Vacunas最新文献_第7页

Recent advancements in cancer vaccines: A systematic review 癌症疫苗的最新进展：系统综述

Vacunas Pub Date : 2024-01-01 DOI: 10.1016/j.vacun.2023.10.005

Stuti Srivastava , Devendra Singh , Sunil Kumar Verma , Minakshi Pandey , Avinash Sharma , Himanshu Pandey , Anshu Mishra

引用次数: 0

Calendario de vacunaciones e inmunizaciones. No olvidemos la historia 疫苗接种和免疫计划。不要忘记历史

Vacunas Pub Date : 2024-01-01 DOI: 10.1016/j.vacun.2023.11.001

Fernando Moraga-Llop , José Antonio Navarro-Alonso

引用次数: 0

Reticencia vacunal: una introducción conceptual 不愿意接种疫苗：概念介绍

Vacunas Pub Date : 2024-01-01 DOI: 10.1016/j.vacun.2023.09.002

Luis Salleras , Montserrat Salleras , Diana Toledo , Àngela Domínguez

引用次数: 0

Vigilancia epidemiológica de la tosferina en Cataluña 2011-2018 2011-2018 年加泰罗尼亚百日咳流行病学监测

Vacunas Pub Date : 2024-01-01 DOI: 10.1016/j.vacun.2023.10.001

Glòria Carmona-Parcerisa , Laura Ruiz-Mitjavila , Carme Fernández-Gutiérrez , Mireia Jané-Checa , Ana Martínez Mateo , Pilar Ciruela Navas

{"title":"Vigilancia epidemiológica de la tosferina en Cataluña 2011-2018","authors":"Glòria Carmona-Parcerisa , Laura Ruiz-Mitjavila , Carme Fernández-Gutiérrez , Mireia Jané-Checa , Ana Martínez Mateo , Pilar Ciruela Navas","doi":"10.1016/j.vacun.2023.10.001","DOIUrl":"10.1016/j.vacun.2023.10.001","url":null,"abstract":"<div><h3>Introduction</h3><p>The objective of the article is to describe the main results of pertussis surveillance in Catalonia and to evaluate its evolution in recent years.</p></div><div><h3>Material and methods</h3><p>According to the case definition in Catalonia, suspicious and confirmed cases notified to the Obligatory Disease Declaration System (MDO) for the period 2011-2018 have been included, after the validation of the notification made by health professionals to this system has been completed.</p></div><div><h3>Results</h3><p>In 2011, a reemergence of whooping cough was observed in Catalonia which remained during the study period (2011-2018), although since 2016 a decrease in incidence has been observed. The highest rate for the period was that of 2015, which reached the value of 49.2 per 100,000 inhabitants. Children under one year showed the highest incidence rates, but decreased over the period.</p><p>The recommendation to vaccinate against pertussis pregnant women in the third trimester of pregnancy, that started in 2014, has impacted on the incidence in children under the age of 1 and especially in children under 2 months, which has decreased significantly. The high percentage of cases in children between 5-18 years with 4-5 doses of acellular vaccine shows the lower effectiveness of this vaccine induced immunity.</p></div><div><h3>Conclusions</h3><p>Control of whooping cough is currently a challenge that public health surveillance services have to face.</p></div>","PeriodicalId":53407,"journal":{"name":"Vacunas","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139454267","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Autoimmune diseases related to post-SARS-CoV-2 vaccination: A rheumatology perspective 与sars - cov -2疫苗接种后相关的自身免疫性疾病:风湿病学观点

Vacunas Pub Date : 2023-10-01 DOI: 10.1016/j.vacun.2023.06.001

Farhad Dadgar , Jorge Casseb , Masoud Keikha

引用次数: 0

The polymorphisms of TNF-α related-gene and antibody production following third dose of COVID-19 vaccination: A pilot study 第三剂COVID-19疫苗接种后TNF-α相关基因多态性和抗体产生:一项初步研究

Vacunas Pub Date : 2023-10-01 DOI: 10.1016/j.vacun.2023.04.002

Phey Liana , Zen Hafy , Soilia Fertilita , Ella Amalia , Veny Larasati , Tungki Pratama Umar

{"title":"The polymorphisms of TNF-α related-gene and antibody production following third dose of COVID-19 vaccination: A pilot study","authors":"Phey Liana , Zen Hafy , Soilia Fertilita , Ella Amalia , Veny Larasati , Tungki Pratama Umar","doi":"10.1016/j.vacun.2023.04.002","DOIUrl":"10.1016/j.vacun.2023.04.002","url":null,"abstract":"<div><h3>Introduction</h3><p>Vaccination is one of the most pertinent prevention strategies for the Coronavirus Disease 2019 (COVID-19) pandemic. Several factors, both intrinsic (particularly genetic) and extrinsic, can influence vaccine efficacy. However, very little research has been conducted into the genetic component's impact on immunogenicity following COVID-19 vaccination. Therefore, we present the antibody formation in thirteen people who received a third vaccination (booster) dose of the Moderna mRNA-1273 vaccine and the differences in the polymorphism Tumor Necrosis Factor-Alpha (TNF-α) related genes in this population.</p></div><div><h3>Methods</h3><p>Our study included 13 participants with no comorbidities or a history of COVID-19 infection. The Chemiluminescent Microparticle Immunoassay (CMIA) was used to measure antibody production in serum. Polymorphism was recognized using the polymerase chain reaction (PCR) amplification technique.</p></div><div><h3>Results</h3><p>In this study, TNF-α related gene (GG) significantly influenced the formation of the antiSARS-CoV-2 spike protein IgG antibody level (p = 0.005) in our sample.</p></div><div><h3>Conclusion</h3><p>Although the polymorphism of the cytokine gene, particularly TNF-α, seems to influence antibody levels in our study population, a more comprehensive analysis is required for better generalization due to the nature of our pilot study.</p></div>","PeriodicalId":53407,"journal":{"name":"Vacunas","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10083208/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9720366","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Adverse events following COVID-19 vaccination among pregnant women attending primary health centers: An active-surveillance study 在初级卫生中心就诊的孕妇接种COVID-19疫苗后的不良事件:一项主动监测研究

Vacunas Pub Date : 2023-10-01 DOI: 10.1016/j.vacun.2023.05.003

Narayana Goruntla , Basappa Karisetty , Nandini Nandini , Bharadwaj Bhupasamudram , Himaja Reddy Gangireddy , Kasturi Vishwanathasetty Veerabhadrappa , Joseph Obiezu Chukwujekwu Ezeonwumelu , Vishnuvandana Bandaru

{"title":"Adverse events following COVID-19 vaccination among pregnant women attending primary health centers: An active-surveillance study","authors":"Narayana Goruntla , Basappa Karisetty , Nandini Nandini , Bharadwaj Bhupasamudram , Himaja Reddy Gangireddy , Kasturi Vishwanathasetty Veerabhadrappa , Joseph Obiezu Chukwujekwu Ezeonwumelu , Vishnuvandana Bandaru","doi":"10.1016/j.vacun.2023.05.003","DOIUrl":"10.1016/j.vacun.2023.05.003","url":null,"abstract":"<div><h3>Introduction</h3><p>Vaccine safety is a major barrier to the uptake of the COVID-19 vaccine by pregnant women. To bring confidence among pregnant women towards vaccine intake, there is a need to synthesize evidence on safety profile of vaccination.</p></div><div><h3>Objective</h3><p>To assess adverse events (AEs) following COVID-19 vaccination among pregnant women.</p></div><div><h3>Materials and methods</h3><p>A vaccine safety surveillance was conducted at 2 rural primary health centers (PHC) located in Anantapur District, India. A total of 420 pregnant women were monitored for AEs following COVID-19 vaccination for a period of 30 min and followed for 1 month for late reactions through telephonic interviews. All AEs were subjected to causality and severity assessment. Descriptive statistics were used to represent adverse events.</p></div><div><h3>Results</h3><p>The COVID-19 vaccine acceptance rate among pregnant women was 64.4%. A total of 420 pregnant women received 670 vaccine doses (Covishield = 372, Covaxin = 298) against COVID-19. Majority of vaccine intake was observed during the second trimester. The incidence rate of AEs following the COVID-19 vaccine among pregnant women was 93.8%, and the majority include injection site pain (28.4%, 29.6%), fever (25.5%, 19.0%), myalgia (8.21%, 12.3%), and malaise (13.6%, 8.4%). Most AEs notified are probable and mild in nature.</p></div><div><h3>Conclusion</h3><p>The COVID-19 vaccine acceptance rate among pregnant women was 64.4%. A 30 days incidence rate of AEs following COVID-19 vaccination among pregnant women was 93.8%, with the most common mild events like injection site pain, and fever. A further follow-up cohort study by taking an adequate sample size was recommended to capture fetal–maternal outcomes.</p></div>","PeriodicalId":53407,"journal":{"name":"Vacunas","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10192595/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9720368","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Effects of sub-inhibitory concentration of antibiotic and heat stress on the expression of type II TA system genes in Brucella spp. 抗生素亚抑制浓度和热应激对布鲁氏菌ⅱ型TA系统基因表达的影响。

Vacunas Pub Date : 2023-10-01 DOI: 10.1016/j.vacun.2023.03.002

Fatemeh Amraei , Negar Narimisa , Shiva Mirkalantari , Shabnam Razavi , Behrooz Sadeghi Kalani , Faramarz Masjedian Jazi

{"title":"Effects of sub-inhibitory concentration of antibiotic and heat stress on the expression of type II TA system genes in Brucella spp.","authors":"Fatemeh Amraei , Negar Narimisa , Shiva Mirkalantari , Shabnam Razavi , Behrooz Sadeghi Kalani , Faramarz Masjedian Jazi","doi":"10.1016/j.vacun.2023.03.002","DOIUrl":"10.1016/j.vacun.2023.03.002","url":null,"abstract":"<div><h3>Objective</h3><p>Bacteria can react to stress conditions using the Toxin-Antitoxin (TA) system. This study investigated the expression of TA system genes under heat and antibiotic stresses in <span><em>Brucella</em></span> spp.</p></div><div><h3>Methods</h3><p><span><span>To determine the effects of sub-inhibitory concentration (sub-MIC) of rifampin on </span>bacterial survival<span> and growth, a colony-forming unit was quantitated, and turbidity was assessed following the treatment of </span></span><em>Brucella</em><span> isolates, with ½ minimum inhibitory concentration (MIC) of antibiotic at different time intervals. Also, </span><em>Brucella</em> isolates were exposed to heat stress (42 °C) compared to the control (37 °C). Finally, the expression of TA system genes in <em>Brucella</em><span> isolates was evaluated one hour after treatment using the quantitative reverse transcription PCR (qRT-PCR) method.</span></p></div><div><h3>Results</h3><p>Our results showed that the growth of the <em>Brucella</em> isolates reduced in the presence of the sub-MIC of antibiotics compared to the control. The results of the qPCR assay showed that, in the presence of rifampicin the expression of the TA system genes increased and, under the heat stress conditions, the expression of the TA system genes increased compared to controls expect brnT / brnA system.</p></div><div><h3>Conclusion</h3><p>Although the exact role of the TA system in response to various stresses is not yet fully understood, our study provided information on the effectiveness of the type II TA system under heat and antibiotic stress conditions by examining the gene expression of type II systems in <em>Brucella</em> isolates.</p></div>","PeriodicalId":53407,"journal":{"name":"Vacunas","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41257257","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The feasibility of including human papillomavirus vaccine in Iran's national immunization program 将人乳头瘤病毒疫苗纳入伊朗国家免疫规划的可行性

Vacunas Pub Date : 2023-10-01 DOI: 10.1016/j.vacun.2023.06.002

Maryam Honarvar , Reza Goudarzi , Mohammadreza Amiresmaili , Asrin Amiri , Abdul Sami Saeed Paul

{"title":"The feasibility of including human papillomavirus vaccine in Iran's national immunization program","authors":"Maryam Honarvar , Reza Goudarzi , Mohammadreza Amiresmaili , Asrin Amiri , Abdul Sami Saeed Paul","doi":"10.1016/j.vacun.2023.06.002","DOIUrl":"10.1016/j.vacun.2023.06.002","url":null,"abstract":"<div><h3>Aim</h3><p>Cervical cancer is the second most common form of cancer in women. In order to prevent this disease, several vaccines like Cervarix<span> [2vHPV], Cecolin, Cervarix quadrivalent and Gardasil [9vHPV]), have been included in the vaccination program of some countries. This study as a part of Health Technology Assessment (HTA), aimed to assess the feasibility of inclusion of Human Papilloma Virus (HPV) vaccine in the national vaccination program of Iran.</span></p></div><div><h3>Subject and methods</h3><p>This is a qualitative case study composed of semi structured interviews with a purposive sample of experts working extensively in the field of women's health. Data saturation reached at the 12th interview. The data was analyzed using the framework method.</p></div><div><h3>Results</h3><p>A total of 14 subthemes under 6 themes of the need for vaccines, lack of knowledge, cost factors, administration at early ages, creating a negative mindset, and empowering the society were identified.</p></div><div><h3>Conclusion</h3><p>Including HPV vaccine in the national vaccination program not only seems justifiable, but also its absence in the vaccination program violates some aspects of medical ethics<span> principles. Therefore, the government must take steps to increase public awareness about human papillomavirus and include the aforementioned vaccine in the national vaccination program.</span></p></div>","PeriodicalId":53407,"journal":{"name":"Vacunas","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42068625","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The global spread of human monkeypox virus: Challenges and opportunities for prevention 人类猴痘病毒的全球传播:预防的挑战和机遇

Vacunas Pub Date : 2023-10-01 DOI: 10.1016/j.vacun.2023.07.002

Muhammad Safdar , Shafeeq Ur Rehman , Furqan Shafqat , Muhammad Shan , Samiha S. Khan , Faiz-ul Hassan , Hafiz Khawar Ali , Mehmet Ozaslan

{"title":"The global spread of human monkeypox virus: Challenges and opportunities for prevention","authors":"Muhammad Safdar , Shafeeq Ur Rehman , Furqan Shafqat , Muhammad Shan , Samiha S. Khan , Faiz-ul Hassan , Hafiz Khawar Ali , Mehmet Ozaslan","doi":"10.1016/j.vacun.2023.07.002","DOIUrl":"https://doi.org/10.1016/j.vacun.2023.07.002","url":null,"abstract":"<div><p><span>This review comprehensively analyses human monkeypox<span><span> caused by the monkeypox virus (MPXV), including its origins, transmission, pathogenesis, immune responses, genetic variations, evolutionary changes, and potential therapeutic strategies. The MPXV belongs to the </span>Poxviridae family and is responsible for the </span></span>zoonotic<span><span> viral disease known as human monkeypox (MPX). A multi-nation monkeypox epidemic was declared by the WHO in May 2022, with over 64 290 laboratory-confirmed cases recorded worldwide in several non-endemic countries. Symptoms of MPX include fever, headache, muscular aches, </span>lymphadenopathy<span><span>, and a recognizable rash that progresses into papules, vesicles, and pustules before finally scabbing over and healing. MPXV is endemic to sub-Saharan Africa, affecting wild animals and resulting in zoonotic epidemics. Delayed vaccination, commerce in exotic animals, international travel, and increased human sensitivity have contributed to the spread of MPXV to new locations. The </span>smallpox vaccination may provide cross-protection against MPXV due to antigenic similarities. Basic health precautions should be followed, including frequent handwashing, nose and mouth covering when coughing, and avoiding ill individuals and overcrowded areas. Safe sexual practices are also recommended in countries reporting monkeypox transmission. Although vaccines are available, but they are limited. The review highlights the need for effective preventive and therapeutic strategies to manage human monkeypox.</span></span></p></div>","PeriodicalId":53407,"journal":{"name":"Vacunas","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"92013974","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0