{"title":"Errata corrige","authors":"Errata Corrige","doi":"10.1007/BF00211540","DOIUrl":"https://doi.org/10.1007/BF00211540","url":null,"abstract":"","PeriodicalId":54170,"journal":{"name":"Translational Medicine at UniSa","volume":"20 1","pages":"32 - 32"},"PeriodicalIF":1.5,"publicationDate":"2019-01-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/BF00211540","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45060111","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A Garzi, G Ardimento, U Ferrentino, S Brongo, R M Di Crescenzo, E Calabrò, M S Rubino, E Clemente
{"title":"Laparoscopic Splenectomy: Postero-Lateral Approach.","authors":"A Garzi, G Ardimento, U Ferrentino, S Brongo, R M Di Crescenzo, E Calabrò, M S Rubino, E Clemente","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>In paediatric population, the laparoscopic splenectomy has been preferred to the open surgery during the last years. Due to the improvement of the technique and the devices, the indications to the laparoscopic splenectomy have been increased, even though there is still a variety of conditions in which the execution of this technique is arduous. During the preoperative consult there is the need to carefully evaluate the existence of cholecystic lithiasis, the haemoglobin level in patients with SCA, platelet count in children with ITP and the vaccination status. An anterior and a lateral or hanging spleen approach are primarily used for laparoscopic splenectomy. In the last four years, near the Section of Pediatric Surgery of the Department of Pediatrics, Obstetrics and Medicine of the Reproduction of Siena University, 8 cases of splenomegaly have been treated, 7 by lateral videolaparoscopic splenectomy (5 males and 2 females, with medium age of 10,5 years) and 1 by anterior approach (10 years). The advantages shown by these techniques allow the laparoscopic splenectomy to be considered as a valid alternative to the open surgery. In children's laparoscopic splenectomy, the rate of complications is considerably low and the the major problem is the intraoperative hemorrhage. With increasing surgical experience, the minimally invasive approach appears to be superior in terms of faster postoperative recovery, shorter hospital stay, perioperative and postoperative advantages. Therefore, the laparoscopic technique may soon be accepted as the standard method in patients requiring splenectomy.</p>","PeriodicalId":54170,"journal":{"name":"Translational Medicine at UniSa","volume":"20 ","pages":"9-12"},"PeriodicalIF":1.5,"publicationDate":"2019-01-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6910149/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37468780","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A Garzi, U Ferrentino, G Ardimento, S Brongo, M S Rubino, E Calabrò, E Clemente, R M Di Crescenzo
{"title":"Congenital Cystic Adenomatoid Malformation of the Lung Tipe II: Three Cases Report.","authors":"A Garzi, U Ferrentino, G Ardimento, S Brongo, M S Rubino, E Calabrò, E Clemente, R M Di Crescenzo","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Congenital cystic adenomatoid malformation (CCAM) is a rare congenital lung lesion. It may appear since birth (30-35%) with difficulty breathing or may have a late onset (60-65%) with recurring pulmonary infections or growth failure; in a small percentage of cases, the lesion can be completely asymptomatic. Fetal or post-natal surgery can be used as surgical treatment of these lesions. Postnatal surgery consists of a lobectomy, bilobectomy or pneumonectomy, based on the size of the lesion. The best age to undergo this surgery is around 2 years, but only if the injury is stable and the child has no complications. The study describes three cases of CCAM, observed at the Pediatric Surgery Section of the University of Siena. We analyzed those 3 cases whose approach was defined by the onset of symptoms, age and clinical condition of patients. In the first case the surgery was performed a few hours after birth due to the worsening of the clinical conditions; in the other two cases it was delayed because the patients were asymptomatic. The purpose of this study is to review the management of patients with CCAM in relation to clinical onset and the type of injury.</p>","PeriodicalId":54170,"journal":{"name":"Translational Medicine at UniSa","volume":"20 ","pages":"4-8"},"PeriodicalIF":1.5,"publicationDate":"2019-01-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6910145/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37468779","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
J Apóstolo, E Bobrowicz-Campos, I Gil, R Silva, P Costa, F Couto, D Cardoso, A Barata, M Almeida
{"title":"Cognitive Stimulation in Older Adults: An Innovative Good Practice Supporting Successful Aging and Self-Care.","authors":"J Apóstolo, E Bobrowicz-Campos, I Gil, R Silva, P Costa, F Couto, D Cardoso, A Barata, M Almeida","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The project Cognitive Stimulation in Older Adults: Intervention on Cognitive Frailty and Promotion of Self-Care (in brief the ECOG project) arises in a context of worldwide demographic aging, and is fostered by the need to provide a sustainable solution to the progressive increase in the prevalence of age-related cognitive impairment. The main goal of the ECOG project is to promote active citizenship in old age through the empowerment for autonomy and self-care. Namely, the ECOG team is working on the development of evidence-based programs and tools that promote gains in health in cognitively frail and cognitively impaired older adults from the community. It is also working on the transfer of ECOG products to the practice of health and social care, promoting active involvement of geriatric care institutions in the implementation of the ECOG programs and tools, and ensuring appropriate training of professionals. Finally, the ECOG team is deploying a digital platform to reach out to the broadest audience possible and support the remote access and scaling up of the ECOG products. The impacts expected at an individual level include improvements in cognition, functionality, and autonomy of older adults, with simultaneous reduction of depressive symptomatology, and increase in quality of life of both person cared and his/her caregiver. Regarding societal gains, we anticipate an increase in life expectancy and significant postponement of institutionalization associated with geriatric problems. We also believe that the wide implementation of the ECOG products will reduce the costs of interventions for cognitively impaired citizens, contributing to sustainability and efficiency of health systems.</p>","PeriodicalId":54170,"journal":{"name":"Translational Medicine at UniSa","volume":"19 ","pages":"90-94"},"PeriodicalIF":1.1,"publicationDate":"2019-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6581488/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141749754","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mauro Cataldi, V. D. Luca, G. Tramontano, C. D. Giudice, I. Grimaldi, P. Cuccaro, P. Speranza, G. Iadicicco, V. Iadicicco, F. Carotenuto, P. A. Riccio, G. D. Spigna, A. Renzullo, L. Vuolo, L. Barrea, S. Savastano, Annamaria Colao, Giuseppe Liotta, G. Iaccarino, Pasquale Abete, P. Buono, Miriam Marie Rosé Vollenbroek-Hutten, M. Illario
{"title":"An Approach to Prevent Frailty in Community Dwelling Older Adults: a pilot study performed in Campania region in the framework of the PERSSILAA project","authors":"Mauro Cataldi, V. D. Luca, G. Tramontano, C. D. Giudice, I. Grimaldi, P. Cuccaro, P. Speranza, G. Iadicicco, V. Iadicicco, F. Carotenuto, P. A. Riccio, G. D. Spigna, A. Renzullo, L. Vuolo, L. Barrea, S. Savastano, Annamaria Colao, Giuseppe Liotta, G. Iaccarino, Pasquale Abete, P. Buono, Miriam Marie Rosé Vollenbroek-Hutten, M. Illario","doi":"10.14273/UNISA-2725","DOIUrl":"https://doi.org/10.14273/UNISA-2725","url":null,"abstract":"We developed and tested an innovative physical training method in older adults that embeds the gym program into everyday life in the most conservative way possible. Physical training was included in the activities of local parishes where older women from Southern Italy spend most of their free time and was delivered by trained physical therapists with the support of an ICT tool known as CoCo. 113 older women (aged 72.0 [69.0–75.0] years) noncompliant to conventional exercise programs participated to the study. 57 of them underwent the final anthropometric assessment and 50 the final physical tests. In study completers handgrip strength and physical performance evaluated with the chair-stand, the two minutes step and the chair-sit and -reach tests significantly improved. Quality of life as evaluated with the EuroQol-5dimension (EQ-5D) questionnaire improved as well. In conclusion, a training program designed to minimally impact on life habits of older people is effective in improving fitness in patients noncompliant to other to physical exercise programs.","PeriodicalId":54170,"journal":{"name":"Translational Medicine at UniSa","volume":"19 1","pages":"42 - 48"},"PeriodicalIF":1.5,"publicationDate":"2019-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45726963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
J. Bousquet, M. Illario, J. Farrell, N. Batey, A. Carriazo, J. Malva, J. Hajjam, E. Colgan, Nick A. Guldemond, M. Perälä-Heape, G. Onorato, A. Bedbrook, L. Leonardini, V. Stroetman, S. Birov, C. Abreu, A. Abrunhosa, A. Agrimi, T. Alalääkkölä, N. Allegretti, F. Alonso-Trujillo, M. Alvarez-Benito, S. Angioli, Joao Apostolo, G. Armitage, S. Arnavielhe, M. Baena-ParejoI, P. D. Bamidis, A. Balenović, M. Barbolini, I. Baroni, H. Blain, P. L. Bernard, M. Bersani, E. Berti, L. Bogatyrchuk, R. Bourret, J. Brehm, L. Brussino, D. Buhr, D. Bultje, E. Cabeza, Antonio Cano, C. Capitani, E. Carantoña, Ana F. Cardoso, J. I. C. Clavero, B. Combe, D. Conforti, Liliana Coppola, F. Corti, Enrico Coscioni, Elísio Costa, G. Crooks, António Cunha, C. Daien, Dantas, J. D. Sierra, M. Davoli, A. D. Baraldes, V. D. Luca, L. D. Nardi, M. D. Ciano, A. Dozet, B. Ekinci, S. Ervé, J. M. E. Almendro, A. Fait, R. Fensli, S. F. Nocelo, P. Galvez-Daza, J. Gámez-Payá, M. G. Sáez, I. G. Sanchez, B. Gemicioğlu, W. Goetzke, E. Goossens, M. Geur
{"title":"The Reference Site Collaborative Network of the European Innovation Partnership on Active and Healthy Ageing","authors":"J. Bousquet, M. Illario, J. Farrell, N. Batey, A. Carriazo, J. Malva, J. Hajjam, E. Colgan, Nick A. Guldemond, M. Perälä-Heape, G. Onorato, A. Bedbrook, L. Leonardini, V. Stroetman, S. Birov, C. Abreu, A. Abrunhosa, A. Agrimi, T. Alalääkkölä, N. Allegretti, F. Alonso-Trujillo, M. Alvarez-Benito, S. Angioli, Joao Apostolo, G. Armitage, S. Arnavielhe, M. Baena-ParejoI, P. D. Bamidis, A. Balenović, M. Barbolini, I. Baroni, H. Blain, P. L. Bernard, M. Bersani, E. Berti, L. Bogatyrchuk, R. Bourret, J. Brehm, L. Brussino, D. Buhr, D. Bultje, E. Cabeza, Antonio Cano, C. Capitani, E. Carantoña, Ana F. Cardoso, J. I. C. Clavero, B. Combe, D. Conforti, Liliana Coppola, F. Corti, Enrico Coscioni, Elísio Costa, G. Crooks, António Cunha, C. Daien, Dantas, J. D. Sierra, M. Davoli, A. D. Baraldes, V. D. Luca, L. D. Nardi, M. D. Ciano, A. Dozet, B. Ekinci, S. Ervé, J. M. E. Almendro, A. Fait, R. Fensli, S. F. Nocelo, P. Galvez-Daza, J. Gámez-Payá, M. G. Sáez, I. G. Sanchez, B. Gemicioğlu, W. Goetzke, E. Goossens, M. Geur","doi":"10.14273/UNISA-2721","DOIUrl":"https://doi.org/10.14273/UNISA-2721","url":null,"abstract":"Seventy four Reference Sites of the European Innovation Partnership on Active and Healthy Ageing (EIP on AHA) have been recognised by the European Commission in 2016 for their commitment to excellence in investing and scaling up innovative solutions for active and healthy ageing. The Reference Site Collaborative Network (RSCN) brings together the EIP on AHA Reference Sites awarded by the European Commission, and Candidate Reference Sites into a single forum. The overarching goals are to promote cooperation, share and transfer good practice and solutions in the development and scaling up of health and care strategies, policies and service delivery models, while at the same time supporting the action groups in their work. The RSCN aspires to be recognized by the EU Commission as the principal forum and authority representing all EIP on AHA Reference Sites. The RSCN will contribute to achieve the goals of the EIP on AHA by improving health and care outcomes for citizens across Europe, and the development of sustainable economic growth and the creation of jobs.","PeriodicalId":54170,"journal":{"name":"Translational Medicine at UniSa","volume":"19 1","pages":"66 - 81"},"PeriodicalIF":1.5,"publicationDate":"2019-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46653888","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
P. M. D. Santos, R. O’Caoimh, A. Svendrovski, C. Casanovas, F. Pernas, M. Illario, W. Molloy, Constança Paúl
{"title":"The RAPid COmmunity COGnitive screening Programme (RAPCOG): Developing the Portuguese version of the Quick Mild Cognitive Impairment (Qmci-P) screen as part of the EIP on AHA Twinning Scheme","authors":"P. M. D. Santos, R. O’Caoimh, A. Svendrovski, C. Casanovas, F. Pernas, M. Illario, W. Molloy, Constança Paúl","doi":"10.14273/UNISA-2720","DOIUrl":"https://doi.org/10.14273/UNISA-2720","url":null,"abstract":"As populations age and the prevalence of cognitive impairment increases, healthcare professionals and researchers require short, validated cognitive screening instruments (CSIs). As part the EIP-on-AHA Twinning Support Scheme (2016), four reference sites developed the RAPid COmmunity COGnitive screening Programme (RAPCOG) twinning project to validate translated versions of the Quick Mild Cognitive Impairment (Qmci) screen that could be adapted quickly for use with future eHealth screening and assessment programmes. Here we present the cultural adaption and translation of the Qmci-Portuguese (Qmci-P) screen as part of RAPCOG and explore its subsequent validation against two commonly-used CSIs (MMSE-P and MoCA-P) with 93 participants aged ≥65, attending ten day care centres or resident in two long-term care institutions; median age 74 (+/−15), 66% female. The Qmci-P’s internal consistency was high (Cronbach’s Alpha 0.82), compared with the MoCA (0.79) and SMMSE (0.54). Qmci-P screen scores moderately correlated with the SMMSE (r=0.61, 95% CI:0.45–0.72, p<0.001) and MoCA (r=0.63, 95% CI:0.36–0.80, p<0.001). The Qmci-P screen demonstrates high internal consistency and concurrent validity against more established CSIs and given its brevity (3–5mins), may be preferable for use in community settings. This project shows the potential of the EIP-on-AHA Twinning initiative to promote the scaling-up of innovative good practices.","PeriodicalId":54170,"journal":{"name":"Translational Medicine at UniSa","volume":"19 1","pages":"82 - 89"},"PeriodicalIF":1.5,"publicationDate":"2019-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41465329","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. Peluso, D. Turchino, A. Petrone, A. Giribono, R. Bracale, L. del Guercio, U. Bracale
{"title":"Standard Carotid Endarterectomy versus Carotid Artery Stenting with Closed-Cell Stent Design and Distal Embolic Protection: does the age matter?","authors":"A. Peluso, D. Turchino, A. Petrone, A. Giribono, R. Bracale, L. del Guercio, U. Bracale","doi":"10.14273/UNISA-2722","DOIUrl":"https://doi.org/10.14273/UNISA-2722","url":null,"abstract":"Carotid artery endarterectomy (CEA) is considered the gold standard for treatment of symptomatic and asymptomatic carotid disease. Carotid artery stenting (CAS) is a less invasive approach and therefore could be considered a viable alternative to CEA, especially in high-risk patients or those with relative contraindications to CEA (i.e. actinic stenosis, post-CEA restenosis, previous neck or tracheostomy surgery, contralateral laryngeal nerve paralysis, etc.). Methods The aim of this study is to evaluate the short- and medium-term outcomes of CAS performed with a single type of closed-cell stent design and distal filter protection by comparing the procedure with CEA based upon 3 endpoints: overall survival rate, stroke free survival rate and restenosis free survival rate. The same endpoints were also evaluated in 2 different age groups, more and less than 70 years, to show possible age-based differences on outcomes. Among 105 patients (77 males, 28 females), 74 were submitted to CEA and 31 were subject to CAS. In all cases the same self-expanding stent with closed-cell design (XACT Carotid Stent, Abbott Vascular) and the same distal embolic protection device (Emboshield NAV, Abbott Vascular) were employed. Results At 12 months, no statistically significant difference was observed in overall survival rates (CEA 93.2% vs CAS 93.5%, p=0.967) and restenosis free survival rates (CEA 94.5% vs CAS 96.8%, p=0.662). An increased stroke free survival rate was observed in the CEA group when compared to the CAS group (CEA 100.0% vs CAS 93.5%, p=0.028). The age-based endpoints didn’t show any significant difference. Conclusion These results suggest that CEA still remains the gold standard of treatment for carotid stenosis given its greater efficacy in the prevention of stroke CAS. However, CAS could be considered as an alternative treatment to CEA to be used in select cases only.","PeriodicalId":54170,"journal":{"name":"Translational Medicine at UniSa","volume":"19 1","pages":"60 - 65"},"PeriodicalIF":1.5,"publicationDate":"2019-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42276369","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
C Dantas, W van Staalduinen, A Jegundo, J Ganzarain, M Van der Mark, F Rodrigues, M Illario, V De Luca
{"title":"Smart Healthy Age-Friendly Environments - Policy Recommendations of the Thematic Network <i>SHAFE</i>.","authors":"C Dantas, W van Staalduinen, A Jegundo, J Ganzarain, M Van der Mark, F Rodrigues, M Illario, V De Luca","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The European Commission (DG SANTE) launched a call for proposals in November 2017 on strategic initiatives for a Joint Statement in 2018. Ten proposals were voted until December 7th in the European Union Health Policy Platform[1]; the proposal under the theme <i>Smart Healthy Age-Friendly Environments</i> (SHAFE)[2] was the most voted and was confirmed by the European Commission in March 2018. In this context, since March 2018, Cáritas Coimbra and AFEdemy Ltd are thus coordinating one of the three Thematic Networks for 2018, SHAFE, in close cooperation with main partners, such as the European Innovation Partnership on Active and Healthy Ageing (EIP-AHA), the European Innovation Partnership on Smart Cities and Communities (EIP-SCC), the Reference Sites Collaborative Network, the European Covenant on Demographic Change, Eurocities, the European Health Telematics Association (EHTEL), the European Connected Health Alliance (ECHAlliance), the European Construction, Built Environment and Energy Efficient Building Technology Platform (ECTP) and the European Centre for Social Welfare Policy and Research. SHAFE aims to facilitate the creation of healthy and friendly environments for all ages through the use of new technologies, towards the production of a comprehensive and participatory Joint Statement. This document was presented to the European Commission on 12 November 2018, with five main areas of recommendations to the EC, Member States and other local, regional and national organisations and is open for endorsement and implementation from this date onwards.</p>","PeriodicalId":54170,"journal":{"name":"Translational Medicine at UniSa","volume":"19 ","pages":"103-108"},"PeriodicalIF":1.5,"publicationDate":"2019-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6581501/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41220040","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M Illario, E Coscioni, V De Luca, M Cataldi, A Postiglione, G Iaccarino
{"title":"Editorial: Multi-Actor Collaboration in Healthcare to Address the Emerging Health Needs of an Aging Population.","authors":"M Illario, E Coscioni, V De Luca, M Cataldi, A Postiglione, G Iaccarino","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":54170,"journal":{"name":"Translational Medicine at UniSa","volume":"19 ","pages":"1-4"},"PeriodicalIF":1.1,"publicationDate":"2019-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6581499/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141749755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}