Alzheimer''s and Dementia: Diagnosis, Assessment and Disease Monitoring最新文献_第5页

Associations between lifestyle, genetic risk for Alzheimer's disease, and longitudinal brain atrophy in the UK Biobank (N = 3265). 英国生物银行（N = 3265）的生活方式、阿尔茨海默病遗传风险和纵向脑萎缩之间的关系

IF 4.4

Alzheimer''s and Dementia: Diagnosis, Assessment and Disease Monitoring Pub Date : 2026-08-31 eCollection Date: 2026-07-01 DOI: 10.1002/dad2.70470

Yating You, Laura M Lyall, Frederick K Ho, Claire E Hastie, Donald M Lyall

{"title":"Associations between lifestyle, genetic risk for Alzheimer's disease, and longitudinal brain atrophy in the UK Biobank (N = 3265).","authors":"Yating You, Laura M Lyall, Frederick K Ho, Claire E Hastie, Donald M Lyall","doi":"10.1002/dad2.70470","DOIUrl":"10.1002/dad2.70470","url":null,"abstract":"Introduction: The associations of modifiable daily lifestyle variables (e.g., smoking, diet, alcohol intake, sedentary behavior, and physical activity) with structural brain atrophy, and interaction with apolipoprotein E (APOE) ε4 genetic risk, remain unclear.Methods: Among 3265 UK Biobank participants with repeated magnetic resonance imaging (MRI) data (mean follow-up 2.6 years), we assessed the relations between lifestyle, APOE ε4 genotype, and volumetric changes in 15 structural brain phenotypes, using linear regression.Results: APOE ε4 presence showed greater atrophy by 25.1 mm3 in the left hippocampus (β: -0.115 standard deviations, 95% confidence interval [CI] [-0.192, -0.039] and 187.7 mm3 in frontal pole gray matter (β: -0.112, 95% CI [-0.186, -0.039]) (q < 0.05). Unfavorable lifestyle accelerated left hippocampal atrophy, and smoking increased white matter hyperintensity volumes (q > 0.05). No interactions were observed.Discussion: Our study reinforces the independent effect of APOE ε4 on longitudinal brain atrophy. Lifestyle may help preserve structural brain health, and our findings provide no evidence this varies by APOE ε4 genotype.","PeriodicalId":53226,"journal":{"name":"Alzheimer''s and Dementia: Diagnosis, Assessment and Disease Monitoring","volume":"18 3","pages":"e70470"},"PeriodicalIF":4.4,"publicationDate":"2026-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13529823/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148876471","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Lecanemab in symptomatic PSEN1 p.Met233Val early-onset Alzheimer's disease: Neuroimaging safety, regional amyloid-PET dynamics, and longitudinal plasma biomarkers. Lecanemab治疗早发性早发性阿尔茨海默病：神经影像学安全性、区域淀粉样蛋白- pet动力学和纵向血浆生物标志物

IF 4.4

Alzheimer''s and Dementia: Diagnosis, Assessment and Disease Monitoring Pub Date : 2026-08-30 eCollection Date: 2026-07-01 DOI: 10.1002/dad2.70468

Min-Young Noh, Wonjae Sung, Hyunkee Kim, Bugyeong Son, Young-Eun Kim, Yun Young Choi, David M Holtzman, Seung Hyun Kim

{"title":"Lecanemab in symptomatic PSEN1 p.Met233Val early-onset Alzheimer's disease: Neuroimaging safety, regional amyloid-PET dynamics, and longitudinal plasma biomarkers.","authors":"Min-Young Noh, Wonjae Sung, Hyunkee Kim, Bugyeong Son, Young-Eun Kim, Yun Young Choi, David M Holtzman, Seung Hyun Kim","doi":"10.1002/dad2.70468","DOIUrl":"10.1002/dad2.70468","url":null,"abstract":"Introduction: The presenilin 1 (PSEN1) p.Met233Val variant is a Dominantly Inherited Alzheimer Network-Trials Unit (DIAN-TU)-eligible autosomal-dominant Alzheimer's disease (ADAD) variant for which lecanemab response data are unavailable.Methods: A 34-year-old symptomatic PSEN1 p.Met233Val carrier (APOE ε3/ε3) was prospectively followed through 26 lecanemab infusions over 12 months, with serial magnetic resonance imaging (MRI), amyloid positron emission tomography (PET), and plasma biomarkers.Results: No amyloid-related imaging abnormalities occurred. Composite Centiloid increased modestly (+7.2), masking regional divergence: basal ganglia (-24.5) and medial temporal cortex (-22.1) declined, whereas posterior cortical regions accrued amyloid. Plasma amyloid beta (Aβ) 42/40 rose to 122% by T22, with concurrent decreases in phosphorylated tau at threonine 217 (p-tau217), p-tau181, neurofilament light chain (NfL), and glial fibrillary acidic protein (GFAP). Global Clinical Dementia Rating (CDR) score remained 0.5; caregiver reports noted improvements in spasticity, dystonia, and affective features.Discussion: Lecanemab demonstrated neuroimaging safety and evidence of biological target engagement in this symptomatic PSEN1 p.Met233Val ADAD carrier. These longitudinal neuroimaging and plasma biomarker findings may help inform interpretation of treatment responses in genetically defined ADAD.","PeriodicalId":53226,"journal":{"name":"Alzheimer''s and Dementia: Diagnosis, Assessment and Disease Monitoring","volume":"18 3","pages":"e70468"},"PeriodicalIF":4.4,"publicationDate":"2026-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13526897/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148867812","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Multilingual characteristics and cognition among older adults in India. 印度老年人的多语言特征和认知。

IF 4.4

Alzheimer''s and Dementia: Diagnosis, Assessment and Disease Monitoring Pub Date : 2026-08-30 eCollection Date: 2026-07-01 DOI: 10.1002/dad2.70469

Miguel Arce Rentería, Iris M Strangmann, Pranali Khobragade, Madeleine G Snider, Sarah Petrosyan, Shrikanth Narayanan, Erik Meijer, Emma Nichols, Leon M Aksman, Jinkook Lee

{"title":"Multilingual characteristics and cognition among older adults in India.","authors":"Miguel Arce Rentería, Iris M Strangmann, Pranali Khobragade, Madeleine G Snider, Sarah Petrosyan, Shrikanth Narayanan, Erik Meijer, Emma Nichols, Leon M Aksman, Jinkook Lee","doi":"10.1002/dad2.70469","DOIUrl":"10.1002/dad2.70469","url":null,"abstract":"Introduction: Leveraging the Longitudinal Aging Study in India-Diagnostic Assessment of Dementia (LASI-DAD), we describe the linguistic profile of multilingual older Indian adults and the association of second language (L2) age of acquisition (AoA), proficiency, and daily use with cognition.Methods: Participants (N = 492) completed a language history questionnaire and cognitive battery assessing executive functioning, memory, and language. Models were stratified by education and adjusted for sociodemographic factors.Results: While L1s varied, the most common L2 was Hindi. Most participants acquired L2 during childhood and reported high understanding and speaking proficiencies. Acquisition location, language use, and reading/writing proficiencies differed by education. L2 proficiency was associated with executive functioning among those with (β = 0.09,[0.01,0.19]) and without (β = 0.07,[0.01,0.13]) formal schooling. Early AoA was associated with better language abilities (β = 0.36,[0.001,0.72]) among those without formal schooling.Discussion: In India, multilingualism is heterogenous across educational levels. Aspects of multilingualism were associated with cognition but differed by educational background.","PeriodicalId":53226,"journal":{"name":"Alzheimer''s and Dementia: Diagnosis, Assessment and Disease Monitoring","volume":"18 3","pages":"e70469"},"PeriodicalIF":4.4,"publicationDate":"2026-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13526898/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148867822","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical impact of amyloid PET in memory clinic: A 2-year longitudinal real-world study in Taiwan. 淀粉样PET对记忆临床的影响：台湾一项为期2年的纵向真实世界研究。

IF 4.4

Alzheimer''s and Dementia: Diagnosis, Assessment and Disease Monitoring Pub Date : 2026-08-27 eCollection Date: 2026-07-01 DOI: 10.1002/dad2.70454

Chia-Ju Chou, Yi-Fang Chuang, Yen-Ling Chiu, Shu-Ching Wu, Yu-Ming Fan, Yi-Chien Liu

{"title":"Clinical impact of amyloid PET in memory clinic: A 2-year longitudinal real-world study in Taiwan.","authors":"Chia-Ju Chou, Yi-Fang Chuang, Yen-Ling Chiu, Shu-Ching Wu, Yu-Ming Fan, Yi-Chien Liu","doi":"10.1002/dad2.70454","DOIUrl":"10.1002/dad2.70454","url":null,"abstract":"Introduction: Longitudinal evidence on amyloid positron emission tomography (PET) for Alzheimer's disease (AD) diagnosis in Taiwan and Asian memory clinics remains limited. This study evaluated the diagnostic and prognostic impact of florbetaben PET in a Taiwanese cohort.Methods: This prospective cohort study enrolled 206 memory clinic participants who underwent florbetaben amyloid PET, volumetric magnetic resonance imaging, apolipoprotein E genotyping, and neuropsychological assessment, with 2-year longitudinal follow-up.Results: Amyloid positivity was present in 48% of participants and drove diagnostic reclassification in 49.5% of the cohort. Receiver operating characteristic curve analysis identified an optimal Centiloid (CL) threshold of 21.60 (sensitivity 91.18%, specificity 99.04%, area under the curve [AUC] = 0.98). Amygdala, inferior parietal, and superior temporal atrophy were strong structural predictors of amyloid positivity (AUC = 0.79).Discussion: These findings establish a locally validated amyloid threshold and provide actionable diagnostic and prognostic stratification in a real-world Asian memory clinic.","PeriodicalId":53226,"journal":{"name":"Alzheimer''s and Dementia: Diagnosis, Assessment and Disease Monitoring","volume":"18 3","pages":"e70454"},"PeriodicalIF":4.4,"publicationDate":"2026-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13519893/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148841835","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Associations between essential trace elements and Alzheimer's disease and related dementias. 必需微量元素与阿尔茨海默病及相关痴呆之间的关系。

IF 4.4

Alzheimer''s and Dementia: Diagnosis, Assessment and Disease Monitoring Pub Date : 2026-08-26 eCollection Date: 2026-07-01 DOI: 10.1002/dad2.70467

Xin Wang, Roger L Albin, Bruno Giordani, Bhramar Mukherjee, Henry L Paulson, Kelly M Bakulski

{"title":"Associations between essential trace elements and Alzheimer's disease and related dementias.","authors":"Xin Wang, Roger L Albin, Bruno Giordani, Bhramar Mukherjee, Henry L Paulson, Kelly M Bakulski","doi":"10.1002/dad2.70467","DOIUrl":"10.1002/dad2.70467","url":null,"abstract":"Introduction: Dysregulation of essential trace elements has been implicated in Alzheimer's disease (AD) pathogenesis, yet comprehensive epidemiologic evidence remains limited. We investigated associations of seven plasma essential trace elements, including manganese, iron, cobalt, copper, zinc, selenium, and molybdenum, with AD and all-cause dementia risk.Methods: We analyzed 1,737 participants from the National Alzheimer's Coordinating Center. Cross-sectional analyses assessed prevalent disease; longitudinal analyses evaluated incident cases among 1,101 initially dementia-free participants (median follow-up: 2.05 years). Multivariable logistic regression, Cox proportional hazards models, and quantile-based g-computation evaluated individual and mixture effects.Results: A simultaneous one-quartile increase in the seven-element mixture was associated with lower prevalent AD (odds ratio [OR] = 0.69; 95% confidence interval [CI]: 0.52-0.91). Longitudinally, higher plasma iron was associated with lower incident AD (hazard ratio [HR] = 0.41; 95% CI: 0.19-0.92, Q4 vs. Q1), while selenium predicted higher incident AD risk (HR = 2.42; 95% CI: 1.11-5.27, Q4 vs. Q1).Discussion: Lower plasma iron and higher plasma selenium were each associated with greater dementia risk, identifying iron and selenium as potentially modifiable factors for dementia prevention, especially in selenium-replete populations.","PeriodicalId":53226,"journal":{"name":"Alzheimer''s and Dementia: Diagnosis, Assessment and Disease Monitoring","volume":"18 3","pages":"e70467"},"PeriodicalIF":4.4,"publicationDate":"2026-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13508569/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148834594","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Decreased cerebral metabolic rate of oxygen (CMRO₂) is associated with increased tau deposition in Alzheimer's disease. 阿尔茨海默病中脑氧代谢率（cro2）降低与tau沉积增加有关

IF 4.4

Alzheimer''s and Dementia: Diagnosis, Assessment and Disease Monitoring Pub Date : 2026-08-26 eCollection Date: 2026-07-01 DOI: 10.1002/dad2.70442

Hangwei Zhuang, Liangdong Zhou, Xiuyuan Hugh Wang, Emily B Tanzi, Yi Li, Pascal Spincemaille, Ilhami Kovanlikaya, Thanh D Nguyen, Yi Wang, Gloria C Chiang

{"title":"Decreased cerebral metabolic rate of oxygen (CMRO2) is associated with increased tau deposition in Alzheimer's disease.","authors":"Hangwei Zhuang, Liangdong Zhou, Xiuyuan Hugh Wang, Emily B Tanzi, Yi Li, Pascal Spincemaille, Ilhami Kovanlikaya, Thanh D Nguyen, Yi Wang, Gloria C Chiang","doi":"10.1002/dad2.70442","DOIUrl":"10.1002/dad2.70442","url":null,"abstract":"Introduction: Transgenic Alzheimer's (AD) mouse models and post mortem studies have shown that tau pathology disrupts the mitochondrial electron transport chain and results in mitochondrial damage and synaptic dysfunction. We assessed whether magnetic resonance imaging (MRI)-derived measures of oxygen metabolism, oxygen extraction fraction (OEF), and cerebral metabolic rate of oxygen (CMRO2) were associated with tau deposition in vivo.Methods: We assessed tau using 18F-MK-6240 positron emission tomography and CMRO2/OEF using multi-echo gradient-recalled echo with QQ processing, as well as pseudo-continuous arterial spin-labeling MRI in cognitively normal (CN) elderly and subjects with mild cognitive impairment/AD (N = 42). Associations among imaging measures were evaluated across cortical lobes, including comparisons between regions with and without tau deposition.Results: Across all subjects, higher tau standardized uptake value ratio (SUVR) was associated with lower cerebral blood flow (CBF) and CMRO2. Tau SUVR was negatively associated with Montreal Cognitive Assessment scores, whereas OEF, CBF, and CMRO2 were positively associated. Within subjects, CMRO2 was lower in tau-positive temporal regions in both CN and MCI/AD subjects, and CBF was lower in tau-positive temporal regions in CN subjects.Discussion: MRI-derived CBF and CMRO2 were associated with regional tau deposition, particularly in the temporal lobe, which suggests they have potential as non-invasive markers of metabolic alterations accompanying tau pathology.","PeriodicalId":53226,"journal":{"name":"Alzheimer''s and Dementia: Diagnosis, Assessment and Disease Monitoring","volume":"18 3","pages":"e70442"},"PeriodicalIF":4.4,"publicationDate":"2026-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13508576/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148834627","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Structural MRI signature predicts tau staging in Alzheimer's disease. 结构MRI特征预测阿尔茨海默病的tau分期。

IF 4.4

Alzheimer''s and Dementia: Diagnosis, Assessment and Disease Monitoring Pub Date : 2026-08-26 eCollection Date: 2026-07-01 DOI: 10.1002/dad2.70451

Martina Pulze, Sara Garbarino, Luigi Lorenzini, Alessio Cirone, Shahzad Ali, Lorenzo Gualco, Federico Massa, Dario Arnaldi, Beatrice Orso, Mattia Losa, Wendy Kreshpa, Stefano Caneva, Matteo Parodi, Luca Sofia, Stefano Raffa, Gianmario Sambuceti, Massimo Caulo, Emanuele Pravatà, Fabrizio Levrero, Marco Bozzali, Silvia Morbelli, Michele Piana, Antonio Uccelli, Luca Roccatagliata, Andrea Chincarini, Matteo Pardini

{"title":"Structural MRI signature predicts tau staging in Alzheimer's disease.","authors":"Martina Pulze, Sara Garbarino, Luigi Lorenzini, Alessio Cirone, Shahzad Ali, Lorenzo Gualco, Federico Massa, Dario Arnaldi, Beatrice Orso, Mattia Losa, Wendy Kreshpa, Stefano Caneva, Matteo Parodi, Luca Sofia, Stefano Raffa, Gianmario Sambuceti, Massimo Caulo, Emanuele Pravatà, Fabrizio Levrero, Marco Bozzali, Silvia Morbelli, Michele Piana, Antonio Uccelli, Luca Roccatagliata, Andrea Chincarini, Matteo Pardini","doi":"10.1002/dad2.70451","DOIUrl":"10.1002/dad2.70451","url":null,"abstract":"Introduction: Tau positron emission tomography (PET) probes Alzheimer's disease (AD) severity via regional tau spread but is not widely available. We tested whether multiregion structural magnetic resonance imaging (MRI) could approximate individual tau burden.Methods: We studied 378 Alzheimer's Disease Neuroimaging Initiative (ADNI) participants with mild cognitive impairment (MCI)-AD or AD dementia with paired T1-MRI and [18F]flortaucipir tau-PET (≤6 months apart). Regional cortical thickness and volume were extracted with FreeSurfer. Principal component analysis and multivariable linear regression yielded MRI signatures of tau-PET standardized uptake value ratio (SUVR) in Braak composite regions (I, III-IV, V-VI), a meta-temporal region of interest (ROI), and a global neocortical meta-ROI. Performance and high/low tau classification were evaluated by leave-one-out cross-validation against published cut-offs.Results: MRI signatures were significantly associated with tau-PET burden across all regions (p < 0.001). High-versus-low tau discrimination varied: AUC ≈ 0.70 in Braak I, ≈0.89 in Braak V-VI, and ≈0.90 globally.Discussion: Here we provide proof-of-concept evidence that multiregion T1-MRI patterns can inform on tau-PET burden in AD and may support approximate tau staging when tau-PET is unavailable, especially in subjects with more advanced tau burden.","PeriodicalId":53226,"journal":{"name":"Alzheimer''s and Dementia: Diagnosis, Assessment and Disease Monitoring","volume":"18 3","pages":"e70451"},"PeriodicalIF":4.4,"publicationDate":"2026-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13508572/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148834739","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Real-world evidence for amyloid-targeted therapies: Lecanemab and donanemab. 淀粉样蛋白靶向治疗的现实证据：Lecanemab和donanemab。

IF 4.4

Alzheimer''s and Dementia: Diagnosis, Assessment and Disease Monitoring Pub Date : 2026-08-26 eCollection Date: 2026-07-01 DOI: 10.1002/dad2.70404

Ryan Hakim, Kristofer Harris, Livia Merrill, Amanda Falk-Vargas, Eileen Whalen, Tianxu Xia, Olga Ochoa, David Hunter, Paul Ernest Schulz

{"title":"Real-world evidence for amyloid-targeted therapies: Lecanemab and donanemab.","authors":"Ryan Hakim, Kristofer Harris, Livia Merrill, Amanda Falk-Vargas, Eileen Whalen, Tianxu Xia, Olga Ochoa, David Hunter, Paul Ernest Schulz","doi":"10.1002/dad2.70404","DOIUrl":"10.1002/dad2.70404","url":null,"abstract":"Introduction: Real-world safety data on amyloid-targeted therapies in early Alzheimer's disease remain limited, particularly for modified donanemab titration and direct lecanemab-donanemab comparisons.Methods: Retrospective review of 172 amyloid-positive patients treated with lecanemab (n = 89) or donanemab (original titration n = 21; modified n = 62). The cohort included patients with ≥2 chronic comorbidities (72.7%), systemic autoimmune or hematologic disorders, and concurrent immunomodulators.Results: Amyloid-related imaging abnormalities (ARIA) occurred in 11.2% (10/89) with lecanemab and 13.3% (11/83) with donanemab-less than in pivotal trials. Modified donanemab titration reduced ARIA versus the original protocol (8.1% vs 28.6%; p = 0.03) and TRAILBLAZER-ALZ 6 (23.6%). No anaphylaxis occurred. Surveillance magnetic resonance imaging captured 95.2% of ARIA events. Within-center comparison showed comparable safety between lecanemab and modified-titration donanemab (all p's > 0.40). IRRs occurred in 12.0% (donanemab) and 9.0% (lecanemab).Discussion: In a real-world cohort representing patients excluded from trials, ARIA and IRR rates matched or improved upon pivotal trials, supporting safe ATT use under FDA-approved MRI intervals.","PeriodicalId":53226,"journal":{"name":"Alzheimer''s and Dementia: Diagnosis, Assessment and Disease Monitoring","volume":"18 3","pages":"e70404"},"PeriodicalIF":4.4,"publicationDate":"2026-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13518372/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148841849","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

MMSE-CDR-SB residual as an exploratory indicator of deviation from an Alzheimer's disease-typical cognitive-functional pattern. MMSE-CDR-SB残留作为偏离阿尔茨海默病典型认知功能模式的探索性指标。

IF 4.4

Alzheimer''s and Dementia: Diagnosis, Assessment and Disease Monitoring Pub Date : 2026-08-26 eCollection Date: 2026-07-01 DOI: 10.1002/dad2.70460

Ambre Mounié, Kenichiro Sato, Saki Nakashima, Masanori Kurihara, Ryoko Ihara, Yoshiki Niimi, Atsushi Iwata, Takeshi Iwatsubo

{"title":"MMSE-CDR-SB residual as an exploratory indicator of deviation from an Alzheimer's disease-typical cognitive-functional pattern.","authors":"Ambre Mounié, Kenichiro Sato, Saki Nakashima, Masanori Kurihara, Ryoko Ihara, Yoshiki Niimi, Atsushi Iwata, Takeshi Iwatsubo","doi":"10.1002/dad2.70460","DOIUrl":"10.1002/dad2.70460","url":null,"abstract":"Introduction: In clinical practice, patients with Alzheimer's disease (AD) often present with cognitive and functional profiles that diverge from what is expected. We tested whether the Mini-Mental State Examination Clinical Dementia Rating Sum of Boxes (MMSE-CDR-SB) residual, defined as observed minus expected CDR-SB from a published MMSE-CDR-SB reference equation, reflects clinically meaningful deviation from the expected cognitive-functional relationship.Methods: Using National Alzheimer's Coordinating Center data, we analyzed an autopsy cohort (n = 1981) and a separate clinical diagnosis cohort (n = 3184). Negative residual values indicated less functional impairment than expected for a given cognitive score, and positive values indicated greater functional impairment than expected. Associations were examined using multivariable logistic regression adjusted for MMSE score range, age, sex, and education.Results: Lower residual values were associated with lower odds of amyloid and AD-type tau pathology. Higher residual values showed a directional association with transactive response DNA binding protein 43 kDa; vascular burden was also associated with the residual index but across a broader range. In the clinical cohort, higher residual values were enriched in progressive supranuclear palsy and frontotemporal lobar degeneration (other), whereas AD cases clustered near the reference pattern.Discussion: The MMSE-CDR-SB residual may help flag less AD-typical presentations for further etiologic evaluation, but cannot be interpreted as a pathology-specific marker due to substantial overlap across diagnostic groups.","PeriodicalId":53226,"journal":{"name":"Alzheimer''s and Dementia: Diagnosis, Assessment and Disease Monitoring","volume":"18 3","pages":"e70460"},"PeriodicalIF":4.4,"publicationDate":"2026-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13508581/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148834662","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Deep learning-based cortical thickness maps for diagnosis of neurodegenerative diseases: a rater study. 基于深度学习的皮层厚度图用于神经退行性疾病的诊断：一项比较研究。

IF 4.4

Alzheimer''s and Dementia: Diagnosis, Assessment and Disease Monitoring Pub Date : 2026-08-25 eCollection Date: 2026-07-01 DOI: 10.1002/dad2.70458

Evamaria O Riedel, Fabian Bongratz, Benedikt Zott, Cornelius Berberich, Paul Eichinger, Igor Yakushev, Timo Grimmer, Christian Wachinger, Dennis M Hedderich

{"title":"Deep learning-based cortical thickness maps for diagnosis of neurodegenerative diseases: a rater study.","authors":"Evamaria O Riedel, Fabian Bongratz, Benedikt Zott, Cornelius Berberich, Paul Eichinger, Igor Yakushev, Timo Grimmer, Christian Wachinger, Dennis M Hedderich","doi":"10.1002/dad2.70458","DOIUrl":"10.1002/dad2.70458","url":null,"abstract":"Introduction: Cortical atrophy patterns on magnetic resonance imaging (MRI) are essential for diagnosing neurodegenerative diseases (NDs), but remain challenging to assess visually. Deep learning enables quantitative evaluation of cortical thickness (CTh) and z-score maps.Methods: 3T three-dimensional T1 MRI from 40 ND patients (Alzheimer's dementia, posterior cortical atrophy, behavioral variant frontotemporal dementia, semantic variant primary progressive aphasia) and 10 controls were retrospectively analyzed. Cortical surfaces were extracted with FreeSurfer and registered to fsaverage, and z-score maps were generated using stochastic cortical self-reconstruction (SCSR). Three neuroradiologists rated CTh or z-score maps, each with or without 3D T1 for ND presence and differential diagnosis. Conventional 3D T1 served as baseline reading condition.Results: Diagnostic accuracy (Acc) was quantitatively highest for z-score maps with 3D T1 (Acc = 0.98) for the detection of ND, though it did not reach statistical significance. However, diagnostic confidence improved for z-score maps versus baseline 3D T1 (adjusted p = 0.017 for Rater 2). Inter-rater agreement improved from κ = 0.525 (baseline 3D T1) to κ = 0.792 (z-score with 3D T1).Discussion: SCSR-generated z-score maps show promise for diagnostic evaluation of ND.","PeriodicalId":53226,"journal":{"name":"Alzheimer''s and Dementia: Diagnosis, Assessment and Disease Monitoring","volume":"18 3","pages":"e70458"},"PeriodicalIF":4.4,"publicationDate":"2026-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13507028/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148834647","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0