HIV & AIDS Review最新文献

{"title":"Infective endocarditis caused by Brucella melitensis in an HIV-positive patient","authors":"H. S. N. Setty, A. Trivedi, J. Kharge, Sathwik Raj, Phani Teja Mundru, Santhosh Jadav, Y. M. Channabasappa, S. Shankar, T. R. Raghu, R. Patil, C. Manjunath","doi":"10.5114/HIVAR.2021.107241","DOIUrl":"https://doi.org/10.5114/HIVAR.2021.107241","url":null,"abstract":"Introduction: Cardiac complications are becoming more critical in patients with human immunodeficiency virus (HIV) infection. The risk of infectious complications in HIV-positive patients has decreased with the availability of highly active antiretroviral therapy, but remains high in developing countries, such as India. HIV patients are at increased risk for recurrent bacterial infections due to acquired immune suppression. Case presentation: We describe a case of a 45-year-old HIV-infected male, on antiretroviral therapy for 4 years, with invasive endocarditis. On admission, his CD4+ count was 274 cells/μl. The patient was hemodynamically stable on arrival and was in congestive heart failure. Pallor was present with no peripheral signs of infective endocarditis. 2D echocardiogram revealed vegetations on the tips of anterior and posterior leaflets of the mitral valve, severe mitral regurgitation, and moderate tricuspid regurgitation. Blood culture was positive for Brucella melitensis . The patient recovered without any sequel after six weeks of antibiotic therapy (gentamycin intravenously + rifampicin p.o.). The patient remains under regular follow-up. Conclusions: Brucellosis in general is a difficult diagnosis to make. Therefore, along with diagnosis, treatment is also delayed leading to devastating outcomes. Cardiac involvement occurs in only 2% of cases but accounts for 80% of mortality due to brucellosis. Brucella endocarditis should be suspected in HIV patients with endocarditis, who have negative blood cultures and risk of exposure. The most accepted treatment for B. endocarditis is a combination of anti-microbial therapy with surgery.","PeriodicalId":53943,"journal":{"name":"HIV & AIDS Review","volume":null,"pages":null},"PeriodicalIF":0.2,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80531050","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence of HIV infection among female sex workers in the Eastern Mediterranean Region countries: a systematic review","authors":"L. Abedi, N. Khanjani, H. Sharifi","doi":"10.5114/hivar.2021.111233","DOIUrl":"https://doi.org/10.5114/hivar.2021.111233","url":null,"abstract":"Introduction: Female sex workers (FSWs) are one of the groups most affected by human immunodeficiency virus (HIV) infection. In Eastern Mediterranean (EM) countries, HIV prevalence among FSWs is often extremely high. However, no review has been conducted on FSWs in EM countries. The purpose of this systematic review was to estimate the prevalence of HIV infection among FSWs in EM countries. Material and methods: Articles published on the prevalence of HIV infection among FSWs in EM countries were searched until September 10, 2020. Appropriate keywords were used in Web of Science, Scopus, PubMed, EMBASE, Ovid, and IMEMER databases. References of each paper and conference abstracts were additionally searched. Papers were selected according to inclusion and exclusion criteria. Results: In total, 21 studies were selected, which were performed in 8 EM countries. The reported prevalence of HIV infection ranged from 0 to 16% among FSWs. The average time women worked as FSWs ranged from 2 to 6 years, and in some papers, FSWs never or rarely used condoms during sexual contact. However, the consistency of using condoms among FSWs was reported as high as 65% in Pakistan, 64% in Lebanon, and 62% In Iran. The prevalence of drug use was high among FSWs, and it ranged from 5% in Pakistan and Sudan, to 91% in Iran and 96.2 % in Egypt. Heterogeneity among the studies and sub-groups was very high, and meta-analysis was not done due to high heterogeneity. Conclusions: The reported prevalence of HIV infection varied differently among female sex workers’ populations in the Eastern Mediterranean Region. More studies are needed from different EM countries.","PeriodicalId":53943,"journal":{"name":"HIV & AIDS Review","volume":null,"pages":null},"PeriodicalIF":0.2,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90920976","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Contributory factors that lead to increase of mother-to-child transmission of HIV in Capricorn district of Limpopo Province, South Africa","authors":"D. Ramathuba, Maria R. Ramashala, N. Mashau","doi":"10.5114/HIVAR.2021.105111","DOIUrl":"https://doi.org/10.5114/HIVAR.2021.105111","url":null,"abstract":"Introduction: Mother-to-child transmission (MTCT) of human immunodeficiency virus (HIV) remains the most prevalent source of pediatric HIV infections. The prevalence of HIV is high among South African women of reproductive age, and the transmission of HIV from mothers to children is a serious concern. The study explored contributory factors, which lead to an increase in mother-to-child transmission of HIV at selected clinics in Capricorn district of Limpopo Province. Material and methods: The study adopted a qualitative descriptive exploratory design to uncover factors leading to MTCT of HIV. The target population were professional nurses trained in primary healthcare. Purposive sampling technique was used to sample eighteen participants from Seshego Zone clinics in Capricorn district. Unstructured interviews were conducted and audio-recorded. The transcribed data was analyzed using Tesch’s’ method of data analysis, and presented in themes and sub-themes. Ethical considerations were ensured throughout the study as well as trustworthiness of findings. Results: The study revealed that poor socio-economic status, traditional and religious beliefs, and lack of knowledge of patients were the major factors contributing to an increase of MTCT of HIV as well as system-related factors. However, the study indicated high knowledge about MTCT and HIV among the nurses. Conclusions: The study revealed that patient-related factors cause high prevalence of MTCT of HIV. For community health awareness, it is highly recommended to encourage women to abandon their beliefs in order to promote PMTCT.","PeriodicalId":53943,"journal":{"name":"HIV & AIDS Review","volume":null,"pages":null},"PeriodicalIF":0.2,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86854014","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationship between stigma and health-related quality of life in patients diagnosed with HIV","authors":"Susana Barradas, C. Finck","doi":"10.5114/hivar.2021.108786","DOIUrl":"https://doi.org/10.5114/hivar.2021.108786","url":null,"abstract":"Introduction: Human immunodeficiency virus (HIV) epidemic is one of the main problems in public health, and health-related quality of life (HRQoL) is usually negatively affected. Stigma is one of the factors related to a lower HRQoL. Material and methods: We aimed to assess this relationship, and felt stigma was measured using HIV felt stigma scale, while HRQoL was measured with EORTC QLQ-C30. We interviewed 140 patients, and 10.9% of our respondents reported feeling severe stigma, 25.4% moderate stigma, 26.1% mild stigma, and 37.7% absence of stigma. Results: Average score for overall HRQoL was 83.3 (SD = 21.4). Higher levels of stigma were associated with lower levels of perceived global HRQoL (β = –0.32, p = 0.001). Moreover, higher levels of stigma were correlated with a lower physical function (β = –0.27, p = 0.005), role function (β = –0.28, p = 0.001), cognitive function (β = –0.30, p = 0.001), social function (β = –0.32, p = 0.001), and emotional function (β = –0.60, p < 0.001). Conclusions: Reducing felt stigma could help improve HRQoL in HIV-positive patients.","PeriodicalId":53943,"journal":{"name":"HIV & AIDS Review","volume":null,"pages":null},"PeriodicalIF":0.2,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84817443","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unusual occurrence of hemophagocytic lymphohistiocytosis in HIV-positive person with visceral leishmaniasis","authors":"I. Kooli, W. Marrakchi, A. Toumi, A. Aouam, Hammouda Baba, M. Chakroun","doi":"10.5114/hivar.2021.111899","DOIUrl":"https://doi.org/10.5114/hivar.2021.111899","url":null,"abstract":"Introduction: Visceral leishmaniasis is a well-recognized opportunistic infection in people living with HIV (PLHIV). Unlike adults, in children this infection is frequently associated with hemophagocytic lymphohistiocytosis (HLH). We report a case of HLH in HIV-positive person with visceral leishmaniasis. Case description: A 25-year-old man known living with HIV since 2013 was admitted to infectious diseases department in March 2017. His clinical examination was clear. His initial viral load was 630,000 copies/mm 3 and CD4+ cells count was 12/mm 3 . No opportunistic infections were noted. The patient was started on antiretroviral therapy. During hospitalization, he developed fever, asthe-nia, rhinorrhea, and odynophagia. The diagnosis of HLH was retained because of pancytopenia, cytolysis, hyponatremia, high level of ferrinemia, and hemophagocytosis. Etiological investigations revealed positive Leishmania PCR. Also, Leishmania was detected in sternal puncture. Patient received meglumine antimoniate (glucantime) 20 mg/kg/day for 21 days with favorable outcomes. To prevent relapse, he received meglumine antimoniate 20 mg/kg/month as long as his CD4+ count was less than 100 cells/mm 3 . After 1-year follow up, no relapse was detected. Conclusions: Clinical and laboratory presentation of visceral leishmaniasis in PLHIV may differ from classic kala-azar. In our case, HLH was the reason for VL discovery.","PeriodicalId":53943,"journal":{"name":"HIV & AIDS Review","volume":null,"pages":null},"PeriodicalIF":0.2,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88504504","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of social capital and AIDS health literacy with AIDS risk perception in adolescents","authors":"N. R. Gilan, S. Ghasemi, A. Mohamadi, M. Khezeli, F. Heydarpour, Shahab Bahrami","doi":"10.5114/HIVAR.2021.105112","DOIUrl":"https://doi.org/10.5114/HIVAR.2021.105112","url":null,"abstract":"Introduction: Human immunodeficiency virus (HIV) infection has become a major health challenge in recent decades. Poor health knowledge can lead to the faster transmission of HIV in the community. This study aimed to investigate the association of social capital and acquired immunodeficiency syndrome (AIDS) health literacy with AIDS risk perception in Iranian adolescents. Material and methods: This cross-sectional study was conducted with 354 high school students of Kermanshah city, the west part of Iran, selected by multi-stage sampling method. Respondents filled out social capital, HIV/AIDS health literacy, and AIDS risk perception questionnaires. Data were analyzed by SPSS-18 using Pearson correlation, regression, ANOVA, and independent t-tests. Results: The mean age of respondents was 17.02 ± 0.84 years. The results of independent t-test showed that girls had more scores in family social capital (p = 0.009) and school social capital domains (p = 0.001).There were a moderate and significant correlations between AIDS health literacy with family social capital (r = 0.178; p = 0.001) and AIDS risk perception (r = 0.317; p = 0.009). Also, regression analysis showed that 12.1% of variations in AIDS risk perception were explained by several variables of the study. Conclusions: Considering the relationship between AIDS health literacy and social capital with AIDS risk perception, it can be concluded that the increased power of visual and written analysis and understanding of adolescents, along with cohesion, respect, trust, and mutual understanding in the family, can be a protective factor against HIV disease. HIV AIDS Rev 2021; 20, 1: 52-58 DOI: https://doi.org/10.5114/hivar.2021.105112","PeriodicalId":53943,"journal":{"name":"HIV & AIDS Review","volume":null,"pages":null},"PeriodicalIF":0.2,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71091077","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The relationship between social capital and mental health in individuals living with HIV in North of Iran","authors":"F. Bakhshi, Fatemeh Nezamdust, E. K. Leili","doi":"10.5114/HIVAR.2021.105110","DOIUrl":"https://doi.org/10.5114/HIVAR.2021.105110","url":null,"abstract":"Introduction: Social capital, as one of the determinants of health, has a significant role on mental health of people especially chronic patients. This study aimed to investigate the relationship between mental health and social capital in HIV patients in North of Iran. Material and methods: In this cross-sectional study, 49 persons with HIV referred to the consultation center of welfare organization in 2017 were included. Social capital of participants was measured by Bullen's social capital scale. Mental health questionnaire (GHQ-28) was used to determine the condition of mental health. Data were analyzed with SPSS 21 software. Pearson’s correlation and regression analysis were applied to investigate the relation between variables. Results: The mean score was 59.2 ± 13.3 for social capital and 31.4 ± 12.2 for mental health. There was a significant relationship between the total score of social capital with better economic condition (p = 0.01, r = 0.33), lower duration of illness (p = 0.001, r = 0.47), and having insurance (p = 0.007, r = 0.38). The correlation between variables showed a negative and significant relationship between dimensions of feeling of trust and safety (r = –0.45, p = 0.002), activity in a social context (r = –0.41, p = 0.004), and value of life (r = –0.81, p = 0.001) with mental health. Conclusions: According to the study results, with increasing attention to health determinants and social capital as one of the international principles of health, mental health of people with AIDS should be promoted. HIV AIDS Rev 2021; 20, 1: 33-38 DOI: https://doi.org/10.5114/hivar.2021.105110","PeriodicalId":53943,"journal":{"name":"HIV & AIDS Review","volume":null,"pages":null},"PeriodicalIF":0.2,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71091463","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Perceived knowledge, attitude towards HIV/AIDS, and sexual behavior among migrant workers in Malaysia: a structural path analysis","authors":"Mizanur Rahman, M. Arif, R. Safii, Z. Tambi, Zulkifli Jantan, Mohd Fahmi Ismail","doi":"10.5114/hivar.2021.109631","DOIUrl":"https://doi.org/10.5114/hivar.2021.109631","url":null,"abstract":"","PeriodicalId":53943,"journal":{"name":"HIV & AIDS Review","volume":null,"pages":null},"PeriodicalIF":0.2,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74243817","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationship of oral candidiasis with salivary lysozyme and lactoferrin in HIV-positive patients: a systematic review","authors":"P. Motahari","doi":"10.5114/HIVAR.2021.105091","DOIUrl":"https://doi.org/10.5114/HIVAR.2021.105091","url":null,"abstract":"Oral candidiasis is one of the main consequences of human immunodeficiency virus (HIV) infection. Saliva contains proteins that play a key role in the health of oral cavity. The aim of this review study was to investigate the relationship of oral candidiasis with salivary lysozyme and lactoferrin in patients with HIV infection. In this systematic review study, all articles with English abstract were searched with the keywords of “Oral Candidiasis” or “Candida” and “Saliva” and “HIV” or “AIDS” and “Lysozyme” and “Lactoferrin” from the Google Scholar, PubMed, Web of Science, Cochrane, and Scopus databases from 1990 until April 2020. Amongst the 16 articles obtained after reviewing the abstracts, 13 appropriate articles were included in this study. In 11 studies, the relationship between salivary lactoferrin and oral candidiasis was investigated, 54% of which showed an increase in salivary lactoferrin in HIV-positive patients with candidiasis. Eight studies examined the relationship between salivary lysozyme and oral candidiasis, 63% of which showed no association. Understanding numerous factors and conditions involved in candida cloning would be broadly related to increasing our understanding of fungal pathogenesis and host defense factors. The results of our study could be useful in diagnosing and designing new strategies for the prevention and treatment of fungal infections in HIV-positive patients. In addition to anti-fungal properties, non-toxicity to human cells could lead to lactoferrin being used in the future as a drug to prevent and treat fungal infections in patients with immunity difficulties. HIV AIDS Rev 2021; 20, 1: 17-20 DOI: https://doi.org/10.5114/hivar.2021.105091","PeriodicalId":53943,"journal":{"name":"HIV & AIDS Review","volume":null,"pages":null},"PeriodicalIF":0.2,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76813311","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Causes and predictors of hospitalization \u0000and in-hospital mortality among HIV/AIDS \u0000patients on highly active antiretroviral \u0000therapy in secondary and tertiary care \u0000hospitals in Oromia Regional State: \u0000multi-center cross-sectional study","authors":"G. Umeta, Legese Chelkeba, Gosaye Mekonen Tefera, Kemal Jemal, K. K. Goro","doi":"10.5114/HIVAR.2021.107236","DOIUrl":"https://doi.org/10.5114/HIVAR.2021.107236","url":null,"abstract":"Introduction: Highly active antiretroviral therapies (HAART) decrease the incidence, morbidity, and mortality of acquired immunodeficiency syndrome (AIDS) dramatically. However, current research reported an increased hospitalization rate among AIDS patients. Therefore, this study aimed to determine causes and predictors of hospital admission as well as in-hospital mortality amongst human immunodeficiency virus (HIV)/AIDS-infected patients on HAART. Material and methods: This was a multi-center cross-sectional study, and included HIV/AIDS patients who were admitted to secondary and tertiary care hospitals in Oromia Regional State from May 1, 2017, to August 30, 2017. Data were collected from hospitalized HIV/AIDS patients using structured checklist and interview. Results were analyzed with Statistical Package for Social Sciences (SPSS) software, version 22. Bivariate and multivariable logistic regression analysis were performed to evaluate association, and p-value < 0.05 was used to determine relationship between dependent and independent variables. Results: Out of 171 participants enrolled, 105 (61%) were hospitalized due to opportunistic infections. Age ranged from 40 to 49 (AOR = 0.30; 95% CI: 0.09-0.98%) vs. 18-29, females (AOR = 2.41; 95% CI: 1.11-5.24%), CD4+ count less than 200 (AOR = 10.32; 95% CI: 3.49-30.52%), and poor adhered (AOR = 2.78; 95% CI: 1.21-6.41%) were significantly related to hospitalization with opportunistic infections (AIDS-related illnesses). Among admitted patients, 20 (11.7%) died in hospital. Poorly adherent patients and those who spent 9 days or more in hospital were more exposed to in-hospital death, with AOR = 3.093; 95% CI: 1.012-9.453% and AOR = 4.533; 95% CI: 1.371-14.985%, respectively. Conclusions: The major causes of hospitalization were HIV/AIDS-related illnesses. Adherence to the HIV drug regimen is warranted to minimize hospitalization with opportunistic infections and HIV/AIDS mortality. HIV AIDS Rev 2021; 20, 2: 102-108 DOI: https://doi.org/10.5114/hivar.2021.107236","PeriodicalId":53943,"journal":{"name":"HIV & AIDS Review","volume":null,"pages":null},"PeriodicalIF":0.2,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82250503","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}