Alzheimer''s and Dementia: Diagnosis, Assessment and Disease Monitoring最新文献_第9页

Management of multimorbidity in the midst of cognitive decline through clinical decision-support software. 通过临床决策支持软件管理认知衰退中的多病。

IF 4.4

Alzheimer''s and Dementia: Diagnosis, Assessment and Disease Monitoring Pub Date : 2026-08-06 eCollection Date: 2026-07-01 DOI: 10.1002/dad2.70395

Mark C Zelek, John Q Walker, Marwan N Sabbagh

{"title":"Management of multimorbidity in the midst of cognitive decline through clinical decision-support software.","authors":"Mark C Zelek, John Q Walker, Marwan N Sabbagh","doi":"10.1002/dad2.70395","DOIUrl":"10.1002/dad2.70395","url":null,"abstract":"Introduction: Multimorbidity - the coexistence of multiple chronic conditions - is common among older adults with cognitive impairment but is rarely addressed in an integrated manner.Methods: We analyzed 17,915 adults aged 55 to 84 years (8997 receiving uMETHOD clinical decision-support care plans and 8918 from the National Health and Nutrition Examination Survey). The mean age was 69.0 years (SD 7.65; 95% CI: 68.86 to 69.1). Multimorbidity was quantified from diagnoses, labs, medications, vitals, and platform-inferred conditions. Associations with cognitive impairment were modeled using age- and sex-adjusted logistic regression.Results: Cognitive impairment was reported in 25.91% of participants (97.5% with ≥2 conditions); each additional condition was associated with higher odds (odds ratio: 1.069; 95% CI: 1.061 to 1.077; p < 0.0001). Prominent clusters included vascular-metabolic disorders and micronutrient deficiencies.Discussion: Cognitive vulnerability rises stepwise with disease burden. Precision, multimorbidity-aware decision support that integrates multidomain data can align cognitive and systemic care in real-world practice.","PeriodicalId":53226,"journal":{"name":"Alzheimer''s and Dementia: Diagnosis, Assessment and Disease Monitoring","volume":"18 3","pages":"e70395"},"PeriodicalIF":4.4,"publicationDate":"2026-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13445244/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148686706","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Role of sex and ethnicity in the relationships among physical activity, cognition, and AD biomarkers in the HABS-HD cohort. 性别和种族在HABS-HD队列中身体活动、认知和AD生物标志物之间的关系中的作用

IF 4.4

Alzheimer''s and Dementia: Diagnosis, Assessment and Disease Monitoring Pub Date : 2026-08-06 eCollection Date: 2026-07-01 DOI: 10.1002/dad2.70437

Jansie H Nel, Joel S Burma, Tamara S Bodnar, Meghan McDonough, Gregory Knell, Melissa Petersen, Sid E O'Bryant, Cindy K Barha

{"title":"Role of sex and ethnicity in the relationships among physical activity, cognition, and AD biomarkers in the HABS-HD cohort.","authors":"Jansie H Nel, Joel S Burma, Tamara S Bodnar, Meghan McDonough, Gregory Knell, Melissa Petersen, Sid E O'Bryant, Cindy K Barha","doi":"10.1002/dad2.70437","DOIUrl":"10.1002/dad2.70437","url":null,"abstract":"Introduction: Dementia prevalence is rising with population aging, disproportionately affecting females and ethnically diverse groups. Physical activity (PA) may mitigate age-related cognitive and brain decline; sex- and ethnicity-specific associations remain poorly understood.Methods: Data from the Health and Aging Brain Study-Health Disparities were analyzed from 3585 participants (63% female). PA was categorized using the Rapid Assessment of Physical Activity (RAPA) questionnaire as no/little (< 4) or moderate/high (≥ 4). Outcomes included cognitive composites, plasma biomarkers, and magnetic resonance imaging-derived hippocampal subregions and dorsolateral prefrontal cortex volumes.Results: Higher PA was associated with higher global cognition and executive functions in all females and in Hispanic males (ps < 0.05), higher episodic memory and larger hippocampal volumes across participants (ps < 0.05), and lower amyloid beta 40, total tau, and larger hippocampal subregion volumes in females (ps < 0.05).Conclusions: Findings support PA as a modifiable factor associated with healthy brain aging, emphasizing the importance of incorporating sex and ethnicity into future research.","PeriodicalId":53226,"journal":{"name":"Alzheimer''s and Dementia: Diagnosis, Assessment and Disease Monitoring","volume":"18 3","pages":"e70437"},"PeriodicalIF":4.4,"publicationDate":"2026-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13445254/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148686677","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cochlear implants are associated with reduced cognitive decline risk: A 20-year cohort study. 人工耳蜗植入与认知能力下降风险降低相关：一项20年队列研究

IF 4.4

Alzheimer''s and Dementia: Diagnosis, Assessment and Disease Monitoring Pub Date : 2026-07-24 eCollection Date: 2026-07-01 DOI: 10.1002/dad2.70409

Filippos Anagnostakis, Michail Kokkorakis, Ilias Papadimopoulos, Junhao Wen, Christos Davatzikos

{"title":"Cochlear implants are associated with reduced cognitive decline risk: A 20-year cohort study.","authors":"Filippos Anagnostakis, Michail Kokkorakis, Ilias Papadimopoulos, Junhao Wen, Christos Davatzikos","doi":"10.1002/dad2.70409","DOIUrl":"10.1002/dad2.70409","url":null,"abstract":"Introduction: We investigated the association between cochlear implantation and the risk of cognitive decline in adults with hearing loss using a national population cohort.Methods: Our cohort comprised 4106 participants who underwent cochlear implantation and matched controls with untreated hearing loss, followed over a median of 7.3 years. Propensity score matching was applied to control for confounders, and Kaplan-Meier analysis was used to assess time-to-event outcomes.Results: Participants with cochlear implants had a significantly reduced risk of all-cause dementia (hazard ratio [HR] 0.61, 95% confidence interval [CI] 0.50-0.74), mild cognitive impairment (HR 0.53, 95% CI 0.40-0.70), and memory loss (HR 0.54, 95% CI 0.45-0.65) compared with controls. These associations remained significant in sex-stratified analyses for both male and female participants.Discussion: These results support early auditory intervention as a dementia prevention strategy and warrant further research with longer follow-up periods across diverse populations.","PeriodicalId":53226,"journal":{"name":"Alzheimer''s and Dementia: Diagnosis, Assessment and Disease Monitoring","volume":"18 3","pages":"e70409"},"PeriodicalIF":4.4,"publicationDate":"2026-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13400825/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148594466","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Focal hippocampal subfield atrophy in cognitively impaired relative to cognitively unimpaired older adults is associated with memory ability. 认知受损的老年人相对于认知未受损的老年人的局灶性海马亚区萎缩与记忆能力有关。

IF 4.4

Alzheimer''s and Dementia: Diagnosis, Assessment and Disease Monitoring Pub Date : 2026-07-24 eCollection Date: 2026-07-01 DOI: 10.1002/dad2.70429

Abi Heller-Wight, David G Ellis, Anna Wilhelm, Caroline Nester Rooney, Nadia Pare, Nicole Sergeyev, Laura Rabin, David E Warren

{"title":"Focal hippocampal subfield atrophy in cognitively impaired relative to cognitively unimpaired older adults is associated with memory ability.","authors":"Abi Heller-Wight, David G Ellis, Anna Wilhelm, Caroline Nester Rooney, Nadia Pare, Nicole Sergeyev, Laura Rabin, David E Warren","doi":"10.1002/dad2.70429","DOIUrl":"10.1002/dad2.70429","url":null,"abstract":"Introduction: We assessed whole hippocampal and subfield volumes, in association with memory ability, in a sample including cognitively unimpaired (CU) older adults and those in early syndromic stages of pathological aging, here subjective cognitive decline (SCD) and mild cognitive impairment (MCI).Methods: Participants completed a battery of neuropsychological tests and a 3T magnetic resonance imaging brain study that included high-resolution T2-weighted images of hippocampus and its subfields: subiculum; cornu ammonis 1, 2, and 3 (CA1, CA2, CA3); and dentate gyrus (DG).Results: Significant differences were found in the left whole hippocampus, left subiculum, CA1, and DG volumes in the MCI group compared to the CU or SCD groups. Least absolute shrinkage and selection operator regression techniques revealed that left subiculum and left CA1 volume significantly predicted memory ability above and beyond whole hippocampal and other subfield volumes.Discussion: We found clinical differences in memory ability in older adults were associated with focal differences in specific hippocampal subfield volumes.","PeriodicalId":53226,"journal":{"name":"Alzheimer''s and Dementia: Diagnosis, Assessment and Disease Monitoring","volume":"18 3","pages":"e70429"},"PeriodicalIF":4.4,"publicationDate":"2026-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13400838/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148594490","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Frontotemporal dementia in Hispanic populations: Regional and national comparisons. 西班牙裔人群的额颞叶痴呆：地区和国家比较。

IF 4.4

Alzheimer''s and Dementia: Diagnosis, Assessment and Disease Monitoring Pub Date : 2026-07-23 eCollection Date: 2026-07-01 DOI: 10.1002/dad2.70396

Shannon B Lavigne, Gabrielle Hromas, Ashley LaRoche, Alicia S Parker, Muhammad S Abdullah, Roman A Fernandez, Chen-Pin Wang, Gabriel de Erausquin, Arash Salardini, Jeremy Tanner, Tiffany F Kautz, Julia Castro, Crystal Mendoza, Sudha Seshadri, A Campbell Sullivan

{"title":"Frontotemporal dementia in Hispanic populations: Regional and national comparisons.","authors":"Shannon B Lavigne, Gabrielle Hromas, Ashley LaRoche, Alicia S Parker, Muhammad S Abdullah, Roman A Fernandez, Chen-Pin Wang, Gabriel de Erausquin, Arash Salardini, Jeremy Tanner, Tiffany F Kautz, Julia Castro, Crystal Mendoza, Sudha Seshadri, A Campbell Sullivan","doi":"10.1002/dad2.70396","DOIUrl":"10.1002/dad2.70396","url":null,"abstract":"Introduction: Although Hispanic/Latine populations experience higher dementia rates, they remain underrepresented in frontotemporal dementia (FTD) research. This study examines clinical manifestations of FTD within a South Texas Hispanic/Latine cohort compared to national data.Methods: Participants diagnosed with FTD were included from (1) our FTD clinic, the South Texas Alzheimer's Disease Research Center, and local Advancing Research and Treatment in Frontotemporal Lobar Degeneration-Longitudinal Evaluation of Familial Frontotemporal Dementia Subjects Longitudinal Frontotemporal Lobar Degeneration cohort (Hispanic: n = 17; White non-Hispanic: n = 22), and (2) the National Alzheimer's Coordinating Center dataset (Hispanic: n = 24; White non-Hispanic: n = 407; National Institute on Aging/National Institutes of Health Grant U24 AG072122). Clinical, neuroimaging, and neuropsychological data were harmonized for cross-cohort comparisons.Results: Hispanic participants presented with more movement-related symptoms and advanced cognitive impairment at diagnosis than non-Hispanic Whites. Diagnostic delays averaged 4 years from symptom onset. Educational disparities significantly contributed to health-care access differences.Discussion: Findings underscore diagnostic severity and systemic barriers faced by Hispanic populations with FTD, emphasizing the need for culturally sensitive diagnostic tools and interventions for equitable dementia care.","PeriodicalId":53226,"journal":{"name":"Alzheimer''s and Dementia: Diagnosis, Assessment and Disease Monitoring","volume":"18 3","pages":"e70396"},"PeriodicalIF":4.4,"publicationDate":"2026-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13392919/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148581371","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact of an 18-month non-native language intervention on episodic memory and the underlying neural mechanisms in cognitively unimpaired older adults. 18个月的非母语干预对认知未受损老年人情景记忆的影响及其潜在的神经机制。

IF 4.4

Alzheimer''s and Dementia: Diagnosis, Assessment and Disease Monitoring Pub Date : 2026-07-23 eCollection Date: 2026-07-01 DOI: 10.1002/dad2.70381

Anne-Laure Turpin, Caitlin Ware, Brigitte Landeau, Florence Mézenge, Asrar Lehodey, Célia Soussi, Marion Delarue, Oriane Hébert, Vincent de la Sayette, Natalie L Marchant, Gaël Chételat, Julie Gonneaud

{"title":"Impact of an 18-month non-native language intervention on episodic memory and the underlying neural mechanisms in cognitively unimpaired older adults.","authors":"Anne-Laure Turpin, Caitlin Ware, Brigitte Landeau, Florence Mézenge, Asrar Lehodey, Célia Soussi, Marion Delarue, Oriane Hébert, Vincent de la Sayette, Natalie L Marchant, Gaël Chételat, Julie Gonneaud","doi":"10.1002/dad2.70381","DOIUrl":"10.1002/dad2.70381","url":null,"abstract":"Introduction: Episodic memory decline impairs daily functioning in aging. This secondary analysis of data from the Age-Well randomized controlled trial (RCT), we examined whether non-native language training (NNLT) benefits memory and its neural correlates in older adults.Methods: Participants from the Age-Well RCT (aged ≥ 65) were assigned to an 18-month NNLT (N = 45), or no-intervention (N = 44) group. Episodic memory (California Verbal Learning Test Second Edition [CVLT-II] and Logical Memory), and hippocampal and medial prefrontal cortex volumes and perfusion were assessed pre- and post-intervention. Linear mixed models tested visit x group interactions. Regressions examined associations between memory and neuroimaging changes, adjusted for age, sex, education, and baseline memory performance.Results: A visit x group interaction was observed (F = 6.77, p = 0.01): the NNLT group maintained CVLT-II delayed free recall performance, while the no-intervention group declined. Within the NNLT group, changes in this score correlated positively with changes in hippocampal perfusion.Discussion: These findings suggest that NNLT may help preserve hippocampus-dependent long-term episodic memory in aging.","PeriodicalId":53226,"journal":{"name":"Alzheimer''s and Dementia: Diagnosis, Assessment and Disease Monitoring","volume":"18 3","pages":"e70381"},"PeriodicalIF":4.4,"publicationDate":"2026-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13392915/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148581365","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Visual read performance of ¹⁸F-Florbetapir and ¹⁸F-NAV4694 Aβ PET compared against Centiloid reference standard in a paired cohort. 配对队列中18F-Florbetapir和18F-NAV4694 a β PET与Centiloid参比标准品的视觉读取性能比较

IF 4.4

Alzheimer''s and Dementia: Diagnosis, Assessment and Disease Monitoring Pub Date : 2026-07-16 eCollection Date: 2026-07-01 DOI: 10.1002/dad2.70426

Ishara Paranawithana, Vincent Doré, Pierrick Bourgeat, Aurora Poon, H B Toh, Tanyaluck Thientunyakit, Tawika Kaewchur, Antony Sutherland, Ashley G Gillman, Kun Huang, Azadeh Feizpour, Jurgen Fripp, Victor L Villemagne, Christopher C Rowe

{"title":"Visual read performance of 18F-Florbetapir and 18F-NAV4694 Aβ PET compared against Centiloid reference standard in a paired cohort.","authors":"Ishara Paranawithana, Vincent Doré, Pierrick Bourgeat, Aurora Poon, H B Toh, Tanyaluck Thientunyakit, Tawika Kaewchur, Antony Sutherland, Ashley G Gillman, Kun Huang, Azadeh Feizpour, Jurgen Fripp, Victor L Villemagne, Christopher C Rowe","doi":"10.1002/dad2.70426","DOIUrl":"10.1002/dad2.70426","url":null,"abstract":"Introduction: Visual assessment remains standard practice to rule out amyloid-β (Aβ) pathology. 18F-NAV4694 (NAV) has high affinity for Aβ potentially detecting lower levels than other F-18 Aβ tracers.Methods: One hundred fifty participants in the AIBL study underwent both 18F-Florbetapir (FBP) and NAV Aβ PET scans. PET scans were assessed by six nuclear medicine physicians against Centiloid (CL) quantification. An optimized reference region was utilized for FBP as it improved CL-visual read correlations. Inter-reader agreement of visual assessment was measured using Fleiss' Kappa.Results: Mean peak accuracy for visual read exceeded 95% for both NAV and FBP. However, peak accuracy for NAV visual reads was achieved at 14-15CL compared to 38-46CL for FBP. Higher inter-reader agreement was observed for NAV compared to FBP.Discussion: For mild to moderate elevation in Aβ, visual read of NAV is more sensitive and consistent than visual read of FBP by both experienced and novice readers.","PeriodicalId":53226,"journal":{"name":"Alzheimer''s and Dementia: Diagnosis, Assessment and Disease Monitoring","volume":"18 3","pages":"e70426"},"PeriodicalIF":4.4,"publicationDate":"2026-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13375940/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148581422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Alteration of glucose neurometabolism and brain morphology in mild behavioral impairment: a neuroimaging study on cognitively healthy individuals. 轻度行为障碍患者葡萄糖神经代谢和脑形态的改变：认知健康个体的神经影像学研究

IF 4.4

Alzheimer''s and Dementia: Diagnosis, Assessment and Disease Monitoring Pub Date : 2026-07-16 eCollection Date: 2026-07-01 DOI: 10.1002/dad2.70425

Rafael Dolezal

{"title":"Alteration of glucose neurometabolism and brain morphology in mild behavioral impairment: a neuroimaging study on cognitively healthy individuals.","authors":"Rafael Dolezal","doi":"10.1002/dad2.70425","DOIUrl":"10.1002/dad2.70425","url":null,"abstract":"Introduction: Regional brain enlargement and increased glucose neurometabolism do not normally indicate neurodegeneration. Mild behavioral impairment (MBI) occurring in cognitively healthy individuals, however, might be significantly affected by these processes.Methods: Three hundred forty-one cognitively normal individuals were analyzed using partial least squares (PLS) regression to determine neurometabolic and brain volumetric determinants of MBI scores. Radiolabeled glucose non-displaceable binding potential and volumes of Schaefer homooxygenation parcels were screened as regressors. PLS models were evaluated with cross-validation, scrambling, and bootstrapping.Results: Hypermetabolism in the left entorhinal cortex and hypertrophy in the left dorsal attention network B contribute substantially to the MBI total score. Significant morpho-functional interactions were observed between the right middle temporal cortex and the right salience-ventral attention B network.Discussion: MBI might depend on cerebral bioenergetic processes and morpho-functional interactions. Relative hypermetabolism and hypertrophy could be considered specific biomarkers of MBI indicating a prodromal maladaptive neural response.","PeriodicalId":53226,"journal":{"name":"Alzheimer''s and Dementia: Diagnosis, Assessment and Disease Monitoring","volume":"18 3","pages":"e70425"},"PeriodicalIF":4.4,"publicationDate":"2026-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13375937/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148581393","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Real-world pharmacovigilance for anti-Aβ therapies using a large language model. 使用大语言模型的抗β治疗的现实世界药物警戒。

IF 4.4

Alzheimer''s and Dementia: Diagnosis, Assessment and Disease Monitoring Pub Date : 2026-07-16 eCollection Date: 2026-07-01 DOI: 10.1002/dad2.70412

Allan Fong, Azade Tabaie, Samantha Paylor, Tien Tran, Rabbiya Iqbal, Raj M Ratwani, Zafar Zafari, Lauren R Bangerter, Nicole J Brandt

{"title":"Real-world pharmacovigilance for anti-Aβ therapies using a large language model.","authors":"Allan Fong, Azade Tabaie, Samantha Paylor, Tien Tran, Rabbiya Iqbal, Raj M Ratwani, Zafar Zafari, Lauren R Bangerter, Nicole J Brandt","doi":"10.1002/dad2.70412","DOIUrl":"10.1002/dad2.70412","url":null,"abstract":"Introduction: Anti-amyloid beta (Aβ) therapies for early Alzheimer's disease require enhanced safety monitoring, yet adverse event (AE) documentation is diffuse across heterogeneous electronic health record documents. Large language models (LLMs) may improve scalable pharmacovigilance.Methods: We analyzed 20,123 clinical documents from 46 patients who received at least one dose of anti-Aβ therapy (June 24, 2024-July 30, 2025) at a large mid-Atlantic health-care system. We compared standard expert review versus an LLM-augmented workflow applied to the same documents. Expert reviewers annotated therapy-related AEs (e.g., amyloid-related imaging abnormalities with edema or hemorrhage, headache, syncope, hypersensitivity, gastrointestinal symptoms, infusion reactions). Discordant cases were adjudicated to establish a reference label.Results: After adjudication, 76% (35/46) patients had an AE. The LLM-augmented workflow achieved 100% sensitivity (positive predictive value [PPV] 89.7%) versus expert review 88.6% sensitivity (PPV 100%).Discussion: Findings provide preliminary indications that LLMs may serve as a pharmacovigilance signal detection tool, with a need for further validation and evaluation of clinical integration.","PeriodicalId":53226,"journal":{"name":"Alzheimer''s and Dementia: Diagnosis, Assessment and Disease Monitoring","volume":"18 3","pages":"e70412"},"PeriodicalIF":4.4,"publicationDate":"2026-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13375930/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148581390","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pharmacogenetic analyses in people with dementia in Northeast Germany. 德国东北部痴呆症患者的药物遗传学分析。

IF 4.4

Alzheimer''s and Dementia: Diagnosis, Assessment and Disease Monitoring Pub Date : 2026-07-14 eCollection Date: 2026-07-01 DOI: 10.1002/dad2.70423

Marleen Julia Meyer-Tönnies, Leefke Schwarz, Diana Wucherer, Wolfgang Hoffmann, Jochen René Thyrian, Mladen Vassilev Tzvetkov

{"title":"Pharmacogenetic analyses in people with dementia in Northeast Germany.","authors":"Marleen Julia Meyer-Tönnies, Leefke Schwarz, Diana Wucherer, Wolfgang Hoffmann, Jochen René Thyrian, Mladen Vassilev Tzvetkov","doi":"10.1002/dad2.70423","DOIUrl":"10.1002/dad2.70423","url":null,"abstract":"Introduction: Pharmacogenetics-guided prescribing may reduce adverse drug reactions by 30%. European and American expert groups (Dutch Pharmacogenetics Working Group and Clinical Implementation Consortium) issue genotype-based dosage recommendations, but pharmacogenetic testing is still not routinely used. Here, we assess the potential of pharmacogenetic testing to optimize pharmacotherapy in people with dementia (PwD).Methods: We genotyped variants in CYP2D6 , CYP2C9, CYP2C19, CYP3A4, CYP3A5, and SLCO1B1 genes and related them to individual medication data in 115 PwD from an epidemiological cohort from Northeast Germany.Results: The vast majority of PwD (93%) carried at least one actionable variant. Fourteen (12%) had at least one strongly actionable variant. Four of them (4%) took the drug affected and carried the strongly actionable genetic variant.Discussion: Pharmacogenetic testing may contribute to improved pharmacotherapy in PwD. The potential improvements were mainly for medications commonly taken by elderly, but also for medications used to treat or associated with progression of dementia.","PeriodicalId":53226,"journal":{"name":"Alzheimer''s and Dementia: Diagnosis, Assessment and Disease Monitoring","volume":"18 3","pages":"e70423"},"PeriodicalIF":4.4,"publicationDate":"2026-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13368705/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148457785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0