{"title":"卡塔尔男性和女性不孕相关因素：病例对照研究","authors":"Haya Alkuwari, Mohamed Ibrahim, Nour Darwish, Hamad Almaraghi, Alyaa Ai-Wuhaili, Fatema Al-Muslamani, Mohamed Iheb Bougmiza, Tawanda Chivese, Mohamed Emara","doi":"10.5339/qmj.2025.83","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Infertility is a rising global and regional concern, yet its associated factors remain underexplored in Qatar. This study investigated demographic, lifestyle, and medical factors linked to infertility, aiming to provide insights that can enhance reproductive healthcare strategies and patient outcomes in the region.</p><p><strong>Methods: </strong>A total of 998,328 eligible individuals from 27 Primary Health Care Centers in Qatar were identified for this case-control study. Data were collected between January 2016 and December 2022. Eligible individuals were aged 18 to 49 years with a documented fertility status. After 1:1 matching by age, gender, and nationality, the final sample included 51,542 participants (25,771 cases, 25,771 controls). Analyses were stratified by gender and nationality.</p><p><strong>Results: </strong>A total of 16,158 female cases and 9,613 male cases with infertility were identified and matched to fertile individuals. After multivariable logistic regression, in Qatari and non-Qatari females, polycystic ovarian syndrome was associated with higher odds of infertility (odds ratio [OR], 4.34 [95% CI, 3.36-5.61]; <i>p</i> < 0.001) and (OR, 5.54 [95% CI, 4.74-6.47]; <i>p</i> < 0.001), respectively. Uterine polyps showed a strong association in both groups (OR, 3.18 [95% CI, 2.21-4.59]; <i>p</i> < 0.001) and (OR, 6.05 [95% CI, 4.57-8.01]; <i>p</i> < 0.001), respectively. In both male groups, varicocele was associated with higher odds of infertility (OR, 39.46 [95% CI, 22.60-68.90]; <i>p</i> < 0.001) and (OR, 37.75 [95% CI, 26.32-54.16]; <i>p</i> < 0.001), respectively. Similarly, in erectile dysfunction (OR, 4.54 [95% CI, 3.32-6.21]; <i>p</i> < 0.001) and (OR, 6.59 [95% CI, 4.74-9.17]; <i>p</i> < 0.001), respectively.</p><p><strong>Conclusion: </strong>In females and males, reproductive diseases and other comorbidities were associated with higher odds of infertility in both Qatari and non-Qatari individuals. Future studies should investigate temporal associations and include additional risk factors to guide effective infertility prevention strategies.</p>","PeriodicalId":53667,"journal":{"name":"Qatar Medical Journal","volume":"2025 3","pages":"83"},"PeriodicalIF":0.0000,"publicationDate":"2025-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12477821/pdf/","citationCount":"0","resultStr":"{\"title\":\"Factors associated with infertility in males and females in Qatar: A case-control study.\",\"authors\":\"Haya Alkuwari, Mohamed Ibrahim, Nour Darwish, Hamad Almaraghi, Alyaa Ai-Wuhaili, Fatema Al-Muslamani, Mohamed Iheb Bougmiza, Tawanda Chivese, Mohamed Emara\",\"doi\":\"10.5339/qmj.2025.83\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Infertility is a rising global and regional concern, yet its associated factors remain underexplored in Qatar. This study investigated demographic, lifestyle, and medical factors linked to infertility, aiming to provide insights that can enhance reproductive healthcare strategies and patient outcomes in the region.</p><p><strong>Methods: </strong>A total of 998,328 eligible individuals from 27 Primary Health Care Centers in Qatar were identified for this case-control study. Data were collected between January 2016 and December 2022. Eligible individuals were aged 18 to 49 years with a documented fertility status. After 1:1 matching by age, gender, and nationality, the final sample included 51,542 participants (25,771 cases, 25,771 controls). Analyses were stratified by gender and nationality.</p><p><strong>Results: </strong>A total of 16,158 female cases and 9,613 male cases with infertility were identified and matched to fertile individuals. After multivariable logistic regression, in Qatari and non-Qatari females, polycystic ovarian syndrome was associated with higher odds of infertility (odds ratio [OR], 4.34 [95% CI, 3.36-5.61]; <i>p</i> < 0.001) and (OR, 5.54 [95% CI, 4.74-6.47]; <i>p</i> < 0.001), respectively. Uterine polyps showed a strong association in both groups (OR, 3.18 [95% CI, 2.21-4.59]; <i>p</i> < 0.001) and (OR, 6.05 [95% CI, 4.57-8.01]; <i>p</i> < 0.001), respectively. In both male groups, varicocele was associated with higher odds of infertility (OR, 39.46 [95% CI, 22.60-68.90]; <i>p</i> < 0.001) and (OR, 37.75 [95% CI, 26.32-54.16]; <i>p</i> < 0.001), respectively. Similarly, in erectile dysfunction (OR, 4.54 [95% CI, 3.32-6.21]; <i>p</i> < 0.001) and (OR, 6.59 [95% CI, 4.74-9.17]; <i>p</i> < 0.001), respectively.</p><p><strong>Conclusion: </strong>In females and males, reproductive diseases and other comorbidities were associated with higher odds of infertility in both Qatari and non-Qatari individuals. Future studies should investigate temporal associations and include additional risk factors to guide effective infertility prevention strategies.</p>\",\"PeriodicalId\":53667,\"journal\":{\"name\":\"Qatar Medical Journal\",\"volume\":\"2025 3\",\"pages\":\"83\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2025-09-23\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12477821/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Qatar Medical Journal\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.5339/qmj.2025.83\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/1/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"Q3\",\"JCRName\":\"Medicine\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Qatar Medical Journal","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.5339/qmj.2025.83","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/1/1 0:00:00","PubModel":"eCollection","JCR":"Q3","JCRName":"Medicine","Score":null,"Total":0}
引用次数: 0
摘要
背景：不孕症是一个不断上升的全球和区域关注，但其相关因素仍未充分探讨在卡塔尔。本研究调查了与不孕症相关的人口统计学、生活方式和医学因素，旨在提供能够提高该地区生殖保健策略和患者预后的见解。方法：来自卡塔尔27个初级卫生保健中心的998,328名符合条件的个体被纳入本病例对照研究。数据收集于2016年1月至2022年12月。符合条件的个体年龄在18至49岁之间，有生育记录。在按年龄、性别和国籍进行1:1匹配后，最终样本包括51,542名参与者（25,771例，25,771例对照）。分析按性别和国籍分层。结果：共鉴定出16158例女性不孕症患者和9613例男性不孕症患者，并与可育个体匹配。多变量logistic回归后，卡塔尔和非卡塔尔女性多囊卵巢综合征与较高的不孕几率相关（比值比[OR]， 4.34 [95% CI, 3.36-5.61], p < 0.001）和（OR, 5.54 [95% CI, 4.74-6.47], p < 0.001）。子宫息肉在两组中表现出较强的相关性（OR, 3.18 [95% CI, 2.21-4.59], p < 0.001）和（OR, 6.05 [95% CI, 4.57-8.01], p < 0.001）。在两个男性组中，精索静脉曲张分别与较高的不育几率相关（OR, 39.46 [95% CI, 22.60-68.90], p < 0.001）和（OR, 37.75 [95% CI, 26.32-54.16], p < 0.001）。同样，在勃起功能障碍方面（OR, 4.54 [95% CI, 3.32-6.21], p < 0.001）和（OR, 6.59 [95% CI, 4.74-9.17], p < 0.001）。结论：在女性和男性中，生殖疾病和其他合并症与卡塔尔人和非卡塔尔人较高的不孕症发生率相关。未来的研究应调查时间相关性，并纳入其他风险因素，以指导有效的不孕症预防策略。
Factors associated with infertility in males and females in Qatar: A case-control study.
Background: Infertility is a rising global and regional concern, yet its associated factors remain underexplored in Qatar. This study investigated demographic, lifestyle, and medical factors linked to infertility, aiming to provide insights that can enhance reproductive healthcare strategies and patient outcomes in the region.
Methods: A total of 998,328 eligible individuals from 27 Primary Health Care Centers in Qatar were identified for this case-control study. Data were collected between January 2016 and December 2022. Eligible individuals were aged 18 to 49 years with a documented fertility status. After 1:1 matching by age, gender, and nationality, the final sample included 51,542 participants (25,771 cases, 25,771 controls). Analyses were stratified by gender and nationality.
Results: A total of 16,158 female cases and 9,613 male cases with infertility were identified and matched to fertile individuals. After multivariable logistic regression, in Qatari and non-Qatari females, polycystic ovarian syndrome was associated with higher odds of infertility (odds ratio [OR], 4.34 [95% CI, 3.36-5.61]; p < 0.001) and (OR, 5.54 [95% CI, 4.74-6.47]; p < 0.001), respectively. Uterine polyps showed a strong association in both groups (OR, 3.18 [95% CI, 2.21-4.59]; p < 0.001) and (OR, 6.05 [95% CI, 4.57-8.01]; p < 0.001), respectively. In both male groups, varicocele was associated with higher odds of infertility (OR, 39.46 [95% CI, 22.60-68.90]; p < 0.001) and (OR, 37.75 [95% CI, 26.32-54.16]; p < 0.001), respectively. Similarly, in erectile dysfunction (OR, 4.54 [95% CI, 3.32-6.21]; p < 0.001) and (OR, 6.59 [95% CI, 4.74-9.17]; p < 0.001), respectively.
Conclusion: In females and males, reproductive diseases and other comorbidities were associated with higher odds of infertility in both Qatari and non-Qatari individuals. Future studies should investigate temporal associations and include additional risk factors to guide effective infertility prevention strategies.
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