{"title":"Underlying brain and genetic mechanisms linking historic phone use patterns, visual decline, and dementia risk in middle-aged and older adults.","authors":"Xiayin Zhang, Yuling Xu, Shan Wang, Ishith Seth, Yu Huang, Xueli Zhang, Zijing Du, Dongli Zhuang, Shunming Liu, Yijun Hu, Xianwen Shang, Mingguang He, Zhuoting Zhu, Honghua Yu","doi":"10.1002/dad2.70117","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>This study aimed to investigate associations between historic phone use, visual decline, and risk of dementia, as well as underlying biological mechanisms.</p><p><strong>Methods: </strong><b>A total of</b> 494,359 participants from UK Biobank were included in the prospective study. Historic phone use, visual acuity, brain imaging, and leukocyte telomere lengths (LTLs) were assessed. Incident dementia was tracked via hospital episode records and mortality data.</p><p><strong>Results: </strong>Over a median follow-up of 12.2 years, participants with better visual acuity were associated with longer use of mobile phone. Longer historic phone use was associated with a 31% lower risk of dementia. Both hippocampal gray matter volumes and LTLs were associated with historic phone use length and significantly mediated the relationship between historic phone use and dementia. Mediation still exists in participants with visual decline.</p><p><strong>Conclusion: </strong>Our findings suggest mobile phone use may serve as a modifiable factor to prevent dementia, even in older adults with visual decline.</p><p><strong>Highlights: </strong>A strong inverse association was observed between longer mobile phone use and lower dementia incidence, potentially mediated by changes in hippocampal gray matter volume and LTL.Mobile phone use may benefit individuals with age-related visual decline by reducing dementia risk, given the well-established link between vision impairment and increased dementia risk.Middle-aged and older adults should be encouraged to use mobile phones as a means to enhance social connectivity.</p>","PeriodicalId":53226,"journal":{"name":"Alzheimer''s and Dementia: Diagnosis, Assessment and Disease Monitoring","volume":"17 3","pages":"e70117"},"PeriodicalIF":4.4000,"publicationDate":"2025-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12284319/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Alzheimer''s and Dementia: Diagnosis, Assessment and Disease Monitoring","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1002/dad2.70117","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/7/1 0:00:00","PubModel":"eCollection","JCR":"Q1","JCRName":"CLINICAL NEUROLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Background: This study aimed to investigate associations between historic phone use, visual decline, and risk of dementia, as well as underlying biological mechanisms.
Methods: A total of 494,359 participants from UK Biobank were included in the prospective study. Historic phone use, visual acuity, brain imaging, and leukocyte telomere lengths (LTLs) were assessed. Incident dementia was tracked via hospital episode records and mortality data.
Results: Over a median follow-up of 12.2 years, participants with better visual acuity were associated with longer use of mobile phone. Longer historic phone use was associated with a 31% lower risk of dementia. Both hippocampal gray matter volumes and LTLs were associated with historic phone use length and significantly mediated the relationship between historic phone use and dementia. Mediation still exists in participants with visual decline.
Conclusion: Our findings suggest mobile phone use may serve as a modifiable factor to prevent dementia, even in older adults with visual decline.
Highlights: A strong inverse association was observed between longer mobile phone use and lower dementia incidence, potentially mediated by changes in hippocampal gray matter volume and LTL.Mobile phone use may benefit individuals with age-related visual decline by reducing dementia risk, given the well-established link between vision impairment and increased dementia risk.Middle-aged and older adults should be encouraged to use mobile phones as a means to enhance social connectivity.
期刊介绍：
Alzheimer''s & Dementia: Diagnosis, Assessment & Disease Monitoring (DADM) is an open access, peer-reviewed, journal from the Alzheimer''s Association® that will publish new research that reports the discovery, development and validation of instruments, technologies, algorithms, and innovative processes. Papers will cover a range of topics interested in the early and accurate detection of individuals with memory complaints and/or among asymptomatic individuals at elevated risk for various forms of memory disorders. The expectation for published papers will be to translate fundamental knowledge about the neurobiology of the disease into practical reports that describe both the conceptual and methodological aspects of the submitted scientific inquiry. Published topics will explore the development of biomarkers, surrogate markers, and conceptual/methodological challenges. Publication priority will be given to papers that 1) describe putative surrogate markers that accurately track disease progression, 2) biomarkers that fulfill international regulatory requirements, 3) reports from large, well-characterized population-based cohorts that comprise the heterogeneity and diversity of asymptomatic individuals and 4) algorithmic development that considers multi-marker arrays (e.g., integrated-omics, genetics, biofluids, imaging, etc.) and advanced computational analytics and technologies.
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