Eurasian Journal of Medicine最新文献_第3页

The Role of Pectin Hydrogel Systems Plus Iodine and Phyto Extract in Second-Degree Burn in Rats. 果胶水凝胶体系加碘和植物提取物在大鼠二度烧伤中的作用。

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Eurasian Journal of Medicine Pub Date : 2024-10-23 DOI: 10.5152/eurasianjmed.2024.24550

Kubra Aliyeva, Abdulmecit Albayrak, Erdem Toktay, Emir Enis Yurdgulu, Yasin Bayir

{"title":"The Role of Pectin Hydrogel Systems Plus Iodine and Phyto Extract in Second-Degree Burn in Rats.","authors":"Kubra Aliyeva, Abdulmecit Albayrak, Erdem Toktay, Emir Enis Yurdgulu, Yasin Bayir","doi":"10.5152/eurasianjmed.2024.24550","DOIUrl":"10.5152/eurasianjmed.2024.24550","url":null,"abstract":"Skin injuries, such as burns, can result in an open wound that can lead to the deterioration of the skin, which acts as a protective barrier against external agents, and can cause serious health problems. Pectin, a plant-derived polysaccharide, is a suitable candidate for wound care due to its gel-forming ability and biocompatibility. Pectin absorbs wound exudates to form a soft gel and is known for its strong anti-inflammatory efects. Pectin-based hydrogel systems promote wound healing by promoting fibroblast proliferation and keratinocyte migration. In the study, 60 male Wistar albino rats were used, and 6 diferent treatment groups were formed: Healthy control, burn control, silver sulfadiazine, pectin-based hydrogel system, pectin-based hydrogel system+iodine, pectin-based hydrogel system+plant extract. Rats with burn wounds were treated for 21 days, and the wound healing process was evaluated by macroscopic, biochemical, and histopathological analysis. The results showed that the pectin-based hydrogel system, iodine, and plant extracts promoted healing in burn wounds. Especially in the groups treated with silver sulfadiazine and plant extracts, the development of granulation tissue and regeneration of collagen fibers showed significant improvement. Furthermore, the pectin-based hydrogel system is thought to contribute to wound healing by maintaining skin moisturization. Vascular endothelial growth factor (VEGF) and transforming growth factor-β (TGF-β) levels decreased in the treatment groups compared to the burn group, and it was determined that these factors play an important role in wound healing. This study shows that pectin-based hydrogel systems can be an efective alternative in burn treatment, and their healing efects can be enhanced by the addition of iodine and plant extracts.","PeriodicalId":53592,"journal":{"name":"Eurasian Journal of Medicine","volume":"56 3","pages":"170-177"},"PeriodicalIF":0.9,"publicationDate":"2024-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11535358/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142802999","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Healthy Lifestyle Behaviors of Research Assistants and Final-Year Students in the Medical Faculty. 研究助理与医学院毕业班学生的健康生活方式行为。

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Eurasian Journal of Medicine Pub Date : 2024-10-23 DOI: 10.5152/eurasianjmed.2024.24412

Nurdan Torun, Aysun Aras, Serhat Vançelik, Zahide Koşan, Sinan Yilmaz

{"title":"Healthy Lifestyle Behaviors of Research Assistants and Final-Year Students in the Medical Faculty.","authors":"Nurdan Torun, Aysun Aras, Serhat Vançelik, Zahide Koşan, Sinan Yilmaz","doi":"10.5152/eurasianjmed.2024.24412","DOIUrl":"10.5152/eurasianjmed.2024.24412","url":null,"abstract":"This study aimed to identify the health-related behaviors and associated factors among research assistants and final-year students at a Faculty of Medicine. In this cross-sectional study, a total of 712 assistant physicians and final-year medical students participated. Data collection involved using a survey form to inquire about participants' sociodemographic characteristics and the \"Healthy Lifestyle Behavior Scale II (HPLP II).\" Descriptive statistics, t-test, ANOVA, Kruskal-Wallis, and Mann-Whitney U tests with Bonferroni correction were employed for data analysis. Among the participants, 52.5% were assistant physicians, 47.5% were final-year students, and 50.4% were women. Physicians scored an average of 120.0 ± 16.5 on the HPLP II, with the lowest in the physical activity subscale and the highest score in the spiritual development subscale. Healthy lifestyles were more prevalent in those aged 23-28, in those not married and who are childless, women, non-shift workers, nonsmokers, those with chronic conditions, and those perceiving their health as good or fair. Factors influencing healthy lifestyle behaviors include age, marital status, parenthood, smoking and alcohol habits, work unit, health perception, and chronic diseases. Analyzing and conducting studies on modifiable characteristics are recommended to enhance health.","PeriodicalId":53592,"journal":{"name":"Eurasian Journal of Medicine","volume":"56 3","pages":"159-162"},"PeriodicalIF":0.9,"publicationDate":"2024-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11535270/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142802712","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical and Laboratory Findings in Children with Hashimoto's Thyroiditis. 儿童桥本甲状腺炎的临床和实验室表现。

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Eurasian Journal of Medicine Pub Date : 2024-10-23 DOI: 10.5152/eurasianjmed.2024.24541

Ayşe Ozden, Hakan Doneray

{"title":"Clinical and Laboratory Findings in Children with Hashimoto's Thyroiditis.","authors":"Ayşe Ozden, Hakan Doneray","doi":"10.5152/eurasianjmed.2024.24541","DOIUrl":"10.5152/eurasianjmed.2024.24541","url":null,"abstract":"Hashimoto's thyroiditis (HT) is the most common cause of goiter and acquired hypothyroidism in children after iodine deficiency. In this study, clinical and laboratory findings and follow-up results of children diagnosed with HT are presented. The data of cases diagnosed with HT between 2004 and 2022 in 2 centers in Erzurum were evaluated retrospectively. Of the 81 children with HT whose ages ranged from 3 to 18 years (11.24 ± 3.72), 67 (82.7%) were girls and 14 (17.3%) were boys. The most common symptoms were neck swelling (37%), fatigue (23.5%), and hair loss (23.5%). There was a family history of HT in 12 cases (9.9%). Fifty-one (63%) of the cases were in the pubertal period and 30 (37%) were in the prepubertal period. There was no goiter in 36 (44.4%) of the patients, second degree goiter in 24 (29.6%), first degree goiter in 14 (17.3%), and third degree goiter in 7 (8.7%). Twenty-two (27.2%) of the cases were euthyroid, 27 (33.3%) were subclinical hypothyroidism, 23 (28.4%) were hypothyroidism, and 9 (11.1%) were hyperthyroidism. While 18 (22.2%) of the cases were followed up without medication, 59 (72.8%) were given levothyroxine and 4 (5%) were given methimazole. The mean follow-up time was 32.1 ± 33.7 months. The study's findings suggest that HT is more common in girls and occurs more frequently after puberty. A personal or family history of an autoimmune disease may be a warning sign for HT. Additionally, HT should be kept in mind in the diferential diagnosis of children presenting with complaints of neck swelling, fatigue, and hair loss.","PeriodicalId":53592,"journal":{"name":"Eurasian Journal of Medicine","volume":"56 3","pages":"178-181"},"PeriodicalIF":0.9,"publicationDate":"2024-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11535305/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142803187","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Current Developments in the Treatment of Postpartum Depression: Zuranolone. 产后抑郁症治疗的最新进展：屈拉诺酮。

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Eurasian Journal of Medicine Pub Date : 2024-10-23 DOI: 10.5152/eurasianjmed.2024.24409

Dogancan Sonmez, Cicek Hocaoglu

{"title":"Current Developments in the Treatment of Postpartum Depression: Zuranolone.","authors":"Dogancan Sonmez, Cicek Hocaoglu","doi":"10.5152/eurasianjmed.2024.24409","DOIUrl":"10.5152/eurasianjmed.2024.24409","url":null,"abstract":"Pregnancy is a period in a woman's life during which she experiences physiological, psychological, and social changes. These changes can lead to various mental illnesses, including postpartum depression (PPD), which is common during the perinatal period. Postpartum depression is a significant cause of morbidity and mortality for both the mother and baby. A peripartum-onset major depressive episode is defined as PPD when it occurs during pregnancy or up to 4 weeks postpartum. The frequency of this condition is extremely high. Its etiology is influenced by biological, psychological, and sociocultural factors. Depressed mood, anhedonia, feelings of guilt, irritability, lack of concentration, psychomotor agitation or retardation, sleep disturbance, and changes in appetite and weight can all be symptoms of PPD. There are various treatment options available, many of which are adapted from those used for major depression. Selective serotonin reuptake inhibitors, serotonin-noradrenaline reuptake inhibitors, tricyclic antidepressants, estradiol, progesterone, psychotherapies, electroconvulsive therapy, and brexanolone can be used to treat PPD. In addition, the newest drug approved by the FDA (Food and Drug Administration) for this condition is oral zuranolone. This review aims to analyze recent developments on zuranolone, the latest drug approved by the FDA for PPD, based on current studies.","PeriodicalId":53592,"journal":{"name":"Eurasian Journal of Medicine","volume":"56 3","pages":"199-204"},"PeriodicalIF":0.9,"publicationDate":"2024-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11535317/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142802799","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Time-Sensitive Quality Metrics of Acute Stroke Care: A Comprehensive Stroke Center Experience. 急性中风护理的时间敏感质量指标：一个全面的中风中心经验。

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Eurasian Journal of Medicine Pub Date : 2024-10-23 DOI: 10.5152/eurasianjmed.2024.24554

Merve Korukcu, Alper Eren

{"title":"Time-Sensitive Quality Metrics of Acute Stroke Care: A Comprehensive Stroke Center Experience.","authors":"Merve Korukcu, Alper Eren","doi":"10.5152/eurasianjmed.2024.24554","DOIUrl":"10.5152/eurasianjmed.2024.24554","url":null,"abstract":"The stroke center approach provides an efective solution for acute stroke management. Our study aims to systematically analyze our stroke center records to identify factors that afect acute stroke time-sensitive quality metrics. Data were prospectively collected from 524 acute stroke patients at the Comprehensive Stroke Center of Atatürk UniversityMedical Faculty Hospital between January 1, 2021, and September 30, 2021. Data collected included sociodemographic, clinical, admission type, initial National Institutes of Health Stroke Scale (NIHSS), treatment modality, and time-sensitive metrics and were statistically analyzed based on stroke quality metrics. Patients with mild NIHSS scores (0-7) had longer onset-to-door (OTD) time, door-to-computed tomography (CT)/neurologist, and hospitalization times (P < .001). The OTD, door-to-CT/neurologist, and hospitalization times varied depending on the treatment methods used (P < .005). The OTD time was influenced by the patient's level of education (P=.004), admission type (P < .001), and geographical location (P=.002). A moderate negative correlation was found between patients' OTD time and baseline NIHSS (r=-0.270; P < 0.001). The results emphasize the significance of several factors, such as admission type, geographical location, and treatment methods, in shaping the time-sensitive quality metrics of stroke care. Additionally, the initial NIHSS score of patients plays a crucial role in both prehospital and in-hospital aspects of acute stroke management.","PeriodicalId":53592,"journal":{"name":"Eurasian Journal of Medicine","volume":"56 3","pages":"182-188"},"PeriodicalIF":0.9,"publicationDate":"2024-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11535306/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142803001","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Analysis of the Effects of SAA1 Gene Polymorphisms on Renal Involvement in a Familial Mediterranean Fever Jordanian Population. SAA1基因多态性对家族性地中海热约旦人群肾脏受累的影响分析。

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Eurasian Journal of Medicine Pub Date : 2024-09-24 DOI: 10.5152/eurasianjmed.2024.24457

Ahmed Sheyyab, Rania Wahdan, Al-Ameen Al-Aitan, Mahmoud Abukhadra, Laith Hussein Ayed Naimat

{"title":"Analysis of the Effects of SAA1 Gene Polymorphisms on Renal Involvement in a Familial Mediterranean Fever Jordanian Population.","authors":"Ahmed Sheyyab, Rania Wahdan, Al-Ameen Al-Aitan, Mahmoud Abukhadra, Laith Hussein Ayed Naimat","doi":"10.5152/eurasianjmed.2024.24457","DOIUrl":"10.5152/eurasianjmed.2024.24457","url":null,"abstract":"Familial Mediterranean Fever (FMF) is an inherited autosomal recessive disorder resulting from the inheritance of MEFV gene mutations. Patients with FMF are at increased risk of secondary amyloidosis, namely type AA. In some Mediterranean populations, the α genotype was associated with the development of renal amyloidosis, a finding not reproduced in other populations. Our study aimed to assess the association of SAA1 genotypes with renal involvement. This is a retrospective analysis of FMF patients which were followed at our institute between January 2016 and August 2022. Familial Mediterranean Fever screening was performed using polymerase chain reaction and reverse hybridization techniques. Statistical analysis was performed using bivariate logistic regression. MEFV analysis of the studied patients (n=427) identified 52 patients with a homozygous genotype (12.1%) and 374 with a heterozygous genotype (87.5%). The heterozygous group were mostly heterozygous carriers of a single FMF variant (81%), while 19% were compound heterozygous. Renal involvement was revealed in 95 patients (22.2%), which were manifested as proteinuria (21.3%) and/or renal impairment in 4 patients (3%). The clinical diagnosis of amyloidosis was suspected in 6 patients only (1.4%). Analysis for SAA1 gene genotype-phenotype correlation showed that patients with the SAA1.1/1.1 (OR=0.54, P=.452) was not statistically associated with renal involvement. Pearson Chi-square was performed to examine the association between FMF homozygosity and each SAA1 genotype, which showed a significant association between FMF gene homozygosity with SAA1.1/1.1 genotype (χ2 = 8.06, P=.018). In our Jordanian FMF population, we report low rates of renal involvement with a high rate of the β haplotype (SAA1.5). Neither the α/α nor the β/β genotypes were associated with evidence of renal involvement.","PeriodicalId":53592,"journal":{"name":"Eurasian Journal of Medicine","volume":"56 3","pages":"153-158"},"PeriodicalIF":0.9,"publicationDate":"2024-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11535276/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142803186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Protective Effects of Oxyresveratrol in IsoproterenolInduced Myocardial Infarction in Rats: A Stereological Study. 氧化白藜芦醇对异丙肾上腺素诱导大鼠心肌梗死的保护作用：一项体视学研究。

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Eurasian Journal of Medicine Pub Date : 2024-09-13 DOI: 10.5152/eurasianjmed.2024.23214

Huseyn Aliyev, Sibel Bilgili, Erdem Toktay, Nubar Nuriyeva, Yasin Bayir

{"title":"Protective Effects of Oxyresveratrol in IsoproterenolInduced Myocardial Infarction in Rats: A Stereological Study.","authors":"Huseyn Aliyev, Sibel Bilgili, Erdem Toktay, Nubar Nuriyeva, Yasin Bayir","doi":"10.5152/eurasianjmed.2024.23214","DOIUrl":"10.5152/eurasianjmed.2024.23214","url":null,"abstract":"The aim of this study is to examine the protective effect of oxyresveratrol (OXY) against isoproterenol-induced myocardial infarction in rats, through routine biochemical parameters and oxidative stress parameters that show heart damage. Oxyresveratrol was administered by oral gavage at doses of 10 and 20 mg/kg, respectively, once a day for 5 days. On the fourth and fifth days, 180 mg/kg isoproterenol was administered intraperitoneally to the OXY treatment group and control groups. Twenty-four hours after the last isoproterenol application, blood and heart tissue were taken under anesthesia and transferred to -80 degrees and formalin for biochemical and histopathological studies. CK-MB and TnI levels were measured in serum obtained from blood. In the heart tissue, antioxidant parameters, superoxide dismutase (SOD), glutathione (GSH) and malondialdehyde (MDA) levels, and histopathological and stereological evaluations were performed. Oxyresveratrol has antioxidant and anti-inflammatory activity depending on the dose. Oxyresveratrol showed potent protective effect against isoproterenol-induced myocardial infarction. It has been proven that at all doses of oxyresveratrol, statistically, isoproterenol decreased the MDA level, which was one of the oxidative stress markers, compared to the control group, and increased SOD activity and GSH levels. Similar to the biochemically determined parameters, oxyresveratrol treatment was also found to have a protective effect at the cell level, histopathologically and stereologically. All results show that oxyresveratrol has strong antioxidant and anti-inflammatory activity, especially at a dose of 20 mg/kg, it significantly reduces myocardial damage and this agent has a cardioprotective effect.","PeriodicalId":53592,"journal":{"name":"Eurasian Journal of Medicine","volume":"1 0","pages":"1-7"},"PeriodicalIF":0.9,"publicationDate":"2024-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12036349/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142814905","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Importance of Multisystem Evaluation in Diagnosing Birt-Hogg- Dubé Syndrome: A Case Report. 多系统评价在诊断Birt-Hogg- dub<s:1>综合征中的重要性：1例报告。

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Eurasian Journal of Medicine Pub Date : 2024-08-14 DOI: 10.5152/eurasianjmed.2024.24499

Alperen Aksakal, Zeynep Karaca Ural, Latifullah Jalal, Gizem Çil, Buğra Kerget, Ömer Araz, Elif Yılmazel Uçar, Leyla Sağlam

引用次数: 0

Evaluation of Oral and Dental Health Results and Competition Stress Levels of Adolescent Athletes in Different Winter Sports Branches. 评估不同冬季运动项目青少年运动员的口腔和牙齿健康状况以及比赛压力水平。

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Eurasian Journal of Medicine Pub Date : 2024-06-01 DOI: 10.5152/eurasianjmed.2024.23281

Buket Sevindik, Fatih Şengül, Fatih Kıyıcı

{"title":"Evaluation of Oral and Dental Health Results and Competition Stress Levels of Adolescent Athletes in Different Winter Sports Branches.","authors":"Buket Sevindik, Fatih Şengül, Fatih Kıyıcı","doi":"10.5152/eurasianjmed.2024.23281","DOIUrl":"10.5152/eurasianjmed.2024.23281","url":null,"abstract":"Background: The aim of the present study was to examine the findings of the intraoral examinations of the 12-16 years old novice (control) and elite athletes across the winter sports branches, which were alpine discipline skiing, snowboarding, biathlon, ski jumping, and ice hockey. Besides, the study aimed to determine the intra- and inter-group relationships by comparing the athletes salivary stress biomarker levels at precompetition, during-match, and post-competition stages.Methods: Ninety-one athletes (71 elite, 20 novice) participated in our study. Oral health status of the athletes were evaluated. In addition, cortisol levels in the saliva samples obtained at pre-competition (rested before the competition), during-match (just before the start), and post-competition (competition ending moment) stages were measured. The data were analyzed statistically with a significance level of 0.05.Results: Ice hockey athletes were the most affected by untreated dental caries (27.3%). No signs of dental trauma caused by sports activities were found in the winter sports branches. Basic erosive wear examination scores of the ice hockey athletes were similar to the ski jumping athletes and lower than other groups (P=.034). The mean cortisol values between sports branches were listed as: biathlon <snowboarding > alpine skiing < ice hockey < ski jumping (P < .001). Test results of the winter sports athletes' saliva samples revealed that their salivary stress levels might vary in accordance with the sports branches, and there was a negative relationship between the levels of salivary stress biomarkers in competitions and oral health.Conclusion: In winter sports activities, measures for improving oral health should be disseminated.","PeriodicalId":53592,"journal":{"name":"Eurasian Journal of Medicine","volume":"56 2","pages":"114-120"},"PeriodicalIF":0.9,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11332273/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141918028","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Potential Using of Resveratrol and Its Derivatives in Medicine. 白藜芦醇及其衍生物在医学中的潜在用途。

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Eurasian Journal of Medicine Pub Date : 2024-06-01 DOI: 10.5152/eurasianjmed.2024.24392

Taha Yasin Koç, Selin Doğan, Mehmet Karadayı

{"title":"Potential Using of Resveratrol and Its Derivatives in Medicine.","authors":"Taha Yasin Koç, Selin Doğan, Mehmet Karadayı","doi":"10.5152/eurasianjmed.2024.24392","DOIUrl":"10.5152/eurasianjmed.2024.24392","url":null,"abstract":"A phytoalexin polyphenolic chemical, resveratrol, can be found in a variety of foods, including cereals, peanuts, grapes, strawberries, and raspberries. It is also known that resveratrol protects the body against cardiovascular diseases as well as various types of cancer. In addition to these health issues, resveratrol is currently the subject of research since it helps treat and prevent a number of illnesses. More clinical research is needed to validate resveratrol's potential as a therapeutic agent, despite the plethora of in vitro and in vivo evidence to support this. When the literature data are evaluated, the fact that resveratrol has a therapeutic effect in these studies, but it is known to be subject to rapid metabolism despite its low bioavailability and oral absorption of approximately 75%, has directed the studies to resveratrol derivatives, especially piceatannol. Based on recent studies, 4 types of resveratrol derivatives were assessed in this work: hydroxylated compounds, methoxylated compounds, glycosides, and oligomers. Because of their advantageous bioactivities, methoxylated, hydroxylated, and halogenated derivatives have drawn the most interest among these classes. However, as a result of these studies, more studies should be conducted to better understand whether resveratrol derivatives can be recommended as therapeutic agents.","PeriodicalId":53592,"journal":{"name":"Eurasian Journal of Medicine","volume":"56 2","pages":"136-141"},"PeriodicalIF":0.9,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11332276/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141918029","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0