IJU Case Reports最新文献

Bilateral Testicular Tumors Recurred 5 Years After Surgery for an Extragonadal Germ Cell Tumor: Case Report. 双侧睾丸肿瘤生殖道外生殖细胞瘤术后5年复发1例。

IJU Case Reports Pub Date : 2026-05-04 eCollection Date: 2026-05-01 DOI: 10.1002/iju5.70190

Hiraku Yamamoto, Isao Hara, Satoshi Muraoka, Takahito Wakaymiya, Shimpei Yamashita, Yasuo Kohjimoto

{"title":"Bilateral Testicular Tumors Recurred 5 Years After Surgery for an Extragonadal Germ Cell Tumor: Case Report.","authors":"Hiraku Yamamoto, Isao Hara, Satoshi Muraoka, Takahito Wakaymiya, Shimpei Yamashita, Yasuo Kohjimoto","doi":"10.1002/iju5.70190","DOIUrl":"https://doi.org/10.1002/iju5.70190","url":null,"abstract":"<p><strong>Introduction: </strong>Extragonadal germ cell tumors (EGCT) account for approximately 3%-7% of all germ cell tumors. Metachronous testicular tumors develop in 5%-7% of patients after EGCT treatment; however, bilateral testicular tumors have not been reported.</p><p><strong>Case presentation: </strong>A 30-year-old man underwent retroperitoneal tumor resection and was diagnosed as teratoma. A cystic lesion in the right testis without malignant features was managed by surveillance. Five years later, he presented with left testicular discomfort. Imaging revealed bilateral testicular tumors, and serum hCG was elevated (11.9 mIU/mL). Bilateral radical orchiectomy revealed pure seminoma (pT1) in the left testis and mixed germ cell tumor with seminoma and teratoma components (pT1) in the right testis.</p><p><strong>Conclusions: </strong>This is the first reported case of bilateral testicular tumors developing after EGCT treatment. In patients with EGCT, the potential presence of testicular germ cell neoplasia in situ should be considered, and long-term follow-up is recommended.</p>","PeriodicalId":52909,"journal":{"name":"IJU Case Reports","volume":"9 ","pages":"e70190"},"PeriodicalIF":0.0,"publicationDate":"2026-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13136946/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147845991","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Essential Renal Bleeding Presenting as Persistent Unilateral Hematuria Successfully Treated With Factor XIII Replacement Therapy: A Case Report. 原发性肾出血表现为持续性单侧血尿，经13因子替代疗法成功治疗1例。

IJU Case Reports Pub Date : 2026-05-04 eCollection Date: 2026-05-01 DOI: 10.1002/iju5.70182

Moe Toyoshima, Shigekatsu Maekawa, Arisa Machida, Kie Sekiguchi, Daiki Ikarashi, Renpei Kato, Mitsugu Kanehira, Jun Sugimura, Wataru Obara

{"title":"Essential Renal Bleeding Presenting as Persistent Unilateral Hematuria Successfully Treated With Factor XIII Replacement Therapy: A Case Report.","authors":"Moe Toyoshima, Shigekatsu Maekawa, Arisa Machida, Kie Sekiguchi, Daiki Ikarashi, Renpei Kato, Mitsugu Kanehira, Jun Sugimura, Wataru Obara","doi":"10.1002/iju5.70182","DOIUrl":"https://doi.org/10.1002/iju5.70182","url":null,"abstract":"<p><strong>Introduction: </strong>Essential renal bleeding is rare and lacks standardized treatment; organ-preserving options are critical in older patients with impaired renal function.</p><p><strong>Case presentation: </strong>A woman in her early 80s with atrial fibrillation treated with edoxaban, chronic heart failure, and advanced chronic kidney disease presented with gross hematuria and bladder tamponade. Bleeding was localized to the right renal pelvis and ureter, with no tumor, urolithiasis, vascular malformation, or glomerular disease; essential renal bleeding was diagnosed. Hematuria persisted despite edoxaban discontinuation, red blood cell and plasma transfusions, and carbazochrome sodium sulfonate administration. Isolated factor XIII activity was 22%. Intravenous plasma-derived factor XIII concentrate achieved sustained hemostasis, renal function remained stable, and reduced-dose edoxaban was safely resumed. Hematuria did not recur within 24 months.</p><p><strong>Conclusion: </strong>In this population, factor XIII deficiency may contribute to persistent unilateral hematuria despite normal conventional coagulation tests.</p>","PeriodicalId":52909,"journal":{"name":"IJU Case Reports","volume":"9 ","pages":"e70182"},"PeriodicalIF":0.0,"publicationDate":"2026-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13137116/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147845953","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Metastasis of Hepatocellular Carcinoma to the Urinary Bladder: A Case Report and Literature Review. 肝细胞癌膀胱转移一例报告及文献复习。

IJU Case Reports Pub Date : 2026-05-03 eCollection Date: 2026-05-01 DOI: 10.1002/iju5.70189

Eri Fukagawa, Suguru Oka, Kazushige Sakaguchi, Shigeki Yamamoto, Masako Ikemura, Norio Akuta, Shinji Urakami

引用次数: 0

Secondary Colonic Adenocarcinoma After Continent Cutaneous Urinary Diversion a.m. Lundiana-An Aggressive Disease Entity With High Risk of Locally Advanced Disease and Metastases. 经皮尿转移后继发性结肠腺癌。lundiana -一种具有局部晚期疾病和转移高风险的侵袭性疾病实体。

IJU Case Reports Pub Date : 2026-04-28 eCollection Date: 2026-05-01 DOI: 10.1002/iju5.70186

Fredrik Liedberg, Mats Bläckberg, Johannes Bobjer

引用次数: 0

A Case of Testicular Malakoplakia With Markedly High Signal Intensity on Fat-Suppressed T1-Weighted Images. 睾丸斑疹在脂肪抑制的t1加权图像上表现为高信号。

IJU Case Reports Pub Date : 2026-04-27 eCollection Date: 2026-05-01 DOI: 10.1002/iju5.70187

Fumiko Yagi, Hirotaka Akita, Takeo Kosaka, Akihisa Ueno, Teppei Kotera, Masato Kobayashi, Hideaki Mekada, Mototsugu Oya, Masahiro Jinzaki

{"title":"A Case of Testicular Malakoplakia With Markedly High Signal Intensity on Fat-Suppressed T1-Weighted Images.","authors":"Fumiko Yagi, Hirotaka Akita, Takeo Kosaka, Akihisa Ueno, Teppei Kotera, Masato Kobayashi, Hideaki Mekada, Mototsugu Oya, Masahiro Jinzaki","doi":"10.1002/iju5.70187","DOIUrl":"https://doi.org/10.1002/iju5.70187","url":null,"abstract":"<p><strong>Introduction: </strong>Testicular malakoplakia is a very rare, chronic granulomatous inflammatory condition that frequently resembles testicular malignancy on imaging studies. Here, we report a case of testicular malakoplakia with characteristic magnetic resonance imaging (MRI) findings and present a brief review of the literature.</p><p><strong>Case presentation: </strong>A man in his 70s presented with left-sided scrotal pain. Ultrasonography revealed a well-defined hypoechoic intratesticular mass without internal vascularity, whereas computed tomography revealed enlargement of the left testis with a relative hyperattenuation area. MRI demonstrated low signal intensity on T2-weighted images, diffusion restriction, and a markedly high signal intensity on fat-suppressed T1-weighted images with contrast enhancement. Based on these findings, a malignant testicular tumor was suspected, and radical orchidectomy was conducted. Histopathological examination confirmed testicular malakoplakia with characteristic Michaelis-Gutmann bodies.</p><p><strong>Conclusion: </strong>This case highlights the importance of recognizing T1 shortening on fat-suppressed T1-weighted MRI as a potential imaging modality for malakoplakia.</p>","PeriodicalId":52909,"journal":{"name":"IJU Case Reports","volume":"9 ","pages":"e70187"},"PeriodicalIF":0.0,"publicationDate":"2026-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13112069/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147788755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Maribavir for Cytomegalovirus Infection in High-Risk Kidney Transplant Recipients: A Case Series. 马里巴韦治疗高危肾移植受者巨细胞病毒感染：一个病例系列。

IJU Case Reports Pub Date : 2026-04-27 eCollection Date: 2026-05-01 DOI: 10.1002/iju5.70183

Daiji Takamoto, Yu Shimada, Yuri Hasegawa, Takeaki Noguchi, Takashi Kawahara, Junichi Teranishi, Kazuhide Makiyama

{"title":"Maribavir for Cytomegalovirus Infection in High-Risk Kidney Transplant Recipients: A Case Series.","authors":"Daiji Takamoto, Yu Shimada, Yuri Hasegawa, Takeaki Noguchi, Takashi Kawahara, Junichi Teranishi, Kazuhide Makiyama","doi":"10.1002/iju5.70183","DOIUrl":"https://doi.org/10.1002/iju5.70183","url":null,"abstract":"<p><strong>Background: </strong>Cytomegalovirus (CMV) infection remains a common complication after kidney transplantation, particularly among high-risk donor-seropositive/recipient-seronegative (D+/R-) recipients. Valganciclovir is the standard first-line therapy; however, its use may be limited by hematological toxicity or impaired graft function. Maribavir is a recently approved antiviral agent with a distinct mechanism of action.</p><p><strong>Case presentation: </strong>We report four high-risk kidney transplant recipients in whom maribavir was introduced because continued valganciclovir therapy was difficult owing to cytopenia or renal dysfunction. After switching therapy, CMV viral loads decreased in all cases, and hematological abnormalities improved following discontinuation of valganciclovir. One patient developed a drug-induced skin eruption, while no other serious adverse events were observed. No CMV recurrence or graft dysfunction occurred during follow-up.</p><p><strong>Conclusion: </strong>These cases highlighted practical clinical considerations for managing CMV infection when standard antiviral therapy cannot be safely continued.</p>","PeriodicalId":52909,"journal":{"name":"IJU Case Reports","volume":"9 ","pages":"e70183"},"PeriodicalIF":0.0,"publicationDate":"2026-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13112181/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147788827","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correction to "Robot-Assisted Partial Nephrectomy via a Retroperitoneal Approach With Selective Arterial Clamping Guided by Blood Flow Analysis in a Horseshoe Kidney: A Case Report". 纠正“马蹄形肾经腹膜后选择性动脉夹闭引导的机器人辅助部分肾切除术：1例报告”。

IJU Case Reports Pub Date : 2026-04-21 eCollection Date: 2026-05-01 DOI: 10.1002/iju5.70184

引用次数: 0

Requiring Caution in the Interpretation of Donor-Derived Cell-Free DNA Levels During Cancer Treatment in a Kidney Transplant Recipient.: A Case Report. 在肾移植受者癌症治疗期间，供体来源的无细胞DNA水平的解释需要谨慎。：病例报告。

IJU Case Reports Pub Date : 2026-04-17 eCollection Date: 2026-05-01 DOI: 10.1002/iju5.70180

Nanaka Katsurayama, Toshihito Hirai, Yu Kijima, Hiroki Ishihara, Hironori Fukuda, Kazuya Omoto, Tomokazu Shimizu, Masashi Inui, Hideki Ishida, Toshio Takagi

{"title":"Requiring Caution in the Interpretation of Donor-Derived Cell-Free DNA Levels During Cancer Treatment in a Kidney Transplant Recipient.: A Case Report.","authors":"Nanaka Katsurayama, Toshihito Hirai, Yu Kijima, Hiroki Ishihara, Hironori Fukuda, Kazuya Omoto, Tomokazu Shimizu, Masashi Inui, Hideki Ishida, Toshio Takagi","doi":"10.1002/iju5.70180","DOIUrl":"10.1002/iju5.70180","url":null,"abstract":"<p><strong>Introduction: </strong>Donor-derived cfDNA (dd-cfDNA) indicates allograft rejection when > 1% of total cfDNA, but tumor-derived cfDNA can interfere in cancer patients.</p><p><strong>Case presentation: </strong>A 61-year-old male kidney transplant recipient with metastatic renal cell carcinoma (RCC) initiated avelumab and axitinib. Following two cycles of Immno-oncology (IO) therapy, serum creatinine (Cr) levels increased to 3.1 mg/dL. Although %dd-cfDNA remained below the conventional 1% threshold, it rose to 0.41%, representing a relative change value (RCV) of +178% from baseline. Two weeks later, Cr increased to 4.5 mg/dL, accompanied by severe hyponatremia, necessitating discontinuation of IO therapy, treated with methylprednisolone and resumed IO therapy; however, Cr remained elevated; he required hemodialysis.</p><p><strong>Conclusion: </strong>RCV from baseline %dd-cfDNA may serve as a more reliable indicator of allograft injury, facilitating earlier intervention in transplant recipients undergoing IO therapy.</p>","PeriodicalId":52909,"journal":{"name":"IJU Case Reports","volume":"9 ","pages":"e70180"},"PeriodicalIF":0.0,"publicationDate":"2026-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13090116/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147724518","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Robot-Assisted Partial Nephrectomy via a Retroperitoneal Approach With Selective Arterial Clamping Guided by Blood Flow Analysis in a Horseshoe Kidney: A Case Report 在血流分析指导下，经腹膜后选择性动脉夹闭的马蹄肾机器人辅助部分肾切除术1例。

IJU Case Reports Pub Date : 2026-04-08 DOI: 10.1002/iju5.70178

Takashi Fujita, Koki Kobayashi, Gaku Hayashi, Shunsuke Kamijo, Fumihiro Ito

{"title":"Robot-Assisted Partial Nephrectomy via a Retroperitoneal Approach With Selective Arterial Clamping Guided by Blood Flow Analysis in a Horseshoe Kidney: A Case Report","authors":"Takashi Fujita, Koki Kobayashi, Gaku Hayashi, Shunsuke Kamijo, Fumihiro Ito","doi":"10.1002/iju5.70178","DOIUrl":"10.1002/iju5.70178","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Introduction</h3>\u0000 \u0000 <p>Horseshoe kidney is the most common congenital renal fusion anomaly and is associated with aberrant anatomy and a complex vascular supply, which can complicate nephron-sparing surgery.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Case Presentation</h3>\u0000 \u0000 <p>A 43-year-old woman was incidentally diagnosed with a small hypovascular tumor in the right renal moiety of a horseshoe kidney. Three-dimensional computed tomography with blood flow analysis using SYNAPSE VINCENT (Fujifilm, Japan) demonstrated that the tumor was supplied exclusively by the upper pole renal artery. Because the right renal moiety was largely covered by the liver, a conventional midaxillary retroperitoneal approach was unsuitable, and the retroperitoneal space was established via a pararectus approach. A hybrid laparoscopic–robotic technique was adopted due to the limited working space.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Preoperative blood flow analysis enabled selective arterial clamping, and a tailored surgical approach allowed safe robot-assisted partial nephrectomy with minimal blood loss and preserved renal function.</p>\u0000 </section>\u0000 </div>","PeriodicalId":52909,"journal":{"name":"IJU Case Reports","volume":"9 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13058432/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147647305","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Central Adrenal Insufficiency Developing After Right Partial Nephrectomy Involving Ectopic Adrenocortical Adenoma Mimicking Right Renal Carcinoma and a Retrospective Diagnosis of Adrenal Cushing's Syndrome: A Case Report 右肾部分切除术合并异位肾上腺皮质腺瘤后出现中枢性肾上腺功能不全及肾上腺库欣综合征的回顾性诊断：1例报告。

IJU Case Reports Pub Date : 2026-04-06 DOI: 10.1002/iju5.70172

Kentaro Arinami, Sayaka Kikuchi, Nobumasa Ohara, Yurie Takizawa, Yohei Ikeda, Kozue Ito, Go Hasegawa, Noboru Hara, Tsutomu Nishiyama

{"title":"Central Adrenal Insufficiency Developing After Right Partial Nephrectomy Involving Ectopic Adrenocortical Adenoma Mimicking Right Renal Carcinoma and a Retrospective Diagnosis of Adrenal Cushing's Syndrome: A Case Report","authors":"Kentaro Arinami, Sayaka Kikuchi, Nobumasa Ohara, Yurie Takizawa, Yohei Ikeda, Kozue Ito, Go Hasegawa, Noboru Hara, Tsutomu Nishiyama","doi":"10.1002/iju5.70172","DOIUrl":"10.1002/iju5.70172","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Introduction</h3>\u0000 \u0000 <p>Ectopic adrenocortical adenomas that produce adrenal hormones and mimic renal cell carcinoma are extremely rare.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Case Presentation</h3>\u0000 \u0000 <p>A 49-year-old woman underwent partial nephrectomy of the upper pole of the kidney following a clinical diagnosis of renal cell carcinoma. The tumor, initially suspected to be renal cell carcinoma, was definitively diagnosed as an ectopic adrenocortical adenoma producing adrenocortical hormones, which was removed surgically. Postoperatively, she developed tertiary adrenal insufficiency. After hydrocortisone therapy, the patient's symptoms gradually improved, and laboratory results also showed improvement. Retrospectively, the patient exhibited signs of Cushing's syndrome.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>If the patient's body habitus suggests Cushing's syndrome, it is important to conduct an endocrinological evaluation before surgery. Additionally, early postoperative monitoring and glucocorticoid supplementation should be performed if necessary.</p>\u0000 </section>\u0000 </div>","PeriodicalId":52909,"journal":{"name":"IJU Case Reports","volume":"9 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-04-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13052496/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147634782","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0