IJU Case Reports最新文献

{"title":"A Case of Hydronephrosis Associated With Horseshoe Kidney Successfully Treated by Retroperitoneoscopic Isthmusectomy Without Pyeloplasty.","authors":"Rento Ito, Renpei Kato, Ayato Ito, Ei Shiomi, Masakazu Abe, Daiki Ikarashi, Shigekatsu Maekawa, Mitsugu Kanehira, Wataru Obara","doi":"10.1002/iju5.70263","DOIUrl":"10.1002/iju5.70263","url":null,"abstract":"<p><p>Pyeloplasty is generally considered the standard treatment for congenital hydronephrosis associated with horseshoe kidney. We report a case successfully managed mainly by retroperitoneoscopic isthmusectomy without pyeloplasty.</p><p><strong>Case presentation: </strong>A 23-year-old man presented with left flank-to-back pain. CT revealed horseshoe kidney and left hydronephrosis. The left ureteropelvic junction was considered compressed by renal malrotation, causing obstruction. Retroperitoneoscopic isthmusectomy was performed using an articulating endoscopic linear stapler, resulting in hydronephrosis improvement.</p><p><strong>Conclusion: </strong>In selected patients with horseshoe kidney in whom congenital hydronephrosis is primarily caused by renal malrotation associated with isthmic fusion and aberrant vessel involvement appears limited, treatment mainly consisting of retroperitoneoscopic isthmusectomy using an articulating stapling device may be effective.</p>","PeriodicalId":52909,"journal":{"name":"IJU Case Reports","volume":"9 5","pages":"e70263"},"PeriodicalIF":0.5,"publicationDate":"2026-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13591112/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149018757","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hemorrhagic Cystitis With Bladder Tamponade Associated With <i>Morganella morganii</i> in an Older Patient Without Recent Catheterization.","authors":"Yoshihiro Kawaguchi","doi":"10.1002/iju5.70271","DOIUrl":"10.1002/iju5.70271","url":null,"abstract":"<p><strong>Introduction: </strong><i>Morganella morganii</i> is an uncommon cause of urinary tract infection, typically associated with catheterization or underlying diseases.</p><p><strong>Case presentation: </strong>I report a rare case of severe hemorrhagic cystitis with massive intravesical clot retention in a 90-year-old woman without recent catheterization or diabetes mellitus. Ultrasonography revealed a large intravesical hematoma requiring clot evacuation. Urine culture yielded <i>M. morganii</i> as the sole organism. The patient improved following antimicrobial therapy and supportive management.</p><p><strong>Conclusion: </strong>This case suggests that <i>M. morganii</i>-associated urinary tract infection may present with severe hemorrhagic cystitis even in the absence of catheterization. Although the underlying mechanism remains uncertain, urease-mediated mucosal injury may have contributed to the clinical presentation.</p>","PeriodicalId":52909,"journal":{"name":"IJU Case Reports","volume":"9 5","pages":"e70271"},"PeriodicalIF":0.5,"publicationDate":"2026-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13591110/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149018755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial Comment to Paraurethral Endometrioid Carcinoma Arising From Ectopic Endometriosis: A Case Report.","authors":"Yosuke Tarumi, Taisuke Mori","doi":"10.1002/iju5.70269","DOIUrl":"10.1002/iju5.70269","url":null,"abstract":"","PeriodicalId":52909,"journal":{"name":"IJU Case Reports","volume":"9 5","pages":"e70269"},"PeriodicalIF":0.5,"publicationDate":"2026-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13590200/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149013150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Germline <i>BRCA2</i> Pathogenic Variant Identified by Multigene Panel Testing in Upper Tract Urothelial Carcinoma.","authors":"Kazuna Matsuo, Kenji Zennami, Mii Yoshida, Miki Hatakeyama, Maki Morikawa, Kyosuke Hattori, Shusuke Akamatsu","doi":"10.1002/iju5.70268","DOIUrl":"10.1002/iju5.70268","url":null,"abstract":"<p><strong>Introduction: </strong>Upper tract urothelial carcinoma (UTUC) is associated with Lynch syndrome; however, increasing evidence suggests broader genetic heterogeneity. Although multigene panel testing (MGPT) is increasingly adopted internationally, syndrome-specific genetic testing (SSGT) remains predominant in Japan, potentially limiting detection of non-Lynch hereditary variants. Appropriate selection for expanded germline evaluation remains challenging.</p><p><strong>Case presentation: </strong>A 41-year-old man with locally advanced UTUC underwent neoadjuvant chemotherapy followed by surgery. His family history included gastrointestinal and breast cancers and did not fit a single hereditary syndrome. Although SSGT was initially considered for Lynch syndrome, germline MGPT was performed after genetic counseling. MGPT identified a germline pathogenic <i>BRCA2</i> frameshift variant, with no mismatch repair gene variants detected.</p><p><strong>Conclusion: </strong>This case highlights the value of comprehensive germline evaluation in selected UTUC patients. Urologists should recognize atypical/mixed family histories and consider early genetic referral. Selective MGPT may improve identification of clinically actionable germline variants.</p>","PeriodicalId":52909,"journal":{"name":"IJU Case Reports","volume":"9 5","pages":"e70268"},"PeriodicalIF":0.5,"publicationDate":"2026-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13583922/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148992288","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Case of a Rare Testicular Tumor With Synchronous Malignancy.","authors":"Leslie Hoyt, Oran Andrew Trimble, Jared Zopp, Kody Heubach, Michael G Stencel","doi":"10.1002/iju5.70256","DOIUrl":"10.1002/iju5.70256","url":null,"abstract":"<p><strong>Introduction: </strong>Leydig cell tumors are an uncommon malignancy accounting for 1%-2% of all testicular tumors. Synchronous, non-testicular malignancy is a rare finding.</p><p><strong>Case presentation: </strong>A 51-year-old male presented with left testicular pain, and a scrotal ultrasound revealed a testicular mass. Radical orchiectomy histology demonstrated a Leydig cell tumor. Staging imaging depicted a large anterior mediastinal mass, with resection demonstrating a thymoma.</p><p><strong>Conclusion: </strong>With the increasing incidence of testicular cancer, it is important to recognize the disease's signs and symptoms. Leydig cell cancer has the potential for metastatic disease, and staging imaging is imperative, with consideration for potential metastatic disease versus synchronous malignancy.</p>","PeriodicalId":52909,"journal":{"name":"IJU Case Reports","volume":"9 5","pages":"e70256"},"PeriodicalIF":0.5,"publicationDate":"2026-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13575973/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148978826","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preoperative Metyrosine Administration for Bilateral Pheochromocytomas Following Pheochromocytoma Crisis: A Case Report","authors":"Nanaho Demizu,&nbsp;Daiji Takamoto,&nbsp;Tosihkazu Koike,&nbsp;Takeaki Noguchi,&nbsp;Masanobu Yamazaki,&nbsp;Akihito Hashizume,&nbsp;Daiki Ueno,&nbsp;Takashi Kawahara,&nbsp;Junichi Teranishi,&nbsp;Kazuhide Makiyama","doi":"10.1002/iju5.70267","DOIUrl":"https://doi.org/10.1002/iju5.70267","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Introduction</h3>\u0000 \u0000 <p>Pheochromocytoma crisis complicated by catecholamine-induced cardiomyopathy is a life-threatening condition requiring careful preoperative management. Although metyrosine has recently been approved in Japan for the perioperative management of pheochromocytoma, clinical experience remains limited.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Case Presentation</h3>\u0000 \u0000 <p>A 46-year-old man presented with pheochromocytoma crisis complicated by reverse Takotsubo cardiomyopathy and was diagnosed with bilateral pheochromocytomas. Given the preceding life-threatening crisis, severe cardiac dysfunction, marked catecholamine excess, and bilateral disease, he was considered at high perioperative risk. Metyrosine was added to conventional α-adrenergic blockade before one-stage bilateral adrenalectomy. Metyrosine was well tolerated, and total urinary metanephrine decreased by approximately 76% without symptomatic hypotension. Although intraoperative blood pressure fluctuations still occurred, bilateral adrenalectomy was completed successfully.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>This case supports the feasibility of preoperative metyrosine administration in a high-risk patient. Although its effect on intraoperative hemodynamic stability remains uncertain, metyrosine may be considered as an adjunct to conventional α-adrenergic blockade in carefully selected patients.</p>\u0000 </section>\u0000 </div>","PeriodicalId":52909,"journal":{"name":"IJU Case Reports","volume":"9 5","pages":""},"PeriodicalIF":0.5,"publicationDate":"2026-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/iju5.70267","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148942925","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preoperative Diagnosis of Bladder Paraganglioma Followed by Robot-Assisted Partial Cystectomy: A Case Report.","authors":"Kimiaki Takagi, Yuka Maekawa, Toyohiro Yamada, Hiroyuki Ozawa, Kenichi Minoshima","doi":"10.1002/iju5.70260","DOIUrl":"10.1002/iju5.70260","url":null,"abstract":"<p><strong>Introduction: </strong>Bladder paraganglioma is a rare neuroendocrine tumor for which accurate preoperative diagnosis is important because tumor manipulation may provoke catecholamine-related hemodynamic instability.</p><p><strong>Case presentation: </strong>A 58-year-old man presented with hematuria. Cystoscopy revealed a submucosal bladder tumor. Contrast-enhanced computed tomography and magnetic resonance imaging demonstrated a 2-cm bladder wall mass with characteristic findings suggestive of paraganglioma. Although catecholamine levels were within normal limits and no adrenergic symptoms were present, metaiodobenzylguanidine scintigraphy showed uptake in the lesion, supporting the diagnosis. To avoid the potential risk associated with TUR, preoperative alpha-adrenergic blockade with doxazosin was administered, followed by robot-assisted partial cystectomy. No significant intraoperative hemodynamic instability occurred. Histopathological examination confirmed paraganglioma.</p><p><strong>Conclusion: </strong>Recognition of characteristic imaging findings may facilitate preoperative diagnosis and safe surgical management of bladder paraganglioma. Robot-assisted partial cystectomy was a feasible minimally invasive treatment option.</p>","PeriodicalId":52909,"journal":{"name":"IJU Case Reports","volume":"9 5","pages":"e70260"},"PeriodicalIF":0.5,"publicationDate":"2026-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13561852/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148957080","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Belzutifan-Associated Reversible Heart Failure With Preserved Ejection Fraction in Metastatic Renal Cell Carcinoma.","authors":"Hikaru Kimura, Shigeaki Nakazawa, Yu Ishizuya, Yoshiyuki Yamamoto, Kentaro Takezawa, Taigo Kato, Koji Hatano, Yoichi Kakuta, Atsunari Kawashima, Norio Nonomura","doi":"10.1002/iju5.70266","DOIUrl":"10.1002/iju5.70266","url":null,"abstract":"<p><strong>Background: </strong>Belzutifan, a hypoxia-inducible factor 2α (HIF-2α) inhibitor, is effective for metastatic renal cell carcinoma (mRCC), although its cardiovascular safety profile remains unclear.</p><p><strong>Case presentation: </strong>A 52-year-old woman with mRCC developed progressive dyspnea and a 6.7-kg weight gain 27 days after initiating belzutifan as third-line therapy. Chest radiography revealed marked cardiomegaly (cardiothoracic ratio 63.4%), and echocardiography showed preserved left ventricular ejection fraction (67.1%) with mild diastolic dysfunction and findings consistent with congestive heart failure. Intensive diuretic therapy led to rapid improvement, with the cardiothoracic ratio decreasing to 42.7% and NT-proBNP declining from 912 to 203 pg/mL. After belzutifan rechallenge at a reduced dose, NT-proBNP increased again and subsequently normalized after discontinuation due to disease progression.</p><p><strong>Conclusion: </strong>Belzutifan may be associated with reversible congestive heart failure with preserved ejection fraction. Cardiac evaluation should be considered in patients who develop dyspnea during belzutifan therapy.</p>","PeriodicalId":52909,"journal":{"name":"IJU Case Reports","volume":"9 5","pages":"e70266"},"PeriodicalIF":0.5,"publicationDate":"2026-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13560926/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148931877","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pathology-Driven Diagnosis of Hereditary Leiomyomatosis and Renal Cell Carcinoma: A Clinicopathological and Genetic Analysis of Three Cases.","authors":"Tomoko Uchiyama, Shunsuke Okazaki, Sayaka Ando, Maiko Takeda, Makito Miyake, Akihiko Yoshizawa","doi":"10.1002/iju5.70259","DOIUrl":"10.1002/iju5.70259","url":null,"abstract":"<p><strong>Introduction: </strong>Hereditary leiomyomatosis and renal cell carcinoma (HLRCC) is an autosomal dominant disorder characterized by three principal clinical features: cutaneous leiomyomas (cLMs), uterine leiomyomas, and fumarate hydratase (FH)-deficient renal cell carcinoma (RCC). Although 200-300 families have been identified worldwide, its true prevalence remains unknown.</p><p><strong>Case presentations: </strong>We present three HLRCC cases in which detailed pathological examination raised initial clinical suspicion. Cases 1 and 2 presented with advanced RCC exhibiting diverse morphologies. Case 3 presented with multiple painful cLMs and no renal tumors. All three cases were confirmed via germline genetic testing, which revealed distinct <i>FH</i> mutations.</p><p><strong>Conclusions: </strong>These cases underscore the importance of careful histopathological and immunohistochemical evaluation for the diagnosis of HLRCC. Multidisciplinary discussion integrating clinical, radiological, pathological, and genetic findings is essential for identifying affected families and initiating timely surveillance.</p>","PeriodicalId":52909,"journal":{"name":"IJU Case Reports","volume":"9 5","pages":"e70259"},"PeriodicalIF":0.5,"publicationDate":"2026-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13557843/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148921745","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Robot-Assisted Radical Prostatectomy in a Patient With Zinner Syndrome: A Case Report.","authors":"Junji Yatsuda, Takashi Watanabe, Narumi Harada, Hidekazu Nishizawa, Toshiki Anami, Ryoma Kurahashi, Takanobu Motoshima, Masaya Baba, Yoji Murakami, Tomomi Kamba","doi":"10.1002/iju5.70248","DOIUrl":"10.1002/iju5.70248","url":null,"abstract":"<p><strong>Introduction: </strong>Zinner syndrome is a rare congenital urogenital anomaly characterized by seminal vesicle cysts, ejaculatory duct obstruction, and ipsilateral renal agenesis. Surgical treatment for prostate cancer in this setting has been reported in only 2 previous cases.</p><p><strong>Case presentation: </strong>A 67-year-old man with congenital left renal agenesis presented with voiding dysfunction. Magnetic resonance imaging identified a 6-cm seminal vesicle cyst and a Prostate Imaging-Reporting and Data System category 4 prostatic lesion. Serum prostate-specific antigen was 1.3 ng/mL. Prostate biopsy revealed Gleason score 3 + 3 = 6 adenocarcinoma. Robot-assisted laparoscopic radical prostatectomy was performed using the posterior approach. Despite anatomical complexity and adhesions, the procedure was completed safely. Postoperative prostate-specific antigen became undetectable, and the patient achieved pad-free continence at 6 months.</p><p><strong>Conclusion: </strong>Robot-assisted laparoscopic radical prostatectomy was safely performed for prostate cancer arising in Zinner syndrome. Robot-assisted surgery is particularly valuable for complex anatomy caused by congenital anomalies.</p>","PeriodicalId":52909,"journal":{"name":"IJU Case Reports","volume":"9 5","pages":"e70248"},"PeriodicalIF":0.5,"publicationDate":"2026-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13549920/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148914363","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}