Qatar Medical Journal最新文献

{"title":"Clinical manifestations of 42 Moroccan patients with chronic granulomatous disease.","authors":"Assma Dably, Ibtihal Benhssaein, Jalila El Bakkouri, Asmaa Drissi Bourhanbour, Leila Jeddane, Ahmed Aziz Bousfiha, Fatima Ailal","doi":"10.5339/qmj.2025.14","DOIUrl":"10.5339/qmj.2025.14","url":null,"abstract":"<p><strong>Background: </strong>Chronic granulomatous disease (CGD) is a primary immunodeficiency due to alterations in the oxidative metabolism of phagocytic cells. This condition is characterized by serious and recurrent infections caused by pyogenic bacteria, particularly <i>Staphylococcus aureus</i>, and fungal pathogens such as <i>Aspergillus</i>. These infections are associated with granuloma formation and inflammatory manifestations.The aim of our study was to report the clinical characteristics, microbiological aspects and outcomes, and prognosis of a cohort comprising 42 Moroccan patients suffering from CGD.</p><p><strong>Methods: </strong>A total of 42 patients were diagnosed for family history, consanguinity, and both clinical and laboratory findings.The diagnosis was confirmed by assessing neutrophil oxidative burst activity, using either the nitroblue tetrazolium (NBT) test or the dihydrorhodamine (DHR) test.</p><p><strong>Results: </strong>The cohort comprised children from 34 different families, including 12 siblings. The age of onset ranged from 4 days to 13 years, with the diagnosis being established between the ages of 25 days and 13 years. The predominant clinical manifestations were skin infections, lymphadenopathy, pneumonia, BCGitis, liver abscess, pulmonary aspergillosis, and inflammatory colitis. The most frequently isolated germs were <i>Aspergillus</i>, <i>Serratia</i>, and <i>Staphylococcus</i>. Among the total of 42 patients, 17 fatalities occurred, with aspergillosis being identified as the primary cause of their deaths.</p><p><strong>Conclusions: </strong>In this study, the clinical characteristics and isolated microorganisms correspond to the pathogens known to be important in CGD. Lung infections represent the most prevalent complication and significantly contribute to high mortality rates, particularly in the case of <i>Aspergillus</i> pneumonia, which is known for its tendency to disseminate. Additionally, BCGitis has been frequently observed in countries where the BCG (Bacille Calmette-Guérin) vaccination is routinely administered. Enterocolitis emerges as the most common inflammatory complication in clinical settings. Unfortunately, CGD remains largely unknown in Morocco, highlighting the urgent need to raise awareness among doctors. This increased awareness could facilitate early diagnosis and improve patient prognosis.</p>","PeriodicalId":53667,"journal":{"name":"Qatar Medical Journal","volume":"2025 1","pages":"14"},"PeriodicalIF":0.0,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12092978/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144121281","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The 6th Qatar International Internal Medicine (6-QIIM) Conference 2025: Enhancing patient care through regional and international collaboration and innovation.","authors":"Abdel-Naser Elzouki, Mohamad M Alkadi, Raza Akbar, Joe Mathew, Muhammad Zahid, Abdullatif Alkhal, Ahmed Al-Mohammed","doi":"10.5339/qmj.2025.1","DOIUrl":"https://doi.org/10.5339/qmj.2025.1","url":null,"abstract":"","PeriodicalId":53667,"journal":{"name":"Qatar Medical Journal","volume":"2025 1","pages":"1"},"PeriodicalIF":0.0,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11976668/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143813064","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Machine learning-based assessment of seizure risk predictors in myelomeningocele patients: A single-center retrospective cohort study.","authors":"Maher Al Rifai, Sultan Jarrar, Mohammad Barbarawi, Mohammad Jamous, Suleiman Daoud, Amer Jaradat, Owais Ghammaz, Bashar Hatem Abulsebaa, Qutaiba Alsumadi, Tala Ali Shibli, Ahmad Osamah Alqudah","doi":"10.5339/qmj.2025.15","DOIUrl":"10.5339/qmj.2025.15","url":null,"abstract":"<p><strong>Background: </strong>Myelomeningocele (MMC) is a severe congenital malformation of the CNS (central nervous system) that often leads to seizures due to factors such as shunt complications and hydrocephalus. This study aims to develop a machine learning model to predict the likelihood of seizures in MMC patients by analyzing various predictors.</p><p><strong>Methods: </strong>This retrospective study involved 103 MMC patients. Factors such as demographics, MMC location, shunt history, and imaging were analyzed using the random forest classifier, the support vector classifier, and logistic regression. Model performance was assessed through bootstrap estimates, cross-validation, classification reports, and area under the curve (AUC).</p><p><strong>Results: </strong>Of the evaluated patients, 11 experienced seizures. The key influencing factors included gestational age, sacral location, hydrocephalus, shunt history, and corpus callosum dysgenesis. Machine learning (ML) models predicted seizure risk with an accuracy of 86-92% and an AUC ranging from 0.764 to 0.865. Significant predictors were imaging findings, shunt infection history, and gestational age.</p><p><strong>Conclusion: </strong>ML models effectively predict seizure risk in MMC patients, with certain variables showing strong associations and significant impact.</p>","PeriodicalId":53667,"journal":{"name":"Qatar Medical Journal","volume":"2025 1","pages":"15"},"PeriodicalIF":0.0,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12093402/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144121287","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Early referral of trauma patients to dedicated trauma psychology service: An observational study screening for post-traumatic stress disorder and depression.","authors":"Tulika Mehta Agarwal, Jain Varghese, Ayman El-Menyar, Amer Mohammad Abualjoud, Jenalyn Amedina Salvador, Ammar Al-Hassani, Hassan Al-Thani","doi":"10.5339/qmj.2025.17","DOIUrl":"10.5339/qmj.2025.17","url":null,"abstract":"<p><strong>Background: </strong>The screening of post-traumatic stress disorder (PTSD) and depression after an injury is essential for improving the patient's quality of life. The aim of this study was to assess the utility of PTSD and depression screening and the early referral to the trauma psychology service at a level 1 trauma center. We hypothesized that as the screening process becomes more established as a standard of care, compliance with screening would improve. Furthermore, early referral of trauma patients to a dedicated psychologist within the trauma care system would be beneficial.</p><p><strong>Methods: </strong>This retrospective study involved 1,245 consecutive eligible patients who were admitted to the trauma service between September 2019 and December 2020. The Injured Trauma Survivor Screen (ITSS) and an additional criteria checklist were used for patient screening, and data were analyzed. The screening was conducted within 24 hours of the admission of trauma patients aged  ≥ 14 years, all of whom had a Glasgow Coma Scale of 15.</p><p><strong>Results: </strong>The findings of the study showed that the integration of the new screening tool into a standard of care requires a significant amount of time. Screening compliance increased from 84% to 100% throughout the duration of the study. Notably, there was a 10% gap in the referral of patients identified through the ITSS tool, with 64% referrals based on the symptom checklist.</p><p><strong>Conclusions: </strong>The current screening methods used as a standard of care show good utility value in identifying trauma patients predisposed to developing PTSD or depression, warranting their continued use. Facilitating direct referrals to trauma psychology service by attending staff, including nurses, could help bridge the gap in patient identification and referral. However, further research is warranted to validate this process.</p>","PeriodicalId":53667,"journal":{"name":"Qatar Medical Journal","volume":"2025 1","pages":"17"},"PeriodicalIF":0.0,"publicationDate":"2025-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12093061/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144121282","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Whooping cough in the most vulnerable: A case series of pertussis in infants younger than three months in Qatar.","authors":"Mohammad Alesali, Mohammad Elhamidi","doi":"10.5339/qmj.2025.18","DOIUrl":"10.5339/qmj.2025.18","url":null,"abstract":"<p><strong>Background: </strong>Pertussis, a highly contagious disease, has made a resurgence following the easing of COVID-19 pandemic restrictions. Infants under three months old are particularly vulnerable due to their immature immune systems and lack of protective vaccination.</p><p><strong>Methods: </strong>This study presents a case series of four infants, aged one to three months, who initially presented with nonspecific respiratory symptoms at Alkhor Hospital between January and June 2024. Subsequent diagnostic testing confirmed pertussis in all four cases. It is noteworthy that all cases involved were previously healthy infants with no underlying health conditions. Additionally, none of the mothers had received the Tdap vaccine during pregnancy.</p><p><strong>Results: </strong>All infants required hospitalization, with one being admitted to the PICU for eight days. Ultimately, all four infants made a full recovery.</p><p><strong>Conclusion: </strong>Pertussis remains a significant cause of morbidity and mortality in infants under three months of age. Given the potential for severe complications and the burden it places on the healthcare system during outbreaks, it is crucial to emphasize preventive measures such as maternal vaccination.</p>","PeriodicalId":53667,"journal":{"name":"Qatar Medical Journal","volume":"2025 1","pages":"18"},"PeriodicalIF":0.0,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12106967/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144163696","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Outcomes of pregnant ICU patients with severe COVID-19 pneumonia in Qatar during the three waves of the COVID-19 pandemic: A retrospective cohort study.","authors":"Layla J M Kily, Sohel M G Ahmed, Tamam A K M Alhusban, Mohammed J Orompurath, Marcus D Lance, Mogahed I H Hussein, Salwa M Abuyaqoub, Huda A Saleh, Eynas Abdalla, Santhosh Gopalakrishnan, Hilal Al-Rifai, Mohamed Hilani, Hayat Elfil","doi":"10.5339/qmj.2025.12","DOIUrl":"https://doi.org/10.5339/qmj.2025.12","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Introduction: &lt;/strong&gt;Pregnant women are considered a high-risk group for COVID-19 infection/pneumonia as they are known to be more vulnerable to viral infections. They require close monitoring and appropriate timely intervention to minimize the impact on both the mother and the fetus. Although the more prevalent Omicron variant led to fewer severe infections and fewer intensive care unit (ICU) admissions globally during the third wave, the effect on pregnant women and pregnancy outcomes was unknown. The vaccination campaign was thoroughly established by the third wave of the pandemic in Qatar. This retrospective descriptive cohort study investigates the characteristics, hospital stay, interventions, vaccination status, and fetal and maternal outcomes of patients admitted to the ICU with severe COVID-19 pneumonia during each of the three COVID-19 waves in Qatar.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;The inclusion criteria were all pregnant patients with a positive polymerase chain reaction antigen test result and/or defined radiological changes at the time of admission that subsequently required admission to the ICU for 24 hours or more. Data were collected from the medical records and chart reviews of patients admitted to Hamad Medical Corporation with COVID-19 pneumonia from March 1, 2020 to February 28, 2022.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;The study included a total of 54 pregnant women. In contrast, during the third wave, the number of patients admitted to the ICU was significantly less than in the first wave. The mean gestational age at presentation for each of the three waves was 213.5, 212, and 245 days, respectively. No pregnant women were vaccinated during the first two waves. However, during the third wave, 90.9% of patients admitted to the ICU were vaccinated. The average length of stay in hospital was (mean ± standard deviation) 22.0 ± 27.6, 15.5 ± 7.8, and 5.0 ± 6.3 days for each of the waves, respectively, and the average length of ICU stay was 13.4 ± 20.9, 6.3 ± 5.5, and 3 ± 2.5 days, respectively. The most common chest X-ray finding on admission was bilateral infiltrates. During the third wave, only one patient required a high-flow nasal cannula. As the severity of the disease increased, the patients received more invasive respiratory support and had a higher likelihood of a preterm delivery. Vaccination status correlated with a significantly higher birth weight (mean weight 3.14 kg). However, it was not associated with better maternal outcome.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusion: &lt;/strong&gt;This extension study of the COVID-19 patients admitted to the ICU in Qatar during all three waves suggests that those admitted to the ICU with COVID-19 pneumonia are more likely to require close monitoring and appropriate interventions to minimize adverse outcomes for both the mother and the fetus. Our data may suggest that vaccination in these patients may contribute to reducing the use of respiratory support modalities for those admitted to the IC","PeriodicalId":53667,"journal":{"name":"Qatar Medical Journal","volume":"2025 1","pages":"12"},"PeriodicalIF":0.0,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12079578/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144081874","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Patient views on the effectiveness of audio-dentistry for emergency triage during COVID-19.","authors":"Shaymaa Abdulreda Ali, Sahar Alaji, Ayah Abdallah Alqaisi, Reem Binrabbaa, Moudi Dakhel Alkhaldi, Suhayla Reda Al Banai, Najah Alhashimi","doi":"10.5339/qmj.2025.13","DOIUrl":"10.5339/qmj.2025.13","url":null,"abstract":"<p><strong>Background: </strong>When Qatar imposed a nationwide lockdown in accordance with WHO guidelines during the first wave of the COVID-19 pandemic, dental healthcare services were disrupted, limiting services to emergencies and postponing elective procedures due to transmission risks. Teledentistry was introduced to remotely manage dental conditions and reduce hospital admissions. The present study examines patient perceptions of audio-dentistry, a form of teledentistry, in managing dental emergencies during the pandemic and explores factors influencing overall patient satisfaction.</p><p><strong>Methods: </strong>A retrospective, cross-sectional telephone questionnaire included 352 participants who used a dental emergency hotline service during the first wave of the COVID-19 pandemic lockdown (March 29-August 31, 2020) in Qatar. A validated, closed-ended questionnaire was administered to explore participants' views on audio-dentistry. The questionnaire explored the influence of variables related to dental problems depending on the specialty required, the years of experience of the responding dentist, and teletriage management decisions on overall satisfaction with audio-dentistry.</p><p><strong>Results: </strong>The response rate was 80.18%. Most participants expressed positive views of audio-dentistry in five domains (usefulness, interaction quality, ease of use and reliability, quality of care, satisfaction, and future use). However, approximately one-third of participants disagreed or strongly disagreed that their dental problem had improved following the call (35.3%) and viewed the lack of physical contact as a disadvantage (31.2%). Overall satisfaction was only influenced by telephone triage outcomes, with patients transferred for chairside management more likely to be satisfied (89.8%) than those managed remotely through self-care instructions and medications (80.4%) or instructions only (75.4%) (<i>p</i> = 0.011).</p><p><strong>Conclusions: </strong>Audio-dentistry effectively sustained oral health services during the COVID-19 pandemic while minimizing face-to-face visits, with patients largely expressing high satisfaction in areas such as usefulness, interaction quality, ease of use, reliability, and overall care. Satisfaction was primarily influenced by call outcomes and referrals or prescription decisions rather than caller demographics or dentist experience. However, some dissatisfaction arose when immediate improvement was not achieved, particularly in conditions such as pulpitis that are challenging to manage remotely.</p>","PeriodicalId":53667,"journal":{"name":"Qatar Medical Journal","volume":"2025 1","pages":"13"},"PeriodicalIF":0.0,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12091247/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144112616","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A comparison of Gam-COVID-Vac vaccination and non-vaccination on neurological symptoms and immune response in post-COVID-19 syndrome.","authors":"Saulesh Kurmangaliyeva, Akzhan Madenbayeva, Saltanat Urazayeva, Kristina Baktikulova, Kairat Kurmangaliyev","doi":"10.5339/qmj.2025.6","DOIUrl":"10.5339/qmj.2025.6","url":null,"abstract":"<p><p>The post-COVID-19 syndrome may present with a range of neurological symptoms such as headaches, sleep disorders, and dizziness. The objective of this study was to examine the effectiveness of the Gam-COVID-Vac vaccine in mitigating the neurological symptoms of post-COVID-19 syndrome. The study involved 95 patients diagnosed with the neurological form of long COVID-19, who were divided into two groups according to their vaccination status. The immunological parameters of humoral immunity were evaluated by enzyme-linked immunosorbent assay (ELISA), while the parameters of cellular immunity were evaluated using flow cytometry. Administration of the vaccination resulted in a reduction in clinical symptoms of the neurological form of long COVID-19. Statistically significant differences (<i>p</i> = 0.035) were found in symptoms such as headaches, sleep disturbances, and dizziness, especially in central nervous system (CNS) disorders, between the groups that received the vaccination and those that did not. More than 90% of patients had elevated levels of Receptor Binding Domain (RBD) immunoglobulin G against the viral S-protein (>2,500 BAU/ml), indicating strong humoral immunity regardless of vaccination status. An increase in B-lymphocyte (CD3^-CD19⁺) counts was noted in both groups, with levels significantly higher in the group that received the vaccination (<i>p</i> < 0.03). Analysis of T-cell profiles and NK (natural killer) cell levels showed no changes. The study suggests that administration of Gam-COVID-Vac vaccination could reduce the occurrence of CNS symptoms in individuals with post-COVID-19 syndrome. Although certain neurological symptoms may continue, immunization has a beneficial influence on their progression. The results emphasize the crucial role of an increased humoral immune response in individuals with post-COVID-19 syndrome, but do not show significant changes in T-cell immune parameters.</p>","PeriodicalId":53667,"journal":{"name":"Qatar Medical Journal","volume":"2025 1","pages":"6"},"PeriodicalIF":0.0,"publicationDate":"2025-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11938678/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143722196","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of morphine versus fentanyl patient-controlled analgesia for postoperative pain management in colorectal surgery.","authors":"Adnan Saad Eddin, Hazem Selim, Roaa Suleiman, Jeena Thomas","doi":"10.5339/qmj.2025.7","DOIUrl":"10.5339/qmj.2025.7","url":null,"abstract":"<p><strong>Introduction: </strong>Postoperative pain management is crucial for recovery from surgery. Patient-controlled analgesia (PCA) with morphine and fentanyl are commonly used, but their comparative efficacy remains uncertain. This study aims to evaluate opioid consumption and pain control in patients receiving PCA morphine versus PCA fentanyl after colorectal surgery.</p><p><strong>Methodology: </strong>A retrospective analysis of adult patients undergoing elective colorectal surgery was conducted. Patients were divided into two groups based on PCA morphine or PCA fentanyl use. Outcomes measured were opioid consumption in morphine equivalents, numerical pain scores expressed as Numerical Rating Scale (NRS), patient demand, and side effects within the first 48 hours postoperatively.</p><p><strong>Results: </strong>Of 370 patients screened, 152 met the inclusion criteria. No significant differences were found in total opioid consumption (median: 38 vs. 28.5 mg, <i>p</i> = 0.095), patient demand (median: 46.5 vs. 35, <i>p</i> = 0.156), or NRS (median: 4 vs. 3.5, <i>p</i> = 0.348). Side effects were comparable between groups. Subgroup analysis revealed higher opioid consumption and demand in females taking fentanyl compared to morphine. Age was negatively correlated with pain-related outcomes, and smokers showed higher opioid consumption and higher pain scores.</p><p><strong>Conclusions: </strong>PCA morphine and fentanyl provide similar postoperative pain relief in colorectal surgery patients, with no significant differences in opioid consumption or side effects. Female patients may respond better to morphine, and age and smoking status significantly influence pain management outcomes. Further prospective studies are recommended to better define these findings and inform postoperative pain strategies.</p>","PeriodicalId":53667,"journal":{"name":"Qatar Medical Journal","volume":"2025 1","pages":"7"},"PeriodicalIF":0.0,"publicationDate":"2025-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11947460/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143733210","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical outcome of OviTex reinforced tissue matrix in hernia repair: A systematic review and meta-analysis.","authors":"Ahmad R Al-Qudimat, Seif B Altahtamouni, Kalpana Singh, Omar M Aboumarzouk, Mohamed Elakkad","doi":"10.5339/qmj.2025.22","DOIUrl":"10.5339/qmj.2025.22","url":null,"abstract":"<p><p><b>Background:</b> This review provides a comprehensive and current overview of the clinical outcomes associated with the use of OviTex reinforced tissue matrix (RTM) in hernia repair. <b>Methods:</b> We conducted a systematic review and meta-analysis according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Our search included research publications related to clinical outcomes involving the use of OviTex RTM in hernia repair up to August 2023. We extensively examined and extracted relevant data from databases such as Embase, PubMed, and Scopus. The meta-analysis included comparisons related to body mass index (BMI) in hernia treatment, primary abdominal wall hernias treated with OviTex, and other relevant factors. The quality of the included studies was assessed using the MINORS (Methodological Index for Non-Randomized Studies) scale. Our systematic review protocol was registered with PROSPERO (International Prospective Register of Systematic Reviews) under registration number CRD42023456009. <b>Results:</b> A total of 9 observational studies involving 990 patients from three countries (USA, Netherlands, and Germany) were included in our study. Pooled results show that the risk of the OviTex group was lower than that of the comparison group (pooled risk ratio (RR) = 0.84; 95% confidence interval (CI): 0.67-1.05; <i>Z</i> = -1.514; <i>p</i> = 0.13). The prevalence rate of primary abdominal wall hernia among the included studies ranged from a minimum of 43% (95% CI: 30-58) to a maximum of 81% (95% CI: 64-91%), the risk was not significantly higher in the comparison group compared with the OviTex group (pooled RR = 1.11; 95% CI: 0.29-4.30; <i>Z</i> = 0.155; <i>p</i> = 0.877), the prevalence of laparoscopic surgery was 12% (95% CI: 6-19%), the BMI was favorable in the comparison group but was not statistically significant (mean difference = 25; 95% CI: -0.02, 0.52; <i>p</i> = 0.073). <b>Conclusion:</b> OviTex RTM has shown promising outcomes in abdominal wall reconstruction and hernia repair. However, it is crucial to conduct further research and clinical studies to confirm these findings and unlock the capabilities of OviTex across different medical scenarios.</p>","PeriodicalId":53667,"journal":{"name":"Qatar Medical Journal","volume":"2025 1","pages":"22"},"PeriodicalIF":0.0,"publicationDate":"2025-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12107482/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144163666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}