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":54170,"journal":{"name":"Translational Medicine at UniSa","volume":null,"pages":null},"PeriodicalIF":1.1,"publicationDate":"2019-01-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6910147/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37468778","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Auditory-Verbal Processing Disorder and Dyslexia in Adulthood.","authors":"C Cassandro, A Manassero, A Scarpa, V Landi, G Aschero, S Lovallo, P Velardo, P De Luca, A Albera, R Albera, E Cassandro","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":54170,"journal":{"name":"Translational Medicine at UniSa","volume":null,"pages":null},"PeriodicalIF":1.1,"publicationDate":"2019-01-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6910146/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37468139","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Current Espghan Guidelines for Celiac Disease in Pediatric Age, Tertiary Care Center Experience: A Proposal for Further Simplification.","authors":"M Malamisura, R Colantuono, V M Salvati, R Croce, G D'Adamo, T Passaro, E D'Angelo, M Boffardi, A Garzi, B Malamisura","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>According to the 2012 ESPGHAN criteria for diagnosis of celiac disease (CD), duodenal biopsy (DB) can be avoided in children with a clear malabsorption syndrome, anti-tissue transglutaminase IgA (tTG2) ≥ 10x the cut-off, anti-endomysium IgA (EMA) and HLA DQ2/DQ8 genes. The aim of this study is to report our experience and evaluate the accuracy of the actual guidelines.</p><p><strong>Patients and methods: </strong>This is a retrospective study conducted on all patients diagnosed CD from 2012 to 2018 in our Center. For all patients enrolled were analyzed: data of family history, symptoms, serology, genetics, Marsh grade and follow-up.</p><p><strong>Results: </strong>A total of 481 children [mean age 6,4 yrs; F:M= 1.8:1] were included in the study. The mean age of patients who were not subject to DB was lower (4.51 yrs) comparing with patients that received DB (6.48 yrs). Out of the 256 patients with anti-tTG2 ≥ 10 fold, 121 underwent DB because of mild symptoms (84/121) or no symptoms (37/121). In all cases Marsh type 3 was found and HLA haplotypes was compatible with CD diagnosis.</p><p><strong>Conclusions: </strong>Our study confirms that the serology has a primary importance to diagnose CD, regardless of the symptoms. These data suggest that biopsy and HLA haplotypes search, in presence of anti-tTG2 IgA ≥ 10x the cut-off, are wasteful and unhelpful for the patients.</p>","PeriodicalId":54170,"journal":{"name":"Translational Medicine at UniSa","volume":null,"pages":null},"PeriodicalIF":1.1,"publicationDate":"2019-01-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6910143/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37468141","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pre and Post-Operative Ph-Metry in Videolaparoscopic Surgery for Gastro Oesophageal Reflux Disease.","authors":"A Garzi, G Ardimento, U Ferrentino, S Brongo, R M Di Crescenzo, E Calabrò, M S Rubino, B Malamisura, E Clemente","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Gastro-oesophageal reflux is common in children, especially in the first year of life, and it may be regarded as physiological. Good functioning of the lower oesophageal sphincter depends largely on the anatomical relationships between oesophagus, stomach and diaphragm hiatus. Relative immaturity of these structures in newborn babies and young children is a risk factor in reflux disease, which may result in a wide variety of typical and/or atypical symptoms and, sometimes, serious complications such as oesophagitis and stenosis. Reflux disease may be diagnosed and studied, basing on morphological and functional aspects and, since the advent of pH-metry, it is possible to personalise the therapeutic approach to children with reflux. Surgical treatment of reflux disease in children has recently been improved due to a mini-invasive surgical approach. Absolute indications are recurrent pneumonia, intractable pain due to oesophagitis and retarded growth, often in association with neurological impairment. In the last three years, 18 children with reflux disease underwent videolaparoscopic surgery in our department, 14 by the Nissen and 4 by the Toupet technique. Post-operative pH-metry always showed a reduction in exposure of the distal oesophagus to acid (integral of H+) and an improvement in oesophageal clearance (short refluxes percentage) indicative of good functioning of the gastro-oesophageal junction. PH-metry proved to be an invaluable technique for planning therapeutic strategy. In follow-up evaluations, it enabled us to monitor functioning of the gastro-oesophageal junction and to avoid other more difficult and invasive tests in patients with severe neurological impairment.</p>","PeriodicalId":54170,"journal":{"name":"Translational Medicine at UniSa","volume":null,"pages":null},"PeriodicalIF":1.1,"publicationDate":"2019-01-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6910148/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37468215","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Errata corrige.","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>[This corrects the article on p. 27 in vol. 19, PMID: 31360664.].</p>","PeriodicalId":54170,"journal":{"name":"Translational Medicine at UniSa","volume":null,"pages":null},"PeriodicalIF":1.5,"publicationDate":"2019-01-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6910144/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37468143","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Auditory-Verbal Processing Disorder and Dyslexia in Adulthood","authors":"C. Cassandro, A. Manassero, A. Scarpa, V. Landi, G. Aschero, S. Lovallo, P. Velardo, P. De Luca, A. Albera, R. Albera, E. Cassandro","doi":"10.14273/UNISA-2791","DOIUrl":"https://doi.org/10.14273/UNISA-2791","url":null,"abstract":"28 Università degli Studi di Salerno Introduction According to the Diagnostic and Statistic Manual of Mental Disorders (DSM-V), the neurodevelopment disorders are characterised by an atypical development of some cognitive domains, with a dysfunctional behavioural correlation supported by phenotypes with a genetic connection. Among these are the specific learning disabilities, which are united by a single condition characterised by difficulty in learning and using academic skills in the presence of an adequate IQ; these include dyslexia, dyscalculia and dysorthography. The clinical features are an inaccurate or slow and laborious reading of the words, difficulty in understanding the meaning of what is read, difficulty in spelling, in written expression, in mastering the concept of number, numerical data ora calculation, and in arithmetic reasoning. Recently, thanks to the better understanding of the neurobiological mechanisms underlying these disorders and thanks to the improvement of neuroimaging and genetic analysis, we better understood the evolution of these pathologies and consequently we have refined the diagnosis and treatment. Studies focused particularly more on dyslexia, both due to its high frequency in general population and to the better understanding of its pathogenesis. Various cognitive models are developed to explain the nature of the processes underlying the recognition of written words; the models explained partially the cause of dyslexia, tracing it back to a phonological deficit of consciousness. Today none of these models seems to prevail, but we believe that, in the context of a general reading disorder, there are several difficulties that can be either phonological or about phonological, motor or visual consciousness, due to the failure of magnocellular/auditory neurons development, because of an altered central processing. Already in the 80s, Tallal et al. recognised the phonological deficit as a symptom of a deficit of sound processing presented in rapid sequence (proper of verbal oral language) and therefore a deficit of elaboration at the auditory temporal cortex. This difficulty in the sounds analysis could lead to a wrong categorization and to a failure to recognise the phoneme as the acoustic characteristics change. From studies carried out on children with dyslexia, deficient performances emerged in conditions of short auditory stimuli presented in rapid sequence, while the performance improved with a longer stimulus interval. These difficulties lead to a need for longer times to discriminate short sounds in rapid sequence. Tallal deduced that children with dyslexia presented not a linguistic deficit but a deficit of temporal elaboration of the variation of the auditory patterns, which then translated into a difficulty in the perception of isolated language. In auditory perception of sounds, both when proposed in rapid sequences and with a longer time intervals, a primary role is played by auditory attention, expeci","PeriodicalId":54170,"journal":{"name":"Translational Medicine at UniSa","volume":null,"pages":null},"PeriodicalIF":1.5,"publicationDate":"2019-01-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44053677","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recurrence of Non-Hydropic Sudden Sensorineural Hearing Loss (SSNHL): A Literature Review.","authors":"C Cassandro,&nbsp;P De Luca,&nbsp;M Ralli,&nbsp;F Gioacchini,&nbsp;F Di Berardino,&nbsp;A Albera,&nbsp;R Albera,&nbsp;E Cassandro,&nbsp;A Scarpa","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":54170,"journal":{"name":"Translational Medicine at UniSa","volume":null,"pages":null},"PeriodicalIF":1.5,"publicationDate":"2019-01-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6910150/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37468221","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Laparoscopic Splenectomy: Postero-Lateral Approach.","authors":"A Garzi,&nbsp;G Ardimento,&nbsp;U Ferrentino,&nbsp;S Brongo,&nbsp;R M Di Crescenzo,&nbsp;E Calabrò,&nbsp;M S Rubino,&nbsp;E Clemente","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>In paediatric population, the laparoscopic splenectomy has been preferred to the open surgery during the last years. Due to the improvement of the technique and the devices, the indications to the laparoscopic splenectomy have been increased, even though there is still a variety of conditions in which the execution of this technique is arduous. During the preoperative consult there is the need to carefully evaluate the existence of cholecystic lithiasis, the haemoglobin level in patients with SCA, platelet count in children with ITP and the vaccination status. An anterior and a lateral or hanging spleen approach are primarily used for laparoscopic splenectomy. In the last four years, near the Section of Pediatric Surgery of the Department of Pediatrics, Obstetrics and Medicine of the Reproduction of Siena University, 8 cases of splenomegaly have been treated, 7 by lateral videolaparoscopic splenectomy (5 males and 2 females, with medium age of 10,5 years) and 1 by anterior approach (10 years). The advantages shown by these techniques allow the laparoscopic splenectomy to be considered as a valid alternative to the open surgery. In children's laparoscopic splenectomy, the rate of complications is considerably low and the the major problem is the intraoperative hemorrhage. With increasing surgical experience, the minimally invasive approach appears to be superior in terms of faster postoperative recovery, shorter hospital stay, perioperative and postoperative advantages. Therefore, the laparoscopic technique may soon be accepted as the standard method in patients requiring splenectomy.</p>","PeriodicalId":54170,"journal":{"name":"Translational Medicine at UniSa","volume":null,"pages":null},"PeriodicalIF":1.5,"publicationDate":"2019-01-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6910149/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37468780","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Errata corrige","authors":"Errata Corrige","doi":"10.1007/BF00211540","DOIUrl":"https://doi.org/10.1007/BF00211540","url":null,"abstract":"","PeriodicalId":54170,"journal":{"name":"Translational Medicine at UniSa","volume":null,"pages":null},"PeriodicalIF":1.5,"publicationDate":"2019-01-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/BF00211540","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45060111","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}