{"title":"Cochlear implant in Wolfram syndrome: A case report.","authors":"Hetal Marfatia, Anav Rattan, Anushka Jain","doi":"10.1080/14670100.2024.2442826","DOIUrl":"https://doi.org/10.1080/14670100.2024.2442826","url":null,"abstract":"<p><strong>Introduction: </strong>Wolfram syndrome, a rare autosomal recessive disorder, is characterised by diabetes insipidus, juvenile diabetes mellitus, optic nerve atrophy and deafness (DIDMOAD).</p><p><strong>Case report: </strong>We present a case of a 21-year-old male diagnosed with Wolfram syndrome who underwent cochlear implantation due to progressive hearing loss. The patient first complained of bilateral hearing loss at the age of 8 years. As the hearing loss progressed hearing aids provided minimal benefit. A multidisciplinary team evaluated his extensive medical history, which included juvenile-onset diabetes mellitus, seizures, vision abnormalities and hypergonadotrophic hypogonadism. Pure tone audiometry was done which showed sloping bilateral severe to profound hearing loss, more at higher frequencies. Hrct and Mri temporal bone showed normal cochlear architecture and cochlear nerve. The patient received a Nucleus Profile™ CI 632 cochlear implant. Postoperative evaluation revealed significant improvement, with a speech discrimination score of 90% at the most comfortable level three months post-implantation.</p><p><strong>Conclusion: </strong>Wolfram syndrome is a rare genetic disorder with multisystem involvement and debilitating symptoms. High-frequency sensorineural hearing loss is a common association and hearing rehabilitation using hearing aids and cochlear implants must be considered to improve the quality of life.</p>","PeriodicalId":53553,"journal":{"name":"COCHLEAR IMPLANTS INTERNATIONAL","volume":" ","pages":"1-5"},"PeriodicalIF":1.4,"publicationDate":"2024-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142883624","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Larissa Fernandes Gomes, Isabelle Costa de Vasconcelos, Karinna Veríssimo Meira Taveira, Sheila Andreoli Balen, Joseli Soares Brazorotto
{"title":"Functional near-infrared spectrometry for auditory speech stimuli in cochlear implant users: a systematic literature review.","authors":"Larissa Fernandes Gomes, Isabelle Costa de Vasconcelos, Karinna Veríssimo Meira Taveira, Sheila Andreoli Balen, Joseli Soares Brazorotto","doi":"10.1080/14670100.2024.2427506","DOIUrl":"https://doi.org/10.1080/14670100.2024.2427506","url":null,"abstract":"<p><strong>Objective: </strong>This study aims to identify the acquisition features of functional near-infrared spectroscopy (fNIRS) in cochlear implant users.</p><p><strong>Methods: </strong>A systematic literature review was conducted following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. PubMed, EMBASE, LILACS, Web of Science, Scopus, PsycINFO, IEEE Xplore, Google Scholar, and ProQuest Dissertations & Theses Global were searched using the PECOS acronym. Inclusion criteria encompassed studies involving fNIRS with speech stimuli in cochlear implant users of any age, with information on acquisition parameters and features. Risk of bias assessment was performed using the Joanna Briggs Institute tool.</p><p><strong>Results: </strong>Nineteen studies were included, with thirteen exhibiting a low risk of bias. Noteworthy uniformity was observed in certain fNIRS acquisition features among cochlear implant users, including the waking state (awake), auditory stimuli of words or phrases presented in a free field, visual stimuli displayed during data collection as a secondary task, recording of responses in the bilateral temporal lobe, and a three-centimeter distance between optodes. Variations in acquisition were attributed to differing study purposes.</p><p><strong>Conclusion: </strong>This review identifies common acquisition characteristics for fNIRS in cochlear implant users. Multicenter research efforts are advocated to further advance the utility of fNIRS in this population.</p>","PeriodicalId":53553,"journal":{"name":"COCHLEAR IMPLANTS INTERNATIONAL","volume":" ","pages":"1-14"},"PeriodicalIF":1.4,"publicationDate":"2024-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142689720","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Silicone allergy can lead to cochlear implant complication and explantation: a case report.","authors":"Syed Ahsan","doi":"10.1080/14670100.2024.2413265","DOIUrl":"https://doi.org/10.1080/14670100.2024.2413265","url":null,"abstract":"<p><strong>Introduction: </strong>We report an unusual case of cochlear implant complication and eventual explantation secondary to an allergic reaction to silicone.</p><p><strong>Case report: </strong>A 62-year-old man who underwent cochlear implantation for asymmetric hearing loss developed an allergic response to the implant within a few weeks of the surgery. This led to subsequent explantation. Patch testing using the various parts of the implant revealed a hypersensitive response to the silicone component of the receiver stimulator. There have only been 6 reported cases of cochlear implant explantation secondary to allergic reactions to cochlear implants. The inflammatory reaction has been to the silicone component of the cochlear implant found in the silicone used in Cochlear America's implants.</p><p><strong>Conclusion: </strong>Although rare, it's important to be aware of delayed hypersensitivity reactions to the silicone component of a cochlear implant. Attention should be made to associate symptoms such as pruritis, urticaria and loss of hair as symptoms and signs of possible allergic reaction to the implanted component. Steroids may help to alleviate symptoms; however, symptoms have been shown to recur after cessation of steroids. Treatment requires the removal of the device.</p>","PeriodicalId":53553,"journal":{"name":"COCHLEAR IMPLANTS INTERNATIONAL","volume":" ","pages":"1-4"},"PeriodicalIF":1.4,"publicationDate":"2024-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142480598","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Teresa Y C Ching, Vicky Zhang, Esti Nel, Sanna Hou, Paola Incerti, Anke Plasmans
{"title":"Effects of automatic auditory scene classification on speech perception in noise and real-world functional communication in children using cochlear implants.","authors":"Teresa Y C Ching, Vicky Zhang, Esti Nel, Sanna Hou, Paola Incerti, Anke Plasmans","doi":"10.1080/14670100.2024.2415193","DOIUrl":"https://doi.org/10.1080/14670100.2024.2415193","url":null,"abstract":"<p><strong>Objectives: </strong>To investigate the effects of automatic scene classification (SCAN) on speech perception in noise and real-world functional performance in children using cochlear implants (CIs).</p><p><strong>Methods: </strong>We used a within-subjects repeated measures design in two studies. The first study assessed speech perception in noise with or without SCAN enabled in 25 school-aged children. The second study evaluated functional auditory performance in real life. Parents of 18 children provided ratings using the Parents' Evaluation of Aural/oral Performance of Children (PEACH) questionnaire; and children provided ratings using the Self Evaluation of Listening Function (SELF) questionnaire. Analyses of variance with repeated measures were used to examine the effect of SCAN.</p><p><strong>Results: </strong>On average, speech perception in noise was significantly better with SCAN enabled (mean SRT: -4.1 dB; SD: 4.0), compared to SCAN disabled (mean SRT: 0.5 dB; SD: 3.5). Children's functional performance in real life was similar between the two device settings.</p><p><strong>Conclusion: </strong>Automatic auditory scene classification provides significant benefits for speech perception in noise (4.6 dB improvement). On average, there were no perceived detrimental or beneficial effects in real life. These findings support the use of SCAN in CIs for young children.</p>","PeriodicalId":53553,"journal":{"name":"COCHLEAR IMPLANTS INTERNATIONAL","volume":" ","pages":"1-12"},"PeriodicalIF":1.4,"publicationDate":"2024-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142480597","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Beata Diosi, Zsofia Bere, Angela Csomor, Tamara Tapai, Zoltan Toth, Edina Kovacs, Balint Posta, Miklos Csanady, Antal Nogradi, Zsigmond Tamas Kincses, Laszlo Rovo, Adam Perenyi
{"title":"Artefacts on magnetic resonance imaging with Osia®2 bone conduction hearing aid: A cadaver study.","authors":"Beata Diosi, Zsofia Bere, Angela Csomor, Tamara Tapai, Zoltan Toth, Edina Kovacs, Balint Posta, Miklos Csanady, Antal Nogradi, Zsigmond Tamas Kincses, Laszlo Rovo, Adam Perenyi","doi":"10.1080/14670100.2024.2398833","DOIUrl":"https://doi.org/10.1080/14670100.2024.2398833","url":null,"abstract":"<p><strong>Objectives: </strong>Hearing implants often limit the assessment of magnetic resonance examinations due to susceptibility artefacts. Our aim was to evaluate the impact of artefacts attributed to the Osia®2 implant system in terms of utility in visualizing selected cranial structures.</p><p><strong>Methods: </strong>A BI300 implant and an OSI200 actuator were implanted into a human cadaver head in the audiologically most favourable position according to the manufacturer's guidelines. Scanning was accomplished using the institutional <i>head and inner ear</i> protocol with a General Electric 1.5 Tesla scanner with retained and removed implant magnet, extended with T1 and T2 weighted sequences with metal-artefact reduction (MAVRIC SL). Image quality was evaluated by three radiologists.</p><p><strong>Results: </strong>The Osia®2 produced significant artefacts in most of the series of standard imaging sequences predominantly on the ipsilateral side of the head. The majority of the artefacts were caused by the implant magnet. Even without removing the magnet, MAVRIC SL improved image quality to such an extent that it became comparable with that after magnet removal.</p><p><strong>Conclusions: </strong>The standard sequences suffer considerable quality loss due to the artefacts, attributed predominantly to the magnetic component. Metal-artefact reduction sequences are effective in obtaining sufficient-to-good quality images without surgical magnet removal.</p>","PeriodicalId":53553,"journal":{"name":"COCHLEAR IMPLANTS INTERNATIONAL","volume":" ","pages":"1-11"},"PeriodicalIF":1.4,"publicationDate":"2024-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142480595","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Vanessa Y J Tan, Rodney Hollow, Sylvia Tari, Alex Rousset, Raoul Wills, Robert J S Briggs, Richard Charles Dowell
{"title":"Cochlear implant usage in single sided deafness and factors affecting usage.","authors":"Vanessa Y J Tan, Rodney Hollow, Sylvia Tari, Alex Rousset, Raoul Wills, Robert J S Briggs, Richard Charles Dowell","doi":"10.1080/14670100.2024.2403224","DOIUrl":"10.1080/14670100.2024.2403224","url":null,"abstract":"<p><strong>Objectives: </strong>The primary objective was to examine duration of daily cochlear implant (CI) usage at 12 and 24 months post-operatively in single sided deafness (SSD). The secondary objective was to examine factors that could affect CI usage.</p><p><strong>Methods: </strong>Retrospective cohort of patients with SSD who received CI from January 2015 to March 2020. CI usage was evaluated at 12 and 24 months. Hearing loss duration, tinnitus scores and signal-to-noise ratio (SNR) were correlated with CI usage at 12 months.</p><p><strong>Results: </strong>Usage data was available for 54 patients at 12 months and 38 patients at 24 months. The mean usage was 8.2 h/day (SD 4.2) at 12 months, 7.0 h/day (SD 5.1) at 24 months. 5 out of 54 (9.3%) and 7 out of 38 patients (18.4%) were non-users at 12 and 24 months post-operatively. An improved mean SNR score from pre-operative 4.4 dB (SD 2.8) to - 0.70 dB (SD 4.2) at 12 months post-operative was positively correlated with CI usage at 12 and 24 months. Hearing loss duration and tinnitus scores were not associated with CI usage.</p><p><strong>Conclusions: </strong>18.4% of our patients were non-users at 24 months. Mean usage at 24 months was 7.0 h/day. Improved hearing in noise at 12 months was correlated with better usage.</p>","PeriodicalId":53553,"journal":{"name":"COCHLEAR IMPLANTS INTERNATIONAL","volume":" ","pages":"387-393"},"PeriodicalIF":1.4,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142395234","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Amy H C Ng, Jessica Banh, Laura Shaw, Yasmeen Aboulhawa, Maria Simone, Trung Le, Vincent Lin, Joseph Chen
{"title":"Comparing remote programming of cochlear implants using two methods: portable laptop and remote hosted site.","authors":"Amy H C Ng, Jessica Banh, Laura Shaw, Yasmeen Aboulhawa, Maria Simone, Trung Le, Vincent Lin, Joseph Chen","doi":"10.1080/14670100.2024.2427507","DOIUrl":"10.1080/14670100.2024.2427507","url":null,"abstract":"<p><strong>Objectives: </strong>Compare two remote programming methods as a clinical service for user satisfaction, ease of use, preparation time and accessibility.</p><p><strong>Method: </strong>Method 1 (Portable Laptop): A 'Programming Kit' including laptop was shipped to cochlear implant users' homes (<i>N</i> = 20). The audiologist at the implant center used remote desktop control of this laptop to adjust subjects' speech processors. Method 2 (Remote Hosted Site): Eight distant clinics were recruited as host sites to house cochlear implant programming hardware and software so that CI users (<i>N</i> = 19) could attend their facility. The audiologist at the implant center used remote desktop control of the host sites' computers to adjust the subjects' CI speech processors. All parties were asked to fill out a questionnaire following their remote session.</p><p><strong>Results: </strong>Remote hosted site method was rated higher for ease of use by the Remote Experts (12/15, 80%), compared to portable laptop method (11/19, 57.9%) and is more accessible to CI users of all levels of computer abilities while requiring less preparation time per session.</p><p><strong>Conclusion: </strong>Remote hosted site method is an easier, more efficient method of remote programming as a clinical service delivery method compared to the Portable Laptop.</p>","PeriodicalId":53553,"journal":{"name":"COCHLEAR IMPLANTS INTERNATIONAL","volume":" ","pages":"360-372"},"PeriodicalIF":1.4,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142734264","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nicole T Jiam, Archana Podury, Alicia M Quesnel, Ophir Handzel
{"title":"Worldwide differences in surgeon intraoperative practices for cochlear implantation.","authors":"Nicole T Jiam, Archana Podury, Alicia M Quesnel, Ophir Handzel","doi":"10.1080/14670100.2024.2367309","DOIUrl":"10.1080/14670100.2024.2367309","url":null,"abstract":"<p><strong>Objective: </strong>To characterize practice patterns of intraoperative imaging and/or functional confirmation of cochlear implant electrode location worldwide.</p><p><strong>Methods: </strong>A cross-sectional survey of otolaryngologists performing cochlear implantation was conducted between March 1 and May 6, 2023. Participants were recruited worldwide using an international otologic society membership email list and at professional meetings. Ninety-seven of the 125 invited participants (78%) completed the survey. Participants were categorized by continent.</p><p><strong>Results: </strong>North American surgeons use intraoperative X-rays more frequently than surgeons in Europe and Asia (<i>p</i> < 0.001). Otolaryngologists in Europe and Asia more frequently use no intraoperative imaging (<i>p</i> = 0.02). There is no regional difference between the intraoperative use of electrophysiologic instruments. European and Asian surgeons implant MED-EL devices (<i>p</i> = 0.012) more frequently than North American surgeons, who more frequently use Cochlear Corporation devices (<i>p</i> = 0.003). MED-EL use is related to less frequent intraoperative X-ray use (<i>p</i> = 0.02). Advanced Bionics use is related to more frequent intraoperative CT use (<i>p</i> = 0.03). No significant association existed between years of practice, number of cochlear implantation surgeries performed yearly, volume of pediatric CI practice, and use of intraoperative tools.</p><p><strong>Conclusion: </strong>Intraoperative practice for radiologic and functional verification of cochlear implant electrode positioning varies worldwide. Practice guidelines may help establish a standard of care for cochlear implantation.</p>","PeriodicalId":53553,"journal":{"name":"COCHLEAR IMPLANTS INTERNATIONAL","volume":" ","pages":"344-351"},"PeriodicalIF":1.4,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141472579","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Reading achievement and deaf students with cochlear implants.","authors":"Connie Mayer, Beverly J Trezek","doi":"10.1080/14670100.2024.2394313","DOIUrl":"10.1080/14670100.2024.2394313","url":null,"abstract":"<p><strong>Objectives: </strong>The purpose of this study was to investigate the reading outcomes of a Canadian cohort of school-aged deaf learners with cochlear implants (CIs). The goal was to investigate whether achievement approached that of hearing age peers and identify demographic factors influencing performance.</p><p><strong>Methods: </strong>Participants represent a subset of 13 students with CIs from a larger sample of 70 deaf students in grades four through 12 educated in inclusive settings within a large school board in central Canada. Data sources included demographic information, teachers' ratings on the Categories of Auditory Performance (CAP), and scores from the <i>Woodcock-Johnson III Diagnostic Reading Battery</i> [WJ III-DRB].Results/Discussion: Participants performed within the low average range in all areas except for Phonological Awareness, which was in the low range; however, there was wide variability in scores across participants. None of the demographic variables (e.g. home language, additional disabilities) had a statistically significant association with performance, although older students had higher mean scores on the Phonological Awareness cluster.</p><p><strong>Conclusion: </strong>These findings add to the body of research on literacy achievement and cochlear implantation, providing evidence that this technology has a significant positive effect on outcomes for a population that has heretofore underperformed in this area.</p>","PeriodicalId":53553,"journal":{"name":"COCHLEAR IMPLANTS INTERNATIONAL","volume":" ","pages":"394-402"},"PeriodicalIF":1.4,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142086399","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Chongxian Yu, Jianfen Luo, Mei Zhong, Ruijie Wang, Xiuhua Chao, Jianxin Qiu, Lei Xu, Petra L Graham, Colleen Psarros
{"title":"Factors impacting outcomes of cochlear implantation in children at two University centres in China: Multi-year analysis from the Paediatric Implanted Recipient Observational Study (P-IROS).","authors":"Chongxian Yu, Jianfen Luo, Mei Zhong, Ruijie Wang, Xiuhua Chao, Jianxin Qiu, Lei Xu, Petra L Graham, Colleen Psarros","doi":"10.1080/14670100.2024.2382579","DOIUrl":"10.1080/14670100.2024.2382579","url":null,"abstract":"<p><strong>Objectives: </strong>To identify factors affecting functional hearing performance and quality of life (QoL) outcomes in paediatric cochlear implantation (CI) recipients at two University centres in mainland China.</p><p><strong>Methods: </strong>Two university centres in mainland China, part of the prospective longitudinal Paediatric Implanted Recipient Observational Study (P-IROS), contributed participant data. Participants were aged under 10 years at time of CI. Functional hearing performance and QoL measures were collected prior to device activation, and at 6-monthly intervals for 2 years post-implantation. Functional hearing endpoints including Categories of Auditory Performance-II (CAP-II) and QoL were evaluated and analysed using ordinal mixed-effects regression models.</p><p><strong>Results: </strong>Data were from 288 children with a mean age at implant of 2.74 years. Overall follow-up at 1 year was 59% and 51% at 2 years. Younger age at implantation (p<0.001) and hearing aid use preimplantation (p=0.026) were associated with significant benefit. Bilateral device users (both CI and bimodal) achieved significantly better functional hearing performance on the CAP-II than unilateral CI users (p<0.001). Slower functional hearing improvements were observed in those with lower parental expectations compared to higher expectations (p<0.001). QoL improved over time but followed a different initial trajectory between centres.</p><p><strong>Conclusion: </strong>All participants demonstrated significant improvements in auditory performance and QoL over time. Younger age at CI, and bilateral/bimodal device fitting contributed to earlier improvements. Other potential factors that could help inform families, professionals, and health authorities about choice of hearing device and educational supports required included aetiology of hearing loss and level of maternal education.</p>","PeriodicalId":53553,"journal":{"name":"COCHLEAR IMPLANTS INTERNATIONAL","volume":" ","pages":"373-386"},"PeriodicalIF":1.4,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141898905","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}