Plasma Medicine最新文献_第8页

Enhancement of PC12 Neurite Extension via Plasma-Activated Medium by Nonthermal Atmospheric-Pressure Plasma-Bubbling System 非热大气压等离子体鼓泡系统增强等离子体活化介质对PC12神经突延伸的影响

Plasma Medicine Pub Date : 2019-01-01 DOI: 10.1615/plasmamed.2020033059

Takanobu Haccho, Atsuru Kanno, H. Ichikawa, Koji Yamamoto, Y. Morita, E. Nakamachi

{"title":"Enhancement of PC12 Neurite Extension via Plasma-Activated Medium by Nonthermal Atmospheric-Pressure Plasma-Bubbling System","authors":"Takanobu Haccho, Atsuru Kanno, H. Ichikawa, Koji Yamamoto, Y. Morita, E. Nakamachi","doi":"10.1615/plasmamed.2020033059","DOIUrl":"https://doi.org/10.1615/plasmamed.2020033059","url":null,"abstract":"In this study, an axonal extension enhancement system was developed using plasma-activated medium (PAM), which was generated through a nonthermal atmospheric-pressure plasma-bubbling system. Until recently, a number of regeneration methods for treatment of an injured central nervous system (CNS) have been proposed and examined. However, problems remain regarding quick recovery. It is also strongly required to establish an efficacious regeneration method for an injured CNS. Therefore, this study aimed to enhance the nerve axonal extension using PAM. The effectiveness of PAM in enhancing axonal extension was evaluated. First, the amounts of reactive species, such as H2O2, NO2, and NO3, in PAM were measured. Second, the stimulating effect of PAM was investigated by morphologically evaluating the PC12 cells after PAM stimulation. Experiments were conducted under 20 conditions to determine an optimal condition. Furthermore, the mechanism of enhancing PC12 neurite extension using PAM was elucidated. It was found that the Ca2+ concentration in PC12 cells was increased upon PAM stimulation and that Erk and CREB were activated, which enhanced the neurite extension. The results show that the PAM exhibited a selective cell-activation property for the treatment of CNS injuries.","PeriodicalId":53607,"journal":{"name":"Plasma Medicine","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1615/plasmamed.2020033059","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67348768","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Effect of Transient Spark Disinfection on Various Endodontics-Relevant Bacteria 瞬态火花消毒对牙髓相关细菌的影响

Plasma Medicine Pub Date : 2019-01-01 DOI: 10.1615/plasmamed.2019032357

L. Ledernez, F. Engesser, M. Altenburger, G. Urban, M. Bergmann

引用次数: 3

Transient Spark for Bacterial Cleaning of Dental Microcavities 细菌清洁牙齿微腔的瞬态火花

Plasma Medicine Pub Date : 2019-01-01 DOI: 10.1615/PLASMAMED.2018027473

L. Ledernez, Richard Bruch, M. Altenburger, M. Bergmann, G. Urban

引用次数: 3

Enhancing Shelf Life of Bananas by Using Atmospheric Pressure Pulsed Cold Plasma Treatment of the Storage Atmosphere 常压脉冲冷等离子体处理香蕉贮藏气氛提高香蕉保质期

Plasma Medicine Pub Date : 2019-01-01 DOI: 10.1615/PLASMAMED.2019026909

Maharshi Trivedi, K. Patel, Hanako Itokazu, Ngoc Van Anh Huynh, M. Kovalenko, Gary Nirenberg, Vandana Miller, A. Fridman, G. Fridman, Jacob Lahne, Jasreen K. Sekhon

引用次数: 9

Cold Atmospheric Plasma and Plasma-Activated Medium: Antitumor Cell Effects with Inherent Synergistic Potential 低温大气等离子体和等离子体活化介质:具有内在协同潜力的抗肿瘤细胞效应

Plasma Medicine Pub Date : 2019-01-01 DOI: 10.1615/PLASMAMED.2019029462

G. Bauer

引用次数: 17

Ex Vivo Study Comparing Three Cold Atmospheric Plasma (CAP) Sources for Biofilm Removal on Microstructured Titanium 三种低温大气等离子体源去除微结构钛上生物膜的离体研究

Plasma Medicine Pub Date : 2019-01-01 DOI: 10.1615/PLASMAMED.2018027314

S. Preissner, Ann Cathrin Poehlmann, A. Schubert, A. Lehmann, T. Arnold, Olaf Nell, S. Rupf

引用次数: 1

Reducing the Toxicity of Tetracycline Solutions and the Kinetics of Decomposition under the Action of DBD in Oxygen 降低四环素溶液的毒性及氧中DBD作用下的分解动力学

Plasma Medicine Pub Date : 2019-01-01 DOI: 10.1615/plasmamed.2019031459

A. Gushchin, V. Grinevich, E. Kvitkova, R. Chugunov, T. Izvekova, N. Kruchinina, V. Emzhina, N. Ivantsova, V. Rybkin

引用次数: 0

Direct Current Helium Plasma for In vivo Delivery of Plasmid DNA Encoding Erythropoietin to Murine Skin. 直流电氦血浆在小鼠皮肤内传递促红细胞生成素质粒DNA。

Plasma Medicine Pub Date : 2017-01-01 DOI: 10.1615/PlasmaMed.2017019506

Mark J Jaroszeski, Taryn Harvey-Chapman, Andrew Hoff, Reginald Atkins, Richard J Connolly

{"title":"Direct Current Helium Plasma for In vivo Delivery of Plasmid DNA Encoding Erythropoietin to Murine Skin.","authors":"Mark J Jaroszeski, Taryn Harvey-Chapman, Andrew Hoff, Reginald Atkins, Richard J Connolly","doi":"10.1615/PlasmaMed.2017019506","DOIUrl":"https://doi.org/10.1615/PlasmaMed.2017019506","url":null,"abstract":"The use of electric fields in vivo to deliver DNA, called electroporation, has the potential to broadly impact vaccination and disease treatment. The evidence for this has emerged from a large number of recently completed and ongoing clinical trials. The methods for applying electric fields to tissues traditionally involve contact between metal electrodes and the tissue. In this study, we investigated the use of helium plasma as a noncontact method for electrically treating tissue in a manner that results in the uptake and expression of foreign DNA in murine skin. More specifically, our goal was to demonstrate that DNA encoding a model-secreted protein could be delivered, detected in the blood, and remain functional to produce its known biological effect. Murine erythropoietin (EPO) was the model-secreted protein. Results clearly demonstrated that an intradermal DNA injection followed by plasma treatment for 2 min resulted in elevated levels of EPO in the blood and corresponding hemoglobin increases that were statistically significant relative to DNA injection alone.","PeriodicalId":53607,"journal":{"name":"Plasma Medicine","volume":"7 3","pages":"261-271"},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1615/PlasmaMed.2017019506","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37041497","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Aqueous Plasma Pharmacy: Preparation Methods, Chemistry, and Therapeutic Applications. 水血浆药学:制备方法、化学和治疗应用。

Plasma Medicine Pub Date : 2016-01-01 DOI: 10.1615/PlasmaMed.2016018618

Jessica M Joslin, James R McCall, Justin P Bzdek, Derek C Johnson, Brooks M Hybertson

{"title":"Aqueous Plasma Pharmacy: Preparation Methods, Chemistry, and Therapeutic Applications.","authors":"Jessica M Joslin, James R McCall, Justin P Bzdek, Derek C Johnson, Brooks M Hybertson","doi":"10.1615/PlasmaMed.2016018618","DOIUrl":"https://doi.org/10.1615/PlasmaMed.2016018618","url":null,"abstract":"Plasma pharmacy is a subset of the broader field of plasma medicine. Although not strictly defined, the term aqueous plasma pharmacy (APP) is used to refer to the generation and distribution of reactive plasma-generated species in an aqueous solution followed by subsequent administration for therapeutic benefits. APP attempts to harness the therapeutic effects of plasma-generated oxidant species within aqueous solution in various applications, such as disinfectant solutions, cell proliferation related to wound healing, and cancer treatment. The subsequent use of plasma-generated solutions in the APP approach facilitates the delivery of reactive plasma species to internal locations within the body. Although significant efforts in the field of plasma medicine have concentrated on employing direct plasma plume exposure to cells or tissues, here we focus specifically on plasma discharge in aqueous solution to render the solution biologically active for subsequent application. Methods of plasma discharge in solution are reviewed, along with aqueous plasma chemistry and the applications for APP. The future of the field also is discussed regarding necessary research efforts that will enable commercialization for clinical deployment.","PeriodicalId":53607,"journal":{"name":"Plasma Medicine","volume":"6 2","pages":"135-177"},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1615/PlasmaMed.2016018618","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34929741","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 21