{"title":"Acute Cardiac Tamponade Following Enfortumab Vedotin Initiation in Metastatic Urothelial Carcinoma: Successful Rescue by Pericardial Fenestration.","authors":"Hiroto Akamatsu, Yu Ishizuya, Kentaro Takezawa, Taigo Kato, Koji Hatano, Yoichi Kakuta, Atsunari Kawashima, Norio Nonomura","doi":"10.1002/iju5.70221","DOIUrl":"10.1002/iju5.70221","url":null,"abstract":"<p><strong>Introduction: </strong>Enfortumab vedotin is a Nectin-4-directed antibody-drug conjugate approved for metastatic urothelial carcinoma. Cardiac adverse events such as pericardial effusion or tamponade associated with enfortumab vedotin are extremely rare.</p><p><strong>Case presentation: </strong>A 50-year-old man with metastatic UC developed chest pain and dyspnea 3 days after the first EV infusion, followed by rapid progression to cardiac tamponade on Day 9. Emergency pericardiocentesis and thoracoscopic pericardial fenestration drained 2400 mL of pericardial and pleural fluid. Pericardial cytology revealed inflammatory cells without malignancy, while pleural nodules confirmed urothelial carcinoma. Infectious causes were excluded, and an acute EV-related inflammatory reaction was suspected. EV was safely resumed on postoperative Day 20, achieving a sustained partial response for 8 months without recurrence of pericardial effusion.</p><p><strong>Conclusion: </strong>This rare case highlights the potential for acute, enfortumab vedotin-related inflammatory pericardial effusion and emphasizes the importance of early recognition and prompt surgical intervention.</p>","PeriodicalId":52909,"journal":{"name":"IJU Case Reports","volume":"9 4","pages":"e70221"},"PeriodicalIF":0.5,"publicationDate":"2026-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13316445/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148363769","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Radiation-Associated Enteric-Type Urethral Adenocarcinoma 20 Years After Prostate Brachytherapy: A Case Treated With Neoadjuvant Gemcitabine-Cisplatin and Robot-Assisted Radical Cystectomy","authors":"Yuki Tanaka, Yui Fujimura, Koya Morishita, Yuta Kashiwagi, Satoshi Katsuno, Tatsuya Nagai, Yuki Okumura","doi":"10.1002/iju5.70216","DOIUrl":"10.1002/iju5.70216","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Introduction</h3>\u0000 \u0000 <p>Brachytherapy is a widely accepted treatment for prostate cancer, in which subsequent radiation-associated enteric-type urethral adenocarcinoma is extremely rare.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Case Presentation</h3>\u0000 \u0000 <p>An 83-year-old man with a history of cholecystitis, appendicitis, and hyperlipidemia who had undergone brachytherapy 20 years earlier presented with dysuria. Transurethral resection of the prostate revealed enteric-type urethral adenocarcinoma. Imaging showed a space-occupying lesion extending from the prostatic to the membranous urethra without distant metastasis. The patient received three cycles of gemcitabine and cisplatin as neoadjuvant chemotherapy, followed by robot-assisted radical cystectomy after confirmation of tumor shrinkage. At 18 months postoperatively, he remained alive with no evidence of recurrence.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>This case illustrates a rare secondary enteric-type urethral adenocarcinoma after brachytherapy and highlights a potential therapeutic strategy for its management.</p>\u0000 </section>\u0000 </div>","PeriodicalId":52909,"journal":{"name":"IJU Case Reports","volume":"9 4","pages":""},"PeriodicalIF":0.5,"publicationDate":"2026-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13316123/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148363797","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Editorial Comment on Rapid Systemic Progression After Ureteroscopic Holmium:YAG Laser Ablation for High-Grade Upper Tract Urothelial Carcinoma in a Solitary Kidney: A Case Report","authors":"Takahiro Kojima","doi":"10.1002/iju5.70217","DOIUrl":"https://doi.org/10.1002/iju5.70217","url":null,"abstract":"<p>Upper tract urothelial carcinoma (UTUC) arising in a solitary kidney presents a particularly challenging clinical scenario, as treatment decisions must balance the competing priorities of maximizing oncologic control and maintaining renal function. Radical nephroureterectomy remains the standard treatment for high-risk disease; however, in patients with a solitary functioning kidney, surgery may inevitably result in dialysis dependence. Conversely, although kidney-sparing approaches can maintain renal function, they are often associated with an increased risk of disease recurrence and progression in patients with high-grade tumors. This case highlights the ongoing challenge of balancing oncologic control with renal preservation in patients with imperative indications for kidney-sparing management [<span>1</span>].</p><p>The strikingly rapid onset of systemic metastatic disease following endoscopic treatment raises an important question as to whether ureteroscopic manipulation could have facilitated tumor dissemination, although a causal relationship remains difficult to establish. Although the authors appropriately discuss possible mechanisms, including increased intrarenal pressure and postoperative inflammation, a causal relationship cannot be established on the basis of a single case. Occult micro-metastases may have already been present at the time of diagnosis and may have substantially influenced the subsequent clinical course. Accordingly, this case should be interpreted primarily as a reflection of the aggressive nature of high-risk UTUC rather than as definitive evidence of procedure-related metastatic spread.</p><p>Current guideline recommendations recognize that nephron-sparing treatment may be a reasonable option for selected patients with high-risk UTUC in whom renal preservation is imperative [<span>2</span>]. However, careful patient selection remains crucial. Future efforts should focus on refining risk stratification through the integration of clinical, pathological, radiographic, and molecular factors to better identify patients who may safely undergo kidney-sparing management while maintaining acceptable oncologic outcomes. Such advances may help define the subset of patients most likely to benefit from renal-preserving strategies without compromising cancer control.</p><p>In addition, advances in systemic therapy may expand future treatment options for patients with imperative indications for renal preservation. For example, enfortumab vedotin plus pembrolizumab (EVP) has demonstrated remarkable efficacy in advanced urothelial carcinoma and is increasingly being incorporated into earlier treatment settings. Although evidence supporting EVP-based kidney-sparing strategies in localized high-risk UTUC is currently lacking, effective tumor downstaging achieved with systemic therapy could potentially facilitate renal-preserving local treatment in carefully selected patients. Future prospective studies and real-world evidence are","PeriodicalId":52909,"journal":{"name":"IJU Case Reports","volume":"9 4","pages":""},"PeriodicalIF":0.5,"publicationDate":"2026-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/iju5.70217","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148324473","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Rio Oshima, Shuji Kariya, Miyuki Nakatani, Yasuyuki Ono, Takuji Maruyama, Yuki Tanaka, Kanji Sugiura, Noboru Tanigawa
{"title":"Lymphatic Embolization for Lymphatic Leakage After Pelvic Lymph Node Dissection: Case Report","authors":"Rio Oshima, Shuji Kariya, Miyuki Nakatani, Yasuyuki Ono, Takuji Maruyama, Yuki Tanaka, Kanji Sugiura, Noboru Tanigawa","doi":"10.1002/iju5.70208","DOIUrl":"https://doi.org/10.1002/iju5.70208","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Introduction</h3>\u0000 \u0000 <p>Radical cystectomy with pelvic lymph node dissection for muscle-invasive bladder cancer may be complicated by postoperative lymphatic leakage when high-output drainage persists despite conservative management. We describe treatment of diffuse lymphoascites after pelvic lymph node dissection using upstream lymphatic embolization.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Case Presentation</h3>\u0000 \u0000 <p>A man in his 70s developed lymphatic leakage with drainage > 1000 mL/day after radical cystectomy and pelvic lymph node dissection. Lymphoscintigraphy showed bilateral iliac leakage with diffuse intraperitoneal spread, making local sclerotherapy unsuitable. Intranodal lymphangiography via bilateral inguinal nodes identified iliac lymphatic duct leaks. Upstream embolization with a N-butyl cyanoacrylate–ethiodized oil mixture through multiple inguinal nodes rapidly reduced drainage, allowing drain removal by day 4 and discharge by day 10 without persistent lymphedema.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Upstream lymphatic embolization is a minimally invasive option for refractory high-output lymphatic leakage after pelvic lymph node dissection.</p>\u0000 </section>\u0000 </div>","PeriodicalId":52909,"journal":{"name":"IJU Case Reports","volume":"9 4","pages":""},"PeriodicalIF":0.5,"publicationDate":"2026-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/iju5.70208","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148324482","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nae Takizawa, Haruyuki Ohsugi, Monta Inoue, Jun Matsushita, Hisanori Taniguchi, Hidefumi Kinoshita
{"title":"Robot-Assisted Laparoscopic Partial Adrenalectomy Utilizing Intraoperative Indocyanine Green Near-Infrared Fluorescence Imaging for Pheochromocytoma: A Case Report","authors":"Nae Takizawa, Haruyuki Ohsugi, Monta Inoue, Jun Matsushita, Hisanori Taniguchi, Hidefumi Kinoshita","doi":"10.1002/iju5.70218","DOIUrl":"https://doi.org/10.1002/iju5.70218","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Introduction</h3>\u0000 \u0000 <p>Indocyanine green (ICG) near-infrared fluorescence (NIRF) imaging facilitates pheochromocytoma identification during adrenal surgery.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Case Presentation</h3>\u0000 \u0000 <p>We report a 21-year-old woman with multiple endocrine neoplasia type 2A and bilateral adrenal tumors who underwent ICG-NIRF–guided, robot-assisted partial adrenalectomy for pheochromocytomas. Following left adrenalectomy, partial right adrenalectomy was performed using intraoperative ICG-NIRF imaging. After intravenous administration of 2.5 mg ICG, the normal adrenal cortex exhibited strong fluorescence, whereas the pheochromocytoma showed no fluorescence. However, fluorescence from the overlying normal adrenal cortex partially obscured the tumor, which was identified by intraoperative ultrasonography. Combined ICG-NIRF imaging and ultrasonography enabled maximal preservation of functional adrenal cortex. Postoperatively, metanephrine and normetanephrine levels normalized, and hydrocortisone was tapered and discontinued.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>ICG-NIRF is a useful adjunct for cortical visualization; however, multimodal guidance is essential for precise tumor delineation during cortical-sparing adrenalectomy.</p>\u0000 </section>\u0000 </div>","PeriodicalId":52909,"journal":{"name":"IJU Case Reports","volume":"9 4","pages":""},"PeriodicalIF":0.5,"publicationDate":"2026-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/iju5.70218","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148324448","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"ASPSCR1: TFE3 Fusion-Positive Epithelioid Angiomyolipoma/PEComa Lacking Melanocytic Markers: A Case Report","authors":"Yuka Kondo, Yoji Nagashima, Kenji Zennami, Megumi Sato, Sayaka Sumiyoshi, Akihiko Sugimoto, Madoka Isomura, Kiyoshi Takahara, Sachiko Minamiguchi","doi":"10.1002/iju5.70213","DOIUrl":"https://doi.org/10.1002/iju5.70213","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Introduction</h3>\u0000 \u0000 <p>Epithelioid angiomyolipoma is a rare perivascular epithelioid cell tumor subtype with malignant potential. Its morphology mimics renal cell carcinoma, posing diagnostic challenges. Half of these cases harbor <i>TSC1</i>/<i>TSC2</i> alterations, and a small subset features <i>TFE3</i> rearrangements, mutually exclusive of <i>TSC</i> mutations. Recently, “perivascular epithelioid cell tumor-like neoplasms” with <i>ASPSCR1::TFE3</i> fusion lacking melanocytic markers were described.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Case Presentation</h3>\u0000 \u0000 <p>A 25-year-old woman presented with a 4.5-cm renal mass. Biopsy suggested <i>TFE3</i>-rearranged renal cell carcinoma because of diffuse TFE3 positivity and no HMB45 immunoreactivity. Postoperatively, despite a complete lack of melanocytic markers, the tumor was diagnosed as <i>TFE3</i>-rearranged epithelioid angiomyolipoma based on its epithelioid morphology and PAX8 negativity, including a retrospective biopsy study. Fluorescence in situ hybridization confirmed <i>ASPSCR1::TFE3</i> fusion, suggesting this rare, newly recognized entity.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p><i>TFE3</i>-rearranged epithelioid angiomyolipoma can lack melanocytic markers. PAX8 immunohistochemistry and genetic testing help distinguish this potentially aggressive tumor from renal cell carcinoma and <i>TSC</i>-mutated subtypes.</p>\u0000 </section>\u0000 </div>","PeriodicalId":52909,"journal":{"name":"IJU Case Reports","volume":"9 4","pages":""},"PeriodicalIF":0.5,"publicationDate":"2026-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/iju5.70213","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148324037","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Lateral Port-Site Hernia Following Robot-Assisted Radical Prostatectomy: Case Reports and Proposal of a Preventive Technique","authors":"Akihiro Kojima, Motohiro Fujiwara, Takumasa Amemiya, Ayaka Koizumi, Junpei Takashima, Masayasu Urushibara, Touko Asano, Hideto Kano, Kazuhiro Ishizaka, Minato Yokoyama","doi":"10.1002/iju5.70214","DOIUrl":"https://doi.org/10.1002/iju5.70214","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Introduction</h3>\u0000 \u0000 <p>Port-site hernia is a rare but serious complication that can occur after robot-assisted radical prostatectomy and requires surgical repair.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Case Presentation</h3>\u0000 \u0000 <p>In 2024, we experienced two cases of port-site hernia after robot-assisted radical prostatectomy. In response, we developed a preventive technique to reduce the risk of port-site hernia. Here, we present one of the two cases of port-site hernia after robot-assisted radical prostatectomy and a case in which port-site hernia did not occur after receiving the new preventive technique. We also describe the preventive method currently employed at our institution, where an anti-adhesion agent is applied to the removal site of a 12-mm port and closure suture involves fascia without peritoneum. This technique is simple, safe, and applicable to all patients.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>We developed a new and simple procedure to prevent port-site hernia based on our experience. Our method may have the potential to effectively prevent its occurrence.</p>\u0000 </section>\u0000 </div>","PeriodicalId":52909,"journal":{"name":"IJU Case Reports","volume":"9 4","pages":""},"PeriodicalIF":0.5,"publicationDate":"2026-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/iju5.70214","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148282606","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Tailored Vascular Approach in Robot-Assisted Nephroureterectomy for a Horseshoe Kidney: A Case Report","authors":"Takanari Kambe, Yosuke Shimizu, Hajime Yoshida, Koken Hayashi, Shotaro Hatano, Tomoaki Okada, Kenji Mitsumori, Hiroyuki Onishi","doi":"10.1002/iju5.70212","DOIUrl":"https://doi.org/10.1002/iju5.70212","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Introduction</h3>\u0000 \u0000 <p>A horseshoe kidney is a rare congenital anomaly with complex vascular variations that increase surgical difficulty. Few reports have specifically addressed the vascular approaches in robot-assisted surgery.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Case Presentation</h3>\u0000 \u0000 <p>A man in his 70s was diagnosed with right ureteral urothelial carcinoma in a horseshoe kidney. Preoperative imaging revealed a short renal artery arising posterior to the isthmus, suggesting difficulty with conventional surgical approaches. Surgery was initiated in the supine position using a medial approach, similar to the medial-to-lateral dissection used for sigmoid colon mobilization, with cranial dissection along the aorta to secure the vessel and isthmus, followed by repositioning and standard robot-assisted nephroureterectomy. Intraoperative indocyanine green fluorescence was used to guide safe isthmus division. The procedure was completed safely without any perioperative complications.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>A tailored approach based on detailed preoperative vascular assessment may facilitate safe and effective robot-assisted surgery in patients with horseshoe kidney and complex vascular anatomy.</p>\u0000 </section>\u0000 </div>","PeriodicalId":52909,"journal":{"name":"IJU Case Reports","volume":"9 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/iju5.70212","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148237941","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Clinical Utility of 68Ga-DOTATOC Positron Emission Tomography/Computed Tomography in Evaluating Metastatic Lesions of Clear Cell Renal Cell Carcinoma: A Case Report","authors":"Yuta Mine, Toru Sakatani, Sho Koyasu, Takashi Ogata, Yuki Teramoto, Akio Sakamoto, Takashi Mizowaki, Yuji Nakamoto, Takashi Kobayashi, Takayuki Goto","doi":"10.1002/iju5.70210","DOIUrl":"https://doi.org/10.1002/iju5.70210","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Introduction</h3>\u0000 \u0000 <p><sup>68</sup>Ga-DOTATOC positron emission tomography/computed tomography (PET/CT) targets somatostatin receptors (SSTRs) and is an established molecular imaging modality for neuroendocrine tumors (NETs). Although SSTR expression has been reported in renal cell carcinoma (RCC), its clinical utility remains unclear.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Case Presentation</h3>\u0000 \u0000 <p>A 76-year-old woman who had undergone open partial nephrectomy for clear cell RCC (grade 2, pT1bN0M0) 3 years before developed a sternal metastasis, which was surgically resected with negative margins. Nine months later, follow-up CT revealed a soft-tissue lesion posterior to the sternum. <sup>68</sup>Ga-DOTATOC PET/CT showed no uptake in this lesion but intense uptake at the Th8 vertebra, indicating metastasis. After stereotactic body radiation therapy (35 Gy in five fractions), persistent uptake was observed 8 months later, suggesting residual viable tumor, which was histopathologically confirmed after resection.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p><sup>68</sup>Ga-DOTATOC PET/CT was useful in evaluating the possibility of recurrence of the soft-tissue lesion, assessing post-radiation viability, and guiding treatment in RCC.</p>\u0000 </section>\u0000 </div>","PeriodicalId":52909,"journal":{"name":"IJU Case Reports","volume":"9 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/iju5.70210","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148237734","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Ruptured Abdominal Aortic Aneurysm as the Initial Manifestation of Undiagnosed Pheochromocytoma","authors":"Kyotaro Fukuta, Kohsuke Miyataka, Yuya Hiroshima, Nobuo Satake, Yuichiro Atagi, Keisuke Ozaki, Takeshi Nakashima, Ryoichi Nakanishi, Hirofumi Izaki, Junya Furukawa","doi":"10.1002/iju5.70211","DOIUrl":"https://doi.org/10.1002/iju5.70211","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Introduction</h3>\u0000 \u0000 <p>Pheochromocytoma is a rare catecholamine-secreting tumor that can cause severe cardiovascular complications. Its association with ruptured abdominal aortic aneurysm is extremely rare.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Case Presentation</h3>\u0000 \u0000 <p>A 57-year-old man with no significant medical history presented with sudden abdominal pain and hemorrhagic shock. Computed tomography revealed a ruptured infrarenal abdominal aortic aneurysm, and emergency endovascular aneurysm repair was successfully performed. Preoperative imaging incidentally detected a hypervascular left adrenal mass. Although biochemical findings were borderline, <sup>123</sup>I-metaiodobenzylguanidine scintigraphy demonstrated intense uptake, leading to a diagnosis of pheochromocytoma. After appropriate α-adrenergic blockade, elective laparoscopic adrenalectomy was safely performed, and histopathology confirmed pheochromocytoma.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>This case highlights the importance of considering pheochromocytoma as an underlying cause of ruptured abdominal aortic aneurysm and demonstrates that a staged strategy with emergency endovascular repair followed by definitive endocrine surgery can be safe and effective.</p>\u0000 </section>\u0000 </div>","PeriodicalId":52909,"journal":{"name":"IJU Case Reports","volume":"9 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/iju5.70211","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148237733","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}