Eurasian Journal of Medicine最新文献

The Effects of Surgical Androgen Deprivation Therapy for Advanced Prostate Cancer on Peripapillary Retinal Nerve Fiber Layer Thickness. 手术雄激素剥夺治疗晚期前列腺癌对乳头周围视网膜神经纤维层厚度的影响。

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Eurasian Journal of Medicine Pub Date : 2025-05-12 DOI: 10.5152/eurasianjmed.2025.24597

Feyzahan Uzun, Hüseyin Fındık, Muhammet Kaim

{"title":"The Effects of Surgical Androgen Deprivation Therapy for Advanced Prostate Cancer on Peripapillary Retinal Nerve Fiber Layer Thickness.","authors":"Feyzahan Uzun, Hüseyin Fındık, Muhammet Kaim","doi":"10.5152/eurasianjmed.2025.24597","DOIUrl":"10.5152/eurasianjmed.2025.24597","url":null,"abstract":"Background: Prostate cancer is the most common malignancy in men, and androgen deprivation therapy (ADT) serves as the primary approach for managing advanced cases. Certain research has suggested the impact of androgens on the physiological homeostasis of the optic nerve. Our aim was to investigate the impact of surgical ADT on peripapillary retinal nerve fiber layer (RNFL) thickness in patients with advanced prostate cancer. Methods: The study comprised 30 patients who had undergone bilateral orchiectomy for advanced prostate cancer, with a total of 60 eyes included in the analysis. Each participant received a standard ophthalmological examination. Peripapillary RNFL thickness measurements were performed preoperatively and 12 months postoperatively using optical coherence tomography. Results: The mean age of the patients was 73.77 ± 8.8 years. At the 12th month following surgery, we observed that the mean average thickness of the right and left RNFL, as well as the thickness of the left nasal, left inferior, and right and left temporal quadrants, was significantly thinner compared to presurgical values (P< .05). However, when comparing pre- and postsurgical measurements, the RNFL thickness in the right and left superior quadrants, as well as the right nasal and right inferior quadrants, showed no statistically significant difference. Conclusion: In this study, a significant difference was observed between the preoperative and 12-months postoperative peripapillary RNFL thickness values in patients who underwent surgical ADT for advanced prostate cancer. Additional research using larger sample sizes is required to clinically examine the impact of ADT on optic nerve homeostasis.","PeriodicalId":53592,"journal":{"name":"Eurasian Journal of Medicine","volume":"57 2","pages":"1-5"},"PeriodicalIF":0.9,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12102613/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144103156","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Clinical Impact of the Decipher Genomic Classifier in Prostate Cancer. 破译基因组分类器在前列腺癌中的临床作用。

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Eurasian Journal of Medicine Pub Date : 2025-05-05 DOI: 10.5152/eurasianjmed.2025.25828

Sophia Li, Stephanie A Berg, Mutlay Sayan

{"title":"The Clinical Impact of the Decipher Genomic Classifier in Prostate Cancer.","authors":"Sophia Li, Stephanie A Berg, Mutlay Sayan","doi":"10.5152/eurasianjmed.2025.25828","DOIUrl":"10.5152/eurasianjmed.2025.25828","url":null,"abstract":"The Decipher genomic classifier (GC) is a 22-gene expression test that refines risk stratification and informs treatment decisions in localized prostate cancer. Traditional clinicopathologic factors, including prostate-specific antigen levels and kinetics, Gleason score, histologic variants, and tumor stage, do not fully capture disease heterogeneity, leading to potential overtreatment or undertreatment. The Decipher GC has demonstrated clinical utility across risk groups, helping to distinguish candidates for active surveillance in low-risk prostate cancer, refine the need for androgen deprivation therapy in intermediate-risk disease, and guide treatment intensification in high-risk patients. In the post-radical prostatectomy setting, the GC aids in determining the need for early salvage radiation therapy and hormonal therapy. While retrospective studies support its prognostic value, limitations include heterogeneity in study designs and the lack of established predictive utility for treatment response. Ongoing prospective trials, such as NRG GU-009 and NRG GU-010, aim to validate further the Decipher GC's role in clinical decision-making and treatment personalization.","PeriodicalId":53592,"journal":{"name":"Eurasian Journal of Medicine","volume":"57 2","pages":"1-4"},"PeriodicalIF":0.9,"publicationDate":"2025-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12102616/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144103153","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Threat Emerging in Patients with Hematological Malignancy: Invasive Magnusiomyces capitatus and Magnusiomyces clavatus Infections. 恶性血液病患者的威胁：侵袭性大写Magnusiomyces和锁骨Magnusiomyces感染。

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Eurasian Journal of Medicine Pub Date : 2025-04-30 DOI: 10.5152/eurasianjmed.2025.24565

Rukiye İnan Sarıkaya, Ayşe Albayrak, Fuat Erdem, Muhammet Hamidullah Uyanık, Şeyma Demirelli, Zafer Bıçakçı, Kemalettin Özden

{"title":"A Threat Emerging in Patients with Hematological Malignancy: Invasive Magnusiomyces capitatus and Magnusiomyces clavatus Infections.","authors":"Rukiye İnan Sarıkaya, Ayşe Albayrak, Fuat Erdem, Muhammet Hamidullah Uyanık, Şeyma Demirelli, Zafer Bıçakçı, Kemalettin Özden","doi":"10.5152/eurasianjmed.2025.24565","DOIUrl":"10.5152/eurasianjmed.2025.24565","url":null,"abstract":"Background: Magnusiomyces capitatus (M. capitatus) and Magnusiomyces clavatus (M. clavatus) are rare cause of fungemia leading to high mortality rates, particularly in neutropenic patients with hematological malignancies. This research set out to explore the clinical characteristics of patients with hematological malignancies with M. capitatus and M. clavatus fungemia. Methods: Eight patients from whom Magnusiomyces spp. were isolated, from among patients hospitalized at the Atatürk University Hospital between October 2017 and November 2022, were enrolled in this retrospective observational study. The 8 patients' medical data were subjected to analysis. Results: Magnusiomyces capitatus emerged as the pathogen in 5 cases and M. clavatus in 3. The patients' median age was 35.5 years. The most common underlying hematological malignancy was acute leukemia. Neutrophil values of 500 cells/mm3 were detected in all patients during Magnusiomyces spp. isolation, with severe neutropenia at less than 100 cells/mm3 in 5. The mean duration of neutropenia prior to Magnusiomyces spp. isolation was 29 days. Breakthrough fungemia developed in 7 patients using echinocandins, fluconazole, and posaconazole. Liposomal amphotericin B and voriconazole were used for initial treatment. The general mortality rate was 37%. All isolates were resistant to echinocandins. Voriconazole possessed the lowest minimum inhibitory concentration value against all isolates. The survival rate was higher among young patients. Mortality was higher among patients followed up in the intensive care unit. Conclusion: Life-threatening Magnusiomyces spp. can spread among patients with long-term neutropenia under treatment for hematological malignancies. Awareness and prompt initiation of treatment can reduce the risk of mortality in invasive infections caused by Magnusiomyces spp.","PeriodicalId":53592,"journal":{"name":"Eurasian Journal of Medicine","volume":"57 1","pages":"1-6"},"PeriodicalIF":0.9,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12102678/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144080708","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Investigation of Hepatitis B Virus (HBsAg, Anti-HBs) and Anti-Hepatitis C Virus Serology in Erzurum Region: 2015-2023. 2015-2023年埃尔祖鲁姆地区乙型肝炎病毒（HBsAg、Anti-HBs）和丙型肝炎病毒血清检测

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Eurasian Journal of Medicine Pub Date : 2025-04-30 DOI: 10.5152/eurasianjmed.2025.24635

Mahmut Uçar, Ahmet Yılmaz, Demet Çelebi, Özgür Çelebi

{"title":"Investigation of Hepatitis B Virus (HBsAg, Anti-HBs) and Anti-Hepatitis C Virus Serology in Erzurum Region: 2015-2023.","authors":"Mahmut Uçar, Ahmet Yılmaz, Demet Çelebi, Özgür Çelebi","doi":"10.5152/eurasianjmed.2025.24635","DOIUrl":"10.5152/eurasianjmed.2025.24635","url":null,"abstract":"Background: Hepatitis B virus (HBV) and hepatitis C virus (HCV) infections are among the problems affecting public health worldwide. In this study, we aimed to retrospectively examine the results of patients whose hepatitis B (hepatitis B surface antigen (HBsAg), anti-HBs (Hepatitis B surface antibody) and hepatitis C serology were analyzed by family physicians in the provincial center of Erzurum and to investigate the change in seroprevalence by gender, age groups, and years. Methods: The serology results of individuals whose HBV and anti-HCV serology were analyzed by family physicians in Erzurum between 2015-2023 were evaluated retrospectively. Hepatitis B virus and anti-HCV analyses of the patients were performed in the Public Health Microbiology Laboratory using the chemilu minescence enzyme immunoassay method in accordance with the study procedure of the producing company. These records of the patients were obtained from the laboratory automation system with permission obtained from the Health Directorate. Results: Our study's population consisted of 150 862 people. The study determined that HBsAg, anti-HBs, and anti-HCV seropositivity rates were 1.7%, 58.0%, and 0.02%, respectively. The difference between HBsAg and anti-HBs seropositivity results was statistically significant between individuals born before 1998 and those born after 1998. Conclusion: In our study, it is significant that the HBsAg positivity rate tends to decrease, and anti-HBs sero- positivity has been observed at higher rates in recent years. The rate of anti-HCV seropositivity was found to be lower compared to other studies conducted in our region.","PeriodicalId":53592,"journal":{"name":"Eurasian Journal of Medicine","volume":"57 1","pages":"1-5"},"PeriodicalIF":0.9,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12102679/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144081664","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact of Cribriform Pattern on Progression-Free Survival After Radical Prostatectomy in Gleason Score 8-10 Prostate Cancer. 筛状模式对Gleason评分8-10分前列腺癌根治性前列腺切除术后无进展生存的影响。

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Eurasian Journal of Medicine Pub Date : 2025-04-21 DOI: 10.5152/eurasianjmed.2025.25804

Tyler Walburn, Yetkin Tuaç, Çağdaş Aktan, Okan Argun, Luke W Chen, David D Yang, Shalini Moningi, Jonathan E Leeman, Peter F Orio, Paul L Nguyen, Anthony V D'Amico, Mutlay Sayan

{"title":"Impact of Cribriform Pattern on Progression-Free Survival After Radical Prostatectomy in Gleason Score 8-10 Prostate Cancer.","authors":"Tyler Walburn, Yetkin Tuaç, Çağdaş Aktan, Okan Argun, Luke W Chen, David D Yang, Shalini Moningi, Jonathan E Leeman, Peter F Orio, Paul L Nguyen, Anthony V D'Amico, Mutlay Sayan","doi":"10.5152/eurasianjmed.2025.25804","DOIUrl":"10.5152/eurasianjmed.2025.25804","url":null,"abstract":"Background: Although extensive research highlights the detrimental effect of cribriform pattern 4 (CP4) on survival in non-high-risk prostate cancer (PC), its prognostic significance in high-risk PC is not well understood. Methods: The individual patient data from the The Cancer Genome Atlas (TCGA) database following radical prostatectomy was retrospectively examined. A predefined statistical analysis was conducted to evaluate the potential association between CP4 and progression-free survival (PFS). Results: Of the 135 patients examined, CP4 was present in 66 (48.9%). Median follow-up was 45.93 months (interquartile range: 22.87, 80.10). Cribriform pattern 4 was associated with a significantly reduced PFS (subdistribution hazard ratio, 1.99; 95% CI, 1.01-3.92; P=.045) following adjustment for covariates. Conclusions: The presence of CP4 in high-risk Gleason 8-10 PC portends worse PFS. Further studies are warranted to fully understand its implications in risk stratification and post-operative management of PC.","PeriodicalId":53592,"journal":{"name":"Eurasian Journal of Medicine","volume":"57 1","pages":"1-5"},"PeriodicalIF":0.9,"publicationDate":"2025-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12038371/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144081662","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

New Gene Targets for Diagnosis and Therapy of Diabetic Retinopathy. 糖尿病视网膜病变诊断和治疗的新基因靶点。

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Eurasian Journal of Medicine Pub Date : 2025-04-19 DOI: 10.5152/eurasianjmed.2025.24559

Emine Çinici, Mehmet Enes Arslan, Özge Çağlar Yıldırım, Nilay Dilekmen, Bahadır Utlu, Özkan Çinici, Zehra Sağlam, Hasan Türkez

{"title":"New Gene Targets for Diagnosis and Therapy of Diabetic Retinopathy.","authors":"Emine Çinici, Mehmet Enes Arslan, Özge Çağlar Yıldırım, Nilay Dilekmen, Bahadır Utlu, Özkan Çinici, Zehra Sağlam, Hasan Türkez","doi":"10.5152/eurasianjmed.2025.24559","DOIUrl":"10.5152/eurasianjmed.2025.24559","url":null,"abstract":"Objective: Diabetic retinopathy (DR), considered one of the most common microvascular complications associated with diabetes mellitus (DM), involves both neuronal and vascular dysfunctions in the retina. Neuronal damage and vision loss occur progressively in patients with DR. A number of genetic targets have been identified for DR and gene-related treatments as well as early diagnostic techniques have been developed. Despite some medical advances, DR remains a devastating complication of diabetes. This study aimed to identify new gene targets that can be used for the prognosis and treatment of DR.. Materials and Methods: Eight candidate genes were analyzed using Synergy Brands Green (SYBR-green)- based real-time polymerase chain reaction in peripheral blood mononuclear cells (PBMCs) from 45 individuals: DR patients (n=15), DM patients without DR (n=15), and healthy controls (n=15). STRING v11 was used for protein-protein interaction analysis. Gene expression differences were evaluated using ANOVA, with significance set at P < .05. Results: HIF1A and VEGFA were significantly upregulated in both DR and DM groups compared to controls (HIF1A: fold change 5.28; VEGFA: fold change 5.20 for DR group). SERPING1 was specifically upregulated in DR patients (fold change 3.42). CX3CR1 and BDNF were downregulated in both DR and DM groups (CX3CR1: fold change 8.32; BDNF: fold change 3.21), while IGFBP3 was significantly downregulated only in DR patients (fold change 6.5). STRING analysis revealed strong interactions between SERPING1 and complement pathway components, while IGFBP3 was linked to insulin-like growth factor signaling. Conclusion: In light of these findings, we observed that SERPING1 and IGFBP3 genes might be proposed as targets for early diagnosis and treatment for DR.","PeriodicalId":53592,"journal":{"name":"Eurasian Journal of Medicine","volume":"57 1","pages":"1-6"},"PeriodicalIF":0.9,"publicationDate":"2025-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12036348/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144081706","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Diagnostic Performance of Sarcopenia Screening Tests in Chronic Lung Disease Patients. 慢性肺病患者肌少症筛查试验的诊断价值

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Eurasian Journal of Medicine Pub Date : 2025-04-17 DOI: 10.5152/eurasianjmed.2025.25806

Aslı Görek Dilektaşlı, Demet Kerimoğlu, Ayten Odabaş, Abdurrahman Doğan, Arzu Özpehlivan, Nilüfer Aylin Acet Öztürk, Özge Aydın Güçlü, Ezgi Demirdöğen, Funda Coşkun, Ahmet Ursavaş, Esra Uzaslan, Mehmet Karadağ

{"title":"Diagnostic Performance of Sarcopenia Screening Tests in Chronic Lung Disease Patients.","authors":"Aslı Görek Dilektaşlı, Demet Kerimoğlu, Ayten Odabaş, Abdurrahman Doğan, Arzu Özpehlivan, Nilüfer Aylin Acet Öztürk, Özge Aydın Güçlü, Ezgi Demirdöğen, Funda Coşkun, Ahmet Ursavaş, Esra Uzaslan, Mehmet Karadağ","doi":"10.5152/eurasianjmed.2025.25806","DOIUrl":"10.5152/eurasianjmed.2025.25806","url":null,"abstract":"Objective: Sarcopenia, the gradual decline in skeletal muscle mass (SMM), strength, and functionality, has negative health consequences such as premature death and disability. It is prevalent in chronic lung disease (CLD). Timely recognition of sarcopenia is required for focused therapy. This study sought to analyze the rate of sarcopenia in patients with CLD and to assess the diagnostic accuracy of the sarcopenia screening tests: the SARC-F, SARC-CalF, and Ishii tests. Materials and Methods: This study comprised individuals diagnosed with CLD and referred for pulmonary rehabilitation. Sarcopenia was evaluated based on the European Working Group on Sarcopenia in Older People criteria (EWGSOP and EWGSOP2), utilizing handgrip strength, SMM index, and gait speed. The diagnostic accuracy of screening tests (SARC-F, SARC-CalF, and Ishii) was assessed by sensitivity, specificity, and the area under the curve (AUC) in the Receiver Ooperating Ccharacteristics. Results: A total of 227 patients, with a mean age of 59.00 ± 13.98 years, of whom 50.7% had chronic obstructive pulmonary disease (COPD), were included. The rate of probable sarcopenia was 41.2%, confirmed sarcopenia 2.5%, and severe sarcopenia 0.5%. The Ishii test exhibited the highest sensitivity (71.59%) and specificity (90.48%) for probable sarcopenia (AUC: 0.810); it also showed 100% sensitivity and substantial specificity (78.57%, AUC: 0.893) for confirmed sarcopenia. Conclusion: Sarcopenia is highly prevalent in CLD patients, underscoring the need for routine screening. Among the screening tools, the Ishii test exhibited the highest diagnostic accuracy, making it a valuable tool for early detection. Routine assessment and targeted interventions for sarcopenia could improve functional outcomes in CLD patients.","PeriodicalId":53592,"journal":{"name":"Eurasian Journal of Medicine","volume":"57 1","pages":"1-7"},"PeriodicalIF":0.9,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12036431/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144081624","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effectiveness of 4-Factor Prothrombin Complex Concentrate with and without Vitamin K in Managing Warfarin-Associated Major Bleeding. 含或不含维生素K的4因子凝血酶原复合浓缩物在治疗华法林相关性大出血中的有效性。

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Eurasian Journal of Medicine Pub Date : 2025-04-14 DOI: 10.5152/eurasianjmed.2025.25710

Şeyma Arzu Temür, Mustafa Selçuk Ayar, Yiğit Kurnaz, Fatih Çalışkan

{"title":"Effectiveness of 4-Factor Prothrombin Complex Concentrate with and without Vitamin K in Managing Warfarin-Associated Major Bleeding.","authors":"Şeyma Arzu Temür, Mustafa Selçuk Ayar, Yiğit Kurnaz, Fatih Çalışkan","doi":"10.5152/eurasianjmed.2025.25710","DOIUrl":"10.5152/eurasianjmed.2025.25710","url":null,"abstract":"Background: Major bleeding is a common and severe complication associated with vitamin K antagonist use. Rapid reversal of anticoagulation is crucial in cases of acute bleeding. Prothrombin complex concentrates (PCC) have emerged as an effective option. This study examines the efficacy of 4-factor PCC (4F-PCC) alone and in combination with vitamin K for International Normalized Ratio (INR) control in patients with life-threatening bleeding due to warfarin. Methods: This retrospective cross-sectional study included 50 patients who presented with bleeding and coagulopathy to the Ondokuz Mayıs University Health Practice and Research Center Adult Emergency Department between January 1, 2022, and January 1, 2023. Patients were divided into 2 groups based on vitamin K administration within 24 hours: group 1 received only 4F-PCC, while group 2 received both 4F-PCC and vitamin K. Results: The median age of patients was 72 years, 56% were male. The most common indication for warfarin use was heart valve disease (54%). Gastrointestinal hemorrhage was the leading cause of bleeding (44%). Mortality was 26%, with all deaths occurring within 72 hours of admission. Group 2 had significantly lower INR levels at 24th-hour than group 1 (P=.048). No significant differences were found in INR levels between the 1st and 24th hours within either group (P > .05). Conclusion: The study demonstrates that the combination of 4F-PCC and vitamin K is more effective in controlling INR than 4F-PCC alone, though it does not significantly impact rebound INR increases. Further prospective, multicenter studies are needed to confirm these findings and explore long-term outcomes.","PeriodicalId":53592,"journal":{"name":"Eurasian Journal of Medicine","volume":"57 1","pages":"1-4"},"PeriodicalIF":0.9,"publicationDate":"2025-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12036368/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144081692","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Immediate Effects of Different Types of Tea Consumption on Ocular Biometric and Specular Microscopic Parameters in Healthy Subjects. 不同类型的茶消费对健康受试者眼部生物特征和镜面显微参数的直接影响。

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Eurasian Journal of Medicine Pub Date : 2025-04-07 DOI: 10.5152/eurasianjmed.2025.24589

Feyzahan Uzun, Emre Aydın, Hasan Akgöz, Mehmet Gökhan Aslan, Hüseyin Fındık

{"title":"The Immediate Effects of Different Types of Tea Consumption on Ocular Biometric and Specular Microscopic Parameters in Healthy Subjects.","authors":"Feyzahan Uzun, Emre Aydın, Hasan Akgöz, Mehmet Gökhan Aslan, Hüseyin Fındık","doi":"10.5152/eurasianjmed.2025.24589","DOIUrl":"10.5152/eurasianjmed.2025.24589","url":null,"abstract":"Background: Tea ranks among the most popular beverages globally. In this study, we assessed the short-term changes in ocular biometric and specular microscopic parameters in healthy subjects following the consumption of different types of tea. Methods: A total of 144 subjects were randomly assigned to 3 groups (black, green, and white tea groups) in this study. Ocular parameters, including axial length (AL), aqueous depth (AD), lens thickness (LT), and central corneal thickness (CCT), were measured using optic biometry. Endothelial cell density (ECD), coefficient of variation (CV), number of hexagonal cells (A6A), and average cell area (AVG) were evaluated using non-contact specular microscopy before, as well as 1 hour and 4 hours after, consuming a cup of tea (containing 60 mg of caffeine per 100 mL). Results: The average age of the subjects was 32.9 ± 5.9 years. A significant increase in AD values was observed specifically at the 1st hour following the consumption of black, green, or white tea in healthy subjects. Additionally, black and white tea significantly reduced LT in the 1st hour of the study. The differences in AL and CCT values, as well as in specular microscopy parameters, were not significant among all participants after consuming different types of tea. Conclusion: Black, green, and white tea induce a significant increase in AD, particularly observed 1 hour after oral intake. Furthermore, a reduction in LT parameters was observed in the black and white tea groups, respectively.","PeriodicalId":53592,"journal":{"name":"Eurasian Journal of Medicine","volume":"57 1","pages":"1-5"},"PeriodicalIF":0.9,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12036367/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144081748","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Unraveling the Enigma: Exploring the Periphery's Influence in Alzheimer's Pathophysiology-Cause or Consequence? 解开谜团：探索外围区对阿尔茨海默病病理生理的影响——原因还是结果？

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Eurasian Journal of Medicine Pub Date : 2025-04-04 DOI: 10.5152/eurasianjmed.2025.24592

Gamze Sönmez, Yiğit Yazarkan, Özlem Erden Aki, Ebru Bodur

{"title":"Unraveling the Enigma: Exploring the Periphery's Influence in Alzheimer's Pathophysiology-Cause or Consequence?","authors":"Gamze Sönmez, Yiğit Yazarkan, Özlem Erden Aki, Ebru Bodur","doi":"10.5152/eurasianjmed.2025.24592","DOIUrl":"10.5152/eurasianjmed.2025.24592","url":null,"abstract":"Alzheimer's disease (AD) remains a formidable challenge, impacting individuals, families, caregivers, and soci- ety. Despite being identified over a century ago, effective drug treatments for AD remain elusive, with numerous clinical trials failing to produce meaningful results. The pathological hallmarks of AD, including the accumulation of beta-amyloid plaques and tau protein tangles, are well-established contributors to cogni- tive decline. However, recent research has raised questions about the efficacy of therapies targeting these abnormalities. Emerging evidence suggests that AD should not be viewed purely as a brain-centered disease but as a systemic condition involving complex interactions between the brain and peripheral organs. While the mechanisms linking peripheral processes and AD pathology remain unclear, studies indicate that these systems may contribute to or be affected by the disease. Recognizing AD as a heterogeneous disorder with systemic implications opens new opportunities for therapeutic innovation. Multimodal therapies targeting both central and peripheral aspects of AD pathology-such as amyloid-beta deposition, neuroinflammation, and systemic dysfunction-hold promise for slowing disease progression. This review aims to critically assess the current understanding of AD pathology, with a particular focus on the peripheral system's involvement and its interplay with the brain. Additionally, it will explore novel therapeutic strategies and emphasize the importance of interdisciplinary collaboration to advance our knowledge and develop effective treatments.","PeriodicalId":53592,"journal":{"name":"Eurasian Journal of Medicine","volume":"57 1","pages":"1-8"},"PeriodicalIF":0.9,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12036350/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144081783","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0