Eurasian Journal of Medicine最新文献

{"title":"Current Developments in the Treatment of Postpartum Depression: Zuranolone.","authors":"Dogancan Sonmez, Cicek Hocaoglu","doi":"10.5152/eurasianjmed.2024.24409","DOIUrl":"10.5152/eurasianjmed.2024.24409","url":null,"abstract":"<p><p>Pregnancy is a period in a woman's life during which she experiences physiological, psychological, and social changes. These changes can lead to various mental illnesses, including postpartum depression (PPD), which is common during the perinatal period. Postpartum depression is a significant cause of morbidity and mortality for both the mother and baby. A peripartum-onset major depressive episode is defined as PPD when it occurs during pregnancy or up to 4 weeks postpartum. The frequency of this condition is extremely high. Its etiology is influenced by biological, psychological, and sociocultural factors. Depressed mood, anhedonia, feelings of guilt, irritability, lack of concentration, psychomotor agitation or retardation, sleep disturbance, and changes in appetite and weight can all be symptoms of PPD. There are various treatment options available, many of which are adapted from those used for major depression. Selective serotonin reuptake inhibitors, serotonin-noradrenaline reuptake inhibitors, tricyclic antidepressants, estradiol, progesterone, psychotherapies, electroconvulsive therapy, and brexanolone can be used to treat PPD. In addition, the newest drug approved by the FDA (Food and Drug Administration) for this condition is oral zuranolone. This review aims to analyze recent developments on zuranolone, the latest drug approved by the FDA for PPD, based on current studies.</p>","PeriodicalId":53592,"journal":{"name":"Eurasian Journal of Medicine","volume":"56 3","pages":"199-204"},"PeriodicalIF":0.9,"publicationDate":"2024-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11535317/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142802799","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Time-Sensitive Quality Metrics of Acute Stroke Care: A Comprehensive Stroke Center Experience.","authors":"Merve Korukcu, Alper Eren","doi":"10.5152/eurasianjmed.2024.24554","DOIUrl":"10.5152/eurasianjmed.2024.24554","url":null,"abstract":"<p><p>The stroke center approach provides an efective solution for acute stroke management. Our study aims to systematically analyze our stroke center records to identify factors that afect acute stroke time-sensitive quality metrics. Data were prospectively collected from 524 acute stroke patients at the Comprehensive Stroke Center of Atatürk UniversityMedical Faculty Hospital between January 1, 2021, and September 30, 2021. Data collected included sociodemographic, clinical, admission type, initial National Institutes of Health Stroke Scale (NIHSS), treatment modality, and time-sensitive metrics and were statistically analyzed based on stroke quality metrics. Patients with mild NIHSS scores (0-7) had longer onset-to-door (OTD) time, door-to-computed tomography (CT)/neurologist, and hospitalization times (P < .001). The OTD, door-to-CT/neurologist, and hospitalization times varied depending on the treatment methods used (P < .005). The OTD time was influenced by the patient's level of education (P=.004), admission type (P < .001), and geographical location (P=.002). A moderate negative correlation was found between patients' OTD time and baseline NIHSS (r=-0.270; P < 0.001). The results emphasize the significance of several factors, such as admission type, geographical location, and treatment methods, in shaping the time-sensitive quality metrics of stroke care. Additionally, the initial NIHSS score of patients plays a crucial role in both prehospital and in-hospital aspects of acute stroke management.</p>","PeriodicalId":53592,"journal":{"name":"Eurasian Journal of Medicine","volume":"56 3","pages":"182-188"},"PeriodicalIF":0.9,"publicationDate":"2024-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11535306/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142803001","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of the Effects of SAA1 Gene Polymorphisms on Renal Involvement in a Familial Mediterranean Fever Jordanian Population.","authors":"Ahmed Sheyyab, Rania Wahdan, Al-Ameen Al-Aitan, Mahmoud Abukhadra, Laith Hussein Ayed Naimat","doi":"10.5152/eurasianjmed.2024.24457","DOIUrl":"10.5152/eurasianjmed.2024.24457","url":null,"abstract":"<p><p>Familial Mediterranean Fever (FMF) is an inherited autosomal recessive disorder resulting from the inheritance of MEFV gene mutations. Patients with FMF are at increased risk of secondary amyloidosis, namely type AA. In some Mediterranean populations, the α genotype was associated with the development of renal amyloidosis, a finding not reproduced in other populations. Our study aimed to assess the association of SAA1 genotypes with renal involvement. This is a retrospective analysis of FMF patients which were followed at our institute between January 2016 and August 2022. Familial Mediterranean Fever screening was performed using polymerase chain reaction and reverse hybridization techniques. Statistical analysis was performed using bivariate logistic regression. MEFV analysis of the studied patients (n=427) identified 52 patients with a homozygous genotype (12.1%) and 374 with a heterozygous genotype (87.5%). The heterozygous group were mostly heterozygous carriers of a single FMF variant (81%), while 19% were compound heterozygous. Renal involvement was revealed in 95 patients (22.2%), which were manifested as proteinuria (21.3%) and/or renal impairment in 4 patients (3%). The clinical diagnosis of amyloidosis was suspected in 6 patients only (1.4%). Analysis for SAA1 gene genotype-phenotype correlation showed that patients with the SAA1.1/1.1 (OR=0.54, P=.452) was not statistically associated with renal involvement. Pearson Chi-square was performed to examine the association between FMF homozygosity and each SAA1 genotype, which showed a significant association between FMF gene homozygosity with SAA1.1/1.1 genotype (χ2 = 8.06, P=.018). In our Jordanian FMF population, we report low rates of renal involvement with a high rate of the β haplotype (SAA1.5). Neither the α/α nor the β/β genotypes were associated with evidence of renal involvement.</p>","PeriodicalId":53592,"journal":{"name":"Eurasian Journal of Medicine","volume":"56 3","pages":"153-158"},"PeriodicalIF":0.9,"publicationDate":"2024-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11535276/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142803186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Protective Effects of Oxyresveratrol in IsoproterenolInduced Myocardial Infarction in Rats: A Stereological Study.","authors":"Huseyn Aliyev, Sibel Bilgili, Erdem Toktay, Nubar Nuriyeva, Yasin Bayir","doi":"10.5152/eurasianjmed.2024.23214","DOIUrl":"10.5152/eurasianjmed.2024.23214","url":null,"abstract":"<p><p>The aim of this study is to examine the protective effect of oxyresveratrol (OXY) against isoproterenol-induced myocardial infarction in rats, through routine biochemical parameters and oxidative stress parameters that show heart damage. Oxyresveratrol was administered by oral gavage at doses of 10 and 20 mg/kg, respectively, once a day for 5 days. On the fourth and fifth days, 180 mg/kg isoproterenol was administered intraperitoneally to the OXY treatment group and control groups. Twenty-four hours after the last isoproterenol application, blood and heart tissue were taken under anesthesia and transferred to -80 degrees and formalin for biochemical and histopathological studies. CK-MB and TnI levels were measured in serum obtained from blood. In the heart tissue, antioxidant parameters, superoxide dismutase (SOD), glutathione (GSH) and malondialdehyde (MDA) levels, and histopathological and stereological evaluations were performed. Oxyresveratrol has antioxidant and anti-inflammatory activity depending on the dose. Oxyresveratrol showed potent protective effect against isoproterenol-induced myocardial infarction. It has been proven that at all doses of oxyresveratrol, statistically, isoproterenol decreased the MDA level, which was one of the oxidative stress markers, compared to the control group, and increased SOD activity and GSH levels. Similar to the biochemically determined parameters, oxyresveratrol treatment was also found to have a protective effect at the cell level, histopathologically and stereologically. All results show that oxyresveratrol has strong antioxidant and anti-inflammatory activity, especially at a dose of 20 mg/kg, it significantly reduces myocardial damage and this agent has a cardioprotective effect.</p>","PeriodicalId":53592,"journal":{"name":"Eurasian Journal of Medicine","volume":"1 0","pages":"1-7"},"PeriodicalIF":0.9,"publicationDate":"2024-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12036349/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142814905","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Importance of Multisystem Evaluation in Diagnosing Birt-Hogg- Dubé Syndrome: A Case Report.","authors":"Alperen Aksakal, Zeynep Karaca Ural, Latifullah Jalal, Gizem Çil, Buğra Kerget, Ömer Araz, Elif Yılmazel Uçar, Leyla Sağlam","doi":"10.5152/eurasianjmed.2024.24499","DOIUrl":"10.5152/eurasianjmed.2024.24499","url":null,"abstract":"","PeriodicalId":53592,"journal":{"name":"Eurasian Journal of Medicine","volume":"56 3","pages":"213-215"},"PeriodicalIF":0.9,"publicationDate":"2024-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11535357/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142802986","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of Oral and Dental Health Results and Competition Stress Levels of Adolescent Athletes in Different Winter Sports Branches.","authors":"Buket Sevindik, Fatih Şengül, Fatih Kıyıcı","doi":"10.5152/eurasianjmed.2024.23281","DOIUrl":"10.5152/eurasianjmed.2024.23281","url":null,"abstract":"<p><strong>Background: </strong> The aim of the present study was to examine the findings of the intraoral examinations of the 12-16 years old novice (control) and elite athletes across the winter sports branches, which were alpine discipline skiing, snowboarding, biathlon, ski jumping, and ice hockey. Besides, the study aimed to determine the intra- and inter-group relationships by comparing the athletes salivary stress biomarker levels at precompetition, during-match, and post-competition stages.</p><p><strong>Methods: </strong> Ninety-one athletes (71 elite, 20 novice) participated in our study. Oral health status of the athletes were evaluated. In addition, cortisol levels in the saliva samples obtained at pre-competition (rested before the competition), during-match (just before the start), and post-competition (competition ending moment) stages were measured. The data were analyzed statistically with a significance level of 0.05.</p><p><strong>Results: </strong> Ice hockey athletes were the most affected by untreated dental caries (27.3%). No signs of dental trauma caused by sports activities were found in the winter sports branches. Basic erosive wear examination scores of the ice hockey athletes were similar to the ski jumping athletes and lower than other groups (P=.034). The mean cortisol values between sports branches were listed as: biathlon <snowboarding > alpine skiing < ice hockey < ski jumping (P < .001). Test results of the winter sports athletes' saliva samples revealed that their salivary stress levels might vary in accordance with the sports branches, and there was a negative relationship between the levels of salivary stress biomarkers in competitions and oral health.</p><p><strong>Conclusion: </strong> In winter sports activities, measures for improving oral health should be disseminated.</p>","PeriodicalId":53592,"journal":{"name":"Eurasian Journal of Medicine","volume":"56 2","pages":"114-120"},"PeriodicalIF":0.9,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11332273/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141918028","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Potential Using of Resveratrol and Its Derivatives in Medicine.","authors":"Taha Yasin Koç, Selin Doğan, Mehmet Karadayı","doi":"10.5152/eurasianjmed.2024.24392","DOIUrl":"10.5152/eurasianjmed.2024.24392","url":null,"abstract":"<p><p>A phytoalexin polyphenolic chemical, resveratrol, can be found in a variety of foods, including cereals, peanuts, grapes, strawberries, and raspberries. It is also known that resveratrol protects the body against cardiovascular diseases as well as various types of cancer. In addition to these health issues, resveratrol is currently the subject of research since it helps treat and prevent a number of illnesses. More clinical research is needed to validate resveratrol's potential as a therapeutic agent, despite the plethora of in vitro and in vivo evidence to support this. When the literature data are evaluated, the fact that resveratrol has a therapeutic effect in these studies, but it is known to be subject to rapid metabolism despite its low bioavailability and oral absorption of approximately 75%, has directed the studies to resveratrol derivatives, especially piceatannol. Based on recent studies, 4 types of resveratrol derivatives were assessed in this work: hydroxylated compounds, methoxylated compounds, glycosides, and oligomers. Because of their advantageous bioactivities, methoxylated, hydroxylated, and halogenated derivatives have drawn the most interest among these classes. However, as a result of these studies, more studies should be conducted to better understand whether resveratrol derivatives can be recommended as therapeutic agents.</p>","PeriodicalId":53592,"journal":{"name":"Eurasian Journal of Medicine","volume":"56 2","pages":"136-141"},"PeriodicalIF":0.9,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11332276/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141918029","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Involvement of the Serotonergic System in Ketamine and Fluoxetine Combination-induced Cognitive Impairments in Mice.","authors":"Emre Uyar, Meral Erdinç, İlker Kelle, Levent Erdinç, Uğur Şeker, Yusuf Nergiz","doi":"10.5152/eurasianjmed.2024.23219","DOIUrl":"10.5152/eurasianjmed.2024.23219","url":null,"abstract":"<p><strong>Background: </strong> Glutamatergic N-methyl-D-aspartate (NMDA) receptors play vital roles in memory formation. Changes in the activity of these receptors influence memory processes. Ketamine is a noncompetitive NMDA receptor antagonist drug with promising mood-altering and pain-reducing effects in low doses. These effects are believed to be related to altered serotonergic transmission.</p><p><strong>Methods: </strong> The present study investigated the involvement of the serotonergic system in low-dose ketamine administrations' effects on memory acquisition, consolidation, and retrieval processes. Sixty-four male BALB/c mice were used in this experiment and separated into 8t groups. Mice were treated subchronically with a selective serotonin reuptake inhibitor, fluoxetine, and a serotonin depletion agent, p-chlorophenylalanine (pCPA). A serotonin antagonist, methiothepin, and ketamine were acutely administered 60 minutes before or after the behavioral tests. A passive avoidance (PA) test measured emotional memory acquisition, consolidation, and retrieval processes. Hippocampi malondialdehyde (MDA) levels were analyzed, and histopathological examinations were performed.</p><p><strong>Results: </strong> Ketamine alone did not significantly affect memory encoding processes in the PA test, while the ketamine-fluoxetine combination disrupted memory consolidation. Fluoxetine negatively affected the memory acquisition process, which was normalized during the consolidation and retrieval trials. Drug applications did not significantly alter hippocampal MDA levels. In all ketamine-applied groups, histopathologic alterations were evident.</p><p><strong>Conclusion: </strong> Low-dose ketamine administration induces neurodegeneration, and it also impairs memory functions when combined with fluoxetine, indicating increased serotonergic transmission may be involved in the memory-impairing and neurotoxic effects of ketamine.</p>","PeriodicalId":53592,"journal":{"name":"Eurasian Journal of Medicine","volume":"56 2","pages":"102-107"},"PeriodicalIF":0.9,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11332274/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141918030","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Utility of [18]F-Fluorocholine Positron Emission Computed Tomography and [18]F-Fluorodeoxyglucose Positron Emission Tomography-Computed Tomography in Evaluating Breast Cancer Phenotypes: A Pilot Study.","authors":"Mohd Hazeman Zakaria, Shazreen Shaharudin, Fathinul Fikri Ahmad Saad","doi":"10.5152/eurasianjmed.2024.23047","DOIUrl":"10.5152/eurasianjmed.2024.23047","url":null,"abstract":"<p><p>The utility of the [18]F fluorodeoxyglucose positron emission tomography-computed tomography ([18]F FDG PET-CT) marker for breast cancer is well established. Given its limitations in localizing FDG-negative malignant tumors, the expression of [18]F-fluorocholine ([18]-FCH) may potentially be helpful to improve the overall accuracy in evaluating breast cancer. This study determined the potential of [18]- FCH PET CT as a potential marker in assessing breast cancer phenotypes. We recruited consecutive patients with biopsy-proven breast carcinoma who underwent [18] F-FCH PET-CT following the [18]F-FDG PET-CT imaging. The subjects were dichotomized into human epidermal growth factor receptor 2 (HER2)-negative and HER2-positive genotypes. The maximum standardized uptake value (SUVmax; g/dL) was used to predict the two groups of variables. Global health status (GHS) score based on the EORTC quality of life questionnaire (QLQ) was used to evaluate the outcome of the cohort subjects at 6, 12, and 24 months. There were 21 females with a mean age of 54.48 ± 12.17 years. Eighteen patients had invasive ductal carcinoma (18/21;85.8%) on histology, with 11 (52.4%) were HER2-negative genotype. There was higher sensitivity and specificity of [18]-FCH-PET/CT in breast lesions at 40% and 68.8% compared to [18]FDGPET/CT with 33.3% and 66.7%, respectively. There were significant differences between [18]F-FCH SUVmax (g/dL) of the HER-negative as compared to the HER2- positive group (1.99 g/dL vs. 0.2 g/dL; P < .05). High SUVmax (g/dL) of [18]F-FCH had predicted the HER-negative genotype at the cutoff value of 0.75 (P < .05). High [18]F-FCH showed significantly poor scoring of GHS parameters compared to low FCH at 6 months (mean SUVmax 8.06 vs. 5.40 respectively; P < .05). [18]F-FCH PET-CT is a potential marker in localizing and predicting aggressive breast carcinoma phenotypes.</p>","PeriodicalId":53592,"journal":{"name":"Eurasian Journal of Medicine","volume":"56 2","pages":"78-85"},"PeriodicalIF":0.9,"publicationDate":"2024-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11332258/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141983893","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Extracorporeal Shock Wave Therapy with Low-Energy Flux Density Treatment Applied to Hemiplegia Patients on Somatosensory Functions and Spatiotemporal Parameters.","authors":"Gülnihal Deniz, Furkan Bilek, Arif Gülkesen, Murteza Çakır","doi":"10.5152/eurasianjmed.2024.23270","DOIUrl":"10.5152/eurasianjmed.2024.23270","url":null,"abstract":"<p><p>We aimed to investigate the efect of Extracorporeal Shock Wave Therapy (ESWT) applied to patients with hemiplegia on somatosensory data, spatiotemporal parameters, posture, and muscle tone. This was a double-blind, randomised, controlled trial. Patients were randomised within pairs to either the experimental (ESWT) group (n=20) or the control group (n=20). All patients participated in the same conventional stroke rehabilitation program for 60 minutes of treatment a day, 5 times a week for 6 weeks (30 sessions). Patients assigned to the ESWT group received additional ESWT over the plantar fascia 3 days/week for 6 weeks. Timed Up and Go (TUG) test, Modified Ashworth Scale (MAS) score, Posture Assessment Scale for Stroke Patients (PASS), spatiotemporal parameters, Semmes-Weinstein monofilament (SWM) test, and vibration sensation test (VST) were performed in all participant before and after treatment. In the ESWT and control groups, statistically, significant diferences were obtained in the posttreatment analysis than pre-treatment. Significant diferences were found in foot angle, step cycle duration, swing phase, cadence, gait cycle distance, and VST values after ESWT treatment (P < .01). When combined with a neurological rehabilitation program, it was determined that ESWT applied to the plantar face of the foot in individuals with hemiplegia increased somatosensory functions and was more successful in developing postural control and balance.</p>","PeriodicalId":53592,"journal":{"name":"Eurasian Journal of Medicine","volume":"56 1","pages":""},"PeriodicalIF":0.9,"publicationDate":"2024-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11059815/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141898907","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}