IJU Case Reports最新文献_第2页

Simultaneous Ureterovaginal and Rectovaginal Fistulas Caused by a Cube Pessary: A Case Report 立方体子宫托致输尿管阴道瘘及直肠阴道瘘1例。

IF 0.5

IJU Case Reports Pub Date : 2026-10-06 DOI: 10.1002/iju5.70279

Tetsuhiro Yano, Yutaro Sasaki, Riyo Kinouchi, Hideya Kashihara, Haruka Itami, Saki Kobayashi, Tomoya Fukawa, Takeshi Iwasa, Akihiko Soyama, Junya Furukawa

{"title":"Simultaneous Ureterovaginal and Rectovaginal Fistulas Caused by a Cube Pessary: A Case Report","authors":"Tetsuhiro Yano, Yutaro Sasaki, Riyo Kinouchi, Hideya Kashihara, Haruka Itami, Saki Kobayashi, Tomoya Fukawa, Takeshi Iwasa, Akihiko Soyama, Junya Furukawa","doi":"10.1002/iju5.70279","DOIUrl":"10.1002/iju5.70279","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Introduction</h3>\u0000 \u0000 <p>We present a case of simultaneous ureterovaginal and rectovaginal fistulas caused by continuous placement of a cube pessary without daily removal, successfully managed through a multidisciplinary approach.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Case Presentation</h3>\u0000 \u0000 <p>An 84-year-old female managed with a cube pessary presented with hematochezia. Initial imaging revealed simultaneous pessary penetration into the rectum and right ureterovesical junction. A previous hospital first performed a sigmoid colostomy and an unsuccessful transvaginal rectovaginal fistula closure. Following this, a ureteral stent was placed for the ureterovaginal fistula, but it also failed to close due to extensive tissue defects. She was referred to our hospital, where a multidisciplinary surgery incorporating retroperitoneal extravesical ureteroneocystostomy, transvaginal fistula closure, and anterior colporrhaphy was performed.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Cube pessaries require daily self-management, and continuous placement in elderly patients can lead to severe ischemic complications. Multidisciplinary surgical reconstruction is crucial to preserve renal function and restore quality of life.</p>\u0000 </section>\u0000 </div>","PeriodicalId":52909,"journal":{"name":"IJU Case Reports","volume":"9 6","pages":""},"PeriodicalIF":0.5,"publicationDate":"2026-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13641096/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149118089","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prostatic Adenosquamous Carcinoma With a Minute Squamous Component in the Initial Biopsy and Early Liver Metastasis: A Case Report 前列腺腺鳞状癌早期活检有微小鳞状成分及早期肝转移一例报告。

IF 0.5

IJU Case Reports Pub Date : 2026-10-04 DOI: 10.1002/iju5.70262

Yohei Tsubouchi, Taku Naiki, Aya Naiki-Ito, Rei Unno, Toshiki Etani, Takashi Nagai, Toshiharu Morikawa, Daiki Ishikawa, Hiroko Suzuki, Takahiro Yasui

{"title":"Prostatic Adenosquamous Carcinoma With a Minute Squamous Component in the Initial Biopsy and Early Liver Metastasis: A Case Report","authors":"Yohei Tsubouchi, Taku Naiki, Aya Naiki-Ito, Rei Unno, Toshiki Etani, Takashi Nagai, Toshiharu Morikawa, Daiki Ishikawa, Hiroko Suzuki, Takahiro Yasui","doi":"10.1002/iju5.70262","DOIUrl":"10.1002/iju5.70262","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Introduction</h3>\u0000 \u0000 <p>We report a case of de novo prostatic adenosquamous carcinoma with a minute squamous component in the initial biopsy and early liver metastasis despite a marked prostate-specific antigen response.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Case Presentation</h3>\u0000 \u0000 <p>A 72-year-old man was diagnosed with locally advanced prostate cancer with nodal and multiple bone metastases. Prostate biopsy initially showed adenocarcinoma with a Gleason score of 4 + 5. After leuprolide and abiraterone plus radiotherapy, prostate-specific antigen decreased from 13.0 to 0.22 ng/mL; however, a liver metastasis developed. Re-evaluation of the prostate biopsy revealed minute squamous differentiation, and liver biopsy showed metastatic squamous cell carcinoma. Immunohistochemistry showed retained MLH1 and PMS2 expression with loss of MSH2 and MSH6 in both specimens. Genomic profiling showed microsatellite instability-high status.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Repeat biopsy and molecular-pathological reassessment may be important when radiographic progression is discordant with prostate-specific antigen kinetics.</p>\u0000 </section>\u0000 </div>","PeriodicalId":52909,"journal":{"name":"IJU Case Reports","volume":"9 6","pages":""},"PeriodicalIF":0.5,"publicationDate":"2026-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13635683/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149118041","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Near-Obliterative Bulbar Urethral Stricture 12 Years After Artificial Urinary Sphincter Implantation: A Case Report 人工尿道括约肌植入术12年后近闭塞性球尿道狭窄1例。

IF 0.5

IJU Case Reports Pub Date : 2026-10-01 DOI: 10.1002/iju5.70278

Tokiko Niimura, Akio Horiguchi, Shinji Niimura

{"title":"Near-Obliterative Bulbar Urethral Stricture 12 Years After Artificial Urinary Sphincter Implantation: A Case Report","authors":"Tokiko Niimura, Akio Horiguchi, Shinji Niimura","doi":"10.1002/iju5.70278","DOIUrl":"10.1002/iju5.70278","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Introduction</h3>\u0000 \u0000 <p>Artificial urinary sphincter implantation is guideline-supported for post-prostatectomy stress urinary incontinence; however, ultra-late urethral deterioration remains poorly characterized.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Case Presentation</h3>\u0000 \u0000 <p>A 66-year-old man underwent radical retropubic prostatectomy in December 2006, followed by salvage radiotherapy in April 2007. Twelve years after artificial urinary sphincter implantation, intraluminal cuff exposure was incidentally detected on cystoscopy before urethral catheterization for orthopedic surgery. Urinalysis at diagnosis and pre-explant urine culture were unremarkable. Explantation was delayed for 5 months because of patient preference after counseling about infection and urethral injury risks. At explantation, the bulbar urethra showed near-obliterative circumferential collapse with loss of architecture, requiring excision and primary anastomosis urethroplasty (EPA). Obstructive symptoms recurred within 2 months, and recurrent stricture was confirmed endoscopically; suprapubic cystostomy was required at 3 months.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>This case demonstrates ultra-late advanced urethral deterioration beyond focal cuff erosion or simple atrophy. In high-risk radiated patients, explantation may not restore urethral integrity.</p>\u0000 </section>\u0000 </div>","PeriodicalId":52909,"journal":{"name":"IJU Case Reports","volume":"9 6","pages":""},"PeriodicalIF":0.5,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13630474/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149118111","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Curative-Intent Pancreatectomy for Pancreatic Metastasis From Renal Cell Carcinoma 30 Years After Nephrectomy Following Lenvatinib Plus Pembrolizumab Therapy: A Case Report Lenvatinib + Pembrolizumab治疗肾细胞癌切除术后30年胰腺转移的治疗意图胰腺切除术：一例报告。

IF 0.5

IJU Case Reports Pub Date : 2026-09-30 DOI: 10.1002/iju5.70277

Yuta Kaneko, Reo Kotorii, Kaishi Shimizu, Kazuma Miura, Yosuke Nakanishi, Ken Nakamura, Seiya Hattori, Yasuto Yagi, Toru Nishiyama, Tetsuo Momma

{"title":"Curative-Intent Pancreatectomy for Pancreatic Metastasis From Renal Cell Carcinoma 30 Years After Nephrectomy Following Lenvatinib Plus Pembrolizumab Therapy: A Case Report","authors":"Yuta Kaneko, Reo Kotorii, Kaishi Shimizu, Kazuma Miura, Yosuke Nakanishi, Ken Nakamura, Seiya Hattori, Yasuto Yagi, Toru Nishiyama, Tetsuo Momma","doi":"10.1002/iju5.70277","DOIUrl":"10.1002/iju5.70277","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Introduction</h3>\u0000 \u0000 <p>Renal cell carcinoma (RCC) is the most common primary site of pancreatic metastases, and complete resection confers a favorable prognosis. Lenvatinib plus pembrolizumab (LEN + PEM) is standard first-line therapy for advanced RCC; however, induction therapy before resection of pancreatic metastasis has not been reported.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Case Presentation</h3>\u0000 \u0000 <p>A 77-year-old man presented with weight loss, anemia, and elevated inflammatory markers 30 years after radical nephrectomy for RCC. Contrast-enhanced computed tomography revealed a 42-mm pancreatic head mass compressing the inferior vena cava, considered resectable, but high risk. Endoscopic ultrasound-guided fine-needle aspiration confirmed metastatic clear cell RCC. After LEN + PEM induction, the tumor decreased to 29 mm, vena cava compression resolved, and subtotal stomach-preserving pancreaticoduodenectomy achieved R0 resection. The patient remained recurrence-free at 5 months.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>LEN + PEM induction enabled R0 resection of pancreatic RCC metastasis, a site for which this strategy has not previously been reported.</p>\u0000 </section>\u0000 </div>","PeriodicalId":52909,"journal":{"name":"IJU Case Reports","volume":"9 6","pages":""},"PeriodicalIF":0.5,"publicationDate":"2026-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13626972/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149118021","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Metastatic Urachal Carcinoma With Microsatellite Stability and Low Tumor Mutational Burden Achieving a Durable Response to Pembrolizumab After Platinum Failure 具有微卫星稳定性和低肿瘤突变负担的转移性尿路癌在铂治疗失败后对派姆单抗的持久反应

IF 0.5

IJU Case Reports Pub Date : 2026-09-27 DOI: 10.1002/iju5.70276

Fumihiro Ito, Koki Kobayashi, Gaku Hayashi, Shunsuke Kamijo, Takashi Fujita

{"title":"Metastatic Urachal Carcinoma With Microsatellite Stability and Low Tumor Mutational Burden Achieving a Durable Response to Pembrolizumab After Platinum Failure","authors":"Fumihiro Ito, Koki Kobayashi, Gaku Hayashi, Shunsuke Kamijo, Takashi Fujita","doi":"10.1002/iju5.70276","DOIUrl":"10.1002/iju5.70276","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Introduction</h3>\u0000 \u0000 <p>Urachal carcinoma is a rare and aggressive malignancy with no established systemic therapy after platinum failure. Evidence for immune checkpoint inhibitors (ICIs) remains limited, particularly in tumors without established favorable biomarkers such as microsatellite instability-high status or high tumor mutational burden.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Case Presentation</h3>\u0000 \u0000 <p>A 55-year-old woman with metastatic urachal adenocarcinoma progressed after seven cycles of gemcitabine–cisplatin. Pembrolizumab (200 mg every three weeks) was initiated, resulting in a durable partial response lasting over 12 months without immune-related adverse events. Molecular profiling showed microsatellite stability, low tumor mutational burden, and insufficient tissue for (Programmed death-ligand 1) PD-L1 assessment.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>This case demonstrates durable disease control with pembrolizumab in metastatic urachal carcinoma despite microsatellite stability and low tumor mutational burden. These findings suggest the potential efficacy of pembrolizumab in selected patients with platinum-refractory disease.</p>\u0000 </section>\u0000 </div>","PeriodicalId":52909,"journal":{"name":"IJU Case Reports","volume":"9 6","pages":""},"PeriodicalIF":0.5,"publicationDate":"2026-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13616505/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149070604","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Rapidly Progressive Metastatic Sertoli Cell Tumor Associated With an Adenomatous Polyposis Coli Mutation: A Case Report and Literature Review 快速进展的转移性支持细胞肿瘤与腺瘤性大肠息肉病突变相关：1例报告和文献复习。

IF 0.5

IJU Case Reports Pub Date : 2026-09-27 DOI: 10.1002/iju5.70274

Kotaro Obayashi, Mika Terasaki, Hiroya Hasegawa, Hikaru Mikami, Masato Yanagi, Hayato Takeda, Yuki Endo, Yuka Toyama, Ryuji Ohashi, Jun Akatsuka

{"title":"Rapidly Progressive Metastatic Sertoli Cell Tumor Associated With an Adenomatous Polyposis Coli Mutation: A Case Report and Literature Review","authors":"Kotaro Obayashi, Mika Terasaki, Hiroya Hasegawa, Hikaru Mikami, Masato Yanagi, Hayato Takeda, Yuki Endo, Yuka Toyama, Ryuji Ohashi, Jun Akatsuka","doi":"10.1002/iju5.70274","DOIUrl":"10.1002/iju5.70274","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Introduction</h3>\u0000 \u0000 <p>Sertoli cell tumors are rare testicular sex cord-stromal tumors, and clinically malignant behavior is uncommon. We report a rapidly progressive metastatic Sertoli cell tumor associated with an <i>APC</i> mutation.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Case Presentation</h3>\u0000 \u0000 <p>A 27-year-old man with familial adenomatous polyposis (FAP) presented with painless right scrotal enlargement. Computed tomography revealed a right testicular tumor and multiple pulmonary nodules suspicious for metastases. Right high inguinal orchiectomy was performed. Histopathological and immunohistochemical findings, including nuclear β-catenin staining, supported Sertoli cell tumor. Despite bleomycin, etoposide, and cisplatin chemotherapy initially achieving stable disease, metastases progressed after three cycles. Comprehensive genomic profiling identified a pathogenic <i>APC</i> variant likely germline due to his FAP; however, no actionable therapeutic target was identified. Widespread systemic metastases developed. The patient died 11 months post-orchiectomy.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>This case highlights the aggressive potential of <i>APC</i>-associated Sertoli cell tumors, characterized by metastatic presentation, limited response to chemotherapy, and a rapidly fatal course.</p>\u0000 </section>\u0000 </div>","PeriodicalId":52909,"journal":{"name":"IJU Case Reports","volume":"9 6","pages":""},"PeriodicalIF":0.5,"publicationDate":"2026-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13616820/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149076748","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Paraurethral Endometrioid Carcinoma Arising From Ectopic Endometriosis: A Case Report 异位子宫内膜异位症致尿道旁子宫内膜样癌1例。

IF 0.5

IJU Case Reports Pub Date : 2026-09-27 DOI: 10.1002/iju5.70255

Keita Ogasawara, Takashi Tsuyukubo, Mizuki Hisano, Hiromitsu Fujisawa, Shigekatsu Maekawa, Mitsugu Kanehira, Mitsumasa Osakabe, Naoki Yanagawa, Hiroaki Itamochi, Wataru Obara

{"title":"Paraurethral Endometrioid Carcinoma Arising From Ectopic Endometriosis: A Case Report","authors":"Keita Ogasawara, Takashi Tsuyukubo, Mizuki Hisano, Hiromitsu Fujisawa, Shigekatsu Maekawa, Mitsugu Kanehira, Mitsumasa Osakabe, Naoki Yanagawa, Hiroaki Itamochi, Wataru Obara","doi":"10.1002/iju5.70255","DOIUrl":"10.1002/iju5.70255","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Introduction</h3>\u0000 \u0000 <p>Malignant transformation of endometriosis is rare and most commonly involves the ovary; transformation from paraurethral endometriosis is exceedingly rare.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Case Presentation</h3>\u0000 \u0000 <p>A 73-year-old postmenopausal woman with prior ovarian endometrioma presented with dysuria and voiding difficulty. Positron emission tomography–computed tomography revealed a paraurethral mass at the bladder neck, whereas cystoscopy and urine cytology were normal. Transvaginal biopsy demonstrated adenocarcinoma; however, immunohistochemistry did not identify the primary site. After radical cystectomy with urethrectomy and partial vaginectomy, histopathology showed endometrioid carcinoma arising from paraurethral endometriosis with lymph node metastasis. Comprehensive genomic profiling identified alterations consistent with endometrioid/Müllerian-type carcinoma and compatible with endometriosis-associated carcinogenesis. Despite chemotherapy and immune checkpoint inhibitors, the patient died approximately 16 months after diagnosis.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Paraurethral endometrioid carcinoma is exceptionally rare. Accurate diagnosis relies on careful correlation of imaging with histopathology, while comprehensive genomic profiling provides corroborative molecular evidence.</p>\u0000 </section>\u0000 </div>","PeriodicalId":52909,"journal":{"name":"IJU Case Reports","volume":"9 6","pages":""},"PeriodicalIF":0.5,"publicationDate":"2026-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13617304/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149076669","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Penile Strangulation by Four Stainless Steel Rings Requiring Multiple Approaches for Removal: A Case Report 四个不锈钢环勒死阴茎需要多种方法切除：1例报告

IF 0.5

IJU Case Reports Pub Date : 2026-09-26 DOI: 10.1002/iju5.70265

Yoshifumi Miyauchi, Toru Sugihara, Daichi Hirata, Hiroto Kishino, Risako Watanabe, Masayuki Kurokawa, Hayato Hoshina, Eiichiro Takaoka, Satoshi Ando, Tetsuya Fujimura

{"title":"Penile Strangulation by Four Stainless Steel Rings Requiring Multiple Approaches for Removal: A Case Report","authors":"Yoshifumi Miyauchi, Toru Sugihara, Daichi Hirata, Hiroto Kishino, Risako Watanabe, Masayuki Kurokawa, Hayato Hoshina, Eiichiro Takaoka, Satoshi Ando, Tetsuya Fujimura","doi":"10.1002/iju5.70265","DOIUrl":"https://doi.org/10.1002/iju5.70265","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Introduction</h3>\u0000 \u0000 <p>Penile strangulation is a rare urological emergency requiring prompt intervention. Stainless steel rings may resist conventional cutters because of their rigidity.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Case Presentation</h3>\u0000 \u0000 <p>A 62-year-old man presented with severe penile pain after applying four stainless steel rings to treat phimosis. One ring was trapped at the coronal sulcus and three at the penile base. The glans was congested with partial blistering. Initial attempts using the string method and manual ring cutters failed. Aspiration of approximately 10 mL of blood from the glans allowed removal of the distal ring. The remaining rings required general anesthesia, corporal blood aspiration, temporary penile-base compression, partial cutting of one ring, and manual decompression. All rings were removed within approximately 6 h after application. No clinical evidence of urethral injury was found, and no sensory disturbance was noted.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>A stepwise approach may be required for penile strangulation caused by multiple stainless steel rings.</p>\u0000 </section>\u0000 </div>","PeriodicalId":52909,"journal":{"name":"IJU Case Reports","volume":"9 6","pages":""},"PeriodicalIF":0.5,"publicationDate":"2026-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/iju5.70265","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149048486","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pseudoprogression During Enfortumab Vedotin Plus Pembrolizumab Therapy in Muscle-Invasive Bladder Cancer Achieving Pathological Complete Response: A Case Report 在肌侵性膀胱癌中，强制维多汀联合派姆单抗治疗获得病理完全缓解的假进展：1例报告

IF 0.5

IJU Case Reports Pub Date : 2026-09-25 DOI: 10.1002/iju5.70270

Yosuke Nakanishi, Yohei Kawashima, Masanao Shinohara, Kazuhisa Hagiwara, Kohei Inui, Kazue Ogawa, Daiji Fujimori, Shingo Moriyama, Hanako Oba, Sato Satoshi

{"title":"Pseudoprogression During Enfortumab Vedotin Plus Pembrolizumab Therapy in Muscle-Invasive Bladder Cancer Achieving Pathological Complete Response: A Case Report","authors":"Yosuke Nakanishi, Yohei Kawashima, Masanao Shinohara, Kazuhisa Hagiwara, Kohei Inui, Kazue Ogawa, Daiji Fujimori, Shingo Moriyama, Hanako Oba, Sato Satoshi","doi":"10.1002/iju5.70270","DOIUrl":"https://doi.org/10.1002/iju5.70270","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Introduction</h3>\u0000 \u0000 <p>Enfortumab vedotin plus pembrolizumab has emerged as a standard first-line therapy for advanced urothelial carcinoma (UC). However, pseudoprogression during this combination remains poorly characterized.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Case Presentation</h3>\u0000 \u0000 <p>A 71-year-old man with muscle-invasive bladder cancer and lymph node metastasis received enfortumab vedotin plus pembrolizumab. During treatment, imaging suggested tumor progression with new hydronephrosis. Repeat transurethral resection revealed no viable tumor. Because of persistent symptoms, robot-assisted radical cystectomy was performed. Histopathological examination demonstrated no residual tumor cells, indicating pathological complete response (ypT0N0), with prominent CD8- and CD4-positive T-cell infiltration and minimal CD20-positive B-cell infiltration.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>This case suggests that pseudoprogression may occur during enfortumab vedotin plus pembrolizumab therapy. Careful interpretation of radiological findings is essential to avoid premature treatment discontinuation.</p>\u0000 </section>\u0000 </div>","PeriodicalId":52909,"journal":{"name":"IJU Case Reports","volume":"9 6","pages":""},"PeriodicalIF":0.5,"publicationDate":"2026-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/iju5.70270","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149048283","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Definitive Histologic Diagnosis of Bone Marrow Carcinomatosis Followed by Dose-Adjusted Chemotherapy in Metastatic Urothelial Carcinoma: A Case Report. 转移性尿路上皮癌骨髓癌伴剂量调整化疗的明确组织学诊断：1例报告。

IF 0.5

IJU Case Reports Pub Date : 2026-09-20 eCollection Date: 2026-09-01 DOI: 10.1002/iju5.70261

Shohei Yamaki, Yuki Endo, Jun Akatsuka, Hikaru Mikami, Shunsuke Ikuma, Kotaro Obayashi, Masato Yanagi, Yuka Toyama, Go Kimura, Yukihiro Kondo

{"title":"Definitive Histologic Diagnosis of Bone Marrow Carcinomatosis Followed by Dose-Adjusted Chemotherapy in Metastatic Urothelial Carcinoma: A Case Report.","authors":"Shohei Yamaki, Yuki Endo, Jun Akatsuka, Hikaru Mikami, Shunsuke Ikuma, Kotaro Obayashi, Masato Yanagi, Yuka Toyama, Go Kimura, Yukihiro Kondo","doi":"10.1002/iju5.70261","DOIUrl":"10.1002/iju5.70261","url":null,"abstract":"<p><strong>Introduction: </strong>Bone marrow carcinomatosis (BMC) is a rare manifestation of metastatic urothelial carcinoma (UC) that may mimic hematologic disease and cause severe cytopenia, diagnostic difficulty, and rapid clinical deterioration.</p><p><strong>Case presentation: </strong>A 65-year-old man presented with back pain, thrombocytopenia, and leukoerythroblastosis. Bone marrow aspiration resulted in a dry tap, but biopsy revealed diffuse carcinoma-cell infiltration consistent with UC, establishing BMC as the cause of marrow failure. Because of profound marrow dysfunction, reduced-dose gemcitabine and cisplatin chemotherapy was initiated, leading to hematologic recovery and radiologic improvement. The patient subsequently received standard-dose chemotherapy and avelumab maintenance and survived for 12.4 months after diagnosis.</p><p><strong>Conclusion: </strong>Histologic confirmation is essential to distinguish UC-related BMC from primary hematologic disease and may support individualized systemic treatment in carefully selected patients.</p>","PeriodicalId":52909,"journal":{"name":"IJU Case Reports","volume":"9 5","pages":"e70261"},"PeriodicalIF":0.5,"publicationDate":"2026-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13590240/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149018798","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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