Excessive sleep is associated with worse cognition, cognitive decline, and dementia in mild cognitive impairment.

IF 4 Q1 CLINICAL NEUROLOGY

Alzheimer''s and Dementia: Diagnosis, Assessment and Disease Monitoring Pub Date : 2025-02-24 eCollection Date: 2025-01-01 DOI:10.1002/dad2.70093

Marieclaire Overton, Shireen Sindi, Rani Basna, Sölve Elmståhl

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Abstract

Introduction: This study examines the link between daytime and nighttime excessive sleep and cognition, cognitive decline, and dementia in individuals with existing mild cognitive impairment (MCI).

Methods: Using data from the Swedish longitudinal study Good Aging in Skåne, participants aged 60-102 years were retrospectively classified as MCI based on cognitive testing. The average follow-up time was 6.59 years. Mixed linear models assessed cross-sectional and longitudinal associations between excessive sleep patterns (napping ≥2 h or nighttime sleep ≥9 h) and multiple cognitive domains. Cox regressions estimated dementia risk for excessive sleep.

Results: Of 4930 participants, 2052 (41%) had MCI. Excessive daytime napping and nighttime sleep were associated with worse cognition and cognitive decline. Excessive napping and nighttime sleep were also linked to higher dementia risk (hazard ratios: 1.75 and 1.86, respectively).

Discussion: These findings suggest that excessive sleep in MCI is associated with further cognitive decline and dementia.

Highlights: Excessive daytime napping and nighttime sleep are linked cognitive decline for those with MCI.Excessive sleep during the day or at night heighten dementia risk.Worse test scores across multiple cognitive domains were observed for excessive daytime nappers.Excessive sleep in MCI may be a warning sign for further cognitive decline.

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过度睡眠与认知能力下降、认知能力下降和轻度认知障碍痴呆有关。

本研究探讨了存在轻度认知障碍（MCI）个体的白天和夜间过度睡眠与认知、认知衰退和痴呆之间的联系。方法：使用瑞典纵向研究sk Good Aging的数据，根据认知测试将60-102岁的参与者回顾性地归类为轻度认知损伤。平均随访时间为6.59年。混合线性模型评估了过度睡眠模式（午睡≥2小时或夜间睡眠≥9小时）与多个认知领域之间的横断面和纵向关联。Cox回归估计了过度睡眠的痴呆风险。结果：4930名参与者中，2052名（41%）患有轻度认知障碍。白天小睡过多和夜间睡眠过多与认知能力下降和认知能力下降有关。过度打盹和夜间睡眠也与更高的痴呆风险有关（风险比分别为1.75和1.86）。讨论：这些发现表明，轻度认知损伤患者睡眠过多与进一步的认知能力下降和痴呆有关。重点：过度的白天小睡和夜间睡眠与轻度认知障碍患者的认知能力下降有关。白天或晚上睡眠过多会增加患痴呆症的风险。白天过度午睡的人在多个认知领域的测试成绩都较差。轻度认知障碍患者睡眠过多可能是认知能力进一步下降的警告信号。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Alzheimer''s and Dementia: Diagnosis, Assessment and Disease Monitoring Medicine-Psychiatry and Mental Health

CiteScore

7.80

自引率

7.50%

发文量

101

审稿时长

8 weeks

期刊介绍： Alzheimer''s & Dementia: Diagnosis, Assessment & Disease Monitoring (DADM) is an open access, peer-reviewed, journal from the Alzheimer''s Association® that will publish new research that reports the discovery, development and validation of instruments, technologies, algorithms, and innovative processes. Papers will cover a range of topics interested in the early and accurate detection of individuals with memory complaints and/or among asymptomatic individuals at elevated risk for various forms of memory disorders. The expectation for published papers will be to translate fundamental knowledge about the neurobiology of the disease into practical reports that describe both the conceptual and methodological aspects of the submitted scientific inquiry. Published topics will explore the development of biomarkers, surrogate markers, and conceptual/methodological challenges. Publication priority will be given to papers that 1) describe putative surrogate markers that accurately track disease progression, 2) biomarkers that fulfill international regulatory requirements, 3) reports from large, well-characterized population-based cohorts that comprise the heterogeneity and diversity of asymptomatic individuals and 4) algorithmic development that considers multi-marker arrays (e.g., integrated-omics, genetics, biofluids, imaging, etc.) and advanced computational analytics and technologies.