Royce Shakespeare, Alicja R Rudnicka, Roshan Welikala, Sarah A Barman, Anthony P Khawaja, Paul J Foster, Christopher G Owen
{"title":"Retinal vasculometry associations with cognition status in UK Biobank.","authors":"Royce Shakespeare, Alicja R Rudnicka, Roshan Welikala, Sarah A Barman, Anthony P Khawaja, Paul J Foster, Christopher G Owen","doi":"10.1002/dad2.70087","DOIUrl":null,"url":null,"abstract":"<p><strong>Introduction: </strong>Retinal vasculometry (RV) provides a neurovascular biomarker which may relate to cognitive status. However, the presence and form of association remains unclear and unexamined at scale.</p><p><strong>Methods: </strong>Artificial intelligence-enabled RV measures from 66,350 UK Biobank study participants were related to combined cognition scores. Differences in RV were examined per standard deviation (SD) increase in cognitive score, using multilevel linear regression, adjusted for age, sex, measurement center, ethnicity, and within-person RV clustering.</p><p><strong>Results: </strong>One hundred ten thousand two hundred eighty-two retinal images from 63,165 (95%) participants (mean age 56.6 years, 55.5% female) were analyzed. A one SD increase in cognition score was strongly associated with increased arteriolar width, arteriolar tortuosity, increased venular width particularly among those < 50 years and venular area among those > 50 years; also, inversely associated with venular tortuosity, and arteriolar and venular width variance.</p><p><strong>Discussion: </strong>These easily accessible, affordable, and non-invasive RV measures should be evaluated further as an early predictor of future neurodegenerative disease.</p><p><strong>Highlights: </strong>How cognitive status relates to retinal vasculometry (RV) measures remains uncertain and unexamined at scale.Using data from a large population-based study (UK Biobank) we show strong graded associations between cognitive status and RV, which contrast with some RV associations observed with aging. Specifically, increased arteriolar tortuosity, arteriolar and venular width (at younger ages), and area are positively associated, and venular tortuosity and arteriolar and venular width variability are inversely associated with higher cognitive status, all showing strong, graded, precise relationships. These associations appeared to be strongest for fluid intelligence and prospective memory tests.These easily accessible, non-invasive RV measures provide a neurovascular marker indicative of cognitive status, which should be evaluated as early predictors of neurodegenerative disease.</p>","PeriodicalId":53226,"journal":{"name":"Alzheimer''s and Dementia: Diagnosis, Assessment and Disease Monitoring","volume":"17 1","pages":"e270087"},"PeriodicalIF":4.0000,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11848343/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Alzheimer''s and Dementia: Diagnosis, Assessment and Disease Monitoring","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1002/dad2.70087","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/1/1 0:00:00","PubModel":"eCollection","JCR":"Q1","JCRName":"CLINICAL NEUROLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Introduction: Retinal vasculometry (RV) provides a neurovascular biomarker which may relate to cognitive status. However, the presence and form of association remains unclear and unexamined at scale.
Methods: Artificial intelligence-enabled RV measures from 66,350 UK Biobank study participants were related to combined cognition scores. Differences in RV were examined per standard deviation (SD) increase in cognitive score, using multilevel linear regression, adjusted for age, sex, measurement center, ethnicity, and within-person RV clustering.
Results: One hundred ten thousand two hundred eighty-two retinal images from 63,165 (95%) participants (mean age 56.6 years, 55.5% female) were analyzed. A one SD increase in cognition score was strongly associated with increased arteriolar width, arteriolar tortuosity, increased venular width particularly among those < 50 years and venular area among those > 50 years; also, inversely associated with venular tortuosity, and arteriolar and venular width variance.
Discussion: These easily accessible, affordable, and non-invasive RV measures should be evaluated further as an early predictor of future neurodegenerative disease.
Highlights: How cognitive status relates to retinal vasculometry (RV) measures remains uncertain and unexamined at scale.Using data from a large population-based study (UK Biobank) we show strong graded associations between cognitive status and RV, which contrast with some RV associations observed with aging. Specifically, increased arteriolar tortuosity, arteriolar and venular width (at younger ages), and area are positively associated, and venular tortuosity and arteriolar and venular width variability are inversely associated with higher cognitive status, all showing strong, graded, precise relationships. These associations appeared to be strongest for fluid intelligence and prospective memory tests.These easily accessible, non-invasive RV measures provide a neurovascular marker indicative of cognitive status, which should be evaluated as early predictors of neurodegenerative disease.
期刊介绍：
Alzheimer''s & Dementia: Diagnosis, Assessment & Disease Monitoring (DADM) is an open access, peer-reviewed, journal from the Alzheimer''s Association® that will publish new research that reports the discovery, development and validation of instruments, technologies, algorithms, and innovative processes. Papers will cover a range of topics interested in the early and accurate detection of individuals with memory complaints and/or among asymptomatic individuals at elevated risk for various forms of memory disorders. The expectation for published papers will be to translate fundamental knowledge about the neurobiology of the disease into practical reports that describe both the conceptual and methodological aspects of the submitted scientific inquiry. Published topics will explore the development of biomarkers, surrogate markers, and conceptual/methodological challenges. Publication priority will be given to papers that 1) describe putative surrogate markers that accurately track disease progression, 2) biomarkers that fulfill international regulatory requirements, 3) reports from large, well-characterized population-based cohorts that comprise the heterogeneity and diversity of asymptomatic individuals and 4) algorithmic development that considers multi-marker arrays (e.g., integrated-omics, genetics, biofluids, imaging, etc.) and advanced computational analytics and technologies.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
