Comparing retrospective informant assessments to prospectively collected cognitive measures in the Health and Retirement Study.

IF 4.4 Q1 CLINICAL NEUROLOGY
Ali G Hamedani, Dylan Thibault, Katya Rascovsky, Allison W Willis, Kenneth M Langa
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引用次数: 0

Abstract

Introduction: Clinicians and researchers frequently ask informants about changes in a person's cognition, but whether informant assessments correspond to objectively measured change is unclear.

Methods: A subset (n = 2710) of US Health and Retirement Study participants and their informants completed the Harmonized Cognitive Assessment Protocol (HCAP). Using generalized estimating equations, we compared informant-reported change in memory and daily functioning to prospectively collected delayed word recall and instrumental activities of daily living (iADL) in the 10 years preceding HCAP.

Results: Informant reports of worsened memory were associated with declining word recall, and informant-reported iADL loss was associated with declining iADLs. Informant-reported memory impairment was more strongly associated with declining word recall when informants saw the respondent weekly or more compared to one to three times monthly or less (p < 0.0001 for interaction).

Discussion: Informant assessments of memory and iADLs are generally consistent with prospective measurements, but this relationship depends significantly on frequency of informant contact.

Highlights: Informant ratings of a person's memory and daily functioning are generally reliable.Quality of reporting depends on frequency of informant contact.Knowing an informant's characteristics is important for interpreting responses.

Abstract Image

Abstract Image

比较健康与退休研究中回顾性的信息者评估和前瞻性收集的认知测量。
临床医生和研究人员经常询问举报人关于一个人的认知变化,但举报人的评估是否符合客观测量的变化尚不清楚。方法:美国健康与退休研究的一个子集(n = 2710)参与者及其信息提供者完成了统一认知评估方案(HCAP)。使用广义估计方程,我们比较了信息者报告的记忆和日常功能的变化,前瞻性地收集了HCAP前10年的延迟单词回忆和日常生活工具活动(iADL)。结果:举报人报告的记忆恶化与单词回忆能力下降有关,举报人报告的日常生活水平下降与日常生活水平下降有关。与每月1 - 3次或更少相比,当举报人每周或更多次与被调查者见面时,举报人报告的记忆障碍与单词回忆能力下降的关系更强(p)。讨论:举报人对记忆和iadl的评估通常与预期测量一致,但这种关系在很大程度上取决于举报人接触的频率。亮点:对一个人的记忆和日常功能的评估通常是可靠的。报告的质量取决于与举报人接触的频率。了解被调查者的特点对于解释他们的回答很重要。
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来源期刊
CiteScore
7.80
自引率
7.50%
发文量
101
审稿时长
8 weeks
期刊介绍: Alzheimer''s & Dementia: Diagnosis, Assessment & Disease Monitoring (DADM) is an open access, peer-reviewed, journal from the Alzheimer''s Association® that will publish new research that reports the discovery, development and validation of instruments, technologies, algorithms, and innovative processes. Papers will cover a range of topics interested in the early and accurate detection of individuals with memory complaints and/or among asymptomatic individuals at elevated risk for various forms of memory disorders. The expectation for published papers will be to translate fundamental knowledge about the neurobiology of the disease into practical reports that describe both the conceptual and methodological aspects of the submitted scientific inquiry. Published topics will explore the development of biomarkers, surrogate markers, and conceptual/methodological challenges. Publication priority will be given to papers that 1) describe putative surrogate markers that accurately track disease progression, 2) biomarkers that fulfill international regulatory requirements, 3) reports from large, well-characterized population-based cohorts that comprise the heterogeneity and diversity of asymptomatic individuals and 4) algorithmic development that considers multi-marker arrays (e.g., integrated-omics, genetics, biofluids, imaging, etc.) and advanced computational analytics and technologies.
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