Qatar Medical JournalPub Date : 2026-06-29eCollection Date: 2026-01-01DOI: 10.5339/qmj.2026.45
Sidra German, Daniya Tarique, Tajammul Waqar, Sajid Islam Bhatti, Huda Raja, Labiqa Khowaja
{"title":"Pregnancy-associated dense deposit disease with neurological complications caused by Salmonella Typhi: A case report.","authors":"Sidra German, Daniya Tarique, Tajammul Waqar, Sajid Islam Bhatti, Huda Raja, Labiqa Khowaja","doi":"10.5339/qmj.2026.45","DOIUrl":"10.5339/qmj.2026.45","url":null,"abstract":"<p><strong>Background: </strong>Membranoproliferative glomerulonephritis (MPGN) is an uncommon cause of renal dysfunction and is increasingly being reclassified into immune complex-mediated and complement-mediated forms. Infections, particularly in endemic regions, may act as disease triggers. Pregnancy further complicates renal pathology through physiological and immunological changes.</p><p><strong>Case presentation: </strong>We describe a 22-year-old pregnant woman presenting with generalized edema, proteinuria, and cola-colored urine. Renal biopsy revealed diffuse endocapillary proliferation with mesangial and capillary wall C3 deposition, consistent with immune complex-mediated MPGN, with ultrastructural features suggestive of dense deposit disease (DDD). During hospitalization, she developed fever, papilledema, and neurological deficits. Blood cultures grew <i>Salmonella</i> Typhi, and urine cultures isolated vancomycin-resistant <i>Enterococcus</i>. Targeted antimicrobial therapy improved systemic symptoms, while cyclosporine was initiated for persistent proteinuria.</p><p><strong>Discussion: </strong>This case report illustrates an atypical presentation of DDD during pregnancy, potentially triggered by typhoid fever and complicated by neurological involvement. It underscores the diagnostic challenges in resource-limited settings and the complex interplay among infection, complement dysregulation, and gestation.</p><p><strong>Conclusion: </strong>This case report illustrates an atypical presentation of MPGN during pregnancy, triggered by typhoid fever and complicated by multidrug-resistant infection and neurological involvement. The patient's renal and neurological symptoms improved with antibiotics and supportive care; however, the pregnancy resulted in intrauterine fetal demise at 28 weeks. Early recognition and multidisciplinary care were pivotal to maternal stabilization and fetal management.</p>","PeriodicalId":53667,"journal":{"name":"Qatar Medical Journal","volume":"2026 2","pages":"45"},"PeriodicalIF":0.0,"publicationDate":"2026-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13451941/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148698438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Qatar Medical JournalPub Date : 2026-06-29eCollection Date: 2026-01-01DOI: 10.5339/qmj.2026.48
Ahmad Fateh Khader, Abdulaziz Fahad A Samandar, Yousof Mohammad Shah
{"title":"Superonasal orbital traumatic neuroma mimicking a dermoid cyst in a young patient: A case report.","authors":"Ahmad Fateh Khader, Abdulaziz Fahad A Samandar, Yousof Mohammad Shah","doi":"10.5339/qmj.2026.48","DOIUrl":"10.5339/qmj.2026.48","url":null,"abstract":"<p><strong>Background: </strong>Orbital traumatic neuromas are rare lesions that can mimic common orbital pathologies, such as dermoid cysts, particularly in the superonasal region.</p><p><strong>Case presentation: </strong>A 17-year-old female presented with a long-standing, slowly enlarging superonasal orbital mass that had initially been diagnosed as a dermoid cyst. Computed tomography revealed a well-defined, non-enhancing extraconal lesion measuring approximately 3.1×1.5×1.3 cm with associated bone remodeling. Surgical excision revealed a solid, vascular lesion complicated by retrobulbar hemorrhage, which was promptly managed. Histopathological examination confirmed a traumatic neuroma.</p><p><strong>Conclusion: </strong>Traumatic neuroma can mimic a dermoid cyst and should be considered when intraoperative findings are atypical. Definitive diagnosis relies on histopathological examination.</p>","PeriodicalId":53667,"journal":{"name":"Qatar Medical Journal","volume":"2026 2","pages":"48"},"PeriodicalIF":0.0,"publicationDate":"2026-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13451943/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148698443","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Qatar Medical JournalPub Date : 2026-06-24eCollection Date: 2026-01-01DOI: 10.5339/qmj.2026.43
Engy Abdelhamed, Shajitha Thekke Veettil
{"title":"Lipoid proteinosis in a 36-year-old woman: An index case from Qatar.","authors":"Engy Abdelhamed, Shajitha Thekke Veettil","doi":"10.5339/qmj.2026.43","DOIUrl":"10.5339/qmj.2026.43","url":null,"abstract":"<p><strong>Background: </strong>Lipoid proteinosis (LP) is a rare autosomal recessive disorder caused by mutations in the extracellular matrix protein 1 (<i>ECM1</i>) gene. Reporting index cases is important for enhancing clinical recognition and understanding phenotypic variability.</p><p><strong>Case presentation: </strong>A 36-year-old woman presented with bilateral pruritic eyelid papules and long-standing hoarseness. Clinical examination revealed moniliform blepharosis, oral cobblestone plaques, and a broad tongue. Neuroimaging showed symmetrical calcifications in the medial temporal lobes. Fiberoptic laryngoscopy demonstrated an infantile larynx, an uncommon finding in LP. A positive family history and parental consanguinity supported the diagnosis. The patient declined genetic testing and neurological treatment despite experiencing a seizure episode and mood disturbances. Topical and systemic corticosteroids were ineffective. She continues ophthalmology follow-up but has discontinued dermatological and genetic care.</p><p><strong>Conclusion: </strong>This case highlights the classic features of LP, a potentially novel laryngeal finding, and emphasizes the need for early diagnosis and multidisciplinary management to address neurological and psychosocial complications.</p>","PeriodicalId":53667,"journal":{"name":"Qatar Medical Journal","volume":"2026 2","pages":"43"},"PeriodicalIF":0.0,"publicationDate":"2026-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13451945/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148698358","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The Impact of Artificial Intelligence on Women's Healthcare: A Systematic Review.","authors":"Saheed Akinola Shittu, Hanen Mrabet, Sufia Athar, Mohamed Ezzeldin Gaber, Tamara Alshdafat, Salwa Alrawaili, Parwaneh Shibani, Lolwa Alansari, Moayyad Younis","doi":"10.5339/qmj.2026.36","DOIUrl":"10.5339/qmj.2026.36","url":null,"abstract":"<p><strong>Background: </strong>Artificial intelligence (AI) is rapidly transforming healthcare delivery with substantial implications for women's health. This systematic review synthesizes current evidence on AI applications in women's healthcare, evaluates their contributions and limitations, and identifies key challenges for clinical implementation.</p><p><strong>Methods: </strong>A systematic analysis of peer-reviewed literature was conducted through database searches, including PubMed, Scopus, Web of Science and the Cochrane Library, focusing on AI applications in the Obstetrics and Gynecology domains.</p><p><strong>Results: </strong>The analysis reveals extensive AI development across obstetrics and gynecology subfields, particularly in obstetric imaging, fetal monitoring, gynecologic oncology, and predictive models for delivery outcomes. Both machine learning (59% of studies) and knowledge-based systems (38% of studies) are represented. Most publications (82%) represent preliminary work such as proof-of-concept algorithms or methods, with clinical validation remaining largely unreported. Key implementation challenges include limited external validation, ethical concerns, and the need for specialized clinician competencies.</p><p><strong>Conclusion: </strong>AI demonstrates significant potential to enhance diagnostic precision, personalized treatment, and support clinical decision-making in women's health. However, most applications remain investigational with substantial barriers to clinical translation. Future work should prioritize robust validation, standardized reporting, and interdisciplinary collaboration to realize AI's potential in women's healthcare.</p>","PeriodicalId":53667,"journal":{"name":"Qatar Medical Journal","volume":"2026 2","pages":"36"},"PeriodicalIF":0.0,"publicationDate":"2026-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13430817/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148671443","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Spontaneous splenic rupture as the first manifestation of chronic myeloid leukemia: A case report.","authors":"Albaraa Rustom, Zeinab Ibrahim, Yaman Alahmad, Omar Jamil, Rayan Mahgoub, Salman Mirza","doi":"10.5339/qmj.2026.47","DOIUrl":"10.5339/qmj.2026.47","url":null,"abstract":"<p><strong>Background: </strong>Spontaneous splenic rupture (SSR) is an uncommon life-threatening complication of chronic myeloid leukemia (CML); however, it rarely occurs as the initial presentation of the disease. A contrast-enhanced computed tomography (CT) scan is the preferred method for confirming the diagnosis. The definitive treatment is radical splenectomy.</p><p><strong>Case presentation: </strong>We report the case of a 37-year-old previously healthy man who presented to the Emergency Department with severe, vague abdominal pain and nausea of one day's duration. On physical examination, he had epigastric tenderness and palpable splenomegaly, while his vital signs were within the normal limits. Contrast-enhanced CT revealed massive splenomegaly and splenic rupture with active bleeding. Subsequently, the patient became hemodynamically unstable and required an urgent total splenectomy. Molecular cytogenetic tests showed abnormalities consistent with CML. The patient's condition gradually improved, and he was discharged home on the 10th postoperative day.</p><p><strong>Discussion: </strong>SSR typically occurs in patients with preexisting hematologic disorders or constitutional symptoms. This case is unique because the patient, who had no history of trauma, constitutional symptoms, or a known hematologic disorder, presented with massive splenomegaly and extremely elevated leukocytosis and was found to have undiagnosed CML. The patient's massive splenomegaly and abrupt splenic rupture highlight that SSR can occur even in the absence of classic B symptoms, posing significant diagnostic and management challenges. Timely multidisciplinary intervention is crucial, and thorough post-splenectomy care is essential.</p><p><strong>Conclusion: </strong>SSR as the initial manifestation of CML is an uncommon and unexpected clinical presentation. This case demonstrates that extreme leukocytosis and massive splenomegaly can precipitate splenic rupture in the absence of prodromal symptoms. Timely surgical intervention, comprehensive post-splenectomy care, and the prompt initiation of targeted therapy are indispensable for achieving optimal clinical outcomes, as demonstrated in our patient.</p>","PeriodicalId":53667,"journal":{"name":"Qatar Medical Journal","volume":"2026 2","pages":"47"},"PeriodicalIF":0.0,"publicationDate":"2026-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13451940/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148698476","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Qatar Medical JournalPub Date : 2026-06-23eCollection Date: 2026-01-01DOI: 10.5339/qmj.2026.39
Muhammad Asim, Essa Abdulla Abuhelaiqa, Hassan Ali Al Malki
{"title":"Breaking barriers: A decade-long institutional journey to sustain mandated living kidney-donor follow-up in Qatar.","authors":"Muhammad Asim, Essa Abdulla Abuhelaiqa, Hassan Ali Al Malki","doi":"10.5339/qmj.2026.39","DOIUrl":"10.5339/qmj.2026.39","url":null,"abstract":"<p><strong>Introduction: </strong>Living kidney donation is essential for expanding transplant opportunities, given the worldwide scarcity of deceased donor organs. Kidney donors experience a slight but detectable long-term increase in risks such as hypertension, diabetes, and end-stage kidney disease, making sustained follow-up essential. However, adherence to post-donation surveillance remains inconsistent worldwide.</p><p><strong>Methods: </strong>This descriptive evaluation included living kidney donors enrolled in Qatar's national follow-up program at Hamad Medical Corporation, implemented in January 2017. The program mandates nephrology follow-up at 1 and 6 months post-donation and annually thereafter, with standardized clinical and laboratory monitoring. Adherence rates from 2017 to 2024 were assessed against institutional benchmarks (>90%).</p><p><strong>Results: </strong>Of 349 registered donors nationwide, 233 donated after program implementation. Despite a fourfold increase in eligible donors between 2017 and 2024, 1- and 6-month follow-up rates remained near 100%, and annual adherence consistently exceeded 90% from 2020 onward. Compliance with the nephrologist-led review of clinical and laboratory data approached 100% among attendees. Sustained performance was temporally associated with system-level interventions, including coordinator-led outreach, structured process redesign, enhanced donor education, and continuous quality improvement initiatives. Follow-up rates also remained robust during the COVID-19 pandemic despite the transition to telephone-based consultations.</p><p><strong>Conclusion: </strong>A centralized, quality-driven national framework can achieve durable, high-level adherence to long-term follow-up among living kidney donors, even amid rapid program expansion. This scalable model provides a strong foundation for registry-based outcome monitoring and evidence-informed donor care.</p>","PeriodicalId":53667,"journal":{"name":"Qatar Medical Journal","volume":"2026 2","pages":"39"},"PeriodicalIF":0.0,"publicationDate":"2026-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13439641/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148680999","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Qatar Medical JournalPub Date : 2026-06-22eCollection Date: 2026-01-01DOI: 10.5339/qmj.2026.42
Mavia Najam, Zara Muhammad Nayyar, Omar Khyatt, Haris Iftikhar
{"title":"Catheter malposition leading to superior vena cava perforation: A rare but serious complication of hemodialysis access.","authors":"Mavia Najam, Zara Muhammad Nayyar, Omar Khyatt, Haris Iftikhar","doi":"10.5339/qmj.2026.42","DOIUrl":"10.5339/qmj.2026.42","url":null,"abstract":"<p><strong>Background: </strong>Central venous catheterization through the internal jugular vein is a standard procedure for hemodialysis access in end-stage renal disease (ESRD). Although generally safe, serious and life-threatening complications can occur.</p><p><strong>Case presentation: </strong>We present a rare case of superior vena cava (SVC) perforation during tunneled dialysis catheter (PermCath) insertion in a patient with chronic renal failure. The injury led to mediastinal hematoma, bilateral hemothoraces, and hemorrhagic shock, requiring emergency thoracotomy and surgical repair.</p><p><strong>Discussion: </strong>Perforation of the SVC is an exceptionally rare but critical complication of central venous catheterization. Early symptoms are often nonspecific, making diagnosis challenging. Imaging modalities such as ultrasonography and urgent computed tomography (CT) are vital for detecting extravascular catheter placement and associated mediastinal bleeding.</p><p><strong>Conclusion: </strong>Early recognition and coordinated management were crucial in stabilizing the patient. Following emergency thoracotomy and surgical repair, the patient achieved hemodynamic recovery and was successfully weaned from ventilatory support. This case highlights the importance of high clinical vigilance, appropriate imaging, and multidisciplinary coordination in the early recognition and management of catheter-related vascular injuries.</p>","PeriodicalId":53667,"journal":{"name":"Qatar Medical Journal","volume":"2026 2","pages":"42"},"PeriodicalIF":0.0,"publicationDate":"2026-06-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13439640/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148680927","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Qatar Medical JournalPub Date : 2026-06-22eCollection Date: 2026-01-01DOI: 10.5339/qmj.2026.46
Khaled Zammar, Omar Mohammed Alhatou, Abeer Safan, Majd Aboualrob, Mohammad Alhatou, Yahia Imam
{"title":"Large saccular aneurysms of the vertebrobasilar arteries with segmental chronic mural ectasia: A case report and review of management strategies.","authors":"Khaled Zammar, Omar Mohammed Alhatou, Abeer Safan, Majd Aboualrob, Mohammad Alhatou, Yahia Imam","doi":"10.5339/qmj.2026.46","DOIUrl":"10.5339/qmj.2026.46","url":null,"abstract":"<p><strong>Background: </strong>Large saccular aneurysms of the basilar artery associated with chronic mural ectasia are rare and difficult to manage because of their high risk of thrombus formation and rupture. We present a case that highlights the complexities involved in the diagnosis and treatment decision-making of this condition.</p><p><strong>Case presentation: </strong>A 54-year-old male with hypertension and ischemic cardiomyopathy presented to the Emergency Department via emergency medical services with confusion and unresponsiveness. Neuroimaging revealed a large basilar artery aneurysm with a mural thrombus and posterior circulation infarcts. Despite conservative management and planned angiography, the patient's condition rapidly deteriorated, and he was declared brain dead within 36 h.</p><p><strong>Discussion: </strong>This case underscores the difficulties associated with managing basilar artery aneurysms, particularly in patients with mural ectasia. It examines the rationale for the initial conservative treatment and evaluates the potential benefits of early endovascular intervention. Literature insights are integrated to explore the implications for vessel integrity, thromboembolic risk, and intervention timing.</p><p><strong>Conclusion: </strong>This case highlights the urgent need for standardized guidelines for the management of basilar artery aneurysms. Future research should focus on comparing surgical and endovascular approaches, assessing long-term aneurysm progression, and developing risk-based treatment protocols.</p>","PeriodicalId":53667,"journal":{"name":"Qatar Medical Journal","volume":"2026 2","pages":"46"},"PeriodicalIF":0.0,"publicationDate":"2026-06-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13451942/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148698427","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Three decades of tuberculosis research in Qatar (1993-2022): A scoping review and future direction.","authors":"Nahlah AlMesbah, Reshma Javed, Abid Saeed, Hamad Eid Al-Romaihi, Devendra Bansal, Iheb Bougmiza","doi":"10.5339/qmj.2026.38","DOIUrl":"10.5339/qmj.2026.38","url":null,"abstract":"<p><strong>Background: </strong>Tuberculosis (TB) remained the deadliest infectious disease in 2023, with 8.2 million newly diagnosed cases-the highest number recorded since 1995. In Qatar, the estimated TB incidence was 37 per 100,000 population in 2024. This review aimed to identify gaps in TB research conducted in Qatar and inform future research priorities.</p><p><strong>Methods: </strong>PubMed, Scopus, Web of Science, and the Cochrane Library were systematically searched using relevant Medical Subject Headings (MeSH) terms and keywords. Peer-reviewed original research articles on TB with data from Qatar published between 1993 and 2022 were included, while reviews and editorials were excluded.</p><p><strong>Results: </strong>Thirty-six studies met the inclusion criteria. Most were retrospective observational studies focusing on extrapulmonary TB and used nonprobability purposive sampling. The most common research theme was clinical and diagnostic research.</p><p><strong>Conclusion: </strong>Key research gaps include the evaluation of TB treatment, the epidemiology of drug-resistant TB, and delays in TB diagnosis. The absence of studies on pediatric TB highlights the need to prioritize this population. Strengthening TB research in Qatar will require dedicated funding and a focus on underexplored and high-priority areas.</p>","PeriodicalId":53667,"journal":{"name":"Qatar Medical Journal","volume":"2026 2","pages":"38"},"PeriodicalIF":0.0,"publicationDate":"2026-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13439643/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148680997","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Qatar Medical JournalPub Date : 2026-06-16eCollection Date: 2026-01-01DOI: 10.5339/qmj.2026.44
Muhammad Bilal Jamshaid, Afia Aziz, Huma Munir, Sarah Obiedat, Samir Alhyassat, Adel AlBozom, Basem Awadh, Samar AlEmadi
{"title":"Papillary thyroid carcinoma presenting as paraneoplastic acral vascular syndrome in a 37-year-old female: A case report.","authors":"Muhammad Bilal Jamshaid, Afia Aziz, Huma Munir, Sarah Obiedat, Samir Alhyassat, Adel AlBozom, Basem Awadh, Samar AlEmadi","doi":"10.5339/qmj.2026.44","DOIUrl":"10.5339/qmj.2026.44","url":null,"abstract":"<p><strong>Background: </strong>Paraneoplastic acral vascular syndrome is a rare condition associated with various malignancies, most commonly adenocarcinomas. It manifests as digital ischemia, including Raynaud's phenomenon, acrocyanosis, and digital gangrene. Reported cases typically show improvement after treatment of the underlying cancer. We describe the first known case of paraneoplastic acral vascular syndrome secondary to papillary thyroid carcinoma (PTC), with complete resolution following thyroidectomy.</p><p><strong>Case presentation: </strong>A 37-year-old previously healthy woman was referred from the vascular surgery clinic for evaluation of episodic digital discoloration. She reported a four-year history of recurrent Raynaud-like color changes affecting the middle fingers of both hands and the lateral four toes of both feet. She denied symptoms suggestive of connective tissue disease, inflammatory arthritis, autoimmune disorders, or cardiovascular disease, as well as tobacco or alcohol use. On examination, her feet were cold, with ulcers on the first and second toes of the right foot. Peripheral pulses in the lower extremities were diminished, with bilaterally weak dorsalis pedis pulses, more pronounced on the right.Her autoimmune panel was positive for anti-nuclear, anti-dsDNA, and anti-centromere antibodies. Capillaroscopy and arterial Doppler ultrasound of the lower limbs were unremarkable. Her symptoms progressed despite multiple treatments, leading to gangrene of the first and second toes of the right foot. A positron emission tomography (PET) scan showed no evidence of vasculitis but revealed focal uptake in a 1.14 cm nodule in the right thyroid lobe. Fine-needle aspiration suggested PTC. She underwent thyroidectomy, and histopathology confirmed papillary carcinoma along with medium-sized vessels showing intimal thickening and marked luminal narrowing, consistent with vasculitis. At 18month followup, she demonstrated complete clinical resolution with no new ulcerations.</p><p><strong>Conclusion: </strong>Paraneoplastic acral vascular syndrome is a rare condition that resembles Raynaud's phenomenon and may improve after treatment of the associated cancer. This case emphasizes the importance of considering occult cancer in patients with unexplained digital ischemia.</p>","PeriodicalId":53667,"journal":{"name":"Qatar Medical Journal","volume":"2026 2","pages":"44"},"PeriodicalIF":0.0,"publicationDate":"2026-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13451944/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148698433","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}