Cold Atmospheric Plasma and Plasma-Activated Medium: Antitumor Cell Effects with Inherent Synergistic Potential

Q3 Physics and Astronomy

Plasma Medicine Pub Date : 2019-01-01 DOI:10.1615/PLASMAMED.2019029462

G. Bauer

引用次数: 17

Abstract

Nitrite and H2O2, long-lived molecular species from cold atmospheric plasma (CAP) and plasma-activated medium (PAM), reach tumor target cells in vitro and in vivo. Through several steps, the interaction between nitrite and H2O2 leads to generation of singlet oxygen ( O2). O2 dinucleotide phosphate (NADPH) oxidase. As a result, local inactivation of catalase by minute secondary singlet oxygen generation and catalase inactivation. This process is driven by tumor as H2O2 and nitrite have multiple functions in this process. Catalase-mediated oxidation of nitrite enhances generation of nitrogen dioxide, which is rate limiting for singlet oxygen generation. Before singlet oxygen–mediated inactivation of catalase and, subsequently, reactivated intercel2O2 into cells. CAPand PAM-dependent immunogenic cell death triggers a strong immune response in vivo

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低温大气等离子体和等离子体活化介质:具有内在协同潜力的抗肿瘤细胞效应

亚硝酸盐和H2O2是低温大气等离子体(CAP)和等离子体活化介质(PAM)中的长寿命分子，它们可以在体外和体内到达肿瘤靶细胞。经过几个步骤，亚硝酸盐与H2O2相互作用生成单线态氧(O2)。氧二核苷酸磷酸氧化酶。结果，过氧化氢酶的局部失活由微小的次级单线态氧产生和过氧化氢酶失活。这个过程是由肿瘤驱动的，H2O2和亚硝酸盐在这个过程中有多种作用。过氧化氢酶介导的亚硝酸盐氧化促进了二氧化氮的生成，这是单线态氧生成的速率限制。在单线态氧介导过氧化氢酶失活之前，随后，intercel2O2被重新激活进入细胞。capa和pam依赖的免疫原性细胞死亡在体内引发强烈的免疫反应

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Plasma Medicine Physics and Astronomy-Physics and Astronomy (all)

CiteScore

1.40

自引率

0.00%

发文量

期刊介绍： Technology has always played an important role in medicine and there are many journals today devoted to medical applications of ionizing radiation, lasers, ultrasound, magnetic resonance and others. Plasma technology is a relative newcomer to the field of medicine. Experimental work conducted at several major universities, research centers and companies around the world over the recent decade demonstrates that plasma can be used in variety of medical applications. It is already widely used surgeries and endoscopic procedures. It has been shown to control properties of cellular and tissue matrices, including biocompatibility of various substrates. Non-thermal plasma has been demonstrated to deactivate dangerous pathogens and to stop bleeding without damaging healthy tissue. It can be used to promote wound healing and to treat cancer. Understanding of various mechanisms by which plasma can interact with living systems, including effects of reactive oxygen species, reactive nitrogen species and charges, has begun to emerge recently. The aim of the Plasma Medicine journal will be to provide a forum where the above topics as well as topics closely related to them can be presented and discussed. Existing journals on plasma science and technology are aimed for audiences with primarily engineering and science background. The field of Plasma Medicine, on the other hand, is highly interdisciplinary. Some of prospective readers and contributors of the Plasma Medicine journal are expected to have background in medicine and biology. Others might be more familiar with plasma science. The goal of the proposed Plasma Medicine journal is to bridge the gap between audiences with such different backgrounds, without sacrificing the quality of the papers be their emphasis on medicine, biology or plasma science and technology.