Translational Medicine at UniSa最新文献_第9页

Evidence on the Need for an Integrated Approach to the Management of Diabetes: The Diagnostic Perspective if Osteomyelitis is Suspected. 需要综合方法来管理糖尿病的证据:如果怀疑骨髓炎的诊断观点。

IF 1.5

Translational Medicine at UniSa Pub Date : 2020-02-20 eCollection Date: 2020-01-01

B R Saleem

引用次数: 0

Focusing on Diabetic Ulcers. 关注糖尿病溃疡。

IF 1.5

Translational Medicine at UniSa Pub Date : 2020-02-20 eCollection Date: 2020-01-01

C Setacci, D Benevento, G De Donato, E Viviani, U M Bracale, L Del Guercio, G Palasciano, F Setacci

引用次数: 0

A Single-Center Experience on Below-The-Knee Endovascular Treatment in Diabetic Patients. 糖尿病患者膝下血管内治疗的单中心经验。

IF 1.5

Translational Medicine at UniSa Pub Date : 2020-02-20 eCollection Date: 2020-01-01

E Dinoto, F Pecoraro, D Mirabella, F Ferlito, A Farina, N Lo Biundo, P Orlando-Conti, G Bajardi

{"title":"A Single-Center Experience on Below-The-Knee Endovascular Treatment in Diabetic Patients.","authors":"E Dinoto, F Pecoraro, D Mirabella, F Ferlito, A Farina, N Lo Biundo, P Orlando-Conti, G Bajardi","doi":"","DOIUrl":"","url":null,"abstract":"Diabetic ulceration of the foot is a major global medical, social and economic problem and is the most frequent end-point of diabetic complications. A retrospective analysis from February 2017 to May 2019 of diabetic patients presenting below-the-knee artery disease (PAD) was carried out. Only patients treated with endovascular techniques as first choice treatment were evaluated. Outcome measured was perioperative mortality and morbidity. Freedom from occlusion, secondary patency and amputation rate were all registered. Additional maneuvers including stenting or angioplasty with drug eluting balloon (DEB) were reported. A total of 167 (101 male/66 female) patients with a mean age of 71 years were included in the study. A Rutherford 3, 4, 5 and 6 categories were reported in 5, 7, 110 and 45 patients, respectively. No perioperative mortality was reported. Morbidity occurred in 4 (4.4%) cases and consisted of pseudoaneurysm. Additional stenting during first procedure was required in 7 (4%) patients, drug eluting balloon was needed in 56 (33%) patients. At 1-year follow-up, estimated freedom from occlusion and secondary patency was 70% and 80% respectively. Major amputation rate was 2.4%, minor amputation rate was 41.9%. In our experience, extreme revascularization in search of distal direct flow reduce the rate of amputations with an increase in ulcer healing. New materials and techniques such as drug eluting technology, used properly, can improve outcome.","PeriodicalId":54170,"journal":{"name":"Translational Medicine at UniSa","volume":null,"pages":null},"PeriodicalIF":1.5,"publicationDate":"2020-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7039268/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37698818","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Influence of Diabetes Mellitus on the Outcome of Superficial Femoral Artery Recanalization is Debatable 糖尿病对股浅动脉再通术结果的影响值得商榷

IF 1.5

Translational Medicine at UniSa Pub Date : 2020-02-20 DOI: 10.14273/UNISA-2809

L. Rizzo, A. D'andrea, N. Stella, P. Orlando, M. Taurino

{"title":"The Influence of Diabetes Mellitus on the Outcome of Superficial Femoral Artery Recanalization is Debatable","authors":"L. Rizzo, A. D'andrea, N. Stella, P. Orlando, M. Taurino","doi":"10.14273/UNISA-2809","DOIUrl":"https://doi.org/10.14273/UNISA-2809","url":null,"abstract":"Notwithstanding technological improvements in endovascular devices treatment of steno-obstructive lesions of the superficial femoral artery (SFA) remains a challenge for today’s vascular surgeon. Current opinion dictates that the diabetic population may have worse outcome after revascularization of the lower extremities. Herein we examine the effects of endovascular treatment on steno-obstructive lesions of the SFA in diabetic and non-diabetic patients. Methods A retrospective analysis was carried out on 110 patients who had undergone endovascular treatment of the SFA from 2010 to 2017 comparing outcomes in diabetic (DM) vs non-diabetic patients (nDM). Results 56 (50.9%) of the patients were diabetic and 54 were non-diabetic (49.1%). 52.7% (62.7% DM vs 35.2% nDM, p = 0.0003) were patients with critical limb ischemia. SFA occlusion was present in 65.5% (60.7% DM vs 70.4% nDM, p = 0.29) of all patients. All had undergone PTA of the SFA and 40.9% had received adjunctive stenting (44.6% DM vs 37.0% nDM, p = 0.41). A multilevel treatment was executed in 39.1% (51.8% DM vs 25.9% nDM) of the cases whereas an infra-popliteal procedure was associated in 27.3% (37.5% DM vs 16.7% nDM). In both groups the presence of diabetes was significantly associated (p = 0.005 e p = 0.014, respectively). Reintervention rate was 22.7%; 13 in the diabetic group (23.2%) and 12 in the non-diabetic group (22.2%). Of those who had had reintervention (p = 0.77); 9 patients (8.2%) had undergone an open surgical operation, 6 of whom had diabetes (p = 0.32). 5 patients (4.5%) had had major amputation, 4 of whom were diabetic (p = 0.20). Curves assessing freedom from target lesion restenosis were substantially overlapping between the two groups. Conclusion No statistical associations between diabetes and reintervention or amputation rates were found. Indication to treat the SFA were not influenced by the presence of diabetes but further investigation is required to verify our hypothesis.","PeriodicalId":54170,"journal":{"name":"Translational Medicine at UniSa","volume":null,"pages":null},"PeriodicalIF":1.5,"publicationDate":"2020-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45043141","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Early Results of Mechanochemical Ablation with Flebogrif® in great Saphenous Vein Insufficiency: does Polidocanol Concentration Affect Outcome? Flebogrif®机械化学消融治疗大隐静脉功能不全的早期结果:聚多坎醇浓度是否影响预后?

IF 1.5

Translational Medicine at UniSa Pub Date : 2020-02-20 eCollection Date: 2020-01-01

R P Ammollo, A Petrone, A M Giribono, L Ferrante, L Del Guercio, U M Bracale

{"title":"Early Results of Mechanochemical Ablation with Flebogrif® in great Saphenous Vein Insufficiency: does Polidocanol Concentration Affect Outcome?","authors":"R P Ammollo, A Petrone, A M Giribono, L Ferrante, L Del Guercio, U M Bracale","doi":"","DOIUrl":"","url":null,"abstract":"Background: Flebogrif® (Balton, Poland) is a novel mechanochemical ablation (MOCA) device for saphenous vein insufficiency. It combines endothelial damage performed by radial retractable cutting hooks together with chemical ablation through sclerosant injection of 3% polidocanol foam according to its IFU. The objective of this study is to evaluate Flebogrif's efficacy in terms of recanalization rate and recurrence by varying polidocanol foam concentrations.Methods: We performed 24 MOCAs on 23 patients with Flebogrif® between January and May 2019. In 12 cases the polidocanol foam was prepared at a 3% concentration, and in another 12 at 1.5%. Great saphenous vein (GSV) recanalization and truncular recurrence were evaluated at 1 and 3 months with a Duplex Ultrasound Anatomy (DUS) examination.Results: At 1- and 3-month follow-ups, none of the 14 patients treated with the polidocanol 3% foam were observed to have had great saphenous vein GSV recanalization and truncular recurrence. Only 2 of the 14 (14.3%) cases treated with polidocanol 1.5% foam showed evidence of recanalization within the first centimetres from the sapheno-femoral junction (p > .05). All patients experienced clinical benefits without recurrence of symptoms.Conclusion: MOCA with Flebogrif® is a safe, relatively inexpensive and effective alternative to standard methods in the treatment of saphenous insufficiency with encouraging short-term results. Despite our relatively small patient sample, no statistical significance in evidence of recurrence in the group of patients treated with 3% foam and those treated with 1.5% foam was noted. Longer term analysis of GSV patency and recurrence is necessary to further evaluate Flebogrif's impact and actual indications in the treatment of chronic venous disease.","PeriodicalId":54170,"journal":{"name":"Translational Medicine at UniSa","volume":null,"pages":null},"PeriodicalIF":1.5,"publicationDate":"2020-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7039266/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37698715","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Digital Innovation in Healthcare: A Device with A Method for Monitoring, Managing and Preventing the Risk of Chronic Polypathological Patients. 医疗保健中的数字创新:一种具有监测、管理和预防慢性多病理患者风险方法的设备。

IF 1.5

Translational Medicine at UniSa Pub Date : 2020-02-20 eCollection Date: 2020-01-01

G Improta, V De Luca, M Illario, M Triassi

引用次数: 0

Harmonic Focus Versus Conventional Electrocautery for Femoral Artery Exposure: a "Direct" Comparison on the Same Patients. 谐波聚焦与传统电灼对股动脉暴露:同一患者的“直接”比较。

IF 1.5

Translational Medicine at UniSa Pub Date : 2020-02-20 eCollection Date: 2020-01-01

M Maisto, L Ferrante, A M Giribono, M Sodo, M Panagrosso, A Peluso, L Del Guercio, U M Bracale

{"title":"Harmonic Focus Versus Conventional Electrocautery for Femoral Artery Exposure: a \"Direct\" Comparison on the Same Patients.","authors":"M Maisto, L Ferrante, A M Giribono, M Sodo, M Panagrosso, A Peluso, L Del Guercio, U M Bracale","doi":"","DOIUrl":"","url":null,"abstract":"Surgical access complications during endovascular aneurysm repair (EVAR) are reported relatively frequent. HARMONIC FOCUS® (HF; Ethicon Endo-Surgery Inc., Cincinnati, Ohio, USA) is a device developed to improve bleeding control and reduce heat-related damage stemming from surgical preparation. The aim of this study was to evaluate outcomes and safety of HF versus conventional haemostasis with electrocautery, both techniques used in the same patient. Five patients developed bilateral wound's thickening (13.9%) demonstrated at the CT scan, two of whom had no clinical manifestation while in three cases the thickening was associated with lymphocele (4.54%), 2 of which were in the side where the EC was used (5.5%), and 1 case (2.7%), in the HF applied side. One isolated lymphocele occurred at the left groin (2.7%) (tables n.2-3). A Fisher's exact test was conducted between EC and HF on the occurrence of wound healing complications (3/36 for EC and 1/36 for HF) that resulted statistically significant at p<0.05. Focus Harmonic Scalpel has certain advantages than conventional haemostasis in avoiding surgical access complications.","PeriodicalId":54170,"journal":{"name":"Translational Medicine at UniSa","volume":null,"pages":null},"PeriodicalIF":1.5,"publicationDate":"2020-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7039272/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37698817","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Withholding and withdrawing in real life. 现实生活中的克制和退缩。

IF 1.5

Translational Medicine at UniSa Pub Date : 2019-01-20 eCollection Date: 2018-11-01

O Piazza

引用次数: 0

Treatment of de novo femoro-popliteal lesions with a new Drug Coated Balloon: early experience of a single Center in the first 50 patients. 新型药物包覆球囊治疗新发股腘窝病变:前50例单中心患者的早期经验

IF 1.5

Translational Medicine at UniSa Pub Date : 2019-01-20 eCollection Date: 2018-11-01

U M Bracale, M Di Filippo, A De Capua, L Vanni, D Narese, F Pecoraro, A M Giribono, R Bracale

{"title":"Treatment of de novo femoro-popliteal lesions with a new Drug Coated Balloon: early experience of a single Center in the first 50 patients.","authors":"U M Bracale, M Di Filippo, A De Capua, L Vanni, D Narese, F Pecoraro, A M Giribono, R Bracale","doi":"","DOIUrl":"","url":null,"abstract":"Angioplasty with drug-coated balloon (DCB) is an emerging and reliable method for the treatment of femoro-popliteal lesions. We report our experience with the Stellarex™ DCB in the first 50 patients.Methods: From July 2015 to November 2017, 50 patients (41 M, 9F), medium age (64 ± 7.4 year) were subject to 33 angioplasties (PTAs) for femoro-popliteal lesions with a paclitaxel-coated balloon (Stellarex™). Based upon clinical data sixteen patients had severe claudication (56% - Rutherford class 3); ten patients suffered from ischemic rest pain (34% - Rutherford class 4); and five presented minor tissue loss (10% - Rutherford class 5). 42% of patients showed femoro-popliteal lesion TASC-II B, and 58% presented lesions pertaining to TASC-II C.Results: Immediate technical success was 100% without perioperative complications. Primary patency rate was 94% at twelve months. In three cases restenosis (6%) was detected within a year from procedure, and a further PTA DCB was performed with primary assisted patency rates of 100% at twelve months. Two patients underwent major lower limb amputation. Three patients died during follow-up and one patient was lost at follow-up.Conclusion: DCB angioplasty with Stellarex™ is a viable alternative to traditional endovascular procedures proving satisfactory primary patency rates at twelve months. Based on our experience, treatment with DCB is a first choice technique for non-complex de novo lesions of the femoro - popliteal tract.","PeriodicalId":54170,"journal":{"name":"Translational Medicine at UniSa","volume":null,"pages":null},"PeriodicalIF":1.5,"publicationDate":"2019-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6350779/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36973419","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Errata corrige. 勘误表。

IF 1.5

Translational Medicine at UniSa Pub Date : 2019-01-20 eCollection Date: 2018-11-01

引用次数: 0