Alzheimer''s and Dementia: Diagnosis, Assessment and Disease Monitoring最新文献_第8页

Associations between serum uric acid levels and risk of dementia in community-dwelling older adults. 社区居住老年人血清尿酸水平与痴呆风险之间的关系

IF 4.4

Alzheimer''s and Dementia: Diagnosis, Assessment and Disease Monitoring Pub Date : 2026-08-12 eCollection Date: 2026-07-01 DOI: 10.1002/dad2.70440

Md Golam Rabbani, Sheikh M Alif, Joanne Ryan, Zhen Zhou, Cammie Tran, Amanda J Rickard, Catherine Robb, Robyn L Woods, Suzanne G Orchard, Raj C Shah, Anne M Murray, John J McNeil, Md Nazmul Karim

{"title":"Associations between serum uric acid levels and risk of dementia in community-dwelling older adults.","authors":"Md Golam Rabbani, Sheikh M Alif, Joanne Ryan, Zhen Zhou, Cammie Tran, Amanda J Rickard, Catherine Robb, Robyn L Woods, Suzanne G Orchard, Raj C Shah, Anne M Murray, John J McNeil, Md Nazmul Karim","doi":"10.1002/dad2.70440","DOIUrl":"https://doi.org/10.1002/dad2.70440","url":null,"abstract":"Introduction: Evidence on the association between serum uric acid (SUA) and dementia risk is inconsistent, and prospective data in older adults are limited. This study examined associations of SUA levels and trajectories with incident dementia.Methods: This study included 11,411 community-dwelling adults aged ≥70 years without dementia at baseline. Incident dementia was diagnosed using Diagnostic and Statistical Manual of Mental Disorders - Fourth Revision (DSM-IV) criteria. Sex-stratified Cox proportional hazards models assessed associations of baseline SUA and 3-year SUA changes with dementia risk.Results: Over a median 9-year follow-up, 1000 (8.8%) participants developed dementia. Low SUA levels were associated with higher dementia risk among females (age-adjusted hazard ratio [HR]: 1.31, 95% confidence interval [CI]: 1.07-1.61; fully adjusted HR: 1.24, 95% CI: 1.01-1.53), but not males. A decline in SUA over time was associated with higher dementia risk among males only (age-adjusted HR: 1.30, 95% CI: 1.03-1.63; fully adjusted HR: 1.29, 95% CI: 1.02-1.62).Discussion: Associations between SUA and dementia risk varied by sex and SUA trajectory, suggesting potential sex-specific biological mechanisms.","PeriodicalId":53226,"journal":{"name":"Alzheimer''s and Dementia: Diagnosis, Assessment and Disease Monitoring","volume":"18 3","pages":"e70440"},"PeriodicalIF":4.4,"publicationDate":"2026-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13469351/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148760202","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Quantification of global gray matter amyloid-β plaque from ¹⁸F-Florbetaben PET/MRI and correlation to BAPL score in patients with cognitive impairment. 认知障碍患者18F-Florbetaben PET/MRI整体灰质淀粉样蛋白-β斑块定量及与BAPL评分的相关性

IF 4.4

Alzheimer''s and Dementia: Diagnosis, Assessment and Disease Monitoring Pub Date : 2026-08-12 eCollection Date: 2026-07-01 DOI: 10.1002/dad2.70449

Adam Farag, Seyed Ali Mirshahvalad, Claudia Ortega, Carmela Tartaglia, Patrick Veit-Haibach, Ur Metser

{"title":"Quantification of global gray matter amyloid-β plaque from 18F-Florbetaben PET/MRI and correlation to BAPL score in patients with cognitive impairment.","authors":"Adam Farag, Seyed Ali Mirshahvalad, Claudia Ortega, Carmela Tartaglia, Patrick Veit-Haibach, Ur Metser","doi":"10.1002/dad2.70449","DOIUrl":"10.1002/dad2.70449","url":null,"abstract":"Introduction: Multiple standardized uptake value ratio (SUVR) and Centiloid (CL) thresholds exist for amyloid‑β (Aβ) positron emission tomography (PET) to classify scans as negative or positive, yet none reliably stratify brain amyloid plaque load (BAPL). This study proposes a global gray matter-based SUVR/CL model to determine amyloid status and quantitatively differentiate BAPL scores.Methods: Two 18F-Florbetaben (FBB) PET datasets were analyzed to derive SUVRs and CL values from global gray and white matter. SUVR/CL were integrated with visual assessment and BAPL scoring, resulting in CL thresholds to distinguish amyloid status and cognitive stage. The CL thresholds were validated in an independent local cohort.Results: Global gray-to-white matter CL best stratified amyloid status and BAPL scores, yielding CL thresholds of < 21 and > 38 and high diagnostic accuracy.Discussion: The integrated global CL-BAPL model reliably stratified amyloid positivity and BAPL level, suggesting that it could serve as a complementary tool to visual assessment.","PeriodicalId":53226,"journal":{"name":"Alzheimer''s and Dementia: Diagnosis, Assessment and Disease Monitoring","volume":"18 3","pages":"e70449"},"PeriodicalIF":4.4,"publicationDate":"2026-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13463316/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148724112","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Biomarkers for Alzheimer's disease to differentiate normal, SCD, and MCI subjects and their correlation with cognitive function. 区分正常、SCD和MCI受试者的阿尔茨海默病生物标志物及其与认知功能的相关性

IF 4.4

Alzheimer''s and Dementia: Diagnosis, Assessment and Disease Monitoring Pub Date : 2026-08-11 eCollection Date: 2026-07-01 DOI: 10.1002/dad2.70419

Allal Boutajangout, Ricardo S Osorio, Arjun V Masurkar, Ludovic Debure, Mobeena Ghuman, Wajiha Ahmed, Elizabeth Pirraglia, Alok Vedvyas, Jon Links, Brianna Vega, Karyn Marsh, Joshua Chodosh, Yongzhao Shao, Thomas Wisniewski

{"title":"Biomarkers for Alzheimer's disease to differentiate normal, SCD, and MCI subjects and their correlation with cognitive function.","authors":"Allal Boutajangout, Ricardo S Osorio, Arjun V Masurkar, Ludovic Debure, Mobeena Ghuman, Wajiha Ahmed, Elizabeth Pirraglia, Alok Vedvyas, Jon Links, Brianna Vega, Karyn Marsh, Joshua Chodosh, Yongzhao Shao, Thomas Wisniewski","doi":"10.1002/dad2.70419","DOIUrl":"10.1002/dad2.70419","url":null,"abstract":"Introduction: We assessed plasma biomarkers for the diagnosis of early Alzheimer's disease (AD).Methods: Subjects were divided into three groups: cognitively unimpaired (CU) (without subjective cognitive decline [SCD]) (n = 113), CU with SCD (n = 152), and mild cognitive impairment (MCI, n = 45). Plasma assays for amyloid beta (Aβ) 40, Aβ42, neurofilament light chain protein, glial fibrillary acidic protein, and phosphorylated tau181 levels were measured using single molecule array (Simoa) technology. Neuroinflammation and blood-brain barrier (BBB) biomarkers were measured using the Corplex cytokine 10-Plex kit and the angiogenesis 6-Plex kit, respectively.Results: Biomarker levels were regressed by cognitive group, age, sex, race, and apolipoprotein E apoE ε4 status, yielded significant positive associations between age and numerous AD, neuroinflammation, cytokine, and BBB plasma markers.Discussion: Linear regression analysis, adjusted for age, sex, race, and ApoE status, revealed significant differences between cognitive groups in levels of several plasma biomarkers and associations with age and sex. Neuroinflammation and BBB dysfunction showed significant positive associations with age across different stages of AD.","PeriodicalId":53226,"journal":{"name":"Alzheimer''s and Dementia: Diagnosis, Assessment and Disease Monitoring","volume":"18 3","pages":"e70419"},"PeriodicalIF":4.4,"publicationDate":"2026-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13461772/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148727035","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Real-world implementation of lecanemab in Korean patients at a tertiary memory clinic: Safety, ARIA risk, and early treatment patterns. 在韩国三级记忆诊所，利卡耐单在患者中的实际应用：安全性、ARIA风险和早期治疗模式。

IF 4.4

Alzheimer''s and Dementia: Diagnosis, Assessment and Disease Monitoring Pub Date : 2026-08-11 eCollection Date: 2026-07-01 DOI: 10.1002/dad2.70447

Jaemin Shin, Sang-Il Suh, Yu Jeong Park, Seungyun Lee, Jimin Kang, Eun Seong Lee, Hye Na Jung, Inseon Ryoo, Seongin Lee, Jae Seon Eo, Kyungmi Oh, Seong-Beom Koh, Sung Hoon Kang

{"title":"Real-world implementation of lecanemab in Korean patients at a tertiary memory clinic: Safety, ARIA risk, and early treatment patterns.","authors":"Jaemin Shin, Sang-Il Suh, Yu Jeong Park, Seungyun Lee, Jimin Kang, Eun Seong Lee, Hye Na Jung, Inseon Ryoo, Seongin Lee, Jae Seon Eo, Kyungmi Oh, Seong-Beom Koh, Sung Hoon Kang","doi":"10.1002/dad2.70447","DOIUrl":"10.1002/dad2.70447","url":null,"abstract":"Introduction: Lecanemab has demonstrated clinical efficacy in early Alzheimer's disease (AD), but real-world data remain limited, particularly in Asian populations.Methods: We prospectively enrolled 127 patients across the AD continuum who initiated lecanemab at a tertiary memory clinic in Korea. Infusion-related reactions (IRRs), amyloid-related imaging abnormalities (ARIAs), and cognitive outcomes were evaluated through clinical assessments, serial magnetic resonance imaging (MRI), and longitudinal Mini-Mental State Examination (MMSE) follow-up.Results: Among 127 patients, 102 completed at least five infusions with follow-up MRI. IRRs occurred in 27 (21.3%) patients, primarily during the first infusion. ARIAs occurred in 9 of 102 (8.8%), including ARIAs with edema in 4 (3.9%) and ARIA with hemorrhage in 7 (6.9%); most events were mild or asymptomatic. Higher microbleed burden and white matter hyperintensity were associated with increased ARIA risk. MMSE scores remained stable over 6 months.Discussion: In this prospective Korean cohort, lecanemab was generally well tolerated. Longer term controlled studies are needed to clarify cognitive outcomes.","PeriodicalId":53226,"journal":{"name":"Alzheimer''s and Dementia: Diagnosis, Assessment and Disease Monitoring","volume":"18 3","pages":"e70447"},"PeriodicalIF":4.4,"publicationDate":"2026-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13461769/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148727218","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Development and validation of the Spatial Navigation and Memory Questionnaire (SPAM). 空间导航与记忆问卷的编制与验证。

IF 4.4

Alzheimer''s and Dementia: Diagnosis, Assessment and Disease Monitoring Pub Date : 2026-08-11 eCollection Date: 2026-07-01 DOI: 10.1002/dad2.70441

Monique S Boord, Sol Morrissey, Hannah A D Keage, Victor R Schinazi, Michael Hornberger, Stephanie Wong

{"title":"Development and validation of the Spatial Navigation and Memory Questionnaire (SPAM).","authors":"Monique S Boord, Sol Morrissey, Hannah A D Keage, Victor R Schinazi, Michael Hornberger, Stephanie Wong","doi":"10.1002/dad2.70441","DOIUrl":"10.1002/dad2.70441","url":null,"abstract":"Introduction: Spatial navigation deficits may provide a sensitive and specific marker of early Alzheimer's disease pathology. However, few spatial navigation assessment tools are available for clinical practice that are accessible, time efficient, and sensitive to cognitive aging.Methods: Exploratory (n = 470) and confirmatory factor analyses (n = 470) were conducted to establish the factor structure of the Spatial Navigation and Memory Questionnaire (SPAM) in healthy older adults. A subset of participants (n = 445) completed the Virtual Supermarket Test (VST) to assess convergent validity. Normative data were reported stratified by age and sex.Results: A two-factor structure reflecting spatial navigation and memory for both subscales of the SPAM was supported, with acceptable to good internal consistency across factors. SPAM spatial navigation scores and VST performance were significantly correlated.Discussion: The SPAM demonstrates a clear and interpretable factor structure, acceptable model fit, and preliminary evidence of validity with an objective measure of spatial navigation performance.","PeriodicalId":53226,"journal":{"name":"Alzheimer''s and Dementia: Diagnosis, Assessment and Disease Monitoring","volume":"18 3","pages":"e70441"},"PeriodicalIF":4.4,"publicationDate":"2026-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13461775/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148723821","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Benchmarking privacy and utility in synthetic tabular cohorts for Alzheimer's disease research. 阿尔茨海默病研究中合成表格队列的隐私和效用基准。

IF 4.4

Alzheimer''s and Dementia: Diagnosis, Assessment and Disease Monitoring Pub Date : 2026-08-10 eCollection Date: 2026-07-01 DOI: 10.1002/dad2.70430

Filip Winzell, Ida Arvidsson, Niels Christian Overgaard, Anders Heyden, Kalle Åström, Linda Karlsson, Jacob W Vogel, Oskar Hansson, Niklas Mattsson-Carlgren

{"title":"Benchmarking privacy and utility in synthetic tabular cohorts for Alzheimer's disease research.","authors":"Filip Winzell, Ida Arvidsson, Niels Christian Overgaard, Anders Heyden, Kalle Åström, Linda Karlsson, Jacob W Vogel, Oskar Hansson, Niklas Mattsson-Carlgren","doi":"10.1002/dad2.70430","DOIUrl":"10.1002/dad2.70430","url":null,"abstract":"Introduction: The scarcity of large, clinically relevant cohorts is becoming a bottleneck in Alzheimer's disease (AD) research, as their sensitive nature makes open data sharing difficult. Privacy-preserving synthetic datasets generated with machine learning may help address this challenge.Methods: We compared five frameworks for generating synthetic tabular data from the Alzheimer's Disease Neuroimaging Initiative and Anti-Amyloid Treatment in Asymptomatic Alzheimer's Disease cohorts, with a set of empirical privacy and utility metrics. Two of the methods, DataSynthesizer and TableDiffusion, provide <math><mrow><mi>ε</mi></mrow> </math> -differential privacy guarantees.Results: Methods with differential privacy achieved high privacy ratings but low levels of utility. Deep learning methods like Tabular Prior-data Fitted Network (TabPFN) and Conditional Generative Adversarial Network (CTGAN) also showed high privacy with limited utility. In contrast, non-private DataSynthesizer and Synthpop offered higher utility at a cost of lower privacy.Discussion: The evaluated methods demonstrated a clear trade-off between privacy and utility. High privacy was generally associated with insufficient utility, highlighting the need for further research into synthetic data generation for AD.","PeriodicalId":53226,"journal":{"name":"Alzheimer''s and Dementia: Diagnosis, Assessment and Disease Monitoring","volume":"18 3","pages":"e70430"},"PeriodicalIF":4.4,"publicationDate":"2026-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13457355/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148714588","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Navigation performance in virtual reality-based cognitive assessment games as a candidate digital cognitive marker of hippocampal vulnerability: a scoping review. 基于虚拟现实的认知评估游戏中的导航性能作为海马脆弱性的候选数字认知标记：范围审查。

IF 4.4

Alzheimer''s and Dementia: Diagnosis, Assessment and Disease Monitoring Pub Date : 2026-08-10 eCollection Date: 2026-07-01 DOI: 10.1002/dad2.70434

Yesoda Bhargava, Saumya Tripathi, Veeky Baths, Bharat Madhusudan Deshpande

{"title":"Navigation performance in virtual reality-based cognitive assessment games as a candidate digital cognitive marker of hippocampal vulnerability: a scoping review.","authors":"Yesoda Bhargava, Saumya Tripathi, Veeky Baths, Bharat Madhusudan Deshpande","doi":"10.1002/dad2.70434","DOIUrl":"10.1002/dad2.70434","url":null,"abstract":"Virtual reality-based cognitive assessment games (VR-CAGs) are an emerging digital paradigm in dementia and Alzheimer's disease research. Although multiple studies report correlations between VR-CAG performance and standard neuropsychological assessments, clinical adoption remains limited, indicating that behavioral evidence alone is insufficient and that consolidated neuroimaging evidence is required. Existing neuroimaging studies link VR-CAG performance to regional brain activation, volumetric change, and brainwave dynamics, but this evidence remains scattered. We conducted a scoping review of 29 neuroimaging studies on VR-CAGs. Three functional neural systems were associated with VR-CAG performance: the spatial map system, the response system, and the executive control system. Two VR-CAG archetypes - hippocampal-based and adaptive navigation - were identified. A reporting and evaluation checklist is proposed to standardize VR-CAG research. Review findings indicate that VR-CAGs based on allocentric and egocentric tasks may be sensitive to hippocampal health, potentially acting as candidate digital markers of dementia-relevant functional cognitive decline.","PeriodicalId":53226,"journal":{"name":"Alzheimer''s and Dementia: Diagnosis, Assessment and Disease Monitoring","volume":"18 3","pages":"e70434"},"PeriodicalIF":4.4,"publicationDate":"2026-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13457350/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148714576","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Semaglutide attenuates a proteomics-based dementia risk signature in older adults with overweight or obesity and cardiovascular disease without diabetes: A post hoc analysis of the SELECT phase 3 trial. Semaglutide降低了超重或肥胖且无糖尿病心血管疾病的老年人的基于蛋白质组学的痴呆风险特征：SELECT 3期试验的事后分析

IF 4.4

Alzheimer''s and Dementia: Diagnosis, Assessment and Disease Monitoring Pub Date : 2026-08-08 eCollection Date: 2026-07-01 DOI: 10.1002/dad2.70432

Martí Jiménez-Mausbach, Betty M Tijms, Clare Paterson, Jan Christian Refsgaard

{"title":"Semaglutide attenuates a proteomics-based dementia risk signature in older adults with overweight or obesity and cardiovascular disease without diabetes: A post hoc analysis of the SELECT phase 3 trial.","authors":"Martí Jiménez-Mausbach, Betty M Tijms, Clare Paterson, Jan Christian Refsgaard","doi":"10.1002/dad2.70432","DOIUrl":"10.1002/dad2.70432","url":null,"abstract":"Introduction: Plasma proteomics detect multi-pathway biological changes preceding dementia onset. The Dementia SomaSignal Test (dSST) is a validated 25-protein score predicting 5- and 20-year all-cause dementia risk. Preclinical and clinical data suggest glucagon-like peptide-1 receptor agonists may have neuroprotective effects.Methods: In a post hoc analysis of the Semaglutide Effects on Heart Disease and Stroke in Patients With Overweight or Obesity (SELECT) trial, adults ≥ 65 years with overweight/obesity and cardiovascular disease without diabetes (n = 2970) were randomized to semaglutide 2.4 mg or placebo. Non-fasted serum samples at baseline and week 104 were analyzed using the dSST.Results: Semaglutide reduced increases in predicted dementia risk versus placebo: 2.5-fold less increase in 5-year risk (26.0% lower predicted event rate; odds ratio [OR] 0.74, 95% confidence interval [CI] 0.65-0.85) and 1.67-fold less increase in 20-year risk (8.8% lower; OR 0.91, 95% CI 0.88-0.94). It also reduced odds of higher dementia risk classification by 36% (β -0.44; P < 0.001).Discussion: Semaglutide slowed progression of a validated proteomics-based dementia risk signature.","PeriodicalId":53226,"journal":{"name":"Alzheimer''s and Dementia: Diagnosis, Assessment and Disease Monitoring","volume":"18 3","pages":"e70432"},"PeriodicalIF":4.4,"publicationDate":"2026-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13452022/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148698377","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Arterial stiffness and risk of dementia in late life: The ARIC neurocognitive study. 动脉僵硬和老年痴呆风险：ARIC神经认知研究。

IF 4.4

Alzheimer''s and Dementia: Diagnosis, Assessment and Disease Monitoring Pub Date : 2026-08-07 eCollection Date: 2026-07-01 DOI: 10.1002/dad2.70427

Jenna Barbee, James Russell Pike, Jingkai Wei, Hirofumi Tanaka, David S Knopman, Anna Kucharska-Newton, A Richey Sharrett, Timothy M Hughes, Kunihiro Matsushita, Thomas H Mosley, Michelle L Meyer, Priya Palta

{"title":"Arterial stiffness and risk of dementia in late life: The ARIC neurocognitive study.","authors":"Jenna Barbee, James Russell Pike, Jingkai Wei, Hirofumi Tanaka, David S Knopman, Anna Kucharska-Newton, A Richey Sharrett, Timothy M Hughes, Kunihiro Matsushita, Thomas H Mosley, Michelle L Meyer, Priya Palta","doi":"10.1002/dad2.70427","DOIUrl":"10.1002/dad2.70427","url":null,"abstract":"Introduction: Associations of arterial stiffness, measured through pulse wave velocity (PWV), with incident dementia may be driven by age-related structural changes to the arterial wall or by elevated blood pressure.Methods: Dementia-free White or Black participants in the community-based Atherosclerosis Risk in Communities (ARIC) cohort study with measures of PWV were examined. The associations of carotid-femoral PWV (cfPWV) and total, structural, and load-dependent PWV with dementia were estimated using Poisson regression models and Cox proportional hazards models. Dementia cases were defined by physician-adjudicated review, telephone interviews, hospitalization records, and death certificates.Results: Of 4818 participants included in the study population (mean age: 75 years; 41% male, 21% Black), 1067 (22%) developed dementia over a median follow-up of 9.0 years. Higher cfPWV, total PWV, structural PWV, and load-dependent PWV were associated with greater dementia risk.Discussion: Both structural and pressure-related arterial stiffness mechanisms may underlie the link between PWV and dementia.","PeriodicalId":53226,"journal":{"name":"Alzheimer''s and Dementia: Diagnosis, Assessment and Disease Monitoring","volume":"18 3","pages":"e70427"},"PeriodicalIF":4.4,"publicationDate":"2026-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13448772/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148690133","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Parallel neuroinflammatory pathways to cerebrovascular burden and amyloid beta in Alzheimer's disease. 阿尔茨海默病脑血管负荷和β淀粉样蛋白的平行神经炎症途径。

IF 4.4

Alzheimer''s and Dementia: Diagnosis, Assessment and Disease Monitoring Pub Date : 2026-08-07 eCollection Date: 2026-07-01 DOI: 10.1002/dad2.70415

Batool Rizvi, Jenna N Adams, Alison Bamford, Soyun Kim, Mithra Sathishkumar, Nicholas J Tustison, Lisa Taylor, Nandita Tuteja, Liv McMillan, Bin Nan, Hengrui Cai, Yuritza Y Escalante, Novelle J Meza, Alyssa L Harris, Rond Malhas, Adam M Brickman, Mark Mapstone, Elizabeth A Thomas, Michael A Yassa

{"title":"Parallel neuroinflammatory pathways to cerebrovascular burden and amyloid beta in Alzheimer's disease.","authors":"Batool Rizvi, Jenna N Adams, Alison Bamford, Soyun Kim, Mithra Sathishkumar, Nicholas J Tustison, Lisa Taylor, Nandita Tuteja, Liv McMillan, Bin Nan, Hengrui Cai, Yuritza Y Escalante, Novelle J Meza, Alyssa L Harris, Rond Malhas, Adam M Brickman, Mark Mapstone, Elizabeth A Thomas, Michael A Yassa","doi":"10.1002/dad2.70415","DOIUrl":"10.1002/dad2.70415","url":null,"abstract":"Introduction: Upstream neuroinflammation plays an important role in Alzheimer's disease (AD) but remains poorly understood. We tested whether two distinct neuroinflammatory markers are associated with cerebrovascular burden and amyloid beta (Aβ), and downstream, with plasma phosphorylated tau (p-tau217), medial temporal lobe (MTL) cortical and hippocampal atrophy, and memory deficits.Methods: Cognitively unimpaired older adults without dementia or mild cognitive impairment were recruited from a community sample (Biomarker Exploration in Aging, Cognition, and Neurodegeneration; [BEACoN]; N = 126). We used structural equation modeling to test whether plasma chitinase-3-like protein 1 (YKL-40) and glial fibrillary acidic protein (GFAP) contribute to distinct pathways.Results: Higher plasma YKL-40 was associated with greater white matter hyperintensity (WMH), whereas higher plasma GFAP was related to increased 18F-florbetapir (FBP) standardized uptake value ratio (SUVR). Higher plasma GFAP, WMH, and FBP SUVR were independently associated with increased p-tau217. Plasma p-tau217 was associated with reduced MTL cortical thickness and hippocampal volume. Reduced hippocampal volume was related to worse memory.Discussion: Future work can further investigate these neuroinflammatory pathways as potential therapeutic targets for AD.","PeriodicalId":53226,"journal":{"name":"Alzheimer''s and Dementia: Diagnosis, Assessment and Disease Monitoring","volume":"18 3","pages":"e70415"},"PeriodicalIF":4.4,"publicationDate":"2026-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13449296/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148698336","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0