Alzheimer''s and Dementia: Diagnosis, Assessment and Disease Monitoring最新文献

{"title":"Association between BrainAGE and Alzheimer's disease biomarkers.","authors":"Yousaf Abughofah, Rachael Deardorff, Aaron Vosmeier, Savannah Hottle, Jeffrey L Dage, Desarae Dempsey, Liana G Apostolova, Jared Brosch, David Clark, Martin Farlow, Tatiana Foroud, Sujuan Gao, Sophia Wang, Henrik Zetterberg, Kaj Blennow, Andrew J Saykin, Shannon L Risacher","doi":"10.1002/dad2.70094","DOIUrl":"10.1002/dad2.70094","url":null,"abstract":"<p><strong>Introduction: </strong>The brain age gap estimation (BrainAGE) method uses a machine learning model to generate an age estimate from structural magnetic resonance imaging (MRI) scans. The goal was to study the association of brain age with Alzheimer's disease (AD) imaging and plasma biomarkers.</p><p><strong>Methods: </strong>One hundred twenty-three individuals from the Indiana Memory and Aging Study underwent structural MRI, amyloid and tau positron emission tomography (PET), and plasma sampling. The MRI scans were processed using the software program BrainAgeR to receive a \"brain age\" estimate. Plasma biomarker concentrations were measured, and partial Pearson correlation models were used to evaluate their relationship with brain age gap (BAG) estimation (BrainAGE = chronological age - MRI estimated brain age).</p><p><strong>Results: </strong>Significant associations between BAG and amyloid and tau levels on PET and in plasma were observed depending on diagnostic categories.</p><p><strong>Discussion: </strong>These findings suggest that BAG is potentially a biomarker of pathology in AD which can be applied to routine brain imaging.</p><p><strong>Highlights: </strong>Novel research that uses an artificial intelligence learning tool to estimate brain age.Findings suggest that brain age gap is associated with plasma and positron emission tomography Alzheimer's disease (AD) biomarkers.Differential relationships are seen in different stages of disease (preclinical vs. clinical).Results could play a role in early AD diagnosis and treatment.</p>","PeriodicalId":53226,"journal":{"name":"Alzheimer''s and Dementia: Diagnosis, Assessment and Disease Monitoring","volume":"17 1","pages":"e70094"},"PeriodicalIF":4.0,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11865712/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143525242","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Accrual of Alzheimer's disease pathology as a function of proximity to parental dementia onset.","authors":"Elina T Ziukelis, Elijah Mak, Craig Ritchie, John T O'Brien, Dag Aarsland","doi":"10.1002/dad2.70092","DOIUrl":"10.1002/dad2.70092","url":null,"abstract":"<p><strong>Introduction: </strong>Whether temporal proximity to parental onset of dementia (PPO) can be used to estimate timing of the preclinical stage of sporadic Alzheimer's disease (AD) remains uncertain.</p><p><strong>Methods: </strong>We investigated cross-sectionally adults aged > 50 without dementia included in the European Prevention of Alzheimer's Dementia (EPAD) study. PPO was tested as a predictor of quantitative levels of cerebrospinal fluid (CSF) β-amyloid (1-42) (Aβ1-42) in those with a parental history of dementia (<i>n</i> = 688) and of phosphorylated tau (p-tau) and EPAD neuropsychological examination (ENE) subscores in an amyloid positive subgroup (<i>n</i> = 226). Possible interactions were explored.</p><p><strong>Results: </strong>Shorter PPO predicted lower CSF Aβ1-42 level (β = 9.357; T = 4.161; <i>p</i> < 0.001), interacting with apolipoprotein E (APOE) -𝜀4 carriage in a dose-dependent manner. Concomitant APOE-𝜀2 carriage appeared to provide protection. PPO did not predict p-tau levels or cognitive performance.</p><p><strong>Discussion: </strong>PPO may provide a valid method of stratifying risk of early AD pathologic change in APOE-𝜀4 carriers, with empirical and clinical applications.</p><p><strong>Highlights: </strong>Proximity to age of parental dementia onset can predict amyloid accrualThe effect is APOE-𝜀4 dose-dependent and APOE-𝜀2 appears to provide protectionPPO does not appear to predict further advancement along the AD continuumIn the era of anti-amyloid treatments, this may inform timing of amyloid screeningUsed as an empirical metric, PPO could help elucidate the natural history of LOAD.</p>","PeriodicalId":53226,"journal":{"name":"Alzheimer''s and Dementia: Diagnosis, Assessment and Disease Monitoring","volume":"17 1","pages":"e70092"},"PeriodicalIF":4.0,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11865705/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143525166","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Excessive sleep is associated with worse cognition, cognitive decline, and dementia in mild cognitive impairment.","authors":"Marieclaire Overton, Shireen Sindi, Rani Basna, Sölve Elmståhl","doi":"10.1002/dad2.70093","DOIUrl":"10.1002/dad2.70093","url":null,"abstract":"<p><strong>Introduction: </strong>This study examines the link between daytime and nighttime excessive sleep and cognition, cognitive decline, and dementia in individuals with existing mild cognitive impairment (MCI).</p><p><strong>Methods: </strong>Using data from the Swedish longitudinal study Good Aging in Skåne, participants aged 60-102 years were retrospectively classified as MCI based on cognitive testing. The average follow-up time was 6.59 years. Mixed linear models assessed cross-sectional and longitudinal associations between excessive sleep patterns (napping ≥2 h or nighttime sleep ≥9 h) and multiple cognitive domains. Cox regressions estimated dementia risk for excessive sleep.</p><p><strong>Results: </strong>Of 4930 participants, 2052 (41%) had MCI. Excessive daytime napping and nighttime sleep were associated with worse cognition and cognitive decline. Excessive napping and nighttime sleep were also linked to higher dementia risk (hazard ratios: 1.75 and 1.86, respectively).</p><p><strong>Discussion: </strong>These findings suggest that excessive sleep in MCI is associated with further cognitive decline and dementia.</p><p><strong>Highlights: </strong>Excessive daytime napping and nighttime sleep are linked cognitive decline for those with MCI.Excessive sleep during the day or at night heighten dementia risk.Worse test scores across multiple cognitive domains were observed for excessive daytime nappers.Excessive sleep in MCI may be a warning sign for further cognitive decline.</p>","PeriodicalId":53226,"journal":{"name":"Alzheimer''s and Dementia: Diagnosis, Assessment and Disease Monitoring","volume":"17 1","pages":"e70093"},"PeriodicalIF":4.0,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11848587/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143494817","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Plasma amyloid-β oligomerization tendency as a potential predictor for conversion from mild cognitive impairment to Alzheimer's dementia: Findings from the GMCII cohort.","authors":"Yuhan Xie, Xue Meng, Tao Li, Haifeng Zhang, Yaonan Zheng, SangYun Kim, Chen Zhang, Xin Yu, Huali Wang","doi":"10.1002/dad2.70064","DOIUrl":"10.1002/dad2.70064","url":null,"abstract":"<p><strong>Introduction: </strong>This study aimed to explore the association between plasma amyloid-β oligomerization tendency (OAβ) and cognitive performance in Alzheimer's disease (AD) and determine its predictive value for outcomes of mild cognitive impairment (MCI).</p><p><strong>Methods: </strong>Plasma from 727 subjects (286 AD, 260 MCI, and 181 controls) in a case registry was analyzed using the multimer detection system (MDS) to measure plasma OAβ.</p><p><strong>Results: </strong>Elevated plasma OAβ was strongly correlated with multidomain cognitive performance in patients with MCI and AD. Patients with MCI with high baseline plasma OAβ demonstrated a higher risk of progressing to dementia (hazard ratio = 1.083, 95% confidence interval [CI] 1.032-1.137). Baseline plasma OAβ effectively predicted MCI-dementia conversion (area under the curve [AUC] = 0.824, 95% CI 0.752-0.897).</p><p><strong>Discussion: </strong>The real-world findings underscore the clinical relevance of plasma OAβ as a potential predictor for the conversion from mild cognitive impairment (MCI) to dementia.</p><p><strong>Highlights: </strong>We recruit study participants of Alzheimer's dementia (AD), mild cognitive impairment (MCI), and cognitively normal controls in a case registry.We use the multimer detection system (MDS) to measure plasma amyloid-β oligomerization tendency (OAβ).We observe that elevated plasma OAβ strongly correlates with multidomain cognitive performance in patients with MCI and AD.MCI individuals with high baseline plasma OAβ demonstrate a higher risk of progressing to dementia.The real-world findings underscore the clinical relevance of plasma Oaβ as a potential predictor for the conversion from MCI to dementia.</p>","PeriodicalId":53226,"journal":{"name":"Alzheimer''s and Dementia: Diagnosis, Assessment and Disease Monitoring","volume":"17 1","pages":"e70064"},"PeriodicalIF":4.0,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11848609/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143494058","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retinal vasculometry associations with cognition status in UK Biobank.","authors":"Royce Shakespeare, Alicja R Rudnicka, Roshan Welikala, Sarah A Barman, Anthony P Khawaja, Paul J Foster, Christopher G Owen","doi":"10.1002/dad2.70087","DOIUrl":"10.1002/dad2.70087","url":null,"abstract":"<p><strong>Introduction: </strong>Retinal vasculometry (RV) provides a neurovascular biomarker which may relate to cognitive status. However, the presence and form of association remains unclear and unexamined at scale.</p><p><strong>Methods: </strong>Artificial intelligence-enabled RV measures from 66,350 UK Biobank study participants were related to combined cognition scores. Differences in RV were examined per standard deviation (SD) increase in cognitive score, using multilevel linear regression, adjusted for age, sex, measurement center, ethnicity, and within-person RV clustering.</p><p><strong>Results: </strong>One hundred ten thousand two hundred eighty-two retinal images from 63,165 (95%) participants (mean age 56.6 years, 55.5% female) were analyzed. A one SD increase in cognition score was strongly associated with increased arteriolar width, arteriolar tortuosity, increased venular width particularly among those < 50 years and venular area among those > 50 years; also, inversely associated with venular tortuosity, and arteriolar and venular width variance.</p><p><strong>Discussion: </strong>These easily accessible, affordable, and non-invasive RV measures should be evaluated further as an early predictor of future neurodegenerative disease.</p><p><strong>Highlights: </strong>How cognitive status relates to retinal vasculometry (RV) measures remains uncertain and unexamined at scale.Using data from a large population-based study (UK Biobank) we show strong graded associations between cognitive status and RV, which contrast with some RV associations observed with aging. Specifically, increased arteriolar tortuosity, arteriolar and venular width (at younger ages), and area are positively associated, and venular tortuosity and arteriolar and venular width variability are inversely associated with higher cognitive status, all showing strong, graded, precise relationships. These associations appeared to be strongest for fluid intelligence and prospective memory tests.These easily accessible, non-invasive RV measures provide a neurovascular marker indicative of cognitive status, which should be evaluated as early predictors of neurodegenerative disease.</p>","PeriodicalId":53226,"journal":{"name":"Alzheimer''s and Dementia: Diagnosis, Assessment and Disease Monitoring","volume":"17 1","pages":"e270087"},"PeriodicalIF":4.0,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11848343/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143494327","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A network perspective on cognition in individuals with Parkinson's disease.","authors":"Daniel Scharfenberg, Elke Kalbe, Monika Balzer-Geldsetzer, Daniela Berg, Rüdiger Hilker-Roggendorf, Jan Kassubek, Inga Liepelt-Scarfone, Brit Mollenhauer, Kathrin Reetz, Oliver Riedel, Sandra Roeske, Jörg B Schulz, Alexander Storch, Claudia Trenkwalder, Karsten Witt, Hans-Ulrich Wittchen, Richard Dodel, Anja Ophey","doi":"10.1002/dad2.70091","DOIUrl":"10.1002/dad2.70091","url":null,"abstract":"<p><strong>Introduction: </strong>In neuropsychological diagnostics, the assignment of cognitive tests to domains is usually not empirically based. Hence, we aimed to assess the dimensionality structure of cognition in individuals with Parkinson's disease (PD) and conceptually replicate the findings in cognitively healthy individuals (CHIs).</p><p><strong>Methods: </strong>We performed Exploratory Graph Analysis (EGA) for dimensionality analysis of cognitive test scores in <i>N </i>= 698 individuals with PD from the DEMPARK/LANDSCAPE study. Redundancy was reduced based on Unique Variable Analysis (UVA) before re-performing EGA. CHI data (<i>N </i>= 60,398) served as a conceptual replication base.</p><p><strong>Results: </strong>EGA identified five dimensions. After removing redundancy identified by UVA, EGA identified a unidimensional structure of cognitive test scores. The findings were conceptually replicated in CHIs.</p><p><strong>Discussion: </strong>The findings imply the need to re-evaluate the composition of cognitive test batteries to reduce redundancy and improve the validity of cognitive diagnostics. Cognition may be better described as a network of interrelated cognitive functions rather than a factorial structure of latent cognitive domains.</p><p><strong>Highlights: </strong>Cognitive test scores of the same paradigm were strongly associated with each other.This finding indicates redundancy in the cognitive test battery.After removing redundancy, scores were best represented by unidimensional structures.The findings in Parkinson's disease were conceptually replicated in healthy controls.The results suggest that cognition should be viewed as a complex \"network\" of interrelated functions.</p>","PeriodicalId":53226,"journal":{"name":"Alzheimer''s and Dementia: Diagnosis, Assessment and Disease Monitoring","volume":"17 1","pages":"e70091"},"PeriodicalIF":4.0,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11848640/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143494811","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Amyloid is associated with accelerated atrophy in cognitively unimpaired individuals.","authors":"Henry Gilreath Stephenson, Tobey J Betthauser, Rebecca Langhough, Erin Jonaitis, Lianlian Du, Carol Van Hulle, Gwendlyn Kollmorgen, Clara Quijano-Rubio, Nathaniel A Chin, Ozioma C Okonkwo, Cynthia M Carlsson, Sanjay Asthana, Sterling C Johnson, Kaj Blennow, Henrik Zetterberg, Barbara B Bendlin","doi":"10.1002/dad2.70089","DOIUrl":"10.1002/dad2.70089","url":null,"abstract":"<p><strong>Introduction: </strong>This study examined the association of longitudinal atrophy with baseline cerebrospinal fluid (CSF) amyloid beta (Aβ, A) and phosphorylated tau (p-tau, T) biomarkers (Aβ42/40, p-tau181) in 406 cognitively unimpaired (CU) individuals (6.670 years of follow-up on average, up to 13 imaging visits) to assess whether A+ is associated with Alzheimer's disease-like atrophy and whether this depends on p-tau181 levels.</p><p><strong>Methods: </strong>An A-T- CU group free from abnormal neurodegeneration (N) was identified using a robust normative approach and used to model normal age-related atrophy via <i>z</i>-scoring. Linear mixed-effects models tested differences in longitudinal atrophy between A+ and A-T-N- individuals and between A/T subgroups.</p><p><strong>Results: </strong>A+ was associated with worse atrophy within and beyond the medial temporal lobe, even at low levels of p-tau181.</p><p><strong>Discussion: </strong>Neurodegeneration likely begins soon after the onset of abnormal Aβ pathology. Clinical intervention at the earliest signs of Aβ pathology may be needed to mitigate further neurodegeneration.</p><p><strong>Highlights: </strong>An A-T-N- control group was identified using a robust normative approachA+ was associated with accelerated atrophy in cognitively unimpaired individualsAtrophy was observed even at low p-tau181 levels.</p>","PeriodicalId":53226,"journal":{"name":"Alzheimer''s and Dementia: Diagnosis, Assessment and Disease Monitoring","volume":"17 1","pages":"e70089"},"PeriodicalIF":4.0,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11848556/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143494814","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Feasibility of assessing cognitive impairment via distributed camera network and privacy-preserving edge computing.","authors":"Chaitra Hegde, Yashar Kiarashi, Allan I Levey, Amy D Rodriguez, Hyeokhyen Kwon, Gari D Clifford","doi":"10.1002/dad2.70085","DOIUrl":"10.1002/dad2.70085","url":null,"abstract":"<p><strong>Introduction: </strong>Mild cognitive impairment (MCI) involves cognitive decline beyond normal age and education expectations. It correlates with decreased socialization and increased aimless motion. We aim to automate detection of these behaviors for improved longitudinal monitoring.</p><p><strong>Methods: </strong>We used a privacy-preserving distributed camera network to collect data from MCI patients in an indoor space. Movement and social interaction features were developed using this data to train machine learning algorithms to differentiate between higher and lower cognitive functioning MCI groups.</p><p><strong>Results: </strong>A Wilcoxon rank-sum test showed significant differences between high- and low-functioning cohorts in the movement and social interaction features. Despite the absence of data linking each person's identity to their specific level of cognitive decline, a machine learning model using key features achieved 71% accuracy.</p><p><strong>Discussion: </strong>We show that an edge computing-based privacy-preserving camera network can differentiate between levels of cognitive impairment based on movements and social interactions during group activities.</p><p><strong>Highlights: </strong>Movement and social interaction features showed significant differences in high- and low-functioning cohorts.Significant features included linear path lengths, walking speed, direction change and velocity entropies, and number of group formations, among others.Differences were observed despite the presence of healthy individuals and the lack of individual identifiers.Data were collected using a 39-camera privacy-preserving edge computing network covering a 1700-m² indoor space.</p>","PeriodicalId":53226,"journal":{"name":"Alzheimer''s and Dementia: Diagnosis, Assessment and Disease Monitoring","volume":"17 1","pages":"e70085"},"PeriodicalIF":4.0,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11848627/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143494820","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical performance of the fully automated Lumipulse plasma p-tau217 assay in mild cognitive impairment and mild dementia.","authors":"Adam H Dyer, Jean Dunne, Helena Dolphin, Laura Morrison, Antoinette O'Connor, Sarah Fullam, Tara Kenny, Aoife Fallon, Sean O'Dowd, Nollaig M Bourke, Niall P Conlon, Sean P Kennelly","doi":"10.1002/dad2.70080","DOIUrl":"10.1002/dad2.70080","url":null,"abstract":"<p><strong>Introduction: </strong>Plasma phosphorylated tau (p-tau)217 is a leading blood-biomarker for the detection of amyloid beta (Aβ) pathology. We assessed the performance of a fully automated plasma p-tau217 immunoassay to detect Aβ pathology in mild cognitive impairment (MCI)/mild dementia.</p><p><strong>Methods: </strong>Paired plasma and cerebrospinal fluid (CSF) samples were obtained at time of diagnostic lumbar puncture (LP) in a specialist memory service. Plasma p-tau217 was measured using the Lumipulse immunoassay platform and ability to detect CSF-defined Aβ positivity assessed.</p><p><strong>Results: </strong>Of 148 participants (69.4 ± 6.5 years; 54.1% female), 101 had MCI and 47 mild dementia. Median plasma p-tau217 was > 4-fold higher in Aβ+ vs Aβ- individuals with an area under the curve of 0.92 (0.87-0.97). Application of 90%, 95%, and 97.5% sensitivity/specificity thresholds for plasma p-tau217 may have obviated the need for more than half of LPs.</p><p><strong>Discussion: </strong>Our real-world data support the clinical use of fully automated plasma p-tau217 immunoassays, although further studies in more diverse cohorts are required.</p><p><strong>Highlights: </strong>Plasma phosphorylated tau (p-tau)217 was measured using a fully automated immunoassay (Lumipulse).P-tau217 was > 4-fold higher in amyloid beta (Aβ)+ versus Aβ- individuals.Plasma p-tau217 had an area under the curve of 0.92 for detection of Aβ status.Using a previously proposed two-threshold approach may avoid more than half of lumbar punctures.</p>","PeriodicalId":53226,"journal":{"name":"Alzheimer''s and Dementia: Diagnosis, Assessment and Disease Monitoring","volume":"17 1","pages":"e70080"},"PeriodicalIF":4.0,"publicationDate":"2025-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11826441/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143434381","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Natural language processing in Alzheimer's disease research: Systematic review of methods, data, and efficacy.","authors":"Arezo Shakeri, Mina Farmanbar","doi":"10.1002/dad2.70082","DOIUrl":"10.1002/dad2.70082","url":null,"abstract":"<p><strong>Introduction: </strong>Alzheimer's disease (AD) prevalence is increasing, with no current cure. Natural language processing (NLP) offers the potential for non-invasive diagnostics, social burden assessment, and research advancements in AD.</p><p><strong>Method: </strong>A systematic review using Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines explored NLP applications in AD, focusing on dataset types, sources, research foci, methods, and effectiveness. Searches were conducted across six databases (ACM, Embase, IEEE, PubMed, Scopus, and Web of Science) from January 2020 to July 2024.</p><p><strong>Results: </strong>Of 1740 records, 79 studies were selected. Frequently used datasets included speech and electronic health records (EHR), along with social media and scientific publications. Machine learning and neural networks were primarily applied to speech, EHR, and social media data, while rule-based methods were used to analyze literature datasets.</p><p><strong>Discussion: </strong>NLP has proven effective in various aspects of AD research, including diagnosis, monitoring, social burden assessment, biomarker analysis, and research. However, there are opportunities for improvement in dataset diversity, model interpretability, multilingual capabilities, and addressing ethical concerns.</p><p><strong>Highlights: </strong>This review systematically analyzed 79 studies from six major databases, focusing on the advancements and applications of natural language processing (NLP) in Alzheimer's disease (AD) research.The study highlights the need for models focusing on remote monitoring of AD patients using speech analysis, offering a cost-effective alternative to traditional methods such as brain imaging and aiding clinicians in both prediagnosis and post-diagnosis periods.The use of pretrained multilingual models is recommended to improve AD detection across different languages by leveraging diverse speech features and utilizing publicly available datasets.</p>","PeriodicalId":53226,"journal":{"name":"Alzheimer''s and Dementia: Diagnosis, Assessment and Disease Monitoring","volume":"17 1","pages":"e70082"},"PeriodicalIF":4.0,"publicationDate":"2025-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11812127/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143400738","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}